Journal of Investigative Surgery最新文献

{"title":"Effect of Prior Bariatric Surgery on the Outcomes of Joint Arthroplasty: A Systematic Review and Meta-Analysis.","authors":"Zhou Zhang, Xiang Shi, Wei Liu, Jianwei Wang, Qingfeng Shen, Guozhu Xu, Jiakuan Bao, Yupeng Dong","doi":"10.1080/08941939.2024.2446579","DOIUrl":"10.1080/08941939.2024.2446579","url":null,"abstract":"<p><strong>Objective: </strong>Obesity is a risk factor for joint arthroplasty complications. With this systematic review and meta-analysis, we assessed whether a positive history of bariatric surgery influences postoperative outcomes in patients undergoing various types of joint arthroplasty.</p><p><strong>Methods: </strong>We conducted a comprehensive search database such as Scopus, PubMed, Medline Ovid, CNKI, and CENTRAL for studies comparing outcomes between patients undergoing arthroplasty with and without a history of bariatric surgery. We extracted data on short-term medical complications, venous thromboembolism (VTE), periprosthetic infections, superficial wound infections, hospital stay length, and operative time. We used the data to conduct meta-analyses using random-effects models and subgroup analyses based on the type of arthroplasty.</p><p><strong>Results: </strong>Overall, 15 studies with nearly 150,000 participants were included. The analysis showed that prior bariatric surgery did not significantly affect overall medical complications post-arthroplasty, with OR of 0.968 (95%CI, 0.706-1.327). For VTE, the results similarly indicated no substantial difference, with an OR of 0.912 (95%CI, 0.644-1.291). In assessing periprosthetic infections, the OR was 0.754 (95%CI, 0.535-1.064), showing comparable rates between patients with and without a history of bariatric surgery.Regarding superficial wound infections, the analysis produced an OR of 2.390 (95%CI, 0.723-7.897), indicating variability but not statistical significance. Hospital stay length was reduced in patients with a history of bariatric surgery, reflected by SMD of -0.113 (95%CI, -0.221 to -0.005). Lastly, operative time also showed a significant reduction, with an SMD of -0.462 (95%CI, -0.865 to -0.059).</p><p><strong>Conclusions: </strong>Prior bariatric surgery does not reduce the risk of short-term complications post-arthroplasty, but it seems to reduce the hospital stay length and operative time. The effects vary significantly across different types of joint arthroplasty, suggesting a need for tailored preoperative assessments and care protocols.</p><p><strong>Protocol registration: </strong>This systematic review and meta-analysis was registered at PROSPERO, with the number: CRD42024539052.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2446579"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Co-Administration of Midazolam and Dexmedetomidine on Haemodynamics and Stress Response in Elderly Patients with Non-Small Cell Lung Cancer.","authors":"Yanjun Zhao, Dongjiao An, Liang Bi","doi":"10.1080/08941939.2024.2445587","DOIUrl":"https://doi.org/10.1080/08941939.2024.2445587","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to evaluate the effect of co-administration of midazolam and dexmedetomidine on hemodynamics and stress response in elderly patients with non-small cell lung cancer (NSCLC).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this prospective, randomized controlled trial, 154 elderly NSCLC patients scheduled for lobectomy in our oncology department from January 2019 to December 2021 were recruited. Patients were randomized 1:1 to receive either dexmedetomidine (control group) or dexmedetomidine plus midazolam (study group) for anesthesia during lobectomy &lt;i&gt;via&lt;/i&gt; the random number table method, with 77 patients in each group. Perioperative indicators, hemodynamics, and stress reactions of the patients were recorded and compared between the two groups to investigate the efficacy of the two different anesthetic protocols.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;No significant differences were observed between the two groups in terms of operative time, anesthesia time, and intraoperative bleeding volume (&lt;i&gt;p&lt;/i&gt; &gt; 0.05). Preoperative pain, pain at anesthesia recovery, and pain levels 7 days postoperatively were also comparable between the two groups. In the study group, the awakening time was 15 ± 2 min significantly shorter compared to the control group (25 ± 3 min). Cooperation within the first hour was significantly faster by 8.5 ± 0.5 min compared to 6.0 ± 1.0 min in the control group (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). The cost of materials used was significantly higher in the study group, with an average of 300 ± 25 USD, compared to 200 ± 20 USD in the control group (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). Additionally, the two groups showed no significant difference in the need for experience and surveillance (&lt;i&gt;p&lt;/i&gt; &gt; 0.05). Significantly lower visual analog scale (VAS) scores were found one day after the surgery in patients given dexmedetomidine plus midazolam than those anesthetized administered with dexmedetomidine only, suggesting an enhanced pain mitigation effect after incorporating midazolam for anesthetic induction. Patients treated with dexmedetomidine plus midazolam presented with a more stable hemodynamic status than those treated with dexmedetomidine only, as evidenced by the significantly lower variability of mean arterial pressure (MAP), oxygen saturation (SpO2), and heart rate (HR). Co-administration of dexmedetomidine plus midazolam for lobectomy anesthesia resulted in significantly lower serum cortisol (Cor) and norepinephrine (NE) concentrations in patients at anesthesia recovery than dexmedetomidine alone. However, this difference was not observed one day postoperatively. There was no statistically significant difference in the incidence of adverse reactions between the two groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The combination of midazolam with dexmedetomidine anesthesia in lobectomy improves the intraoperative hemodynamic status of elderly patients with NSCLC and mitigates their stress response. However, further research is req","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2445587"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Prognostic Analysis of Neoadjuvant Therapy Followed by Breast-Conserving Surgery for Invasive Ductal Carcinoma Combined with Ductal Carcinoma in Situ.","authors":"Sicheng Zhou, Hongyu Xiang, Zehao Huang, Yue Teng, Wei Xing","doi":"10.1080/08941939.2025.2547226","DOIUrl":"10.1080/08941939.2025.2547226","url":null,"abstract":"<p><strong>Objective: </strong>This study aim to investigate the oncological safety of neoadjuvant therapy (NAT) followed by breast-conserving surgery (BCS) for invasive ductal carcinoma (IDC) patients with the presence of ductal carcinoma <i>in situ</i> (DCIS) on pre-NAT biopsy.</p><p><strong>Methods: </strong>The data of women with IDC who underwent radical surgery between January 2013 and December 2021 were retrospectively reviewed from two institutions. The study endpoints were 5-year disease-free survival (DFS) and local recurrence-fee survival (LRFS).</p><p><strong>Results: </strong>Overall, 994 eligible patients were enrolled. Patients with IDC with DCIS (<i>n</i> = 277) and patients undergoing BCS (<i>n</i> = 285) were selected separately for prognostic analysis. For patients with IDC with DCIS, the 5-year DFS (<i>p</i> = 0.517) and 5-year LRFS (<i>p</i> = 0.397) rates of the patients undergoing BCS were similar to those of patients undergoing mastectomy after propensity score matching. In addition, the 285 patients who underwent BCS were divided into the IDC + DCIS and IDC groups. The 5-year DFS (<i>p</i> = 0.394) and 5-year LRFS (<i>p</i> = 0.341) rates were similar between the IDC and IDC + DCIS groups.</p><p><strong>Conclusion: </strong>NAT followed by BCS combined with adjuvant radiotherapy is a safe and feasible treatment option in patients with IDC with DCIS under the premise of strict adherence to the surgical indications and adequate incision margins.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2547226"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Radiofrequency Ablation for Papillary Thyroid Cancer: A Systematic Review and Meta-Analysis.","authors":"Jiuxi Wu, Jian Wang, Jun Gao","doi":"10.1080/08941939.2025.2562263","DOIUrl":"https://doi.org/10.1080/08941939.2025.2562263","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review and meta-analysis aimed to evaluate the efficacy and safety of radiofrequency ablation (RFA) in the management of papillary thyroid cancer (PTC).</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in the PubMed, Embase, Cochrane Library, Web of Science and CNKI databases. Studies reporting outcomes of RFA for PTC were included. Random-effects models were used for meta-analysis, and heterogeneity was assessed using I² statistics.</p><p><strong>Results: </strong>Fifteen retrospective studies involving 1,844 patients were included. The meta-analysis revealed a pooled standardized mean difference of -1.11 (95% CI: -1.39 to -0.84) for volume reduction at 12 months, corresponding to an approximate 88.9% mean volume reduction, with moderate heterogeneity (I² = 55.4%). The pooled risk ratio (RR) for complete disappearance was 1.08 (95% CI: 0.99-1.18), with significant heterogeneity among studies (I² = 71.4%). The local recurrence rate was 0.62% (95% CI: 0.32%-1.21%), with no significant heterogeneity (I² = 0.0%). The RFS analysis showed a pooled RR of 1.00 (95% CI: 0.93-1.08), with no significant heterogeneity (I² = 0.0%). The local tumor progression rate was 1.42% (95% CI: 0.81%-2.48%), also with no significant heterogeneity (I² = 0.0%).</p><p><strong>Conclusion: </strong>This meta-analysis suggests that RFA is an effective and safe treatment for PTC, demonstrating high volume reduction rates, satisfactory complete disappearance rates and low local recurrence rates.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2562263"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Hsa-miR-4741/LILRB2 on Senescence of Nucleus Pulposus Cells and Their Prognostic Values in Lumbar Disc Herniation.","authors":"Zhendong He, Nan Zheng, Xiu-Quan Guo, Gang-Gang Wang, Mingjian Lin","doi":"10.1080/08941939.2025.2458180","DOIUrl":"10.1080/08941939.2025.2458180","url":null,"abstract":"<p><strong>Background: </strong>The incidence of lumbar disk herniation (LDH) is usually caused by lumbar disk degeneration. Surgery is a common treatment strategy for LDH, but it can recur, resulting in recurrent disk herniation (RDH).</p><p><strong>Purpose: </strong>To explore the predictive value of hsa-miR-4741 and LILRB2 in the prognosis of LDH surgery and the mechanism of nucleus pulposus senescence.</p><p><strong>Method: </strong>The ROC curves of RDH based on hsa-miR-4741 and LILRB2 were constructed to evaluate their predictive values in the prognosis of LDH surgery. Human nucleus pulposus cells (NPC) was treated by TNF-α to construct a cell senescence model, studying the senescence mechanism. Oxidative stress and senescence markers were detected after overexpression of hsa-miR-4741 and LILRB2 to evaluate their effects on the senescence of NPC. Dual luciferase assay and the transfection of hsa-miR-4741 mimics or inhibitor were used to investigate the targeted regulation of it to LILRB2.</p><p><strong>Results: </strong>The combination of hsa-miR-4741 and LILRB2 showed higher accuracy in predicting the outcome of RDH (AUC = 0.9367), compared with a single molecule. Overexpression of hsa-miR-4741 enhanced TNF-α-induced oxidative stress and senescence, while LILRB2 overexpression had the opposite effect. Hsa-miR-4741 mimics attenuated the luciferase activity of NPC transfected with wt-LILRB2 vector and significantly down-regulated LILRB2 expression. In addition, the antioxidant NAC reversed the promotion of hsa-miR-4741 on NPC senescence.</p><p><strong>Conclusion: </strong>The combination of hsa-miR-4741 and LILRB2 was a good predictor of LDH prognosis. Hsa-miR-4741 promoted oxidative stress-induced NPC senescence by negatively regulating LILRB2.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2458180"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of miR-143-3p in the Development of Hemorrhoids and Postoperative Wound Healing.","authors":"Qing Liu, Wei Han, Ling Wang, Weifang Shang, Xinyu Cao","doi":"10.1080/08941939.2025.2480799","DOIUrl":"10.1080/08941939.2025.2480799","url":null,"abstract":"<p><strong>Background: </strong>Hemorrhoids refer to a common anorectal disorder that is usually associated with vascular proliferation. The present study investigated the role of miR-143-3p in the development of hemorrhoids and postoperative wound healing, aiming to provide novel ideas for the study of the pathogenesis of hemorrhoids and their clinical treatment.</p><p><strong>Methods: </strong>Hemorrhoid tissues and normal perianal tissues were collected from 42 patients who underwent hemorrhoid surgery. The expressions of miR-143-3p, vascular endothelial markers (CD31, vWF, and VEGFR2), and inflammatory factors (TNF-α, IL-1β, and IL-6) in these tissues were determined using RT-qPCR. The correlation of miR-143-3p with CD31, vWF, and VEGFR2 was analyzed using Pearson's method. The proliferation of HUVEC and HaCaT cells was detected using the CCK-8 assay. The migration of HUVEC and HaCaT cells was detected using Transwell assay. The apoptosis of HUVEC cells was detected using flow cytometry.</p><p><strong>Results: </strong>Reduced expression of miR-143-3p in hemorrhoid tissues was negatively correlated to the mRNA levels of CD31, vWF, and VEGFR2. The mRNA levels of CD31, vWF, and VEGFR2 in the HUVEC cells were reduced after miR-143-3p overexpression. Overexpression of miR-143-3p inhibited the proliferation and migration of HUVEC cells while promoting apoptosis in these cells. Upregulation of miR-143-3p decreased the mRNA levels of TNF-α, IL-1β, and IL-6 in HaCaT cells while promoting cell proliferation and migration in these cells.</p><p><strong>Conclusions: </strong>Downregulation of miR-143-3p was noted in hemorrhoids, which could be linked to the regulation of angiogenesis. MiR-143-3p might have an anti-inflammatory role in postoperative wound healing.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2480799"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Outcomes in Transarterial Embolization for Late Postpancreatectomy Hemorrhage: A Comparison of N-Butyl Cyanoacrylate with Mixed Embolic Agents Versus Mixed Embolic Agents Alone.","authors":"Heng Zhang, Feng Duan, Jin Xin Fu, Jin Long Zhang, Bing Yuan, Yan Wang, Jie Yu Yan, Li Min Meng, Liang Li, Mao Qiang Wang","doi":"10.1080/08941939.2025.2488133","DOIUrl":"https://doi.org/10.1080/08941939.2025.2488133","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to retrospectively compare the efficacy of transarterial embolization (TAE) with N-butyl cyanoacrylate (NBCA) and conventional agents (microcoils, polyvinyl alcohol [PVA], or gelatin sponge) in the treatment of patients with late postpancreatectomy hemorrhage (late-PPH).</p><p><strong>Methods: </strong>From June 2012 to June 2022, this retrospective study enrolled 130 consecutive patients who underwent TAE treatment due to late-PPH at one institution. Of these patients, 56 were treated with NBCA-mixed conventional agents (NBCA-MA group), and 74 were treated with mixed conventional agents alone (MA group). The patients' clinical characteristics and TAE details were gathered. The clinical outcomes in the two groups were compared. Using univariate and multivariate logistic regression analyses, prognostic factors were evaluated for clinical success and 30-day mortality rates.</p><p><strong>Results: </strong>The clinical success in the NBCA-MA group was 80.4% higher than that in the MA group (60.8%). Rebleeding was significantly more common in the MA group (29.7% vs. 8.9%). The 30-day mortality rate of the NBCA-MA group was lower than that of the MA group (16.1% vs. 33.8%). NBCA use was a significant prognostic factor associated with clinical success, while age and NBCA use were significant factors associated with the 30-day mortality rate.</p><p><strong>Conclusion: </strong>In conclusion, we found that TAE with NBCA is a safe and effective method for treating late-PPH.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2488133"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Between Mastectomy and Breast-Conserving Surgery in <i>De Novo</i> Metastatic Breast Cancer: A Propensity Score-Matched Study.","authors":"Yi-Yan Hong, Hong-Liang Zhan, Guan-Qiao Li, Qiu-Yan Chen, San-Gang Wu, Fu-Xing Zhang","doi":"10.1080/08941939.2025.2550774","DOIUrl":"https://doi.org/10.1080/08941939.2025.2550774","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the outcomes between mastectomy (MAST) and breast-conserving surgery (BCS) in patients with <i>de novo</i> metastatic breast cancer (dnMBC).</p><p><strong>Methods: </strong>Patients diagnosed with dnMBC between 2010 and 2020 were retrospectively included. The chi-square test, binomial logistic regression, propensity score matching (PSM), Kaplan-Meier method, and multivariate Cox proportional analysis were used for statistical analyses.</p><p><strong>Results: </strong>A total of 7880 patients were identified, including 2248 (28.5%) patients who underwent BCS and 5632 (71.5%) had achieved MAST. Although no statistically significant difference was found (<i>p</i> = 0.182), patients receiving MAST had a decreasing trend in later years. There were 74.3% (<i>n</i> = 629) of patients receiving MAST in 2010 and 68.5% (<i>n</i> = 366) in 2020. Younger age, advanced tumor stage, and advanced nodal stage were independent predictors of receiving MAST. There were 466 pairs of patients who were completely matched using PSM. The 3-year breast cancer-specific survival (BCSS) was 72.4% and 73.0% in patients treated with BCS and MAST, respectively (<i>p</i> = 0.509). The 3-year overall survival (OS) was 68.4% and 70.5% in patients treated with BCS and MAST, respectively (<i>p</i> = 0.702). The multivariate prognostic analyses showed that MAST had a similar BCSS (<i>p</i> = 0.996) and OS (<i>p</i> = 0.784) than those in BCS group.</p><p><strong>Conclusions: </strong>Our study suggests that BCS and MAST yield similar survival outcomes in dnMBC.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2550774"},"PeriodicalIF":3.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a Self-Inflating Bag Mechanical Ventilator, Maturation in Continuous Use, Safety, and Repeatability for Ventilatory Variables.","authors":"Noe Rodriguez, Carlos Rubio, Leonardo Barriga, Fernando Fonseca, Jorge Soto, Jose Pineda, David Sanchez, Antonio Rojas, David Lopez, Dalia Madrigal, Blanca Villagran, Mayra Sosa, Silvio Ñamendys, Alan Gutierrez, Alain Cueto","doi":"10.1080/08941939.2025.2534857","DOIUrl":"https://doi.org/10.1080/08941939.2025.2534857","url":null,"abstract":"<p><strong>Background: </strong>Researchers proposed mechanical ventilators (MVs) based on the automated compression of a self-inflating bag (SIB) to save lives during the pandemic caused by the SARS-CoV-2 virus. Many proposals had problems with continuous use time, repeatability of ventilatory variables, high partial pressure of carbon dioxide (PaCO₂) values, and a decreasing fraction of inspired oxygen (FiO₂) for high respiratory rates.</p><p><strong>Objective: </strong>This study aimed to demonstrate that our technology, based on automated compression of an SIB, can operate for several days, is repeatable in its ventilatory variables, and is safe in the ventilator-patient interaction.</p><p><strong>Materials and methods: </strong>Ehecatl-4T (EHT) MV was based on SIB. We first validated the repeatability of the ventilatory variables using a lung simulator for different compliances (0.01 up to 0.05 L/cmH₂O) and resistances (5 up to 50 cmH₂O·s/L). Subsequently, we conducted a long-term durability test to maintain the ventilatory parameters. Finally, the EHT was tested in a preclinical study using 12 York-Landrace × Pietrain-Duroc pigs weighing 87 ± 5 kg. Six pigs were assigned to the experimental group and six were assigned to the reference group.</p><p><strong>Results: </strong>The EHT presented a relative error within the allowed margin for both pressure and volume modes. The EHT was operated for over 32 days without affecting the ventilatory variables. In the preclinical study, the PaCO₂ and FiO₂ values were close to the reference levels.</p><p><strong>Conclusion: </strong>The EHT showed potential for continuous use, demonstrating repeatability for ventilatory variables in bench testing. Clinical parameters were maintained according to the industry safety standards.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2534857"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Narrative Review for Mechanisms and Management of Secondary Vertebral Collapse Following Minimally Invasive Bone Cement Augmentation Procedures for Osteoporotic Vertebral Compression Fractures.","authors":"Bing-Yi Yang, Shao-Kuan Song, Huo-Liang Zheng, Qi-Zhu Chen, Hao Cai, Yong Wang, Muradil Mardan, Lei-Sheng Jiang, Sheng-Dan Jiang","doi":"10.1080/08941939.2025.2525343","DOIUrl":"10.1080/08941939.2025.2525343","url":null,"abstract":"<p><strong>Objective: </strong>This review examines the diagnostic criteria, incidence rates, risk factors, preventive strategies and therapeutic approaches for post-cement augmentation vertebral recollapse, aiming to establish standardized preventive protocols.</p><p><strong>Methods: </strong>A systematic literature search was conducted through databases such as PubMed, Web of Science, Embase, and Cochrane, identifying 78 studies meeting predefined criteria. Eligibility criteria focused on imaging outcomes and risk stratification.</p><p><strong>Results: </strong>The incidence of secondary vertebral recollapse after cement augmentation varies widely (8.5-63.3%) due to inconsistent diagnostic standards. Major risk factors include procedure-related (e.g., low cement volume), anatomical (e.g., thoracolumbar location), and patient-specific (e.g., low bone mineral density) factors. Effective prevention strategies encompass standardized diagnostic protocols combining radiological and clinical assessments, precise cement application techniques, and aggressive anti-osteoporosis therapy. Innovative materials, like mineralized collagen-modified bone cement, and tailored postoperative rehabilitation can further reduce recollapse rates. Management is tiered by severity: conservative treatment for minor collapses and surgical interventions for severe cases.</p><p><strong>Conclusion: </strong>Vertebral recollapse is a significant post-PVA complication impacting OVCF patient prognosis. Comprehensive risk assessment, optimized cement use, and ongoing anti-osteoporosis therapy are crucial for reducing incidence. Advancements in cement formulation, technique, and standardized therapeutic frameworks are vital for improving long-term patient outcomes.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2525343"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}