Shaolong Tang, Dan Pan, Siyuan Chen, Hengyuan Li, Zhaoming Ye
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In static settlement testing, the modified cage's yield load was 1020.87 ± 13.22 N, also notably higher than the traditional cage's 939.06 ± 8.03 N (<i>p</i> < 0.05). In static pullout testing, the maximum pullout force of the modified cage with the blade extended reached 534.02 ± 21.24 N, exceeding the 476.97 ± 24.45 N without the blade (<i>p</i> < 0.05), showing advantages in maximum pullout force and stiffness. Biocompatibility tests revealed lower cytotoxicity and a hemolysis rate of less than 5% for the modified cage material, significantly better than the traditional material's 8% (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The new anti-backout TLIF device provides enhanced stability, reduced pain, and improved material compatibility, supporting its potential for clinical application.</p>","PeriodicalId":16200,"journal":{"name":"Journal of Investigative Surgery","volume":"38 1","pages":"2520264"},"PeriodicalIF":3.5000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative Analysis of Biomechanical Stability and Pain Reduction in Novel TLIF Devices.\",\"authors\":\"Shaolong Tang, Dan Pan, Siyuan Chen, Hengyuan Li, Zhaoming Ye\",\"doi\":\"10.1080/08941939.2025.2520264\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aims to evaluate the biomechanical and clinical performance of a new anti-backout TLIF device compared to a traditional device.</p><p><strong>Methods: </strong>This study involved a rat model, with biomechanical tests including static axial compression, static and dynamic settlement, and blade-cutting torque tests. 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Biocompatibility tests revealed lower cytotoxicity and a hemolysis rate of less than 5% for the modified cage material, significantly better than the traditional material's 8% (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>The new anti-backout TLIF device provides enhanced stability, reduced pain, and improved material compatibility, supporting its potential for clinical application.</p>\",\"PeriodicalId\":16200,\"journal\":{\"name\":\"Journal of Investigative Surgery\",\"volume\":\"38 1\",\"pages\":\"2520264\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Investigative Surgery\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/08941939.2025.2520264\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Investigative Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/08941939.2025.2520264","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/4 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
摘要
目的:本研究的目的是评估一种新型的抗反退TLIF装置与传统装置的生物力学和临床性能。方法:采用大鼠模型进行生物力学试验,包括静轴压、静、动沉降和刀切扭矩试验。大鼠疼痛行为(n = 6)和材料相容性通过细胞毒性和溶血试验进行评估。结果:改进后的抗后援椎间融合器在静态轴压试验中屈服载荷为7747.36±274.96 N,显著高于传统TLIF椎间融合器的6933.36±65.00 N (p pp p)。结论:新型抗后援TLIF椎间融合器稳定性增强,疼痛减轻,材料相容性改善,具有临床应用潜力。
Comparative Analysis of Biomechanical Stability and Pain Reduction in Novel TLIF Devices.
Objective: This study aims to evaluate the biomechanical and clinical performance of a new anti-backout TLIF device compared to a traditional device.
Methods: This study involved a rat model, with biomechanical tests including static axial compression, static and dynamic settlement, and blade-cutting torque tests. Pain behavior in rats (n = 6) and material compatibility through cell toxicity and hemolysis tests were also assessed.
Results: The modified anti-backout interbody fusion cage demonstrated a yield load of 7747.36 ± 274.96 N in static axial compression testing, significantly higher than the traditional TLIF cage's 6933.36 ± 65.00 N (p < 0.05), indicating superior load resistance. In static settlement testing, the modified cage's yield load was 1020.87 ± 13.22 N, also notably higher than the traditional cage's 939.06 ± 8.03 N (p < 0.05). In static pullout testing, the maximum pullout force of the modified cage with the blade extended reached 534.02 ± 21.24 N, exceeding the 476.97 ± 24.45 N without the blade (p < 0.05), showing advantages in maximum pullout force and stiffness. Biocompatibility tests revealed lower cytotoxicity and a hemolysis rate of less than 5% for the modified cage material, significantly better than the traditional material's 8% (p < 0.05).
Conclusion: The new anti-backout TLIF device provides enhanced stability, reduced pain, and improved material compatibility, supporting its potential for clinical application.
期刊介绍:
Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.