Journal of Infection and Chemotherapy最新文献

{"title":"A case of post-outbreak acute hepatitis a in a Japanese man who have sex with men infected with RIVM-HAV16-090 strain","authors":"Miho Kozuki ,&nbsp;Satoshi Tanaka ,&nbsp;Tatsuya Shirai ,&nbsp;Naomi Sakon ,&nbsp;Satoshi Harada ,&nbsp;Ayaka Kitagawa ,&nbsp;Kensuke Matsushima ,&nbsp;Yutaro Abe ,&nbsp;Nobuyasu Fukutake ,&nbsp;Hiroko Hasegawa ,&nbsp;Shunsuke Yamamoto ,&nbsp;Yuko Sakakibara ,&nbsp;Ryotaro Sakamori","doi":"10.1016/j.jiac.2025.102673","DOIUrl":"10.1016/j.jiac.2025.102673","url":null,"abstract":"<div><h3>Aim</h3><div>Hepatitis A outbreaks among men who have sex with men (MSM) are a growing global concern. We present a case report of acute hepatitis A in a Japanese MSM who acquired the infection after the conclusion of a recent hepatitis A outbreak in Japan during his subsequent visit to Taiwan.</div></div><div><h3>Case presentation</h3><div>A 27-year-old male had experienced fever, headache, and loss of appetite over the previous eight days. After his jaundiced skin was noted during a routine health examination, he visited our outpatient department that same day. The severe liver dysfunction detected in blood tests necessitated hospitalization for acute hepatitis. Subsequent tests revealed positive HA-IgM antibodies, confirming acute hepatitis A. Further inquiry revealed the patient's MSM status and recent sexual encounter one and a half months earlier during a visit to Taiwan. With conservative treatment, his condition improved and he was discharged after 12 days. Phylogenetic analysis extracted from his stool sample confirmed that the hepatitis A virus (HAV) strain was RIVM-HAV16-090, consistent with strains observed in previous hepatitis outbreaks among MSM populations.</div></div><div><h3>Conclusion</h3><div>To the best of our knowledge, this is the first case report of acute hepatitis A in a Japanese MSM sporadically infected with the RIVM-HAV16-090 strain since the end of the outbreak. This case underscores the persistent risk of hepatitis A transmission among MSM despite the cessation of the outbreak, emphasizing the importance of targeted vaccination campaigns, sexual health education, and ongoing vigilance in mitigating the risk of hepatitis A transmission among MSM.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102673"},"PeriodicalIF":1.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic findings among healthy adults with asymptomatic norovirus infection in Japan: A single-center cross-sectional study","authors":"Kyoko Yokota ,&nbsp;Hisashi Masugata ,&nbsp;Shizuka Yamagata-Uyama ,&nbsp;Kazuki Yamamoto ,&nbsp;Katsunori Masuda ,&nbsp;Mayuko Saito ,&nbsp;Daiki Kobayashi","doi":"10.1016/j.jiac.2025.102672","DOIUrl":"10.1016/j.jiac.2025.102672","url":null,"abstract":"<div><h3>Introduction</h3><div>Norovirus infection, a major cause of acute viral gastroenteritis, is commonly reported during the winter season. Norovirus invades the upper intestinal tract, causing inflammation. In severe cases, endoscopic findings and complications, including duodenal perforation, have been reported. However endoscopic findings in patients with asymptomatic infections have rarely been reported. Therefore, this study aimed to investigate the upper endoscopic findings of patients with asymptomatic norovirus infection.</div></div><div><h3>Methods</h3><div>Healthy adults (aged ≥18 years) who participated in voluntary health examinations between February 2017 and January 2018 were recruited twice a week. Only the individuals who had undergone esophagogastroduodenoscopy (EGD) were included. The primary outcome measure was the presence of any gross findings of EGD.</div></div><div><h3>Results</h3><div>The norovirus genogroup I (GI)-positive group had more duodenal scarring than the norovirus negative group (16.3 % vs 5.9 %, respectively). After adjustment for age category, sex, and alcohol consumption status, duodenal ulcer scarring exhibited a significant association with GI-positive status (adjusted odds ratio: 3.11; 95 % confidence interval: 1.42–6.82; p = 0.005, Bonferroni-corrected, p = 0.015).</div></div><div><h3>Conclusions</h3><div>Healthy adults with asymptomatic norovirus (GI-positive) infection showed predominantly more duodenal ulcer scarring than the norovirus-negative group on EGD.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102672"},"PeriodicalIF":1.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The time to return-to-work in healthcare workers with COVID-19 treated with ensitrelvir, a novel oral inhibitor of 3C-like protease of SARS-CoV-2: An observational study utilizing pre-existing data from a single hospital","authors":"Makoto Katsuta ,&nbsp;Masatoshi Kitazono ,&nbsp;Naohito Nagai ,&nbsp;Hiroto Karibe ,&nbsp;Yusaku Takahashi ,&nbsp;Yasuko Ariwa ,&nbsp;Takuhiro Sonoyama ,&nbsp;Tomoyoshi Yamaguchi","doi":"10.1016/j.jiac.2025.102669","DOIUrl":"10.1016/j.jiac.2025.102669","url":null,"abstract":"<div><div>While treatment with anti-SARS-CoV-2 agents holds promise for managing healthcare workers with COVID-19, studies on this topic are limited. This study evaluated the time to return-to-work and remaining symptoms among healthcare workers with COVID-19 who received ensitrelvir and those who did not receive anti-SARS-CoV-2 drugs. This observational cohort study included healthcare workers diagnosed with COVID-19 between June and September 2023 at a single facility in Japan. Participants returned to work if they met all the following criteria: ≥5 days post-COVID-19 onset, fever resolution, and negative antigen test. The primary endpoint was the days from disease onset to return-to-work. We also evaluated the persistence of each symptom on the date of return-to-work, and the clinical and virological outcomes on the first scheduled date of return-to-work (Trial registration: UMIN000054128). The study enrolled 60 participants in the ensitrelvir group and 42 in the non-antiviral group. The mean number of days (SD) to return-to-work was 6.9 days (±1.6) in the ensitrelvir group and 7.7 days (±1.9) in the non-antiviral group. On the date of return-to-work, 4 participants in the non-antiviral group had taste disorders and 2 had smell disorders. On the first scheduled date of return-to-work (i.e. the date of first antigen test after onset), 56.7 % of participants in the ensitrelvir group and 33.3 % in the non-antiviral group had recovered, with the antigen test negativity in 76.7 % and 52.4 %, respectively. Ensitrelvir treatment for healthcare workers experiencing COVID-19 appeared to be associated with early symptom amelioration with viral load reduction, and shorter time to return-to-work.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102669"},"PeriodicalIF":1.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between severe acute respiratory syndrome coronavirus 2 omicron variant epidemic and acute myocardial infarction: A self-controlled case series study","authors":"Jun Suzuki ,&nbsp;Tomoki Mizuno ,&nbsp;Shota Takahashi ,&nbsp;Haruka Imai ,&nbsp;Hideya Itagaki ,&nbsp;Tomohiro Akaba ,&nbsp;Makiko Yoshida ,&nbsp;Shiro Endo","doi":"10.1016/j.jiac.2025.102666","DOIUrl":"10.1016/j.jiac.2025.102666","url":null,"abstract":"<div><h3>Background</h3><div>The coronavirus disease 2019 (COVID-19) pandemic has led to various complications, including cardiovascular events. Despite the widespread impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant in 2022, no studies have evaluated the relationship between the Omicron variant epidemic and acute myocardial infarction (AMI).</div></div><div><h3>Methods</h3><div>We utilized a Japanese claims database to identify patients diagnosed with COVID-19 between January 1, 2022, and December 31, 2022. We also identified patients who developed AMI within 90 days before and after their COVID-19 diagnosis. A self-controlled case series (SCCS) analysis evaluated the incidence rate ratio (IRR) for AMI.</div></div><div><h3>Results</h3><div>Of the 360,589 patients with COVID-19, 759 were diagnosed with AMI. Excluding the day of exposure, the SCCS analysis showed an IRR for AMI of 6.65 (95 % confidence interval [CI]: 4.66–9.48, P &lt; 0.001) for the 1st week, 1.90 (95 % CI: 1.05–3.50, P = 0.03) for the 2 nd week, and 0.95 (95 % CI: 0.52–1.72, P = 0.87) for the 3rd and 4th weeks following COVID-19. Including the day of exposure, the IRR was 77.4 (95 % CI: 63.2–94.9, P &lt; 0.001) for the 1st week, 1.90 (95 % CI: 1.05–3.50, P = 0.03) for the 2 nd week, and 0.95 (95 % CI: 0.52–1.72, P = 0.87) for the 3rd and 4th weeks following COVID-19.</div></div><div><h3>Conclusions</h3><div>This study showed that the SARS-CoV-2 Omicron variant epidemic increased AMI incidence. These findings highlight AMI as a COVID-19 characteristic, emphasize the importance of SARS-CoV-2 vaccination, and underline the need for continued vigilance, even with variant changes.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102666"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a school-based tutorial about the HPV vaccine for female middle school students on the HPV vaccination rate in Japan: A prospective cohort study","authors":"Yo Murata ,&nbsp;Yuya Saito ,&nbsp;Toshimasa Obonai","doi":"10.1016/j.jiac.2025.102671","DOIUrl":"10.1016/j.jiac.2025.102671","url":null,"abstract":"<div><h3>Background</h3><div>In Japan, the Ministry of Health, Labour and Welfare (MHLW) rescinded recommendations for including the HPV vaccine in the national immunization program in 2013, which led to a drop in the vaccination rate to &lt; 1 %. Despite the MHLW's decision to reinstate the recommendations in 2022, the vaccination rate has remained low. The present study aimed to assess the effect of a school-based vaccine tutorial on the HPV vaccination rate in female middle-school students in Japan.</div></div><div><h3>Methods</h3><div>This prospective cohort study, conducted in Higashimurayama, Tokyo from September 2023 to March 2024, enrolled female students aged 13–14 years in seven middle schools. Four and three schools formed a tutorial group and control group, respectively. The difference between the pre- and post-intervention vaccination rates was assessed using a questionnaire. Additionally, knowledge about the HPV vaccine and the rate of students’ discussion of the vaccine with their family were analyzed.</div></div><div><h3>Results</h3><div>In total, 123 and 175 students from the tutorial and control group, respectively, were analyzed. The pre-intervention vaccination rate was 9.8 % and 7.4 % (p = 0.476), and the post-intervention vaccination rate was 16.3 % and 9.7 %, indicating a corresponding increase of 7.2 % and 2.5 % (p = 0.075). The knowledge increased to a greater degree in the tutorial group.</div></div><div><h3>Conclusion</h3><div>Our study revealed an increasing trend in the HPV vaccination rate resulting from the school-based tutorial although the difference was not statistically significant. School-based tutorials can increase students’ knowledge about the vaccine and enable them to make informed decisions about vaccination.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102671"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous bacterial peritonitis due to Brucella in an HBV-positive cirrhotic patient","authors":"Yasemin Çakır Kıymaz ,&nbsp;Sümeyye Kara Yeşildağ ,&nbsp;Sevgi Baltacı ,&nbsp;Ayşenur Çömez Baysal ,&nbsp;Cihad Baysal ,&nbsp;Ertuğrul Keskin ,&nbsp;Suna Bozkurt ,&nbsp;Mürşit Hasbek ,&nbsp;Seyit Ali Büyüktuna ,&nbsp;Nazif Elaldı","doi":"10.1016/j.jiac.2025.102663","DOIUrl":"10.1016/j.jiac.2025.102663","url":null,"abstract":"<div><div>Spontaneous bacterial peritonitis (SBP) is a severe complication of cirrhosis, occurring in approximately 15 % of cirrhotic patients. The most common causative pathogens of SBP are <em>Escherichia coli</em> and <em>Klebsiella pneumoniae</em>. Although brucellosis can cause various complications, it is a rare cause of peritonitis. Herein, we report a case of a 30-year-old male with chronic hepatitis B who presented with fever, night sweats, weight loss, abdominal pain, and distension. <em>Brucella</em> spp. was isolated from blood and peritoneal fluid cultures. The patient fully recovered following six weeks of treatment with oral doxycycline (100 mg twice daily) and rifampicin (600 mg/day). No relapses or complications were observed during follow-up.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102663"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of ensitrelvir and symptomatic therapy in healthcare workers with mild COVID-19: A single center retrospective analysis in Chiba, Japan","authors":"Jun Hirai ,&nbsp;Yuki Hanai","doi":"10.1016/j.jiac.2025.102668","DOIUrl":"10.1016/j.jiac.2025.102668","url":null,"abstract":"<div><h3>Background</h3><div>Ensitrelvir, a novel oral antiviral targeting the 3CL protease of SARS-CoV-2, has demonstrated efficacy in reducing viral load in clinical trials. Rapid viral clearance in healthcare workers (HCWs) with mild COVID-19 is critical for symptom relief and minimizing secondary transmission. However, real-world evidence on ensitrelvir's effectiveness in this population is limited.</div></div><div><h3>Methods</h3><div>This single-center retrospective study analyzed 407 HCWs with mild COVID-19 treated with either ensitrelvir or symptomatic therapy. Viral load was assessed using reverse transcription-polymerase chain reaction cycle threshold (Ct) values. The primary endpoint was achieving a Ct &gt; 30, indicating low infectivity, on days 5–8 or 9–12. Secondary endpoints included adverse events, hospitalization, disease progression, and all-cause mortality within 30 days of symptom onset. Multivariate logistic regression identified factors associated with achieving Ct &gt; 30.</div></div><div><h3>Results</h3><div>Patients in the ensitrelvir group had significantly higher rates of achieving Ct &gt; 30 on days 5–8 (38.0 % vs. 9.9 %, <em>p</em> &lt; 0.01) and days 9–12 (77.8 % vs. 42.3 %, <em>p</em> &lt; 0.01). Treatment with ensitrelvir was associated with a significantly higher likelihood of symptom improvement within 5–8 days compared to symptomatic therapy (<em>p</em> &lt; 0.01). Multivariate analysis confirmed ensitrelvir as independently associated with Ct &gt; 30 (adjusted odds ratio: 6.498; <em>p</em> &lt; 0.01). No adverse events, hospitalizations, or mortality were observed.</div></div><div><h3>Discussion</h3><div>Ensitrelvir demonstrated superior viral clearance compared to symptomatic therapy, facilitating a safer and earlier return to work for HCWs. However, additional precautions, such as mask use, remain essential for HCWs working in high-risk environments, even after ensitrelvir treatment.</div></div><div><h3>Conclusions</h3><div>Ensitrelvir is a safe and effective option for reducing SARS-CoV-2 viral load in HCWs with mild COVID-19, supporting timely recovery and reducing infectivity.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102668"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial susceptibility of commensal Neisseria species in the Japanese population","authors":"Izumo Kanesaka ,&nbsp;Sheeba Santhini Manoharan-Basil ,&nbsp;Tessa De Block ,&nbsp;Chris Kenyon ,&nbsp;Masahiro Morita ,&nbsp;Takamitsu Ito ,&nbsp;Natsue Yamane ,&nbsp;Akiko Katsuse Kanayama ,&nbsp;Intetsu Kobayashi","doi":"10.1016/j.jiac.2025.102670","DOIUrl":"10.1016/j.jiac.2025.102670","url":null,"abstract":"<div><h3>Objectives</h3><div>We aimed to, for the first time, characterize the antimicrobial susceptibilities of commensal <em>Neisseria</em> species in the general population in Japan. In particular, we assessed if the tetracycline minimum inhibitory concentrations (MICs) of these isolates were changing over time and, given the recent interest in doxycycline post exposure prophylaxis (PEP), if the tetracycline MICs were associated with those of the other antimicrobials.</div></div><div><h3>Methods</h3><div><em>Neisseria</em> spp. were isolated from 1679 patients visiting dental clinics in Japan between 2018 and 2023. The MICs of tetracycline, ceftriaxone, cefixime, penicillin, azithromycin and ciprofloxacin against <em>Neisseria</em> spp. were determined using agar dilution. Linear regression was used to assess if there was an association between MIC and the year the isolate was obtained from, controlling for species identity.</div></div><div><h3>Results</h3><div><em>Neisseria</em> spp. were detected in 424 of 1679 individuals sampled. Of these, 417 (98.3 %) isolates were identified as <em>Neisseria subflava</em>, and the remaining 7 (1.7 %) as <em>Neisseria mucosa</em>. The median tetracycline MIC was 0.5 mg/L (IQR 0.5–1 mg/L). The MICs of penicillin, cefixime, ceftriaxone and ciprofloxacin were lower in <em>N. mucosa</em> than in <em>N. subflava</em>. The tetracycline MICs of <em>Neisseria</em> spp. were positively correlated with penicillin, azithromycin and ciprofloxacin. No significant correlations were found with cefixime or ceftriaxone.</div></div><div><h3>Conclusions</h3><div>Our results suggest that despite the overall decline in antimicrobial use in Japan, MICs for several antimicrobials have increased over time. In particular, the MIC of tetracycline tends to be high in Japan. These results suggest the need to include surveillance of tetracycline MICs of commensal <em>Neisseria</em> spp. in doxycycline PEP implementation studies.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102670"},"PeriodicalIF":1.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycobacterium goodii pulmonary disease in an immunocompetent patient: A case report and literature review","authors":"Toshihiro Shiratori ,&nbsp;Yasuhito Nunomura ,&nbsp;Masamichi Itoga ,&nbsp;Tomonori Makiguchi ,&nbsp;Hisashi Tanaka ,&nbsp;Kageaki Taima ,&nbsp;Kinuyo Chikamatsu ,&nbsp;Akira Kurose ,&nbsp;Satoshi Mitarai ,&nbsp;Sadatomo Tasaka","doi":"10.1016/j.jiac.2025.102665","DOIUrl":"10.1016/j.jiac.2025.102665","url":null,"abstract":"<div><div><em>Mycobacterium goodii</em> is a rapidly growing non-tuberculosis mycobacterium, which is known to cause skin, bone and soft tissue infections, but there are a few reports of respiratory infections due to <em>M. goodii</em>. A 67-year-old man had suffered from productive cough, shortness of breath and weight loss for 6 months. He had a history of total gastrectomy for gastric ulcer perforation. Computed tomography (CT) showed dense consolidation in the right lower lobe and nodular lesions in both lungs. Transbronchial cryobiopsy was performed on a lesion in the right lower lobe and granulomatous lesions were observed pathologically. Because <em>M. goodii</em> was identified from two sputum samples using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), we made a diagnosis of <em>M. goodii</em> pulmonary disease. To confirm the diagnosis, whole genome sequencing analysis was performed, which showed average nucleotide identity of 99.18 %. The patient was responded well to the initial therapy with amikacin, imipenem/cilastatin, doxycycline, sulfamethoxazole/trimethoprim, and clarithromycin, followed by 18 months of ambulatory treatment with doxycycline, sulfamethoxazole/trimethoprim, clarithromycin, and sitafloxacin. The sputum culture remained negative and CT findings also significantly improved 6 months after the introduction of treatment. In this case, the development of <em>M. goodii</em> pulmonary disease is might be associated with the history of gastrectomy. For identifying the pathogen, MALDI-TOF MS and whole genome sequencing analysis were useful and the intensive initial treatment in accordance with the drug susceptibility testing was successful.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102665"},"PeriodicalIF":1.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assignments of antibiotic spectrum coverage scores of antibiotic agents approved in Japan: Utilization of the days of antibiotic spectrum coverage","authors":"Masayuki Maeda ,&nbsp;Satoshi Kakiuchi ,&nbsp;Yuichi Muraki","doi":"10.1016/j.jiac.2025.102667","DOIUrl":"10.1016/j.jiac.2025.102667","url":null,"abstract":"<div><div>Integrating the automated collection of antimicrobial use metrics into national surveillance systems is vital for antimicrobial stewardship evaluation. The days of antibiotic spectrum coverage (DASC) serves as a quantitative metric for assessing de-escalation strategies. A major challenge is that DASC has not yet been integrated into the national surveillance system, partly owing to the omission of commonly used antibiotics in Japan in the initially developed antibiotic spectrum coverage (ASC) scores. This study aimed to establish ASC scores for antibiotics approved in Japan and generate data supporting their integration into the national surveillance system. Antibiotics approved in Japan that had not been assigned ASC scores in the prior study were identified. Their antimicrobial activity was assessed against 16 organism categories using the same methodology as the original study. We analyzed the correlation between the Access, Watch, Reserve (AWaRe) classification and ASC scores for antibiotics approved in Japan. The ASC scores had a range of 3–16, with a median of seven. The AWaRe classification was slightly correlated with ASC scores (Spearman's ρ = 0.234). Our findings highlight the significance of employing diverse antimicrobial use metrics for comprehensively evaluating antimicrobial stewardship. The results of this study will support stakeholders in implementing ASC scores into the national surveillance system.</div></div>","PeriodicalId":16103,"journal":{"name":"Journal of Infection and Chemotherapy","volume":"31 4","pages":"Article 102667"},"PeriodicalIF":1.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}