The Internet Journal of Dermatology最新文献

{"title":"Advanced Stage CTCL, PTCL with Cutaneous Involvement","authors":"J. Messenger, P. Porcu","doi":"10.5580/171b","DOIUrl":"https://doi.org/10.5580/171b","url":null,"abstract":"Dr. Porcu obtained his medical degree in 1987 and Board certification in Medical Oncology in 1991 from the University of Torino, Italy. He then held a post-doctoral laboratory position at Temple University from 1990 to 1992 and was a research associate at Thomas Jefferson University from 1992 to 1993, both in Philadelphia, U.S. He completed a residency in Internal Medicine in 1996 and a Fellowship in Hematology/Oncology in 1999 at Indiana University, Indianapolis, IN. He is currently an Associate Professor of Internal Medicine at The Ohio State University (OSU) and a member of the Viral Oncology Group of the OSU Comprehensive Cancer Center (OSUCCC), where he conducts clinical and translational research in lymphoma. He is a faculty member inductee of the Alpha Omega Alpha. Dr. Porcu’s work has been published in Blood, Journal of Clinical Oncology, Clinical Cancer Research, Cancer Research, PNAS, Oncogene, and Molecular and Cellular Biology. Dr. Porcu was on the editorial board of the journal Leukemia from 2002 to 2005 and is a member of the Scientific Advisory Board of the Cutaneous Lymphoma Foundation (CLF). Since 2000 he has been a member of the NCCN committee for NHL practice guidelines. Currently his research focuses on the biology and experimental therapy of T-cell lymphomas and cutaneous lymphoproliferative disorders. Dr. Porcu also works extensively in the field of lymphoma education and mentoring. He teaches numerous graduate and post-doctoral classes in the College of Medicine on the biology, diagnosis, and treatment of lymphoma and was recently selected as the Cancer Signature Program liaison of the OSUCCC for the OSU Research Education Council Committee. Dr. Porcu is very active in patient education forums, on behalf of patient advocacy organizations, such as the Cutaneous Lymphoma Foundation, CancerCare, and the Leukemia and Lymphoma Society. INTRODUCTION T-cell lymphomas (TCL) are a relatively rare form of nonHodgkin lymphoma (NHL), representing approximately 10-15% of all NHL cases. TCL have a predilection for the skin and are therefore of great clinical interest to dermatologists and hematologists alike. Cutaneous T-cell lymphomas (CTCL) define a heterogeneous group of malignancies encompassing many different clinical and pathological presentations. Mycosis fungoides (MF) is the most common type of CTCL. While MF follows an indolent clinical course, other more aggressive forms of CTCL present a challenge to the clinician from both a diagnostic and treatment standpoint. It is not uncommon that MF and other types of CTCL may coexist in the same patient. Recent advances in drug development have increased the effectiveness of CTCL treatment. INITIAL PRESENTATION A 65-year-old Caucasian female presented to an outside oncologist with a progressively enlarging marble-sized lesion on her left posterior thigh without other cutaneous findings. A biopsy containing more than 90% tumor cells revealed a CD3+ CD4+ CD30small to medium size T-cell l","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133349638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term Complete Response to Bexarotene, Photopheresis and Ampicillin","authors":"M. Duvic, R. Talpur","doi":"10.5580/1f9f","DOIUrl":"https://doi.org/10.5580/1f9f","url":null,"abstract":"Madeleine Duvic, MD, is Professor of Internal Medicine and Dermatology, and Deputy Chairman of the Department of Dermatology at The University of Texas, M. D. Anderson Cancer Center in Houston, Texas. She is a founding member of the United States Cutaneous Lymphoma Consortium (USCLC), a Board member of the International Society for Cutaneous Lymphoma, and also serves as Director of The Cutaneous Lymphoma Clinic at MD Anderson Cancer Center. Dr. Duvic has also served on the Board of Directors of the American Academy of Dermatology (AAD). She is certified in Internal Medicine and Dermatology. She has been a principal and co-principal investigator on numerous clinical trials studying the immunology of T-cell mediated disorders and skin cancers, as well as clinical drug development and translational research in T-cell lymphomas, melanoma, and various skin cancers. A prolific author, she has written manuscripts, book chapters, abstracts, and over 300 peer-reviewed journal articles. She is co-author on a recent book on Retinoids and Carotenoids in Dermatology.","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130996088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of asthmatic bronchoconstriction by percutaneous low voltage vagal nerve stimulation: case report.","authors":"P. Sepúlveda, Gorav Bohill, T. J. Hoffmann","doi":"10.5580/4a7","DOIUrl":"https://doi.org/10.5580/4a7","url":null,"abstract":"Background: A 34 year old Hispanic male patient presented himself in the emergency room with recurring severe asthma that was unresponsive to b-adrenergic and steroid therapy. Spirometry demonstrated significant airflow obstruction. Objective: We sought to test the ability of low voltage vagus nerve stimulation to induce bronchodilation and improve airflow.Method: A percutaneous electrode was inserted into the patient’s neck and positioned to lie in the vicinity of the carotid sheath. Following placement, stimulation was administered and the signal amplitude slowly increased until muscle twitching or discomfort was reported by the patient then reduced to a comfortable level. Results: Within minutes of stimulation, the patient reported reduced dyspnea that was confirmed by spirometry fifteen minutes later (FEV1 increased from 2.70 L to 3.18 L). The FEV1 remained elevated during the 180min treatment (3.29 ± 0.04 L) and at 30min post stimulation (3.36 L). The FEV1 then decreased to 2.84 L 60min after stimulation ended. Conclusion: This finding indicates that low voltage vagus nerve stimulation could be a useful critical care treatment to alleviate smooth muscle bronchoconstriction and offer a new therapeutic approach to the treatment of acute asthma.","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129819033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophil Interaction With Matrix-Producing Lung Cells: An In Vitro Model System Employing AML14.3D10 Eosinophil-Like Cells To Interact With AH1F Fibroblasts And A549 Epithelial Cells","authors":"J. Meerschaert, K. Nkhata, J. Sedgwick, W. Busse, D. Mosher","doi":"10.5580/404","DOIUrl":"https://doi.org/10.5580/404","url":null,"abstract":"The extracellular matrix protein fibronectin is found in the airway space after bronchial provocation and can extend the life of eosinophils in vitro. Herein we describe a system to study the effect of co-culture of eosinophil-like cells with cell lines derived from tissues. We compared integrin engagement on human peripheral blood eosinophils to several eosinophil-like cell lines, including EoL-3, AML 14.3D10, and HL-60 clone 15 cells. Effects of co-incubation of AML 14.3D10 cells with adherent cell AH1F fibroblasts or A549 epithelial cells were examined for adhesion, metabolic activity (reduction of cytochrome C), and fibronectin production. AML 14.3D10 cells had the ability to bind to the adherent cells, however the interaction was not reduced by blocking integrins on the eosinophil-like cells. The amount of fibronectin found in association with the extracellular matrix of AH1F fibroblasts or A549 epithelial cells as measured by ELISA was not altered when AML 14.3D10 cells were included as a co-culture. The co-cultures were separated into three fractions to measure fibronectin that was secreted into the medium or fibronectin associated with non-adherent cells, and also fibronectin associated with adherent cell extracellular matrices. Fibronectin was detected all three fractions, indicating that secreted fibronectin was not limited to incorporation within the extracellular matrix of adherent cells. Thus both fibroblasts and epithelial cells are capable of producing soluble cellular fibronectin and either may be the source of soluble cellular fibronectin found in the lungs of asthmatics after bronchoprovocation.","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131259950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Patient with Advanced Folliculotropic Mycosis Fungoides/Sézary Syndrome with Lenalidomide","authors":"C. Querfeld","doi":"10.5580/26fe","DOIUrl":"https://doi.org/10.5580/26fe","url":null,"abstract":"Christiane Querfeld, MD, a dermatologist from Germany, is currently a resident in the Section of Dermatology at the University of Chicago. Her previous academic appointments included serving as Research Associate and Assistant Professor at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. Her major clinical interest is cutaneous lymphomas and her research focuses on biologic therapies, and signal transduction in these diseases. Dr. Querfeld serves as coprincipal investigator on several translational studies in cutaneous T-cell lymphomas. She has received two Young Investigator Awards; from the Northwestern Memorial Foundation and Cutaneous Lymphoma Foundation recognizing her work on cutaneous lymphomas. In addition, she has authored numerous original articles, reviews, and textbook chapters. Dr. Querfeld serves as reviewer for several journals including European Journal of Cancer, Journal of the European Academy of Dermatology and Venereology, and Leukemia Lymphoma. She received her medical degree from the University of Cologne, Medical School, Germany.","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"250 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133113376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidermolysis bullosa pruriginosa: Report Of A Rare Case","authors":"A. Bansal, V. Mahajan, N. L. Sharma, N. Sud, Anju Lath, N. Gupta","doi":"10.5580/1b05","DOIUrl":"https://doi.org/10.5580/1b05","url":null,"abstract":"Epidermolysis bullosa prurugenosa is an extremely rare variant of dystrophic epidermolysis bullosa in which combination of intense pruritus and skin fragility lead to hypertrophic, lichenified nodules and plaques and show scarring, milia and nail dystrophy. Histologically, features of hyperkeratosis, acanthosis and minimal blistering at dermal-epidermal-sublamina level are characteristic. Most cases are inherited as autosomal recessive, dominant or sporadic. Its onset is often late, the clinical course is unpredictable and various factors leading to intense pruritus remain speculative. Diagnosis is from characteristic clinicopathologic features. The defect in anchoring fibrils has been attributed to mutations in COL7A1 gene mapped to 3p21.3 locus but glycine substitution within triple helical collagen domain of type VII molecule may not be exclusive to this variant. There is no satisfactory treatment and it is not known whether treatment of pruritus would prevent development of other manifestations of the disorder. Genetic counseling, future clinical surveillance and prenatal diagnosis perhaps remain useful. This paper describes a case of this rare disorder revisiting its various aspects.","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"737 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126570439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prick testing in chronic idiopathic urticaria: A report from a tertiary care centre in south India","authors":"A. Nath, Balaji Adityan, D. Thappa","doi":"10.5580/2150","DOIUrl":"https://doi.org/10.5580/2150","url":null,"abstract":"Background: Chronic idiopathic urticaria can be provoked by a number of known and unknown factors and allergens. Some of these allergens can be identified by prick tests. Objectives: To determine the frequency of chronic idiopathic urticaria and to identify the antigens showing positive reactions to skin prick test. Patients and Methods: Fifty patients with chronic idiopathic urticaria were screened from patients attending Skin department of our institute and they were evaluated by prick testing. Results: The mean age of the patients was 33 years. Female to male ratio was 4:1. On skin prick test, 22 patients (44%) had positive response to one or more antigens – 9 patients had positive reaction to single antigens, and 13 patients had positive reaction to more than one antigen. Insects and pollens showed maximum number of positive reactions (12 cases each, 24%), followed by food items (11 cases, 22%), animal danders (7 cases, 14%), house dust mite (6 cases, 12%) and moulds and yeasts (5 cases, 10%). Five most common antigens to show positive reactions in our study were (in descending order of frequency): cockroach (7), house dust mite (6), cat danders (6), housefly (5) and rice grain dust (4). Positive skin prick test reactions were not significantly influenced by age, gender, and duration of the disease. Conclusions: A notable proportion of cases with chronic idiopathic urticaria demonstrate sensitivity to cockroach, house dust mites, pollens and animal danders. Thus, skin prick test is an important diagnostic procedure in such cases, where all other investigations have been fruitless.","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124449632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sublingual immunotherapy (SLIT) in a standard American allergy practice","authors":"R. Garcia-Ibanez, D. Pollina","doi":"10.5580/18d2","DOIUrl":"https://doi.org/10.5580/18d2","url":null,"abstract":"Subcutaneous Immunotherapy (SCIT) has been used in the United States with little modification for almost 100 years. It has been proven effective in the treatment of allergic disease not responsive to pharmacotherapy and appears to prevent the emergence of asthma in the pediatric population affected with allergic rhinitis. It is also effective in the treatment of Hymenoptera venom allergy, and drug allergy. The standard protocol for the treatment of all allergic disease requires injections twice a week for up to 6 months with maintenance biweekly or monthly shots lasting 3 to 5 years. Rush schedules are also possible though they appear to carry higher risks to patients.","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123979059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acantholytic Seborrheic Keratosis","authors":"Jeff F. Wang, Bo Wang, J. Shehan, D. Sarma","doi":"10.5580/128","DOIUrl":"https://doi.org/10.5580/128","url":null,"abstract":"We are reporting a rare case of an acantholytic seborrheic keratosis and briefly reviewing the relevant literature.","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127233857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD34-positive Fibroma of the Lip","authors":"Jeff F. Wang, D. Sarma","doi":"10.5580/19a5","DOIUrl":"https://doi.org/10.5580/19a5","url":null,"abstract":"We are reporting a case of CD34-positive fibroma of the lip. English literature is briefly reviewed. CASE REPORT A 56-year-old female presented with a slightly raised nodule on the lower lip measuring 0.7 x 0.7 cm. This lesion was noted by the patient for about a month. There was no history of trauma or previous biopsy at this site. An excisional biopsy was performed. Microscopically, the lesion showed a dermal benign fibrotic and hyalinized nodule with overlying normal epidermis (Figure 1A). The hyalinized lesion was composed of acellular fibrocollagenous tissue with few stellate fibroblastic cells containing small dark splindle-shaped nuclei (Figure 1B). The stellate fibroblastic cells were strongly positive for CD34 (Figure 2B) and Vimentin (Figure 2B) but were negative for S-100 protein, SMA, and CD31. Figure 1 Figure 1A: Normal epidermis, dermal nodule. Figure 2 Figure 1B: Dermal tumor Figure 3 Figure 2A: CD34 positive. CD34-positive Fibroma of the Lip 2 of 3 Figure 4 Figure 2B: Vimentin positive COMMENT Fibromas occur in any area of the oral mucosa but are most often located on the palate, tongue, cheek, or lip. They typically appear as pink or white elevated submucosal nodules. When such lesions are traumatized, they may appear reddish or blue. They tend to have a smooth surface and may be round, oval or elliptical in shape. The size of a fibroma can vary from a few millimeters to about 2 centimeters. A CD34-positive fibroma is a rare entity. Such a tumor may cause a diagnostic confusion with other CD34positive cutaneous tumors including sclerotic fibroma [1], solitary fibrous tumor, eruptive CD34-postive fibroma [2], pleomorpic fibroma [3], dermatofibrosarcoma protuberans [4], and Kaposi's sarcoma. Most of these lesions can be excluded by the clinical finding, histologic appearance and results of immunohistochemical stains. CD34-positive fibroma is considered a benign, non-recurrent dermal neoplasm, a subset of cutaneous or mucosal fibromas. CORRESPONDENCE TO Deba P Sarma, M.D. Department of Pathology Creighton University Medical School Omaha, NE 68131 debasarma@creighton.edu References 1. Alawi F, Freedman PD. Sporadic sclerotic fibroma of the oral soft tissues. Am J Dermatopathol 2004; 26:182-187. 2. Pursley HG, Williford PM, Groben PA, White WL. CD34-positive eruptive fibroma. J Cutan Pathol 1998; 25:122. 3. Rudolph P, Schubert C, Zelger B, Parwaresch R. Differential expression of CD34 and Ki-M1p in plemomorphic fibroma and dermatofibroma with monster cells. Am J Dermatopathol 1999; 21:414. 4. McNiff JM, Subtil A, Cowper SE, Lazova R, Glusac EJ. Cellular digital fibromas: distinctive CD34-positive lesions that may mimic dermatofibrosarcoma protuberans. J Cutan pathol 2005; 32:413-418. CD34-positive Fibroma of the Lip 3 of 3 Author Information Jeff Wang, M.D. Resident of Pathology, Creighton University Medical Center Deba P. Sarma, M.D. Professor of Pathology, Creighton University Medical Center","PeriodicalId":161194,"journal":{"name":"The Internet Journal of Dermatology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134528594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}