Application of Cyclosporine A Plus Zishen Yutai Pill in the Treatment of Patients with Recurrent Pregnancy Loss.

IF 2.1 4区 医学 Q2 SURGERY
Journal of Investigative Surgery Pub Date : 2025-12-01 Epub Date: 2025-06-13 DOI:10.1080/08941939.2025.2510310
Mingzhe Zhang, Min Xu, Li Li, Min Dong, Haiyan Wang, Keyan Luo
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引用次数: 0

Abstract

Objective: This study analyzed the therapeutic effects of cyclosporine A (CsA) plus Zishen Yutai Pill (ZYP) in the treatment of patients with recurrent pregnancy loss (RPL).

Methods: This study prospectively included 150 RPL patients who were randomized into CsA and CsA + ZYP groups (n = 75 patients/group). The serum levels of hormones estradiol (E2), human chorionic gonadotropin (HCG), progesterone (P), Th1-type cytokines, and Th2-type cytokines were detected by ELISA. Additionally, we compared the proportions of immune cell subsets (T lymphocytes, Th1, Th2), the incidence of adverse reactions, and live birth rates between the two groups. Furthermore, patients treated with CsA plus ZYP were categorized into appropriate age and elderly age groups based on their age to ascertain the therapeutic effects of CsA plus ZYP on RPL patients of different ages.

Results: CsA plus ZYP resulted in markedly higher E2, HCG, and P levels and live birth rates than CsA alone. After treatment with either CsA or CsA plus ZYP, the Th1 cell subset, Th1-type cytokines, and Th1/Th2 ratio significantly decreased but Th2 cell subset and Th2-type cytokines were greatly elevated in both groups, with more pronounced changes induced by CsA plus ZYP. There was no significant difference in the incidence of adverse reactions between the two groups. Furthermore, the therapeutic effect of CsA plus ZYP was better in RPL patients of appropriate age.

Conclusion: CsA plus ZYP significantly improved Th1/Th2 balance and increased live birth rates in RPL patients and was more effective in RPL patients of appropriate age.

环孢素A联合滋肾玉泰丸治疗复发性妊娠丢失的临床应用。
目的:分析环孢素A (CsA)联合滋肾育泰丸(ZYP)治疗复发性妊娠丢失(RPL)的疗效。方法:前瞻性研究纳入150例RPL患者,随机分为CsA组和CsA + ZYP组(n = 75例/组)。ELISA法检测血清中激素雌二醇(E2)、人绒毛膜促性腺激素(HCG)、孕酮(P)、th1型细胞因子、th2型细胞因子水平。此外,我们比较了两组患者的免疫细胞亚群(T淋巴细胞、Th1、Th2)比例、不良反应发生率和活产率。此外,将CsA + ZYP治疗的患者按年龄分为适龄组和老年组,确定CsA + ZYP对不同年龄RPL患者的治疗效果。结果:CsA加ZYP可显著提高E2、HCG、P水平和活产率。CsA和CsA + ZYP治疗后,两组患者Th1细胞亚群、Th1型细胞因子和Th1/Th2比值均显著降低,但Th2细胞亚群和Th2型细胞因子均显著升高,CsA + ZYP组的变化更为明显。两组患者不良反应发生率无显著差异。CsA联合ZYP治疗年龄合适的RPL患者效果更好。结论:CsA联合ZYP可显著改善RPL患者Th1/Th2平衡,提高活产率,且对适龄RPL患者效果更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.
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