Bulletin "Biomedicine and sociology"最新文献

{"title":"SEARCH FOR MOLECULAR TARGETS OF A NOVEL 9-DIHYDROACRIDONE COMPOUND","authors":"Bagdosaryan A.A., Kutorkina E.A., Pakina V.A., Bogoslovskaya E.V., Blinov D.S., Tolstov M.V., S. E.V., B. E.V.","doi":"10.26787/nydha-2618-8783-2023-8-3-48-53","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2023-8-3-48-53","url":null,"abstract":"In this work, the molecular targets of a new compound with antitumor effect, a 9-dihydroacridone derivative, were determined. The study was carried out in a virtual software environment for receptor-oriented flexible docking Autodock 4.2. The ligands were prepared using the MGL Tools 1.5.6. Ligand optimization was performed using the Avogadro software. The crystallographic structures of the active site macromolecules of human folate receptors (FOLR2) and colony stimulating factor kinase 1 (CSF1R) from the Protein Data Bank (PDB ID: 4KN2 and 4R7I, respectively) were used. A new compound, 9-aminium-3,3-dimethyl-3,4-dihydroacridin-1(2Н)-one L-2-hydroxybutanediovatate (laboratory name LHT-17-19), was studied. LHT-17-19 formed a stable complex with the type III receptor of tyrosine kinase of the monocyte and macrophage colony-stimulating factor (CSF1R) and with the folate receptor FOLR2 with Affinity DG -10.2 kcal/M, EDoc -6.82 kcal/M, Ki 9.99 uM and 10.0 kcal/ M, Edoc -7.05 kcal/M, Ki 6.85 uM, respectively. In terms of the main indicators of affinity LHT-17-19 was not inferior to the reference drugs imatinib and pemetrexed. Receptor kinases CSF1R and FOLR2 can be considered as potential molecular targets for novel medication candidate 9-aminium-3,3-dimethyl-3,4-dihydroacridin-1(2H)-one L-2-hydroxybutanediovate.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139334003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-ACETYL-6-AMINOHEXANOIC ACID COMPOUND INHIBITS NERVE FIBERS CONDUCTIVITY","authors":"Mazov Y.A., Dmitriev A.A., Pirozhkov A.S., Blinov D.S., Timoshkin D.E., Turmulaeva R.M., S. E.V., B. E.V.","doi":"10.26787/nydha-2618-8783-2023-8-3-59-64","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2023-8-3-59-64","url":null,"abstract":"Local anesthetic effect of N-acetyl-6-aminohexanoate salt (compound LHT-9-17) in the form of a substance with a purity of 99.8% was studied and also assessed the effect of the substance on the conductivity of single sodium channels and the conductivity of the nerve conductor at normal pH values and against the background of acidosis. Experimental ligature periodontitis was modeled in 20 laboratories male Wistar rats weighing 200-220 g. Local anesthetic effects of 2% LHT-9-17 and 2% lidocaine hydrochloride solution induced by infraorbital administration was assessed at day 12 of the pathology development. Conduction of single Na-channels was assessed by patch-clamp method on isolated giant neurons of Limnea stagnalis. Registration of the action potential of Rana radibunda isolated sciatic nerve was carried out in perfusion chamber contained 0.00001 to 0.01 μM LCT-9-17. Experiments included increasing the force of stimulating incentives until the maximum response. Compound LHT-9-17 has local anesthetic activity, including during the inflammatory process. The analgesic effect is due to the suppression of the conductivity of Na-channels of nerve conductors. The activity kept under inflammatory conditions may be due to the action of substances against the inflammatory state.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139332998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A QUANTUM-LIKE APPROACH IN UNDERSTANDING MODELING COGNITION AND DECISION-MAKING PROCESSES (REVIEW OF FOREIGN LITERATURE)","authors":"Yusupova M.M., Gureev S.A., Mingazov R.N., Mingazova E.N.","doi":"10.26787/nydha-2618-8783-2023-8-3-31-36","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2023-8-3-31-36","url":null,"abstract":"The article presents a review of foreign scientific literature on the quantum-like approach to understanding the modeling of cognition and decision-making processes. It is shown that the current application of quantum physics approaches to consciousness, psychological approaches such as perception, cognition, emotions, consciousness and learning, involves the search for a single objective mathematical model of what underlies the experience of the brain. The use of quantum physics algorithms can help in understanding the mechanisms of brain malfunctions and memory impairments that are found in pathologies such as dementia caused by Alzheimer's disease, schizophrenia, etc. Quantum physics approaches are applicable to issues of modeling cognition and decision-making processes, as well as in cognitive research, information processing by the human brain, artificial intelligence development, psychology, social and political sciences. Application of the abstract mathematical principles of quantum theory can help in understanding human consciousness and behavior. Quantum probability theory is applied to modeling human behavior due to the prevalence of uncertainty in human interaction with the world. Quantum cognitive models are especially useful in research in such areas as errors in decision making, order effects of questions, conceptual combinations, accumulation of evidence, perception, etc. Of particular interest to researchers are issues of quantum-like modeling of cognition and decision-making processes, the apparatus of quantum information and probability theory, useful for such modeling, as well as the use of such apparatus in cognitive research, the development of artificial intelligence, psychology, social and political sciences.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139333890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QUANTUM THEORY OF BRAIN PHYSICS AND THE THEORY OF QUANTUM-LIKE CONSCIOUSNESS (REVIEW OF FOREIGN LITERATURE)","authors":"Yusupova M.M., Gureev S.A., Mingazov R.N., Mingazova E.N.","doi":"10.26787/nydha-2618-8783-2023-8-3-19-24","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2023-8-3-19-24","url":null,"abstract":"The article provides a review of foreign scientific literature on existing approaches in scientists' ideas about the quantum theory of brain physics and the theory of quantum-like consciousness. It is shown that in recent years, physics and psychology have made important scientific advances; the emergence of new tools has led to the development of neuroscience, which makes it possible to study the state of the brain when known mental functions are preserved or impaired. The use of mathematical methods has made it possible to develop computational models that describe the fundamental functions of the brain and implement them in technological applications. The most pressing issues of modern research in the field of mental processes of the brain, such as perception, cognition, emotions, consciousness and learning, researchers call the problems of the universal properties of human behavior in various conditions and cultures; the potential of computational psychiatry to predict, understand and treat mental disorders; neural mechanisms of influence on mental content at higher levels of organization of the hierarchical brain; mechanisms of the emergence of abstract ideas from sensorimotor accidents, etc. Currently, in understanding the cognitive processes of the brain, perception, understanding, cognition, mental lexicon, understanding the generation and nature of emotions, memory, learning, etc. A number of researchers use the theory of quantum or quantum-like consciousness. Research in this area is both empirical and theoretical in nature, with the postulates of the theory being considered mainly related to quantum physics due to the lack of other areas in which quantum-like properties are supposedly manifested. It is believed that despite modern advances in artificial intelligence models, neural networks cannot reach the level of the human brain, partly due to differences in the way information is encoded and processed. In order to develop the potential of brain-based artificial intelligence, quantum neural networks are proposed that are similar to the mechanisms and phenomena in the brain. Interactions between biologically important molecules in the brain may underlie the quantum metalanguage that governs the behavior of humans and animals.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139333769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DISCOVERY OF AN ORIGINAL MODEL TO STUDY THE INFLUENCE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES ON THE RATE OF OXYGEN CONSUMPTION IN THE PROSTATE TISSUE","authors":"Lobkarev A.O.","doi":"10.26787/nydha-2618-8783-2023-8-3-25-30","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2023-8-3-25-30","url":null,"abstract":"The article provides a review of foreign scientific literature on existing approaches in scientists' ideas about the quantum theory of brain physics and the theory of quantum-like consciousness. It is shown that in recent years, physics and psychology have made important scientific advances; the emergence of new tools has led to the development of neuroscience, which makes it possible to study the state of the brain when known mental functions are preserved or impaired. The use of mathematical methods has made it possible to develop computational models that describe the fundamental functions of the brain and implement them in technological applications. The most pressing issues of modern research in the field of mental processes of the brain, such as perception, cognition, emotions, consciousness and learning, researchers call the problems of the universal properties of human behavior in various conditions and cultures; the potential of computational psychiatry to predict, understand and treat mental disorders; neural mechanisms of influence on mental content at higher levels of organization of the hierarchical brain; mechanisms of the emergence of abstract ideas from sensorimotor accidents, etc. Currently, in understanding the cognitive processes of the brain, perception, understanding, cognition, mental lexicon, understanding the generation and nature of emotions, memory, learning, etc. A number of researchers use the theory of quantum or quantum-like consciousness. Research in this area is both empirical and theoretical in nature, with the postulates of the theory being considered mainly related to quantum physics due to the lack of other areas in which quantum-like properties are supposedly manifested. It is believed that despite modern advances in artificial intelligence models, neural networks cannot reach the level of the human brain, partly due to differences in the way information is encoded and processed. In order to develop the potential of brain-based artificial intelligence, quantum neural networks are proposed that are similar to the mechanisms and phenomena in the brain. Interactions between biologically important molecules in the brain may underlie the quantum metalanguage that governs the behavior of humans and animals.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"276 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139332765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF THE IMMUNOMODULATORY ACTIVITY OF THE DRY EXTRACT OF THE HERB OF HELIANTHUS TUBEROSUM L.","authors":"Mikhailova I.V., Filippova Y.V., Smolyagin A.I., Sinegovets A.A., Saybel O.L., Dul V.N., Dargaeva T.D.","doi":"10.26787/nydha-2618-8783-2023-8-3-9-18","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2023-8-3-9-18","url":null,"abstract":". The purpose of the study was to evaluate the immunomodulatory properties of the dry extract of Jerusalem artichoke herb in terms of weight (thymus, spleen), number of cells (thymus, spleen, bone marrow) of the immune system organs, indicators of cellular and humoral immunity in mice on a model of experimental immunodeficiency induced by the cytostatic methotrexate. Materials and methods. The study of the immunomodulatory activity of the dry extract of Jerusalem artichoke herb was evaluated by the ability to restore the mass (thymus, spleen), the number of cells (thymus, spleen, bone marrow) of the immune system organs, indicators of cellular, humoral immunity and phagocytic activity of peritoneal macrophages of outbred mice under conditions of immunosuppression induced by methotrexate, to the level of intact mice, in vivo. Results. Analysis of the effect of the dry extract of Jerusalem artichoke herb in in vivo systems found that the dry extract of the herb Helianthus tuberosum L. had no effect on the mass (thymus, spleen) and the number of cells (thymus, spleen, bone marrow) of the immune system organs, the severity of the delayed-type hypersensitivity reaction, antibody production, phagocytic activity of peritoneal macrophages of intact mice and restored these parameters of the immune system in animals treated with the cytostatic methotrexate to the level of intact animals, which was comparable to the effect of the reference drug \"Immunal\". Conclusion. The dry extract of Jerusalem artichoke herb can be considered as a promising agent that restores the parameters of cellular, humoral immunity, the phagocytic activity of peritoneal macrophages and the cellular composition of the immune system under conditions of immunosuppression induced by methotrexate, to the level of intact animals, the effectiveness of which is comparable to the effect of the comparator drug \"Immunal","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139331740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF PSYCHOSOCIAL FACTORS ON THE HEALTH OF THE WORKING POPULATION FROM THE POINT OF INDUSTRIAL AND RESTORATIVE MEDICINE","authors":"Mingazova E.N., Yusupova M.M., Gureev S.A., Mingazov R.N.","doi":"10.26787/nydha-2618-8783-2023-8-3-3-8","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2023-8-3-3-8","url":null,"abstract":"The article contains data from a review of foreign literature on the prevention of diseases of the working population from the perspective of industrial and restorative medicine. Scientists have identified the most significant measures as: impact on the social determinants of mental health (standard of living and working conditions; measures to prevent and promote health and mental health, including measures to reduce stigma and discrimination; increasing access to evidence-based care through the development of services occupational health and safety, including access to industrial and restorative medicine services. Work intensity is most often considered the main risk factor for constant stress in the workplace/production place, as it correlates with the body's reactions to the adverse effects of production factors. Analysis of the combination of high production demands with social vulnerability at work/work with symptoms of depression and/or anxiety showed a high risk of mental disorder depending on psychosocial factors, regardless of the social status, health status, verbal intelligence and personal qualities of the employee. There is a need for closer attention to issues of gender selection in various professions as part of the study of the gender aspect as a social determinant of health in the context of maintaining/restoring the health of workers. The discrepancy between the efforts made and the rewards received at work is another psychosocial factor that negatively affects the mental health of the population, which also contributes to the abuse of alcohol and various medications that affect cognitive abilities, and reduces the quality of sleep. High personal self-esteem is thought to be a protective resource that reduces the risk of psychological distress, but there is a paucity of research linking self-esteem to neurobiological adaptability.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139333816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTITUMOR ACTIVITY OF SOME PYRIDINECARBOXY ACID COMPOUNDS IN TUMOR CELL CULTURES","authors":"Epishkina A.A., D. O.N., B. D.S., Tumutolova O.N., B. E.V., Kutorkina E.A., Pakina V.A.","doi":"10.26787/nydha-2618-8783-2023-8-2-10-15","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2023-8-2-10-15","url":null,"abstract":"We studied the antitumor activity of two compounds - derivatives of pyridinecarboxylic acids with laboratory codes LHT-13-19 and LHT-17-19 in two cancer cell cultures: colon HT29 and estrogen-sensitive breast cancer MCF-7. Сompounds were synthesized in the department of chemistry, technology of synthetic drugs and analytical control of VNС BAV (Russia). A possible mechanism for the development of secondary chemoresistance was determined on the organoid model of triple-negative breast cancer, provided to us by scientists from the FGBI “N.N. Dmitry Rogachev\" of the Ministry of Health of Russia. Both compounds were shown to be cytotoxic against two human neoplasias with an inhibitory concentration of 1.3 × 10-7 for substance LHT-17-19 and LHT-13-19 – 7.6 × 10-3 M for colon cancer HT29 and 1.6×10-5 (LHT-17-19) and 3.8×1 (LHT-13-19) for MCF-7 breast cancer. During the formation of secondary resistance of triple-negative breast cancer cells to LHT-13-19, the reverse transport of compound molecules is activated, as evidenced by the increase in the concentration of the substance in the cultivation medium after washing the three-dimensional culture. Under the same experimental conditions, although secondary resistance to LHT-17-19 is formed, no efflux of molecules into the medium is observed, which indicates that in this case other mechanisms not related to reverse transport may be involved.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117195986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STRUCTURE OF BRONCHIAL ARTERIES IN RATS WITH TRAUMATIC BRAIN INJURY AND SYSTEMIC INFLAMMATION","authors":"Zinoviev S.V., Plekhova N.G., Shumatov V.B.","doi":"10.26787/nydha-2618-8783-2023-8-2-31-36","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2023-8-2-31-36","url":null,"abstract":"Purpose of the study: to present a histochemical and morphometric assessment of the state of the blood vessels of the bronchial tree and lung parenchyma of rats in experimental traumatic brain injury (TBI). and systemic inflammation caused by the administration of pyrogenal. Materials and methods. The experiment was carried out on mature male Wistar rats (200-250 g). Potentially painful interventions in the ongoing experiments and euthanasia were performed under combined injection anesthesia. The model of the falling weight modified by us for rats was used to reproduce TBI. To initiate systemic inflammation (SI), the animals were intramuscularly injected with pyrogenal solution. The study included the following groups: intact rats (n=12); after applying TBI (n=12)-TBI; triple administration (1, 3, 4 days) of pyrogenal without TBI (n=16)-SV; triple administration of pyrogenal (1, 3, 4 days) after TBI (n=12)-TBI+SV. On days 4 and 6 from the beginning of the experiment, under general anesthesia, the animals were dissected, their lungs were removed, after which histological sections were made.\u0000Morphological and functional changes in the blood vessels of the bronchial tree and lung parenchyma were analyzed in experimental traumatic brain injury (TBI) and systemic inflammation in rats. It has been established that in injured rats, the administration of pyrogenal has a significant effect on the structure of the bronchial blood vessels of the lungs, while the application of only TBI does not initiate such changes. At the same time, a significant change in the morphometric characteristics of blood vessels is detected, a spasm of arterioles is determined with a decrease in the diameter of the lumen on days 4 and 6 of the study, and an accumulation of segmented leukocytes, macrophages and other bronchial secretion cells in the perivascular space of the vessels is noted. Thus, the results of the study show that with the comorbidity of TBI and SI in the lungs, structural changes occur in the elastic framework of the distal bronchial arteries, which manifests itself changes in the structure of the elastic membranes of these blood vessels.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128742688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CURRENT ASPECTS OF DIAGNOSIS, CORRECTION, AND SUPPORT STRATEGIES FOR PEOPLE WITH AUTISM SPECTRUM DISORDERS","authors":"Onbysh T.E., Shapovalova E.A., Loza M.V., Krivorotko A.Y.","doi":"10.26787/nydha-2618-8783-2023-8-2-45-50","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2023-8-2-45-50","url":null,"abstract":"Introduction: Autism spectrum disorder is a widespread disorder characterized by changes in various body systems. Sensory area of patients: It is a heterogeneous neuropsychiatric disorder with a deficit of perception of sensory information, and with expressed disorders in the sphere of communication and speech underdevelopment and limited interests. Motor skills of children: unexpected, spontaneous movements of various parts of the body, and violations of the sequence of basic, habitual actions. Impaired psychomotor development in autism: There is a possibility that the distortion of the mirror neuron system may lead to a lack of speech function, which may cause a lack of ability to learn through imitation mechanisms. Identification, diagnosis of mental development, organization of help: Observations, conversations and medical documentation make it possible to draw a conclusion about the affective development of the child. Principles of medication correction: consist in individual selection of remedies and methods in each individual case and are determined by the child's behavior. Regular and long-term work of qualified specialists consists in selecting the necessary therapy, which includes neuroleptics-risperidone and aripiprazole to reduce negativity, aggression, but they have side effects in the form of carbohydrate metabolism disorders. Conclusion: The article points out the main general task of supporting children with autism spectrum disorders, which is the pursuit of achieving the highest possible level of social adaptation and socialization, which involves knowing the attitudes toward children with autism of different layers of society - from family members to outsiders.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"234 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133565671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}