Journal of Investigative Surgery最新文献

{"title":"Effectiveness of Single-Person Reset Fixed System for Pediatric Supracondylar Humeral Fractures: Case Series and a Meta-Analysis.","authors":"Di Shen, Manman Cui, Qiang Fu, Jiajia Lu, Xiaojian Shi","doi":"10.1080/08941939.2025.2488130","DOIUrl":"https://doi.org/10.1080/08941939.2025.2488130","url":null,"abstract":"<p><strong>Objective: </strong>This study examined the feasibility and effectiveness of utilizing the single-person reset fixed system (RFS) for treating pediatric supracondylar humeral fractures (SHFs) to enhance surgical efficiency and reduce manpower requirements.</p><p><strong>Methods: </strong>A retrospective analysis of 10 pediatric SHF cases treated with the Single-Person RF was conducted from 2022 to 2023. The primary variables of interest were surgical time, fluoroscopy frequency, postoperative outcomes, and complication rates.</p><p><strong>Results: </strong>All patients achieved successful single-stage surgical reduction and fixation without additional surgeries. The surgical time was 55 min, with an average fluoroscopy frequency of 11.8 times. Postoperatively, Baumann's Angle ranged from 64 to 81 degrees, indicating restoration of normal joint mobility as Range of Motion (ROM) exceeded 90%. The meta-analysis highlighted the significant advantage of the Single-Person RFS in improving the excellent treatment rate with low heterogeneity.</p><p><strong>Conclusion: </strong>The single-person RFS demonstrates remarkable effectiveness in pediatric SHF treatment, evident through reduced surgical times, decreased fluoroscopy frequency, minimal complications, and positive functional recovery for patients. The findings emphasize the superiority of the single-person RFS in enhancing treatment outcomes, suggesting future optimization and potential broader applications in fracture management.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2488130"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Preoperative Noninvasive Index Prediction Model for TURP Surgical Outcomes in Patients with Benign Prostatic Hyperplasia.","authors":"Jiyao Yang, Hongjin Shi, Hui Zhan, Haifeng Wang, Xiaorong Yang, Yuan Liang, Ji Li, Qin Zhang, Guifu Zhang, Yidao Liu","doi":"10.1080/08941939.2025.2490536","DOIUrl":"https://doi.org/10.1080/08941939.2025.2490536","url":null,"abstract":"<p><strong>Background: </strong>To investigate the influence of preoperative noninvasive indexes on surgical outcomes of benign prostatic hyperplasia (BPH) patients and to establish a clinical prediction model.</p><p><strong>Methods: </strong>A total of 250 BPH patients treated with transurethral resection of the prostate (TURP) in our center from December 2020 to June 2023 were included. The evaluation was completed by detailed history questionnaire, an international prostate symptom score (IPSS) assessment, and a urological ultrasonography.</p><p><strong>Results: </strong>Among included patients, 185 had effective outcomes, and 65 had ineffective outcomes, with an effective rate of 74%. Univariate and multivariate analyses identified IPSS-voiding/storage (IPSS-V/S) ratio, postvoid residual urine ratio (PVR-R), disease duration, intravesical prostatic protrusion (IPP), history of diabetes, history of urinary retention as independent predictive factors of surgical outcomes, which were further subjected to construct the prediction model. The receiver operating characteristic curve indicated an area under the curve of 0.894. The sensitivity and specificity of the model were 79.46% and 87.69%, respectively. Internal validation and the calibration curve indicated good agreement between the predicted and actual outcomes. Clinical decision curves found that the model had a more significant net clinical benefit than the \"all-intervention\" and \"no-intervention\" scenarios.</p><p><strong>Conclusion: </strong>The results suggested that BPH patients with a shorter disease duration, a larger IPSS-V/S, a larger IPP, a smaller PVR-R, and no history of diabetes or urinary retention were more likely to have a better outcome after TURP.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2490536"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy Analysis of Guided Tissue Regeneration Combined with Microscrew Implant Anchorage Technique in the Treatment of Periodontitis with Malocclusion.","authors":"Yi Liang, Jiajing Zou, Xianmin Meng","doi":"10.1080/08941939.2025.2507233","DOIUrl":"10.1080/08941939.2025.2507233","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to explore the efficacy of guided tissue regeneration (GTR) combined with microscrew implant anchorage technique in treating patients with periodontitis and malocclusion.</p><p><strong>Methods: </strong>Sixty patients with periodontitis accompanied by malocclusion were randomly assigned to either the control group (<i>n</i> = 30, receiving GTR combined with traditional orthodontic treatment) or the observation group (<i>n</i> = 30, receiving GTR combined with microscrew implant anchorage technique). Periodontal indicators [gingival index (GI), sulcus bleeding index (SBI), plaque index (PLI), probing depth (PD), and clinical attachment level (CAL)], chewing function (biting force, chewing efficiency), dental esthetics [pink esthetic score (PES)], as well as interleukin-6 (IL-6), matrix metalloproteinase-8 (MMP-8), and transforming growth factor-β (TGF-β) levels in gingival crevicular fluid (the gingival crevicular fluid was collected from three non-adjacent periodontitis sites) were measured in both groups. The efficacy and complications were also compared.</p><p><strong>Results: </strong>Six months after treatment, the observation group exhibited lower GI, SBI, PLI, PD, and CAL values, and improved bit force, chewing efficiency, and PES than the control group (<i>p</i> < .05). Six weeks after treatment, the observation group showed reduced IL-6 and MMP-8 levels in gingival crevicular fluid and increased TGF-β levels than the control group (<i>p</i> < .05). Additionally, the observation group exhibited higher overall treatment efficacy than the control group (<i>p</i> < .05).</p><p><strong>Conclusion: </strong>GTR combined with microscrew implant anchorage yields superior therapeutic outcomes in patients with periodontitis and malocclusion. This approach effectively improves periodontal health, optimizes the local periodontal microenvironment, enhances masticatory function, and promotes dental esthetic outcomes.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2507233"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphadenectomy Does Not Improve Cancer-Specific Survival for Colorectal Cancer Patients Underwent Endoscopic Therapy: A Population-Based Retrospective Study.","authors":"Xiangying Deng, Yang Zhang, Xiong Guo, Lin Zhou, Xiangzhou Tan","doi":"10.1080/08941939.2025.2484540","DOIUrl":"https://doi.org/10.1080/08941939.2025.2484540","url":null,"abstract":"<p><strong>Methods: </strong>A total of 6626 patients with CRC who were initially referred for endoscopic polypectomy were enrolled from the Surveillance Epidemiology and End Results Database.</p><p><p><b>Results:</b> Most enrolled patients (6557/6626, 99.0%) were at T0-T1 stage (American Joint Committee on Cancer staging system). Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were used to reduce selection bias, which resulted in balanced groups of patients with and without lymphadenectomy, with no difference in CSS (<i>p</i> = .99 and .074, respectively). In the subgroup analysis, insufficient lymphadenectomy (lymph node yield [LNY] < 12) was associated with poor CSS compared with no lymphadenectomy. The multivariate analysis identified adequate lymphadenectomy with an LNY ≥ 12 as an independent favorable prognostic factor. However, nearly half of the patients (59/127, 46.5%) referred for lymph node resection did not undergo adequate lymphadenectomy.</p><p><strong>Conclusions: </strong>The prognosis of CSS cannot be improved by lymphadenectomy for most patients (T0-T1) who are referred for endoscopic therapy because of the low rate of lymph node metastasis. Nonetheless, adequate lymphadenectomy should be performed instead of diagnostic lymph node resection if lymph node involvement is suspected.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2484540"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Energy Ultrapulse CO₂ Fractional Laser Combined with Autologous Platelet-Rich Plasma in Periorbital Rejuvenation Treatment.","authors":"Yanwen Qi, Cheng Sun, Yang Zhou, Lizhou Luo, Chengyuan Wang","doi":"10.1080/08941939.2025.2484543","DOIUrl":"https://doi.org/10.1080/08941939.2025.2484543","url":null,"abstract":"<p><strong>Objective: </strong>This paper focuses on the efficacy of low energy ultrapulsed CO₂ fractional laser (LEUCO₂FL) combined with autologous platelet-rich plasma (PRP) in periorbital rejuvenation treatment.</p><p><strong>Methods: </strong>Eighty patients with periorbital wrinkles and eyelid laxity were randomly assigned to a laser group (<i>n</i> = 40) receiving LEUCO₂FL or a combination group (<i>n</i> = 40) receiving additional autologous PRP. Both groups received treatment once per month for a total of three sessions. Cosmetic outcomes were assessed at three months post-treatment using the Global Esthetic Improvement Scale (GAIS). VISIA (wrinkles, texture), SOFT (skin elasticity, moisture), upper eyelid depression, and infraorbital hollowing were evaluated before and at 1, 3, and 6 months post-treatment. Adverse reactions and patient satisfaction were recorded.</p><p><strong>Results: </strong>The combination group exhibited higher overall effective rate of GAIS, greater improvements in wrinkles, texture, skin elasticity, and moisture at all time points, and lower upper eyelid depression and infraorbital hollowing scores than the laser group. While both treatments were well tolerated, patient satisfaction was higher in the combined group than the laser group.</p><p><strong>Conclusion: </strong>LEUCO₂FL combined with autologous PRP demonstrates favorable cosmetic effects in periorbital rejuvenation, significantly improving periorbital wrinkles and texture, enhancing skin elasticity and hydration, and reducing periorbital hollowness.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2484543"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment and Validation of Diagnostic Model of Microvascular Invasion in Solitary Hepatocellular Carcinoma.","authors":"Xiu-Qin Wang, Ying-Qi Fan, Dong-Xing Hou, Cui-Cui Pan, Ni Zheng, Yuan-Quan Si","doi":"10.1080/08941939.2025.2484539","DOIUrl":"https://doi.org/10.1080/08941939.2025.2484539","url":null,"abstract":"<p><strong>Background: </strong>The microvascular invasion (MVI) score evaluates the presence of MVI in patients with hepatocellular carcinoma (HCC) by integrating multiple factors associated with MVI. We aimed to establish a MVI scoring system for HCC based on the clinical characteristics and serum biomarkers of patients with HCC.</p><p><strong>Methods: </strong>A total of 1027 patients with HCC hospitalized at Shandong Provincial Hospital from January 2016 to August 2021 were included and randomly divided into the development group and validation group at a ratio of 3:1. Univariable and multivariable logistic regression analyses were conducted to identify independent risk factors for MVI in HCC patients. Based on these independent risk factors, the preoperative MVI scoring system (diagnostic model) for HCC was established and verified. The receiver operating characteristic (ROC) curves, calibration curves and decision curve analyses (DCA) were employed to evaluate the discrimination and clinical application of the diagnostic model.</p><p><strong>Results: </strong>Independent risk factors for MVI of HCC involved Hepatitis B virus infection (HBV), large tumor diameter, higher logarithm of Alpha-fetoprotein (Log AFP), higher logarithm of AFP-L3% (Log AFP-L3%), higher logarithm of protein induced by vitamin K absence or antagonist-II (Log PIVKA-II) and higher logarithm of Carbohydrate antigen 125 (Log CA125). The diagnostic model incorporating these six independent risk factors was finally established. The areas under the ROC curve (AUC) assessed by the nomogram in the development cohort and validation cohort were 0.806 (95% CI, 0.773-0.839) and 0.818 (95% CI, 0.763-0.874) respectively. The calibration curve revealed that the results predicted by our diagnostic model for MVI in HCC were highly consistent with the postoperative pathological outcomes. The DCA further indicated promising clinical application of the diagnostic model.</p><p><strong>Conclusion: </strong>An effective preoperative diagnostic model for MVI of HCC based on readily available tumor markers and clinical characteristics has been established, which is both clinically significant and easy to implement for diagnosing MVI.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2484539"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect and Safety of Dexmedetomidine Administration on Mother and Foetus/Neonates During General Anaesthesia in Caesarean Section: A Randomised Controlled Trial.","authors":"Zhiqiang Yu, Yan Liu, Fangqi Duan, Qian Li, Dong Yan, Li Zhang, Zhuangzhuang Wang, Minyu Zhang, Qi Zhao","doi":"10.1080/08941939.2025.2495089","DOIUrl":"10.1080/08941939.2025.2495089","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the safety of dexmedetomidine administration to mothers, fetuses, and neonates during general anesthesia in cesarean section (CS).</p><p><strong>Patients and methods: </strong>A total of 60 parturients scheduled for elective CS under general anesthesia were randomly divided into anesthesia in groups (DEX1 and DEX2) and control (C) groups. Groups DEX1 and DEX2 were induced with dexmedetomidine (induction, 0.4 µg/kg; maintenance, 0.4 µg/kg·h) and dexmedetomidine (induction, 0.6 µg/kg; maintenance, 0.6 µg/kg·h), respectively, until birth. Equivalent volumes of normal saline were administered in group C. Anesthesia was induced with propofol and rocuronium in all groups. The mean arterial blood pressure (MAP) and heart rate (HR) of parturients were monitored and recorded; fetal HR was monitored using color doppler ultrasound. The blood gas analysis from the umbilical artery (UA) and umbilical vein (UV), along with the HR, Apgar score and Neurologic Adaptive Capacity Scores (NACS) of neonates, were recorded.</p><p><strong>Results: </strong>Maternal MAP at intubation/skin incision, maternal HR at intubation/skin incision and delivery were significantly lower in groups DEX1 and DEX2 than in group C, no significant differences were observed between groups DEX1 and DEX2. No significant differences were observed in fetal HR, UA and UV blood gas analyses, Apgar score and NACS of neonates in the three groups.</p><p><strong>Conclusion: </strong>Intravenous 0.4 or 0.6 µg/kg doses of dexmedetomidine with propofol for general anesthesia in CS is beneficial for inhibiting the maternal stress response induced by intubation/skin incision and delivery without significant adverse effects on fetuses or neonates. Our findings suggest that dexmedetomidine is safe for mothers, fetuses, and neonates in obstetric general anesthesia.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2495089"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Cyclosporine A Plus Zishen Yutai Pill in the Treatment of Patients with Recurrent Pregnancy Loss.","authors":"Mingzhe Zhang, Min Xu, Li Li, Min Dong, Haiyan Wang, Keyan Luo","doi":"10.1080/08941939.2025.2510310","DOIUrl":"https://doi.org/10.1080/08941939.2025.2510310","url":null,"abstract":"<p><strong>Objective: </strong>This study analyzed the therapeutic effects of cyclosporine A (CsA) plus Zishen Yutai Pill (ZYP) in the treatment of patients with recurrent pregnancy loss (RPL).</p><p><strong>Methods: </strong>This study prospectively included 150 RPL patients who were randomized into CsA and CsA + ZYP groups (<i>n</i> = 75 patients/group). The serum levels of hormones estradiol (E2), human chorionic gonadotropin (HCG), progesterone (P), Th1-type cytokines, and Th2-type cytokines were detected by ELISA. Additionally, we compared the proportions of immune cell subsets (T lymphocytes, Th1, Th2), the incidence of adverse reactions, and live birth rates between the two groups. Furthermore, patients treated with CsA plus ZYP were categorized into appropriate age and elderly age groups based on their age to ascertain the therapeutic effects of CsA plus ZYP on RPL patients of different ages.</p><p><strong>Results: </strong>CsA plus ZYP resulted in markedly higher E2, HCG, and P levels and live birth rates than CsA alone. After treatment with either CsA or CsA plus ZYP, the Th1 cell subset, Th1-type cytokines, and Th1/Th2 ratio significantly decreased but Th2 cell subset and Th2-type cytokines were greatly elevated in both groups, with more pronounced changes induced by CsA plus ZYP. There was no significant difference in the incidence of adverse reactions between the two groups. Furthermore, the therapeutic effect of CsA plus ZYP was better in RPL patients of appropriate age.</p><p><strong>Conclusion: </strong>CsA plus ZYP significantly improved Th1/Th2 balance and increased live birth rates in RPL patients and was more effective in RPL patients of appropriate age.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2510310"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Prognostic Factors Related to Endovascular Treatment of Acute Basilar Artery Occlusion Within 24 Hours of Onset.","authors":"Changchun Jiang, Yu Fan, Yuechun Li, Wei Ma","doi":"10.1080/08941939.2024.2442382","DOIUrl":"https://doi.org/10.1080/08941939.2024.2442382","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the prognostic effect of endovascular treatment (EVT) in patients with acute base artery occlusion (ABAO) within 24 h of onset, and analyze the factors related to prognosis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on all ABAO patients who received EVT within 24 h of onset in the neurology department of Baotou Central Hospital in Inner Mongolia from May 2016 to October 2022. Good prognosis was defined as a Modified Rankin Scale (mRS) score of 0-3 and poor prognosis mRS score of 4-6 at 90 day follow-up, and factors related to prognosis were analyzed.</p><p><strong>Results: </strong>Among the 77 patients included in the analysis, 68 patients (88.3%) achieved recanalization (modified thrombolysis in cerebral infarction, mTICI 2b/3 grade). Thirty eight patients (49.4%) achieved an overall good prognosis. In univariate analysis, age, baseline Glasgow Coma Scale (GCS), baseline National Institutes of Health Stroke Scale (NIHSS), posterior circulation Acute Stroke Prognostic Early CT score (pc ASPECTS), preoperative intravenous thrombolysis, and mTICI2b-3 were factors affecting good prognosis. Multivariate analysis showed that shorter onset to puncture time (OR 0.069; 95% CI, 0.009-0.519; <i>p</i> = 0.009), lower NIHSS (OR 1.179; 95% CI, 1.019-1.364; <i>p</i> = 0.027), and higher pc ASPECTS (OR 0.489, 95% CI, 0.250-0.959, <i>p</i> = 0.037) were factors influencing good prognosis in this study.</p><p><strong>Conclusions: </strong>In summary, endovascular treatment for patients with acute basilar artery occlusion is safe and effective, but EVT may achieve better prognosis within 6 h of onset. The shorter time from onset to puncture at admission, lower baseline NIHSS score, and higher baseline pc-ASPECTS are factors affecting the good prognosis of patients at 90 days.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2442382"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression Significance and Prognostic Value of GPR27 in Ovarian Cancer.","authors":"Xiulan Peng, Yahong Cai, Bing Tang, Mingtao Zhang, Xia Wang","doi":"10.1080/08941939.2025.2491781","DOIUrl":"https://doi.org/10.1080/08941939.2025.2491781","url":null,"abstract":"<p><strong>Background: </strong>This study explored the prognostic role of GPR27 and its predictive value to platinum-based therapy in ovarian cancer.</p><p><strong>Material and methods: </strong>A survival analysis of GPR27, and the therapeutic response to platinum in ovarian cancer was investigated using data from the cancer genome atlas (TCGA) and Gene Expression Omnibus (GEO) databases. GPR27 expression was assessed using reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry.</p><p><strong>Results: </strong>Database analysis and RT-PCR revealed over-expression of GPR27 mRNA in ovarian cancer tissues compared to normal ovarian tissues. Ovarian cancer patients with up-regulated GPR27 transcription were associated with better overall survival and disease-free survival compared to those with downregulated GPR27 mRNA in the TCGA dataset and Kaplan-Meier plot database (<i>N</i> = 1656). GPR27 demonstrated good predictive value for pathological response in patients with ovarian cancer receiving platinum-based therapy. The predictive performance for 6-month relapse-free survival was higher in endometrioid ovarian cancer (AUC:0.804) than that in serous ovarian cancer. GPR27 protein levels were significantly up-regulated in ovarian cancer tissues compared with normal ovarian tissue, and high GPR27 protein expression correlated with early-stage TNM. ROC analysis revealed that the GPR27 protein, quantified by the immunohistochemistry score, effectively predicted the response to platinum-based therapy response with an AUC of 0.7479 in our cohort.</p><p><strong>Conclusion: </strong>GPR27 was up-regulated in ovarian cancer, compared with that of normal ovarian tissue, and was strongly correlated with survival outcomes and response to platinum-based therapy. GPR27 may serve as a reliable biomarker for platinum -based therapy in ovarian cancer patients.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2491781"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}