Journal of forensic and legal medicine最新文献

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To investigate the pattern of neck injuries and the role of toxicology in cases of hanging and manual/homicidal ligature strangulation in Ireland between 2016 – 2020: A retrospective review and analysis 调查 2016-2020 年间爱尔兰发生的绞刑和徒手/凶器勒死案件中颈部损伤的模式和毒理学的作用:回顾与分析
IF 1.5 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-04-01 DOI: 10.1016/j.jflm.2024.102686
Corey Commins , Margot Bolster , Linda Mulligan
{"title":"To investigate the pattern of neck injuries and the role of toxicology in cases of hanging and manual/homicidal ligature strangulation in Ireland between 2016 – 2020: A retrospective review and analysis","authors":"Corey Commins ,&nbsp;Margot Bolster ,&nbsp;Linda Mulligan","doi":"10.1016/j.jflm.2024.102686","DOIUrl":"https://doi.org/10.1016/j.jflm.2024.102686","url":null,"abstract":"<div><p>The pattern of neck injuries sustained in fatal cases of external compression to the neck is recorded during Post Mortem Examinations (PME), to assist in the interpretation of the circumstances that led to death. In this study, the PMEs performed for 298 cases of hanging and strangulation occurring between 2016 and 2020 in Ireland were retrospectively reviewed for the purpose of recording and collating the external and internal neck injuries observed during each PME, as well as the toxicology results for each decedent. Statistical analysis was performed to investigate potential novel associations between anthropometric variables pertaining to the decedents and the PME findings in cases of hanging and strangulation, serving to add further data to the existing body of research in this area and to assist in the resolution of future cases of hanging or strangulation where there are conflicting findings. In completing statistical analysis, it was found that there was no discernible association between the occurrences of cartilaginous neck fractures (CNFs) with increasing ligature width. Positive associations between increasing weight and BMI of the decedents were identified, and a significantly positive association between the increasing height of the decedent and the incidence of CNFs were identified. Analysis of the toxicology demonstrated that antipsychotics were implicated most frequently in cases of incomplete and complete hanging associated with CNFs and that opioids were implicated most frequently in cases of manual and ligature strangulation associated with CNFs.</p></div><div><h3>Objective</h3><p>To record the pattern of neck injuries sustained in retrospective cases of hanging and manual/ligature strangulation and to collate these findings so as to provide scientific evidence to support the interpretation of the findings in future cases of suicidal hanging and homicidal manual/ligature strangulation for the purpose of medicolegal investigation. To analyse the associations between the occurrence of neck fractures and anthropometric variables pertaining to the victims in cases of complete hanging.</p></div><div><h3>Study design</h3><p>The reports of 298 Post Mortem Examinations (PMEs) performed for cases of hanging and manual/homicidal ligature strangulation between 2016 and 2020 in Ireland were retrospectively reviewed. Pseudoanonymised data sets were recorded for each report, which included the following parameters: neck injuries (soft tissue and cartilaginous), weight, height, BMI and ligature width, toxicology, noose position, ligature material, tongue protrusion, sex and age. Permission for the use of this data was sought from the pathologists and coroners involved in these cases. The data was analysed according to descriptive statistical methods and logistic regression analysis.</p></div><div><h3>Results</h3><p>Logistic regression analysis was undertaken to examine the associations between unit increases in ligature width and inc","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140815291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Performance and characterization of 94 identity-informative SNPs in Northern Han Chinese using ForenSeq ™ DNA signature prep kit 使用 ForenSeq ™ DNA 特征预处理试剂盒分析中国北方汉族 94 个身份信息 SNPs 的性能和特征
IF 1.5 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-03-21 DOI: 10.1016/j.jflm.2024.102678
Fei Guo , Ze Liu , Guannan Long , Biao Zhang , Dahua Liu , Shaobo Yu
{"title":"Performance and characterization of 94 identity-informative SNPs in Northern Han Chinese using ForenSeq ™ DNA signature prep kit","authors":"Fei Guo ,&nbsp;Ze Liu ,&nbsp;Guannan Long ,&nbsp;Biao Zhang ,&nbsp;Dahua Liu ,&nbsp;Shaobo Yu","doi":"10.1016/j.jflm.2024.102678","DOIUrl":"https://doi.org/10.1016/j.jflm.2024.102678","url":null,"abstract":"<div><p>Target and flanking region (FR) variation at 94 identity-informative SNPs (iSNPs) are investigated in 635 Northern Han Chinese using the ForenSeq DNA Signature Prep Kit on the MiSeq FGx Forensic Genomics System. The dataset presents the following performance characteristics (average values): ≥60% bases with a quality score of 20 or higher (%≥ Q20); &gt;700 × of depth of coverage (DoC) from both Sample Details Reports and Flanking Region Reports; &gt;80% of effective reads; ≥60% of allele coverage ratio (ACR); and ≥70% of inter-locus balance, while some stable low-performance characteristics are also observed: low DoC at rs1736442, rs1031825, rs7041158, rs338882, rs2920816, rs1493232, rs719366, and rs2342747; high noise at rs891700; and imbalanced ACR at rs6955448 and rs338882. The average amplicon length is 69 bp, suitable for detecting degraded samples. Bioinformatic concordance achieves 99.99% between the ForenSeq Universal Analysis Software (UAS) and the Integrative Genomic Viewer (IGV) inspection. Discordance results from flanking region deletions of rs10776839, rs8078417, rs2831700, and rs1454361. Due to FR variants within amplicons detected by massively parallel sequencing (MPS), the increases in the number of unique alleles, effective alleles (A<sub>e</sub>), and observed heterozygosity (H<sub>obs</sub>) are 46.81%, 4.51%, and 3.29%, respectively. Twelve FR variants are first reported to dbSNP, such as rs1252699848, rs1665500714, rs1771121532, rs2097285015, rs1851671415, rs2045669877, rs2046758811, rs2044248635, rs1251308240, rs1968822112, rs1981638299, and rs1341756746. All 94 iSNPs from target and amplicon data are in Hardy-Weinberg equilibrium (HWE) and independent within autosomes. As expected, forensic parameters from the amplicon data increase significantly on the combined power of discrimination (CPD = 1 – 3.9876 × 10<sup>−38</sup>) and the combined power of exclusion (CPE = 1 – 6.6690 × 10<sup>−8</sup>). Additionally, the power of the system effectiveness (CPD = 1 − 6.7054 × 10<sup>−72</sup> and CPE = 1 − 4.4719 × 10<sup>−20</sup>) with sequence-based 27 autosomal STRs and 94 iSNP amplicons in combination is substantially improved compared to one type of marker alone. In conclusion, we have established a traditional length-based and current sequence-based reference database with 58 STRs and 94 iSNPs in the Northern Han Chinese population. We hope these data can serve as a solid reference and foundation for forensic practice.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dental age estimation: A comparative study of convolutional neural network and Demirjian's method 牙龄估计:卷积神经网络与 Demirjian 方法的比较研究
IF 1.5 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-03-21 DOI: 10.1016/j.jflm.2024.102679
Mustan Barış Sivri , Shahram Taheri , Rukiye Gözde Kırzıoğlu Ercan , Ünsun Yağcı , Zahra Golrizkhatami
{"title":"Dental age estimation: A comparative study of convolutional neural network and Demirjian's method","authors":"Mustan Barış Sivri ,&nbsp;Shahram Taheri ,&nbsp;Rukiye Gözde Kırzıoğlu Ercan ,&nbsp;Ünsun Yağcı ,&nbsp;Zahra Golrizkhatami","doi":"10.1016/j.jflm.2024.102679","DOIUrl":"10.1016/j.jflm.2024.102679","url":null,"abstract":"<div><p>The aim of this study is to compare a technique using Convolutional Neural Network (CNN) with the Demirjian's method for chronological age estimation of living individuals based on tooth age from panoramic radiographs. This research used 5898 panoramic X-ray images collected for diagnostic from pediatric patients aged 4–17 who sought treatment at Antalya Oral and Dental Health Hospital between 2015 and 2020. The Demirjian's method's grading was executed by researchers who possessed appropriate training and experience. In the CNN method, various CNN architectures including Alexnet, VGG16, ResNet152, DenseNet201, InceptionV3, Xception, NASNetLarge, InceptionResNetV2, and MobieNetV2 have been evaluated. Densenet201 exhibited the lowest MAE value of 0.73 years, emphasizing its superior accuracy in age estimation compared to other architectures. In most age categories, the predicted age closely matches the actual age. The most inconsistent results are observed at ages 12 and 13. The results highlight correspondence between the age predicted by CNN and the Demirjian's approach. In conclusion, the results show that the CNN method is adequate to be an alternative to the Demirjian's age estimation method. We suggest that convolutional neural network can effectively optimize the accuracy of age estimation and can be faster than traditional methods, eliminating the need for additional learning from experts.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140278792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging global trends and development in forensic toxicology: A review 法医毒理学的全球新兴趋势与发展:综述
IF 1.5 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-03-19 DOI: 10.1016/j.jflm.2024.102675
Saurabh Shukla , Sakshum Khanna , Tahir ul Gani Mir , Jyoti Dalal , Deeksha Sankhyan , Kushagra Khanna
{"title":"Emerging global trends and development in forensic toxicology: A review","authors":"Saurabh Shukla ,&nbsp;Sakshum Khanna ,&nbsp;Tahir ul Gani Mir ,&nbsp;Jyoti Dalal ,&nbsp;Deeksha Sankhyan ,&nbsp;Kushagra Khanna","doi":"10.1016/j.jflm.2024.102675","DOIUrl":"10.1016/j.jflm.2024.102675","url":null,"abstract":"<div><p>This study conducts a comprehensive analysis of forensic toxicology research trends, publication patterns, author's contributions, and collaboration. Utilizing the Scopus database, we scrutinized 3259 articles across 348 journals spanning from 1975 to 2023. Analysis employed diverse software tools such as VOSviewer, RStudio, MS Excel, and MS Access to dissect various publication aspects. We observed a notable surge in publications post-2007, indicating heightened research interest. Leading contributors included the United States, Germany, and Italy, with Logan B.K. emerging as the most prolific author. Forensic Science International stood out as the primary journal, publishing 888 articles and accruing significant citations. Keyword co-occurrences such as \"forensic toxicology,\" \"forensic science,\" and \"toxicology\" underscored core thematic areas in the field. Moreover, extensive research collaboration, especially among Western nations in Europe, was evident. This study underscores the imperative for enhanced collaboration between developing and developed nations to foster further advancements in forensic science. Strengthened partnerships can catalyze innovation, facilitate knowledge dissemination, and address emerging challenges, thereby propelling the field of forensic toxicology toward new frontiers of discovery and application.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140182385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Men after the sexual assault: The journey from medical service to court 性侵犯后的男性:从医疗服务到法庭的历程
IF 1.5 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-03-19 DOI: 10.1016/j.jflm.2024.102676
Vanita R. Parekh , Janine McMinn , Anna Brkic , Ash Byron , Katelyn Pomroy , Mick Woodburn
{"title":"Men after the sexual assault: The journey from medical service to court","authors":"Vanita R. Parekh ,&nbsp;Janine McMinn ,&nbsp;Anna Brkic ,&nbsp;Ash Byron ,&nbsp;Katelyn Pomroy ,&nbsp;Mick Woodburn","doi":"10.1016/j.jflm.2024.102676","DOIUrl":"10.1016/j.jflm.2024.102676","url":null,"abstract":"<div><h3>Background</h3><p>There may be significant physical and psychological consequences and impacts for males who experience sexual assault as adults, however, published literature in this context is sparse, specifically for the investigative outcomes in the criminal legal process.</p></div><div><h3>Method</h3><p>This clinical audit tracked 138 adult males who presented for forensic and medical sexual assault care from initial presentation to ACT Police investigation and court outcome from 2004 to 2022.</p></div><div><h3>Results</h3><p>There were 103/138 (74.6%) males who attended for medical and forensic care within 72 h of the reported assault. Pre-existing mental health conditions were self-reported in 59/138 (42.7%) males.</p><p>Nearly half of males 67/138 (48.5%) had a medical evidence kit collected. Males presenting for medical care 44/138 (31.2%) went on to report to ACT Policing, 36/44 (81.2%) of cases did not proceed to court. The most common clearance type was inadequate evidence to proceed (17/44, 38.6%).</p><p>In 8/44 (18.2%) of adult male cases who subsequently reported to ACT Police, the investigation resulted in entry to the judicial process with a suspect charged with a sexual offence. Five of those cases resulting in a conviction.</p></div><div><h3>Conclusions</h3><p>Many adult male patients presented within timeframes that enabled the provision of time critical medical care and provided an opportunity for forensic medical evidence collection. Many adult males 59 (42.7%) self-reported pre-existing mental health conditions upon initial presentation.</p><p>Attrition occurred throughout the patient journey with many males not reporting to police and thus not presenting in the legal process. This further emphasises the need for independent sexual violence patient advisors to support adult male victims through the medical and criminal justice process.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140182262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraoral cultural tattooing: Possible forensic utility 口内文化纹身:可能的法医用途
IF 1.5 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-03-14 DOI: 10.1016/j.jflm.2024.102673
John K. Brooks , Alexander J. Trummer
{"title":"Intraoral cultural tattooing: Possible forensic utility","authors":"John K. Brooks ,&nbsp;Alexander J. Trummer","doi":"10.1016/j.jflm.2024.102673","DOIUrl":"10.1016/j.jflm.2024.102673","url":null,"abstract":"<div><p>The custom of oral tattooing is mainly performed in Ethiopia and Eritrea, and usually results in blue pigmentation of the maxillary gingiva in dentate individuals. However, its usefulness has not been explored in the forensic literature. The aim of this article is to provide a review of this custom and include an unusual case study involving persistent gingival pigmentation. Herein, this report describes a 43-year-old woman from Eritrea who presented with slight bluish hue of the edentulous maxillary ridge associated with cultural tattooing. Elucidation of the cause of subtle blue hyperpigmentation may be challenging as cultural tattooing typically fades with age. Timely recognition of this oral pseudopathologic process may serve as secondary evidence for forensic identification and possibly provide aid in localizing one's ethnogeographic origin.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140156670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimation of the post-mortem interval; added value of mechanical excitability of human skeletal muscle 估计死后间隔;人体骨骼肌机械兴奋性的附加值
IF 1.5 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-03-14 DOI: 10.1016/j.jflm.2024.102664
H. Stigter, T. Krap, W.L.J.M. Duijst
{"title":"Estimation of the post-mortem interval; added value of mechanical excitability of human skeletal muscle","authors":"H. Stigter,&nbsp;T. Krap,&nbsp;W.L.J.M. Duijst","doi":"10.1016/j.jflm.2024.102664","DOIUrl":"10.1016/j.jflm.2024.102664","url":null,"abstract":"<div><p>Estimation of the post-mortem interval (PMI) is mainly based on the state of body cooling, post-mortem lividity (livor mortis) and post-mortem muscle stiffness (rigor mortis). However, the time span of development of these post-mortem phenomena are influenced by a variety of factors concerning the body of the deceased and the environment in which the body is found. Subsequently, this leads to a substantial spread in upper and lower limits of PMI based on determination of the state of these phenomena. Moreover, interpretation of post-mortem phenomena like lividity, rigor and interpretation of the correction factor for Henssge's nomogram is subjective. For this reason, PMI estimations are often broad, possibly too broad to be helpful for answering questions which are relevant for the criminal investigation. Therefore, combining the outcome of different methods for estimating the PMI, the so-called compound method, is recommended. Supravital muscle reaction by mechanical stimulation of skeletal muscle is a less known aspect of the compound method. Here we present a series of cases series in which supravital muscle reaction contributed to a more precise estimation of the PMI.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140150615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative study on informed consent regulation in health care among Italy, France, United Kingdom, Nordic Countries, Germany, and Spain 关于意大利、法国、英国、北欧国家、德国和西班牙医疗保健领域知情同意规定的比较研究
IF 1.5 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-03-14 DOI: 10.1016/j.jflm.2024.102674
Vittorio Bolcato , Chiara Franzetti , Giovanni Fassina , Giuseppe Basile , Rosa Maria Martinez , Livio Pietro Tronconi
{"title":"Comparative study on informed consent regulation in health care among Italy, France, United Kingdom, Nordic Countries, Germany, and Spain","authors":"Vittorio Bolcato ,&nbsp;Chiara Franzetti ,&nbsp;Giovanni Fassina ,&nbsp;Giuseppe Basile ,&nbsp;Rosa Maria Martinez ,&nbsp;Livio Pietro Tronconi","doi":"10.1016/j.jflm.2024.102674","DOIUrl":"10.1016/j.jflm.2024.102674","url":null,"abstract":"<div><p>The information and subsequent expression of will, so-called informed consent, have become the essential element of health right, understood as the right to autonomous choice in health, based on the fiduciary relationship between physician and patient. This gradually leads European Countries to adopt special legislations and to issue frequent judgments on the subject. However, new challenges in daily clinical practice call for further study of legal solutions. The authors analyse and compare the regulations on informed consent in health care of Italy, France, the United Kingdom, the Nordic Countries, Germany, and Spain. The health and legal contexts, existence of special regulations on informed consent and their characteristics are discussed. Informed consent resulted a mandatory requirement. Clear communication about treatment, therapeutic alternatives, and major risks, discussed in conversation, but preferably documented in writing, are agreed upon. The possibility of dissent and withdrawal of consent are also included. There is a growing interest in involving and regulating the entire health team in information and consent. Lowering the age of consent for minors or analysing the maturity of minors are attempts to increase their participation in health decisions. On another side, the protection of adult incapables persons requires greater involvement of family and fiduciaries to better adapt to changing health needs. Health policy must take responsibility for training health professionals and citizens about the value of health information and communication as a shared choice in care planning, to strengthen the bond of trust with the healthcare system and users.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1752928X24000362/pdfft?md5=e8c5935d15555be1111b6e775409eecb&pid=1-s2.0-S1752928X24000362-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140156708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An autopsy case of cerebral hemorrhage in an HIV-infected patient with suspected HIV-associated cerebrovascular disease 一名疑似艾滋病毒相关性脑血管病艾滋病毒感染者脑出血的尸检病例
IF 1.5 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-03-11 DOI: 10.1016/j.jflm.2024.102672
Mio Takayama, Masayuki Kashiwagi, Aya Matsusue, Brian Waters, Shin-ichi Kubo
{"title":"An autopsy case of cerebral hemorrhage in an HIV-infected patient with suspected HIV-associated cerebrovascular disease","authors":"Mio Takayama,&nbsp;Masayuki Kashiwagi,&nbsp;Aya Matsusue,&nbsp;Brian Waters,&nbsp;Shin-ichi Kubo","doi":"10.1016/j.jflm.2024.102672","DOIUrl":"https://doi.org/10.1016/j.jflm.2024.102672","url":null,"abstract":"<div><p>A male in his late 30s was found dead in his home. He was diagnosed with human immunodeficiency virus (HIV) about six years prior. The HIV infection was well controlled before his death. He was 166 cm in height and 75 kg in weight. Aside from discoloration of the skin on the right lower patellar, there were no obvious injuries. His brain weighed 1456 g. A cut surface of the brain revealed left thalamic hemorrhage. Histologically, infiltration of phagocytic cells was observed in the bleeding site. Thalamic hemorrhage was considered to be his cause of death in this case. Due to the effects of anti-HIV therapy, the mortality rate from HIV infection has decreased and the causes of death of HIV-infected persons have changed. HIV-infected persons have been suggested to be associated with cerebrovascular disease, especially juvenile ischemic stroke. Patients with acquired immunodeficiency syndrome (AIDS) have an increased risk of cerebrovascular disease. Possible mechanisms of cerebrovascular disease in HIV-infected individuals include coagulopathy, secondary effects of embolism and central nervous system infection, and direct vascular disease due to HIV. At the time of autopsy, his post-mortem interval was estimated to be approximately two weeks. Therefore, it was difficult to clarify histologically the cerebrovascular disorder that caused his cerebral hemorrhage. In recent years, anti-HIV therapy has reduced the number of AIDS-related deaths, but deaths in HIV-infected people from cardiovascular disease are increasing. This case is considered to be a valuable forensic autopsy case of an HIV-infected patient who actually died due to cerebral hemorrhage in Japan.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140122360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sudden death due to butane abuse – An overview 丁烷滥用导致猝死 - 概述
IF 1.5 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-03-11 DOI: 10.1016/j.jflm.2024.102662
Valeria Piersanti , Gabriele Napoletano , Maria Chiara David , Federica Umani Ronchi , Enrico Marinelli , Lina De Paola , Simona Zaami
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