Journal of Investigative Surgery最新文献

{"title":"Can Uterine Septum be an Etiological Factor for Dysmenorrhea in Primary Infertile Patients?","authors":"Batuhan Turgay, Yavuz Emre Şükür, Batuhan Özmen, Murat Sönmezer, Bülent Berker, Ruşen Aytaç, Cem Somer Atabekoğlu","doi":"10.1080/08941939.2025.2542846","DOIUrl":"https://doi.org/10.1080/08941939.2025.2542846","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study is to investigate the association between uterine septum and dysmenorrhea and to assess the effect of hysteroscopic resection on the severity of dysmenorrhea.</p><p><strong>Method: </strong>The study group (<i>N</i>:50) consisted of women who underwent hysteroscopic septum resection, and the control group (<i>N</i>:74) consisted of women who underwent diagnostic hysteroscopy and had no significant uterine pathologies. The presence and severity of dysmenorrhea were assessed by using a 10 cm visual analog scale (VAS). The main outcome measurement was the difference between preoperative and postoperative dysmenorrhea VAS scores.</p><p><strong>Results: </strong>The mean preoperative VAS score was significantly higher in the study group than the control group (4.6 ± 2.6 cm vs. 3.2 ± 2.4 cm, respectively; <i>p</i> = 0.023). The rates of moderate to severe dysmenorrhea were 52% in the study group and 17.5% in the control group (<i>p</i> = 0.025). The mean dysmenorrhea VAS score of women with uterine septum was significantly improved in postoperative 3rd and 6th months when compared to the preoperative period (3.4 ± 2.4 cm and 3.1 ± 2.3 vs. 4.6 ± 2.6 cm, respectively; <i>P</i>1 = 0.025 and <i>P</i>2 = 0.003).</p><p><strong>Conclusions: </strong>Uterine septum seems to be an etiological factor for dysmenorrhea. Although there is no significant relationship between septum depth and dysmenorrhea severity, hysteroscopic resection of the uterine septum improves dysmenorrhea in the infertile study group.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2542846"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antrum Preservation Versus Antrum Resection in Laparoscopic Sleeve Gastrectomy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Chao Niu, Bo Li, Hongwei Wan, Wendi Jin, Zhiping Zhang, Wanfu Zhang, Xiaogang Li","doi":"10.1080/08941939.2025.2477099","DOIUrl":"10.1080/08941939.2025.2477099","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the effects of laparoscopic sleeve gastrectomy (LSG) with antrum preservation (AP) and antrum resection (AR) on weight loss and postoperative complications.</p><p><strong>Methods: </strong>A meta-analysis of randomized controlled trials (RCTs) followed PRISMA guidelines. The databases searched included PubMed, Web of Science, Embase Medline, and the Cochrane Library up to October 2022. Extracted data included operation time, hospital stay, excess weight loss, total weight loss, body mass index (BMI), weight, and complications.</p><p><strong>Results: </strong>Eleven RCTs were included with 843 patients: 422 with AR and 421 with AP. The AR group exhibited higher total weight loss at 3 months (<i>p</i> = 0.02), 6 months (<i>p</i> < 0.001), and 1 year (<i>p</i> < 0.001) postoperatively. They also showed greater excess weight loss at 6 months (<i>p</i> < 0.001), 1 year (<i>p</i> < 0.001), and 2 years (<i>p</i> = 0.03). BMI reduction was more significant in the AR group at 3 (<i>p</i> = 0.007) and 6 months (<i>p</i> < 0.001). The AR group lost weight more rapidly at 3 months (<i>p</i> = 0.05), 6 months (<i>p</i> = 0.04), and 1 year (<i>p</i> < 0.001). No significant differences were found in operation time, hospital stay, bleeding, staple line disruption, Clavien-Dindo complications, or remission rates of diabetes, hypertension, arthritis/back pain, hyperlipidemia, or gastroesophageal reflux disease (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>LSG with AR offers better short-term weight loss than AP without increasing surgical complications, but the long-term effects and complications need further investigation in larger RCTs.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2477099"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Our Results of Hyperbaric Oxygen or Pars Plana Vitrectomy in Central Retinal Artery Obstruction.","authors":"S Doğruya, B T Altınbay, Ö C Kayıkçıoğlu, M Altınışık, E Kurt, Ö R Kayıkçıoğlu","doi":"10.1080/08941939.2025.2503811","DOIUrl":"https://doi.org/10.1080/08941939.2025.2503811","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to present the results of patients with central retinal artery obstruction (CRAO) who underwent 23-G pars plana vitrectomy (PPV) or hyperbaric oxygen therapy (HBOT) following emergency medical therapy.</p><p><strong>Method: </strong>The files of 15 patients with acute CRAO were retrospectively reviewed. Comprehensive ophthalmological examinations of the patients were performed. Seven patients received HBOT, and eight patients received PPV following emergency medical treatment. The patient's demographic characteristics, initial and final visual acuity, intraocular pressure were examined.</p><p><strong>Results: </strong>The mean age was 65.2 ± 9.9 years in the hyperbaric oxygen therapy group and 58.7 ± 12.8 years in the PPV group. There was no statistically significant difference between the group receiving HBOT and the group undergoing PPV regarding age, initial visual acuity, final visual acuity, visual gain difference between visual acuity improvements, intraocular pressure, and time lag for treatment initiation (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Although some improvement in visual acuity was observed in both treatment groups - particularly in patients who underwent PPV - this change did not reach statistical significance. Therefore, despite timely intervention, the overall visual outcomes in CRAO remain poor.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2503811"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Inflammatory Markers in HBV-Related HCC After Hepatectomy Based on a Clinical Database.","authors":"Tao Zhou, Jiongze Fang, Jing Huang, Xi Yu, Yuying Shan, Shengdong Wu, Shuqi Mao, Caide Lu","doi":"10.1080/08941939.2025.2475020","DOIUrl":"https://doi.org/10.1080/08941939.2025.2475020","url":null,"abstract":"<p><strong>Objective: </strong>Hepatitis B virus (HBV) remains an important risk factor for hepatocellular carcinoma (HCC), and inflammation plays an essential role in tumor development. This study aimed to investigate the impact of inflammatory markers in the postoperative outcomes of patients with HBV-related HCC, providing valuable prognostic indicators after hepatectomy.</p><p><strong>Methods: </strong>We retrospectively analyzed 222 patients with HBV-related HCC after surgical resection. The ROC curve was used to calculate biomarker cutoff values. The Kaplan-Meier method was used to estimate overall survival (OS) and recurrence-free survival (RFS), and univariate and multivariate analyses were used to identify the prognostic factors.</p><p><strong>Results: </strong>The Kaplan-Meier analysis revealed that patients with high albumin-bilirubin (ALBI) score, aspartate aminotransferase to platelet ratio index (APRI), and monocyte to lymphocyte ratio (MLR) had worse OS, while those with high ALBI score and MLR had shorter RFS. Multivariate Cox regression analysis identified alpha-fetoprotein >400 ng/mL (hazard ratio [HR]: 2.447, 95% confidence interval [CI]: 1.273-4.706, <i>p</i> = 0.007), alanine aminotransferase (HR: 0.377, 95% CI: 0.171-0.834, <i>p</i> = 0.016), platelet to lymphocyte ratio (HR: 0.385, 95% CI: 0.196-0.755, <i>p</i> = 0.006), systemic inflammatory response index (HR: 1.844, 95% CI: 1.049-3.239, <i>p</i> = 0.033), ALBI score (HR: 1.808, 95% CI: 1.020-3.203, <i>p</i> = 0.043), APRI score (HR: 3.193, 95% CI: 1.662-6.137, <i>p</i> < 0.001), tumor diameter (HR: 1.083, 95% CI: 1.012-1.160, <i>p</i> = 0.022), and portal vein tumor thrombosis (PVTT) (HR: 6.083, 95% CI: 2.774-13.338, <i>p</i> < 0.0001) as independent predictors for OS. MLR (HR: 2.285, 95% CI: 1.290-4.048, <i>p</i> = 0.005) and PVTT (HR: 2.672, 95% CI: 1.280-5.579, <i>p</i> = 0.009) were confirmed as significant prognostic markers of RFS in patients with HBV-related HCC.</p><p><strong>Conclusions: </strong>ALBI score, APRI, and MLR are effective prognostic predictors in patients with HBV-related HCC after curative resection. Close monitoring and adjuvant therapies should be considered for high-risk patients.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2475020"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radical Resection of Differentiated Thyroid Cancer in Elderly Patients: Evaluation of the Efficacy of the Immunocolloidal Gold Strip Method Combined with Nanocarbon Negative Imaging Tracing Technology for Parathyroid Gland Imaging.","authors":"YanBin Liu, LiJuan Zuo, YunChao Xin, YaChao Liu, ZeDong Tian, XiaoLing Shang","doi":"10.1080/08941939.2024.2447850","DOIUrl":"10.1080/08941939.2024.2447850","url":null,"abstract":"<p><strong>Objective: </strong>Extant imaging methods used for the proper identification of the parathyroid glands to prevent post-operative hypothyroidism associated with the resection of differentiated thyroid cancer (DTC) are limited by factors such as low specificity, high cost, and technical complexity. This study, therefore, sought to investigate the efficacy of the immunocolloidal gold strip method combined with nanocarbon negative imaging tracing technology for parathyroid gland imaging during radical resection of DTC in elderly patients.</p><p><strong>Methods: </strong>A total of 100 elderly patients with DTC were enrolled and randomly divided into two groups: the control group and the observation group. The control group underwent conventional radical thyroidectomy with bilateral cervical lymph node dissection, while the observation group received the immunocolloidal gold strip method combined with nanocarbon negative imaging tracing technology for parathyroid gland imaging during the surgery. The baseline characteristics, intraoperative findings, postoperative parathyroid hormone (PTH), and serum calcium levels, as well as postoperative complications, were compared between the two groups.</p><p><strong>Results: </strong>There were no significant differences in age, gender, body mass index, comorbidities, or smoking history between the two groups. The observation group had a significantly higher number of parathyroid glands identified during surgery compared with the control group. The postoperative PTH and serum calcium levels at postoperative days 1 and 3 and at 6 months were significantly higher in the observation group than those in the control group. The incidence of postoperative hypoparathyroidism was significantly lower in the observation group.</p><p><strong>Conclusion: </strong>The immunocolloidal gold strip method combined with nanocarbon negative imaging tracing technology is effective in identifying and preserving parathyroid glands during radical resection of DTC in elderly patients.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2447850"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Safety of Primary Anastomosis Without Protective Stoma in Emergency Left Colon Surgery: A Meta-Analysis.","authors":"Zhiyan Wang, Wentao Sheng, Senjie Dai, Xuanzhou Li, Guojian Lin, Xiaohong Kang","doi":"10.1080/08941939.2025.2520992","DOIUrl":"10.1080/08941939.2025.2520992","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the safety of primary anastomosis (PA) without a protective stoma in emergency left colon surgery.</p><p><strong>Methods: </strong>A systematic search was conducted in the PubMed, Web of Science, Embase, and Cochrane Library databases, covering articles from the inception of these databases until September 2024. The primary outcome was the incidence of anastomotic leakage.</p><p><strong>Results: </strong>The PA group exhibited a higher incidence of anastomotic leakage compared to the stoma surgery group (odds ratios (OR) = 5.86, <i>p</i> = 0.05). However, in cases of perforated diverticulitis (OR = 3.80, <i>p</i> = 0.19) and malignant obstruction (OR = 5.40, <i>p</i> = 0.23), the PA group did not show an increased risk of anastomotic leakage. In terms of other outcomes, the reoperation rate in the PA group was higher compared to the stoma surgery group (OR = 1.89, <i>p</i> < 0.001). However, there were no statistically significant differences in the mortality rate (OR = 1.04, <i>p</i> = 0.80) or the incidence of postoperative complications (OR = 1.50, <i>p</i> = 0.27) between the two groups.</p><p><strong>Conclusion: </strong>Primary anastomosis without a protective stoma is generally safe and can be considered a viable option in emergency left colon surgery.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2520992"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Screw Density on the Outcomes of Adolescent Idiopathic Scoliosis Correction Surgery: A Multicenter Retrospective Study.","authors":"ZhaoJun Lu, Chong Liu, JiaKun Li, XiaoPeng Qin, Jiarui Chen, Jiang Xue, Hao Li, Tianyou Chen, Tao Chen, XinLi Zhan","doi":"10.1080/08941939.2025.2531589","DOIUrl":"10.1080/08941939.2025.2531589","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the efficacy of low screw density constructs versus high screw density constructs in adolescent idiopathic scoliosis (AIS) surgery.</p><p><strong>Methods: </strong>Data were collected from AIS patients who underwent pedicle screw fixation surgery at two medical centers. Patients were stratified into low and high screw density groups, calculated as pedicle screws per fused vertebral level. The dataset comprised demographics, radiological parameters, surgical outcomes and postoperative complications.</p><p><strong>Results: </strong>Of 213 AIS patients analyzed, 114 and 99 comprised low- and high-density groups respectively. Compared with high-density constructs, low-density constructs demonstrated shorter operative time (median: 17.93 min, IQR: 14.66-20.50 vs. 22.15 min, IQR: 16.80-24.77; <i>p</i> = 6.30e-07), lower intraoperative blood loss (median: 762.29 ml, IQR: 600-900 vs. 954.19 ml, IQR: 800-1030; <i>p</i> = 7.70e-07), fewer postoperative pain (median: 4.719, IQR: 3-7 vs. 5.505, IQR: 3.5-7; <i>p</i> = 0.009), and shorter hospital stays (median: 11.15 days, IQR: 7-13.5 vs. 12.48 days, IQR: 8-15; <i>p</i> = 0.04). Both groups had equivalent Cobb angle correction (median: 67.31%, IQR: 60.50% -76.84% vs. 67.97%, IQR: 62.54%-73.52%; <i>p</i> = 0.90).</p><p><strong>Conclusion: </strong>Optimizing screw density may minimize intraoperative blood loss and postoperative pain without affecting correction efficacy in AIS; however, longitudinal studies are needed to assess long-term functional and quality-of-life outcomes.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2531589"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil-to-Hemoglobin Ratio and Monocyte-to-Hemoglobin Ratio Predict Prolonged Length of Stay in Patients Undergoing Surgery for Pelvic or Acetabular Fractures.","authors":"Wei-Gang Pan, Yu-Ching Chou, Tsu-Te Yeh","doi":"10.1080/08941939.2025.2515067","DOIUrl":"https://doi.org/10.1080/08941939.2025.2515067","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the neutrophil-to-hemoglobin ratio (NHR) and monocyte-to-hemoglobin ratio (MHR) as predictors of prolonged hospital stay in patients undergoing surgery for pelvic or acetabular fractures.</p><p><strong>Methods: </strong>We retrospectively reviewed records of patients aged ≥ 18 years who underwent open reduction and internal fixation (ORIF). NHR and MHR were calculated from blood samples at admission and 24 hours postoperatively. Prolonged hospital length of stay (LOS) was defined as ≥ 25 days (75th percentile). Optimal cutoffs were determined by ROC curve analysis. Multivariable logistic regression identified associations between clinical variables and prolonged LOS.</p><p><strong>Results: </strong>Among 172 patients (mean age 44.5), postoperative NHR > 0.46 and MHR > 0.02 were independently associated with prolonged LOS in patients with acetabular fractures (aOR = 5.90 and 5.42, respectively). No significant associations were found in pelvic fractures.</p><p><strong>Conclusions: </strong>Elevated postoperative NHR and MHR are strongly associated with prolonged LOS in patients with acetabular fractures and may assist in perioperative risk stratification and clinical decision-making.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2515067"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness Analysis of Sevoflurane Combined with Propofol or Remimazolam Anesthesia in Pediatric Laparoscopic Inguinal Hernia Repair and Its Impact on Hemodynamics and Postoperative Pain.","authors":"Renqi Liu, Zhiyi Wang, Yuanyuan Meng, Weiye Chen, Min Zhou","doi":"10.1080/08941939.2025.2500438","DOIUrl":"10.1080/08941939.2025.2500438","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the clinical effectiveness of combined treatment of sevoflurane with propofol or remimazolam in decreasing hemodynamic changes and postoperative pain in pediatric patients undergoing laparoscopic inguinal hernia repair (LIHR).</p><p><strong>Methods: </strong>This study prospectively recruited 287 children with hernia admitted to our hospital from September 2020 to October 2023. These children were allocated into the sevoflurane plus remimazolam and sevoflurane plus propofol groups using the random number table method. General clinical data at admission were collected. Clinical outcomes were compared between the two groups. The primary outcomes included anesthesia quality, intraoperative hemodynamic indicators at different time points (MAP, SpO₂, HR), and the postoperative FLACC score, while the secondary outcomes included the PAED score of the children and the incidence of postoperative adverse reactions.</p><p><strong>Results: </strong>No remarkable difference occurred between these two groups regarding general clinical data. Compared to the sevoflurane plus propofol group, the sevoflurane plus remimazolam group resulted in significantly lower MAP and HR at T1, T2, T3, and T4 (<i>p</i> < .05), shorter postoperative awakening time (mean difference: 2.9 min, <i>p</i> < .01), lower FLACC pain scores at 0.5, 1, and 2 h postoperatively (<i>p</i> < .05), and lower PAED scores at 5, 15, and 30 min postoperatively (<i>p</i> < .05). Adverse effects were lower in the sevoflurane + remimazolam group (5% vs. 12%, <i>p</i> = .076).</p><p><strong>Conclusion: </strong>Sevoflurane plus remimazolam in children receiving LIHR has minimal impact on hemodynamics, reduces pain levels within 4 h postoperatively, lowers PAED and agitation scores, and demonstrates high safety.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2500438"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Epidemiological Study on Survival in Lymphoma of Mucosa-Associated Lymphoid Tissue: A Comparative Analysis by Primary Tumor Location.","authors":"Gui-Ping Chen, Zhen-Zhen Lu, Guan-Zhong Lu, Yi Zhou, San-Gang Wu","doi":"10.1080/08941939.2025.2523858","DOIUrl":"https://doi.org/10.1080/08941939.2025.2523858","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate outcome and local treatment strategy for extranodal mucosa-associated lymphoid tissue (MALT) lymphoma patients.</p><p><strong>Methods: </strong>Retrospectively collected patients using the data from the Surveillance, Epidemiology, and End Results database, including tumor sites with over 200 cases.</p><p><strong>Results: </strong>The cohort comprised 3842 patients, with the gastric region being the most prevalent site (34.9%), followed by salivary gland (16.8%), cutaneous (16.5%), pulmonary (13.3%), intestinal (13.2%), and head and neck (5.4%). The 10-year cancer-specific survival (CSS) was 88.1%, 92.6%, 86.5%, 87.7%, 89.7%, and 97.7% in patients with tumors located in the gastric, salivary gland, pulmonary, head and neck, intestinal, and cutaneous, respectively (<i>p</i> < 0.001). Compared to gastric MALT lymphoma, the cutaneous site exhibited superior CSS (<i>p</i> < 0.001), whereas other sites showed comparable outcomes (all <i>p</i> ≥ 0.05). In gastric MALT lymphoma cases, radiotherapy was associated with better CSS than surgery alone (<i>p</i> < 0.001), while no significant difference was observed between surgery plus radiotherapy versus surgery alone (<i>p</i> = 0.561). Treatment outcomes were similar across the three therapeutic modalities for non-gastric sites.</p><p><strong>Conclusions: </strong>Our findings underscore the biological and clinical heterogeneity of extranodal MALT lymphoma. While localized treatments provide equivalent results across most non-gastric sites, radiotherapy is recommended as the primary noninvasive treatment option.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2523858"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}