Journal of Investigative Surgery最新文献

{"title":"Comparison of Perioperative Outcomes Between V-NOTES and Total Laparoscopic Hysterectomy: A Retrospective Analysis.","authors":"Serkan Sarikaya, Mine Islimye Taskin, Tuba Bozhuyuk Sahin, Gurhan Guney, Mehmet Kececioglu, Selim Afsar, Sergul Selvi Guney","doi":"10.1080/08941939.2025.2488131","DOIUrl":"https://doi.org/10.1080/08941939.2025.2488131","url":null,"abstract":"<p><strong>Background: </strong>This retrospective study compared the perioperative outcomes of vaginal natural orifice transluminal endoscopic surgery (V-NOTES) and total laparoscopic hysterectomy (TLH).</p><p><strong>Materials and methods: </strong>This analysis included 62 patients: 32 underwent V-NOTES and 30 underwent TLH. Patients with a body mass index (BMI) >30, a history of endometriosis, multiple cesarean sections, or a uterine size >12 week were excluded. Perioperative data-including visual analog scale (VAS) scores, analgesia use, mobilization time, hospitalization duration, and hemoglobin deficit-were compared using independent sample <i>t</i> tests and Mann-Whitney <i>U</i> tests.</p><p><strong>Results: </strong>There were no significant differences in BMI, number of pregnancies, or operative time (<i>p</i> > 0.05). VAS scores at 6 and 24 h were significantly lower in the V-NOTES group (<i>p</i> < 0.001). Patients in the V-NOTES group required less analgesia, had shorter mobilization and hospitalization periods, and returned to daily activities sooner (<i>p</i> < 0.001). However, the hemoglobin deficit was higher in the V-NOTES group (1.85 g/dl vs. 0.7 g/dl, <i>p</i> < 0.001). The neutrophil-to-lymphocyte ratio (NLR) was lower in the V-NOTES group (<i>p</i> = 0.013), whereas the platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) did not differ significantly between the two groups.</p><p><strong>Conclusion: </strong>V-NOTES offers advantages such as reduced postoperative pain and faster recovery compared to TLH. The higher hemoglobin deficit observed with V-NOTES may be related to the surgeon's experience. Further randomized studies are warranted to validate these findings and define appropriate patient selection criteria.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2488131"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Immunophenotype in the Diagnosis of Mesenteric Ischemia in Rats: An Experimental Study.","authors":"Aydin Eray Tufan, Pinar Yazici, Elif Tufan, Anil Akkus, Ozlem Ton Eryilmaz, Ufuk Oguz Idiz, Fatih Ozcelik, Cemal Kaya","doi":"10.1080/08941939.2025.2506621","DOIUrl":"https://doi.org/10.1080/08941939.2025.2506621","url":null,"abstract":"<p><strong>Aim: </strong>Acute mesenteric ischemia (AMeI) is a mortal intestinal emergency with vascular origin. Mortality and morbidity can be prevented by early diagnosis and prompt intervention. In this study, an AMeI rat model was established to investigate the efficacy of immunophenotyping to reveal a biomarker of AMeI.</p><p><strong>Material and methods: </strong>Twenty-one adult female Sprague-Dawley rats were divided into three groups. In the Sham group (Group 1), after laparotomy, the superior mesenteric artery (SMA) was found, and no further intervention was performed. In the ischemia-reperfusion group (Group 2), SMA was occluded only for 45 min whereas in Group 3(ischemia group), SMA was permanently occluded. Peripheral blood mononuclear cells were quantified for T cell subsets using flow cytometry.</p><p><strong>Results: </strong>Regarding hematological biomarkers, only mean platelet volume (MPV) values in Group 3 were significantly higher compared to Group 2 (<i>p = 0.0134</i>). Platelet lymphocyte ratio values and D dimer levels were higher in Group 3 compared to the sham Group (<i>p = 0.0219</i>, <i>p = 0.0012</i>; respectively). No statistically significant difference was detected between groups considering the subtypes of lymphocytes surface antigens. However, in the correlation matrix analysis, significant correlations were observed between Chiu histopathological stage of ileum mucosa and CD45+ and CD4 + CD8 + [Spearman <i>r</i> = 0.571 (95% CI: 0.172-0.809) <i>p = 0.0068</i> and Spearman <i>r</i> = 0.4908 (95% CI: 0.061-0.767) <i>p = 0.0239</i>]. Likewise, a positive linear correlation was found between MPV, D-dimer and Chiu score [Spearman <i>r</i> = 0.5155 (95% CI: 0.094 - 0.780; <i>p</i> = 0.0168) and <i>r</i> = 0.7828 (95% CI: 0.520 - 0.910; <i>p</i> < 0.0001), respectively].</p><p><strong>Conclusion: </strong>Blood levels of CD45+ and CD4 + CD8+ were proved to be higher in study groups. Remarkable positive linear correlation with histopathological changes may also play a predictive role to investigate the role of these markers in larger samples.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2506621"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Nomogram for Preoperative Prediction of Early Postoperative Mortality in Patients Undergoing Surgical Revascularization for Acute Myocardial Infarction.","authors":"Yanyi Liu, Ning Yang, Ju Mei, Chao Wang, Zhengyu Lin, Yang Zou, Shi Qiu, Fangbao Ding, Zhaolei Jiang","doi":"10.1080/08941939.2025.2545340","DOIUrl":"https://doi.org/10.1080/08941939.2025.2545340","url":null,"abstract":"<p><strong>Background: </strong>Despite advancements in surgical techniques, coronary artery bypass grafting (CABG) for patients with recent acute myocardial infarction (AMI) remains associated with relatively high mortality. Risk prediction in these patients is essential. The aim of this study was to develop a nomogram model to predict the early postoperative mortality in patients undergoing surgical revascularization for AMI based on preoperative clinical features.</p><p><strong>Method: </strong>We retrospectively analyzed the clinical data of 332 consecutive patients who underwent CABG for AMI at our center from January 2018 to December 2024. Independent predictors for early postoperative death were identified by using univariate and multivariate logistic regression models. A nomogram prediction model was developed based on all independent predictors. Discriminative ability, calibration, and clinical utility of the model were evaluated. Internal validation was performed utilizing the bootstrapping method.</p><p><strong>Results: </strong>The nomogram model incorporated seven independent predictors: preoperative cardiac arrest, previous history of myocardial infarction(MI), left ventricular ejection fraction (LVEF) <50%, MI-to-CABG interval ≤ 3d, age > 75 years, serum albumin < 35g/L and serum creatinine > 2.0 mg/dL. The model achieved good discrimination with an area under the receiver operating characteristic curve (AUC) of 0.905 (95% CI: 0.832-0.978), and showed well-fitted calibration curves with Hosmer-Lemeshow test results (<i>χ</i>² = 3.437, <i>p</i> = 0.944). Decision curve analysis indicated that the model can provide greater clinical net benefits compared to \"operate-all\" or \"operate-none\" strategies in a wide range of threshold probability.</p><p><strong>Conclusions: </strong>The novel nomogram model combining seven preoperative clinical predictors can provide an accurate preoperative estimation of early postoperative death for AMI patients undergoing surgical revascularization, with satisfactory discrimination and calibration.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2545340"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Benefit of Radical Prostatectomy in Newly Diagnosed Metastatic Prostate Cancer Varies by PSA Level and Site of Metastasis.","authors":"Xin Zhang, Sen Pan, Wei Sun, Chuanlin Wang","doi":"10.1080/08941939.2025.2534579","DOIUrl":"https://doi.org/10.1080/08941939.2025.2534579","url":null,"abstract":"<p><strong>Background: </strong>In patients with newly diagnosed metastatic prostate cancer (mPCa), the appropriate population for radical prostatectomy (RP) remains unclear.</p><p><strong>Patients and methods: </strong>Newly diagnosed mPCa patients were identified from the Surveillance, Epidemiology, and End Results (SEER) database and divided into no local therapy (NLT) and RP groups. Propensity score matching (PSM) was used to balance baseline characteristics. Kaplan-Meier curves were used to estimate cancer-specific survival (CSS).</p><p><strong>Results: </strong>A total of 9,215 patients were included, with 8,844 receiving NLT and 371 undergoing RP. After PSM, 321 patients in each group were included. RP was associated with significantly better CSS (HR = 0.38, 95% CI, 0.27-0.54, <i>p</i> < 0.001). Subgroup analyses showed consistent survival benefit of RP except in patients with M1c disease (HR = 0.55, 95% CI, 0.21-1.46, <i>p</i> = 0.229) or PSA ≥60 ng/ml (HR = 1.19, 95% CI, 0.53-2.86, <i>p</i> = 0.673). An exploratory classification defined low tumor burden as PSA <60 ng/ml and M1a/M1b disease, and high tumor burden as PSA ≥60 ng/ml or M1c. RP significantly improved CSS in the low tumor burden group (HR = 0.30, 95% CI, 0.20-0.46, <i>p</i> < 0.001), but not in the high tumor burden group (HR = 0.98, 95% CI, 0.53-1.84, <i>p</i> = 0.961).</p><p><strong>Conclusion: </strong>In patients with newly diagnosed mPCa, the survival benefit of RP varies with tumor burden.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2534579"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Study of the circRNA_0006393/miR-375/IGFBP4 Axis in Fracture Healing Associated with Male Idiopathic Osteoporosis.","authors":"Xiaoyi Guo, Jie Xu, Lin Chen, He Huang, Zewei Gao, Xijia Jiang","doi":"10.1080/08941939.2025.2535522","DOIUrl":"10.1080/08941939.2025.2535522","url":null,"abstract":"<p><strong>Background: </strong>CircRNA_0006393 was reported to promote osteogenesis in glucocorticoid-induced osteoporosis, but its role in male idiopathic osteoporosis (MIO) has not been revealed.</p><p><strong>Aim: </strong>To explore circRNA_0006393's role in MIO.</p><p><strong>Methods: </strong>Dual-luciferase reporter assay was performed to notarize the direct connection among circRNA_0006393, miR-375 and IGFBP4. Their value as biomarkers of MIO was confirmed by the ROC curve. The osteogenic induction was measured by detecting the ALP activity/expression and OCN/RUNX2 expression. The osteoclastic induction was evaluated by detecting TRAP activity and bone resorption capacity. The concentration of Fe²⁺, GSH, and ROS was detected to evaluate ferroptosis.</p><p><strong>Results: </strong>MiR-375 was overexpressed in MIO patients, while circRNA_000639 and IGFBP4 presented low expression. CircRNA_0006393 promoted IGFBP4 expression by sponging miR-375. The AUC of circulating circRNA_0006393, miR-375, IGFBP4, or their combination in distinguishing unhealing and healing individuals with MIO-related fracture was 0.840, 0.851, 0.743, 0.960, respectively. CircRNA_0006393 reduced the ferroptosis process by regulating miR-375/IGFBP4. Iron overload inhibited the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSC) and promoted the osteoclastic differentiation of bone marrow-derived macrophage cells (BMMC).</p><p><strong>Conclusion: </strong>CircRNA_000639 inhibited ferroptosis by regulating the miR-375/IGFBP4 axis, thereby promoting osteogenesis and hindering osteoclastic differentiation, and they are the biomarkers for MIO-related fracture healing.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2535522"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Uterine Septum be an Etiological Factor for Dysmenorrhea in Primary Infertile Patients?","authors":"Batuhan Turgay, Yavuz Emre Şükür, Batuhan Özmen, Murat Sönmezer, Bülent Berker, Ruşen Aytaç, Cem Somer Atabekoğlu","doi":"10.1080/08941939.2025.2542846","DOIUrl":"https://doi.org/10.1080/08941939.2025.2542846","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study is to investigate the association between uterine septum and dysmenorrhea and to assess the effect of hysteroscopic resection on the severity of dysmenorrhea.</p><p><strong>Method: </strong>The study group (<i>N</i>:50) consisted of women who underwent hysteroscopic septum resection, and the control group (<i>N</i>:74) consisted of women who underwent diagnostic hysteroscopy and had no significant uterine pathologies. The presence and severity of dysmenorrhea were assessed by using a 10 cm visual analog scale (VAS). The main outcome measurement was the difference between preoperative and postoperative dysmenorrhea VAS scores.</p><p><strong>Results: </strong>The mean preoperative VAS score was significantly higher in the study group than the control group (4.6 ± 2.6 cm vs. 3.2 ± 2.4 cm, respectively; <i>p</i> = 0.023). The rates of moderate to severe dysmenorrhea were 52% in the study group and 17.5% in the control group (<i>p</i> = 0.025). The mean dysmenorrhea VAS score of women with uterine septum was significantly improved in postoperative 3rd and 6th months when compared to the preoperative period (3.4 ± 2.4 cm and 3.1 ± 2.3 vs. 4.6 ± 2.6 cm, respectively; <i>P</i>1 = 0.025 and <i>P</i>2 = 0.003).</p><p><strong>Conclusions: </strong>Uterine septum seems to be an etiological factor for dysmenorrhea. Although there is no significant relationship between septum depth and dysmenorrhea severity, hysteroscopic resection of the uterine septum improves dysmenorrhea in the infertile study group.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2542846"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antrum Preservation Versus Antrum Resection in Laparoscopic Sleeve Gastrectomy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Chao Niu, Bo Li, Hongwei Wan, Wendi Jin, Zhiping Zhang, Wanfu Zhang, Xiaogang Li","doi":"10.1080/08941939.2025.2477099","DOIUrl":"10.1080/08941939.2025.2477099","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the effects of laparoscopic sleeve gastrectomy (LSG) with antrum preservation (AP) and antrum resection (AR) on weight loss and postoperative complications.</p><p><strong>Methods: </strong>A meta-analysis of randomized controlled trials (RCTs) followed PRISMA guidelines. The databases searched included PubMed, Web of Science, Embase Medline, and the Cochrane Library up to October 2022. Extracted data included operation time, hospital stay, excess weight loss, total weight loss, body mass index (BMI), weight, and complications.</p><p><strong>Results: </strong>Eleven RCTs were included with 843 patients: 422 with AR and 421 with AP. The AR group exhibited higher total weight loss at 3 months (<i>p</i> = 0.02), 6 months (<i>p</i> < 0.001), and 1 year (<i>p</i> < 0.001) postoperatively. They also showed greater excess weight loss at 6 months (<i>p</i> < 0.001), 1 year (<i>p</i> < 0.001), and 2 years (<i>p</i> = 0.03). BMI reduction was more significant in the AR group at 3 (<i>p</i> = 0.007) and 6 months (<i>p</i> < 0.001). The AR group lost weight more rapidly at 3 months (<i>p</i> = 0.05), 6 months (<i>p</i> = 0.04), and 1 year (<i>p</i> < 0.001). No significant differences were found in operation time, hospital stay, bleeding, staple line disruption, Clavien-Dindo complications, or remission rates of diabetes, hypertension, arthritis/back pain, hyperlipidemia, or gastroesophageal reflux disease (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>LSG with AR offers better short-term weight loss than AP without increasing surgical complications, but the long-term effects and complications need further investigation in larger RCTs.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2477099"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Our Results of Hyperbaric Oxygen or Pars Plana Vitrectomy in Central Retinal Artery Obstruction.","authors":"S Doğruya, B T Altınbay, Ö C Kayıkçıoğlu, M Altınışık, E Kurt, Ö R Kayıkçıoğlu","doi":"10.1080/08941939.2025.2503811","DOIUrl":"https://doi.org/10.1080/08941939.2025.2503811","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to present the results of patients with central retinal artery obstruction (CRAO) who underwent 23-G pars plana vitrectomy (PPV) or hyperbaric oxygen therapy (HBOT) following emergency medical therapy.</p><p><strong>Method: </strong>The files of 15 patients with acute CRAO were retrospectively reviewed. Comprehensive ophthalmological examinations of the patients were performed. Seven patients received HBOT, and eight patients received PPV following emergency medical treatment. The patient's demographic characteristics, initial and final visual acuity, intraocular pressure were examined.</p><p><strong>Results: </strong>The mean age was 65.2 ± 9.9 years in the hyperbaric oxygen therapy group and 58.7 ± 12.8 years in the PPV group. There was no statistically significant difference between the group receiving HBOT and the group undergoing PPV regarding age, initial visual acuity, final visual acuity, visual gain difference between visual acuity improvements, intraocular pressure, and time lag for treatment initiation (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Although some improvement in visual acuity was observed in both treatment groups - particularly in patients who underwent PPV - this change did not reach statistical significance. Therefore, despite timely intervention, the overall visual outcomes in CRAO remain poor.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2503811"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Inflammatory Markers in HBV-Related HCC After Hepatectomy Based on a Clinical Database.","authors":"Tao Zhou, Jiongze Fang, Jing Huang, Xi Yu, Yuying Shan, Shengdong Wu, Shuqi Mao, Caide Lu","doi":"10.1080/08941939.2025.2475020","DOIUrl":"https://doi.org/10.1080/08941939.2025.2475020","url":null,"abstract":"<p><strong>Objective: </strong>Hepatitis B virus (HBV) remains an important risk factor for hepatocellular carcinoma (HCC), and inflammation plays an essential role in tumor development. This study aimed to investigate the impact of inflammatory markers in the postoperative outcomes of patients with HBV-related HCC, providing valuable prognostic indicators after hepatectomy.</p><p><strong>Methods: </strong>We retrospectively analyzed 222 patients with HBV-related HCC after surgical resection. The ROC curve was used to calculate biomarker cutoff values. The Kaplan-Meier method was used to estimate overall survival (OS) and recurrence-free survival (RFS), and univariate and multivariate analyses were used to identify the prognostic factors.</p><p><strong>Results: </strong>The Kaplan-Meier analysis revealed that patients with high albumin-bilirubin (ALBI) score, aspartate aminotransferase to platelet ratio index (APRI), and monocyte to lymphocyte ratio (MLR) had worse OS, while those with high ALBI score and MLR had shorter RFS. Multivariate Cox regression analysis identified alpha-fetoprotein >400 ng/mL (hazard ratio [HR]: 2.447, 95% confidence interval [CI]: 1.273-4.706, <i>p</i> = 0.007), alanine aminotransferase (HR: 0.377, 95% CI: 0.171-0.834, <i>p</i> = 0.016), platelet to lymphocyte ratio (HR: 0.385, 95% CI: 0.196-0.755, <i>p</i> = 0.006), systemic inflammatory response index (HR: 1.844, 95% CI: 1.049-3.239, <i>p</i> = 0.033), ALBI score (HR: 1.808, 95% CI: 1.020-3.203, <i>p</i> = 0.043), APRI score (HR: 3.193, 95% CI: 1.662-6.137, <i>p</i> < 0.001), tumor diameter (HR: 1.083, 95% CI: 1.012-1.160, <i>p</i> = 0.022), and portal vein tumor thrombosis (PVTT) (HR: 6.083, 95% CI: 2.774-13.338, <i>p</i> < 0.0001) as independent predictors for OS. MLR (HR: 2.285, 95% CI: 1.290-4.048, <i>p</i> = 0.005) and PVTT (HR: 2.672, 95% CI: 1.280-5.579, <i>p</i> = 0.009) were confirmed as significant prognostic markers of RFS in patients with HBV-related HCC.</p><p><strong>Conclusions: </strong>ALBI score, APRI, and MLR are effective prognostic predictors in patients with HBV-related HCC after curative resection. Close monitoring and adjuvant therapies should be considered for high-risk patients.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2475020"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radical Resection of Differentiated Thyroid Cancer in Elderly Patients: Evaluation of the Efficacy of the Immunocolloidal Gold Strip Method Combined with Nanocarbon Negative Imaging Tracing Technology for Parathyroid Gland Imaging.","authors":"YanBin Liu, LiJuan Zuo, YunChao Xin, YaChao Liu, ZeDong Tian, XiaoLing Shang","doi":"10.1080/08941939.2024.2447850","DOIUrl":"10.1080/08941939.2024.2447850","url":null,"abstract":"<p><strong>Objective: </strong>Extant imaging methods used for the proper identification of the parathyroid glands to prevent post-operative hypothyroidism associated with the resection of differentiated thyroid cancer (DTC) are limited by factors such as low specificity, high cost, and technical complexity. This study, therefore, sought to investigate the efficacy of the immunocolloidal gold strip method combined with nanocarbon negative imaging tracing technology for parathyroid gland imaging during radical resection of DTC in elderly patients.</p><p><strong>Methods: </strong>A total of 100 elderly patients with DTC were enrolled and randomly divided into two groups: the control group and the observation group. The control group underwent conventional radical thyroidectomy with bilateral cervical lymph node dissection, while the observation group received the immunocolloidal gold strip method combined with nanocarbon negative imaging tracing technology for parathyroid gland imaging during the surgery. The baseline characteristics, intraoperative findings, postoperative parathyroid hormone (PTH), and serum calcium levels, as well as postoperative complications, were compared between the two groups.</p><p><strong>Results: </strong>There were no significant differences in age, gender, body mass index, comorbidities, or smoking history between the two groups. The observation group had a significantly higher number of parathyroid glands identified during surgery compared with the control group. The postoperative PTH and serum calcium levels at postoperative days 1 and 3 and at 6 months were significantly higher in the observation group than those in the control group. The incidence of postoperative hypoparathyroidism was significantly lower in the observation group.</p><p><strong>Conclusion: </strong>The immunocolloidal gold strip method combined with nanocarbon negative imaging tracing technology is effective in identifying and preserving parathyroid glands during radical resection of DTC in elderly patients.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2447850"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}