Effectiveness Analysis of Sevoflurane Combined with Propofol or Remimazolam Anesthesia in Pediatric Laparoscopic Inguinal Hernia Repair and Its Impact on Hemodynamics and Postoperative Pain.
Renqi Liu, Zhiyi Wang, Yuanyuan Meng, Weiye Chen, Min Zhou
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引用次数: 0
Abstract
Purpose: This study evaluated the clinical effectiveness of combined treatment of sevoflurane with propofol or remimazolam in decreasing hemodynamic changes and postoperative pain in pediatric patients undergoing laparoscopic inguinal hernia repair (LIHR).
Methods: This study prospectively recruited 287 children with hernia admitted to our hospital from September 2020 to October 2023. These children were allocated into the sevoflurane plus remimazolam and sevoflurane plus propofol groups using the random number table method. General clinical data at admission were collected. Clinical outcomes were compared between the two groups. The primary outcomes included anesthesia quality, intraoperative hemodynamic indicators at different time points (MAP, SpO2, HR), and the postoperative FLACC score, while the secondary outcomes included the PAED score of the children and the incidence of postoperative adverse reactions.
Results: No remarkable difference occurred between these two groups regarding general clinical data. Compared to the sevoflurane plus propofol group, the sevoflurane plus remimazolam group resulted in significantly lower MAP and HR at T1, T2, T3, and T4 (p < .05), shorter postoperative awakening time (mean difference: 2.9 min, p < .01), lower FLACC pain scores at 0.5, 1, and 2 h postoperatively (p < .05), and lower PAED scores at 5, 15, and 30 min postoperatively (p < .05). Adverse effects were lower in the sevoflurane + remimazolam group (5% vs. 12%, p = .076).
Conclusion: Sevoflurane plus remimazolam in children receiving LIHR has minimal impact on hemodynamics, reduces pain levels within 4 h postoperatively, lowers PAED and agitation scores, and demonstrates high safety.
目的:本研究评价七氟醚联合异丙酚或雷马唑仑治疗小儿腹腔镜腹股沟疝修补术(LIHR)患者血流动力学改变和术后疼痛的临床效果。方法:本研究前瞻性招募2020年9月至2023年10月在我院住院的287例疝患儿。采用随机数字表法将这些儿童分为七氟醚加雷马唑仑组和七氟醚加异丙酚组。收集入院时的一般临床资料。比较两组患者的临床结果。主要结局包括麻醉质量、术中不同时间点血流动力学指标(MAP、SpO2、HR)及术后FLACC评分,次要结局包括患儿PAED评分及术后不良反应发生率。结果:两组一般临床资料无显著差异。与七氟醚加异丙酚组相比,七氟醚加雷马唑仑组在T1、T2、T3和T4时MAP和HR显著降低(p p p p p = 0.076)。结论:七氟醚加雷马唑仑对LIHR患儿血流动力学影响最小,术后4 h内疼痛水平降低,PAED和躁动评分降低,安全性高。
期刊介绍:
Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.