{"title":"射频消融治疗甲状腺乳头状癌的疗效和安全性：一项系统综述和荟萃分析。","authors":"Jiuxi Wu, Jian Wang, Jun Gao","doi":"10.1080/08941939.2025.2562263","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This systematic review and meta-analysis aimed to evaluate the efficacy and safety of radiofrequency ablation (RFA) in the management of papillary thyroid cancer (PTC).</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in the PubMed, Embase, Cochrane Library, Web of Science and CNKI databases. Studies reporting outcomes of RFA for PTC were included. Random-effects models were used for meta-analysis, and heterogeneity was assessed using I<sup>2</sup> statistics.</p><p><strong>Results: </strong>Fifteen retrospective studies involving 1,844 patients were included. The meta-analysis revealed a pooled standardized mean difference of -1.11 (95% CI: -1.39 to -0.84) for volume reduction at 12 months, corresponding to an approximate 88.9% mean volume reduction, with moderate heterogeneity (I<sup>2</sup> = 55.4%). The pooled risk ratio (RR) for complete disappearance was 1.08 (95% CI: 0.99-1.18), with significant heterogeneity among studies (I<sup>2</sup> = 71.4%). The local recurrence rate was 0.62% (95% CI: 0.32%-1.21%), with no significant heterogeneity (I<sup>2</sup> = 0.0%). The RFS analysis showed a pooled RR of 1.00 (95% CI: 0.93-1.08), with no significant heterogeneity (I<sup>2</sup> = 0.0%). The local tumor progression rate was 1.42% (95% CI: 0.81%-2.48%), also with no significant heterogeneity (I<sup>2</sup> = 0.0%).</p><p><strong>Conclusion: </strong>This meta-analysis suggests that RFA is an effective and safe treatment for PTC, demonstrating high volume reduction rates, satisfactory complete disappearance rates and low local recurrence rates.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2562263"},"PeriodicalIF":3.5000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficacy and Safety of Radiofrequency Ablation for Papillary Thyroid Cancer: A Systematic Review and Meta-Analysis.\",\"authors\":\"Jiuxi Wu, Jian Wang, Jun Gao\",\"doi\":\"10.1080/08941939.2025.2562263\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This systematic review and meta-analysis aimed to evaluate the efficacy and safety of radiofrequency ablation (RFA) in the management of papillary thyroid cancer (PTC).</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in the PubMed, Embase, Cochrane Library, Web of Science and CNKI databases. Studies reporting outcomes of RFA for PTC were included. Random-effects models were used for meta-analysis, and heterogeneity was assessed using I<sup>2</sup> statistics.</p><p><strong>Results: </strong>Fifteen retrospective studies involving 1,844 patients were included. The meta-analysis revealed a pooled standardized mean difference of -1.11 (95% CI: -1.39 to -0.84) for volume reduction at 12 months, corresponding to an approximate 88.9% mean volume reduction, with moderate heterogeneity (I<sup>2</sup> = 55.4%). The pooled risk ratio (RR) for complete disappearance was 1.08 (95% CI: 0.99-1.18), with significant heterogeneity among studies (I<sup>2</sup> = 71.4%). The local recurrence rate was 0.62% (95% CI: 0.32%-1.21%), with no significant heterogeneity (I<sup>2</sup> = 0.0%). The RFS analysis showed a pooled RR of 1.00 (95% CI: 0.93-1.08), with no significant heterogeneity (I<sup>2</sup> = 0.0%). The local tumor progression rate was 1.42% (95% CI: 0.81%-2.48%), also with no significant heterogeneity (I<sup>2</sup> = 0.0%).</p><p><strong>Conclusion: </strong>This meta-analysis suggests that RFA is an effective and safe treatment for PTC, demonstrating high volume reduction rates, satisfactory complete disappearance rates and low local recurrence rates.</p>\",\"PeriodicalId\":16200,\"journal\":{\"name\":\"Journal of Investigative Surgery\",\"volume\":\"38 1\",\"pages\":\"2562263\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Investigative Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/08941939.2025.2562263\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Investigative Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/08941939.2025.2562263","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/29 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
Efficacy and Safety of Radiofrequency Ablation for Papillary Thyroid Cancer: A Systematic Review and Meta-Analysis.
Objective: This systematic review and meta-analysis aimed to evaluate the efficacy and safety of radiofrequency ablation (RFA) in the management of papillary thyroid cancer (PTC).
Methods: A comprehensive literature search was conducted in the PubMed, Embase, Cochrane Library, Web of Science and CNKI databases. Studies reporting outcomes of RFA for PTC were included. Random-effects models were used for meta-analysis, and heterogeneity was assessed using I2 statistics.
Results: Fifteen retrospective studies involving 1,844 patients were included. The meta-analysis revealed a pooled standardized mean difference of -1.11 (95% CI: -1.39 to -0.84) for volume reduction at 12 months, corresponding to an approximate 88.9% mean volume reduction, with moderate heterogeneity (I2 = 55.4%). The pooled risk ratio (RR) for complete disappearance was 1.08 (95% CI: 0.99-1.18), with significant heterogeneity among studies (I2 = 71.4%). The local recurrence rate was 0.62% (95% CI: 0.32%-1.21%), with no significant heterogeneity (I2 = 0.0%). The RFS analysis showed a pooled RR of 1.00 (95% CI: 0.93-1.08), with no significant heterogeneity (I2 = 0.0%). The local tumor progression rate was 1.42% (95% CI: 0.81%-2.48%), also with no significant heterogeneity (I2 = 0.0%).
Conclusion: This meta-analysis suggests that RFA is an effective and safe treatment for PTC, demonstrating high volume reduction rates, satisfactory complete disappearance rates and low local recurrence rates.
期刊介绍：
Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.
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