Clinical characteristics and antibiotic susceptibility of Lactobacillus bacteremia: A retrospective analysis

IF 1.5 4区医学 Q3 INFECTIOUS DISEASES

Journal of Infection and Chemotherapy Pub Date : 2025-08-15 DOI:10.1016/j.jiac.2025.102794

Yuichi Shibata , Nobuhiro Asai , Mao Hagihara , Hiroshige Mikamo

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引用次数: 0

Abstract

Background

Lactobacillus bacteremia (LB) is an uncommon cause of infection in immunocompetent individuals, owing to its low pathogenicity. However, bacteremia has been reported in immunocompromised patients. In Japan, clinical data on the characteristics and antimicrobial susceptibility of LB remain limited. Hence, a retrospective analysis was conducted at our institution to address this gap.

Methods

Patients in whom Lactobacillus spp. were identified from blood cultures at the Aichi Medical University Hospital between April 2018 and March 2025 were included in our study. Clinical characteristics and antimicrobial susceptibility profiles of the isolates were retrospectively analyzed.

Results

A total of 17 patients (13 men and 4 women) were included in the study and all patients received antibiotic treatment. The most common bacterial species detected was Lacticaseibacillus paracasei (47.1 %). All isolates exhibited 100.0 % susceptibility to ampicillin. Risk factors were present in 82.4 % of patients, and concomitant polymicrobial infections occurred in 70.6 % of the cohort. Candida spp. were the most frequently identified organisms in polymicrobial infections (33.3 %). Six patients (35.3 %) died within 30 days after bacteremia diagnosis, with a median time to death of 26.5 days (range, 2.0–1468.0 days).

Conclusions

The detection rate of L. paracasei in this study was higher than that reported in countries outside of Asia. High susceptibility to penicillin was maintained, suggesting that penicillin remains to be an appropriate choice for both empirical and definitive therapy in Japan.

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乳杆菌血症的临床特点及抗生素敏感性回顾性分析。

背景：乳杆菌血症（Lactobacillus bacteremia， LB）由于致病性低，在免疫正常的个体中是一种罕见的感染原因。然而，在免疫功能低下的患者中也有菌血症的报道。在日本，关于LB的特点和抗菌药物敏感性的临床数据仍然有限。因此，在我们的机构进行了回顾性分析，以解决这一差距。方法：纳入2018年4月至2025年3月期间在爱知医科大学附属医院血液培养中鉴定出乳酸杆菌的患者。回顾性分析分离株的临床特点和药敏情况。结果：共纳入17例患者（男13例，女4例），均接受抗生素治疗。检出最多的菌种为副干酪乳杆菌（Lacticaseibacillus paracasei），占47.1%。所有分离株对氨苄西林的敏感性均为100.0%。82.4%的患者存在危险因素，70.6%的患者伴有多微生物感染。念珠菌是多微生物感染中最常见的细菌（33.3%）。6例患者（35.3%）在菌血症诊断后30天内死亡，中位死亡时间为26.5天（范围为2.0-1468.0天）。结论：本研究中副蜱的检出率高于亚洲以外国家的报道。对盘尼西林的高度敏感性仍然存在，这表明盘尼西林仍然是日本经验性和决定性治疗的适当选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection and Chemotherapy INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

4.10

自引率

4.50%

发文量

303

审稿时长

47 days

期刊介绍： The Journal of Infection and Chemotherapy (JIC) — official journal of the Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases — welcomes original papers, laboratory or clinical, as well as case reports, notes, committee reports, surveillance and guidelines from all parts of the world on all aspects of chemotherapy, covering the pathogenesis, diagnosis, treatment, and control of infection, including treatment with anticancer drugs. Experimental studies on animal models and pharmacokinetics, and reports on epidemiology and clinical trials are particularly welcome.