Journal of forensic and legal medicine最新文献

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Sudden infantile death due to left ventricular myocardial ischemia associated with undiagnosed single coronary artery of Lipton's type LII-B 与未确诊的 Lipton's LII-B 型单支冠状动脉有关的左心室心肌缺血导致婴儿猝死
IF 1.2 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-08-27 DOI: 10.1016/j.jflm.2024.102738
Kyoko Hasuwa , Hideki Uemura , Takeshi Kondo , Shogo Kasuda
{"title":"Sudden infantile death due to left ventricular myocardial ischemia associated with undiagnosed single coronary artery of Lipton's type LII-B","authors":"Kyoko Hasuwa ,&nbsp;Hideki Uemura ,&nbsp;Takeshi Kondo ,&nbsp;Shogo Kasuda","doi":"10.1016/j.jflm.2024.102738","DOIUrl":"10.1016/j.jflm.2024.102738","url":null,"abstract":"<div><p>Single coronary artery (SCA) is a rare malformation, particularly in isolation without other congenital heart defects. Here, we describe a case of sudden infantile death due to myocardial ischemia associated with undiagnosed SCA. A 1-year-and-7-month-old female infant died suddenly after vomiting at home. A medicolegal autopsy revealed that the orifice of the right coronary artery (RCA) was absent. As expected, the left coronary artery was detached from the left coronary sinus; however, the ostium was covered with a flap-like fibrous ridge. The thin RCA originated from the left main trunk (LMT) and passed between the aorta and pulmonary artery trunk. The left circumflex artery branched from the LMT at a right angle. Judging from the origin and course of the anomalous RCA, the deceased was diagnosed with SCA of Lipton's type LII-B. Microscopic examination revealed ischemic changes around the endocardium of the lateral wall of the left ventricle (LV) rather than on the side of the abnormal RCA. This evoked attention, as there appeared to be some discrepancy. To the best of our knowledge, this is the first case report describing sudden infantile death related to LV myocardial ischemia associated with undiagnosed SCA of Lipton's type LⅡ-B.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"107 ","pages":"Article 102738"},"PeriodicalIF":1.2,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A machine learning approach for age prediction based on trigeminal landmarks 基于三叉神经标记的年龄预测机器学习方法
IF 1.2 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-08-26 DOI: 10.1016/j.jflm.2024.102742
Youssef Keyrouz , Marianne Saade , Mona Nahas Gholmieh , Antoine Saadé
{"title":"A machine learning approach for age prediction based on trigeminal landmarks","authors":"Youssef Keyrouz ,&nbsp;Marianne Saade ,&nbsp;Mona Nahas Gholmieh ,&nbsp;Antoine Saadé","doi":"10.1016/j.jflm.2024.102742","DOIUrl":"10.1016/j.jflm.2024.102742","url":null,"abstract":"<div><h3>Objective</h3><p>The aim of this study was to estimate the chronological age (CA) of a growing individual using a new machine learning approach on Cone Beam Computed Tomography (CBCT).</p></div><div><h3>Materials and methods</h3><p>The dataset included 48 CBCT and hand-wrist radiographs of growing individuals. 12 landmarks related to trigeminal trajectories were plotted on each CBCT and principal component analysis was applied for dimensionality reduction. The estimated CA was obtained using a decision tree. Finally, a genetic algorithm was implemented to select the best set of landmarks that would optimize the estimation. The age was also assessed following Greulich and Pyle's (GP) method on hand-wrist radiographs. The results (GP and Machine Learning) were then compared to the true CA.</p></div><div><h3>Results</h3><p>Among the 12 landmarks, the genetic algorithm selected 7 optimal features, and 12 principal components out of 36. The best results for age prediction were obtained by a combination of genetic algorithm, principal component analysis, and regression tree where the Mean Squared Error (MSE) and Mean Absolute Error (MAE) were respectively 1.29 and 0.92. These outcomes showed improved accuracy compared to those of the hand-wrist method (MSE = 2.038 and MAE = 1.775).</p></div><div><h3>Conclusions</h3><p>A numerical application on a dataset of CBCT showed that the proposed machine learning method achieved an improved accuracy compared to conventional methods and had satisfying performance in assessing age for forensic purposes. Validation of the presented method on a larger and more diverse sample would pave the way for future applications in forensic science as a tool for age prediction.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"107 ","pages":"Article 102742"},"PeriodicalIF":1.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A medical child abuse case with spurious bleeding; importance of collecting the evidence 一个有假性出血的医疗虐童案;收集证据的重要性
IF 1.2 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-08-26 DOI: 10.1016/j.jflm.2024.102741
Hasan Fatih Çakmaklı , Mehmet Ertem , Elif Ünal İnce , Zhala Abdullayeva , Talia İleri , Betül Ulukol
{"title":"A medical child abuse case with spurious bleeding; importance of collecting the evidence","authors":"Hasan Fatih Çakmaklı ,&nbsp;Mehmet Ertem ,&nbsp;Elif Ünal İnce ,&nbsp;Zhala Abdullayeva ,&nbsp;Talia İleri ,&nbsp;Betül Ulukol","doi":"10.1016/j.jflm.2024.102741","DOIUrl":"10.1016/j.jflm.2024.102741","url":null,"abstract":"<div><h3>Background</h3><p>Medical Child Abuse (MCA) is a severe form of child abuse. In MCA, the caregiver abuses the child by exaggerating, fabricating, simulating, or inducing symptoms, and unnecessary, potentially harmful medical care harms the child. Bleeding is one of the most common manifestations of MCA. Diagnosis of MCA is challenging, and late diagnosis may increase the severity and complications. Once suspected, it is essential to apply all relevant methods of investigation to support and confirm the diagnosis, as soon as possible, as late diagnosis increases the risks.</p></div><div><h3>Case presentation</h3><p>An 18-month-old boy was referred to the Pediatric Hematology by the Department of the Emergency with multiple admissions in a 2-week period for recurrent said-to-be bleeding episodes from different sites. Previously, he had been investigated for recurrent bleeding episodes in different hospitals for 4 months. In our center, the review of medical history, examination findings, and laboratory results showed some important inconsistencies leading to suspicion of MCA and the mother as the perpetrator. Then he was hospitalized for close observation. During hospitalization, multiple episodes of said-to-be bleeding were reported by the mother, but active bleeding was never observed by any hospital staff. No bleeding foci were detected in the nose or ears, supporting the diagnosis of MCA. After the file was forwarded to the prosecutor's office, the child was taken for institutional care, and no further bleeding was observed after separation from the mother. DNA, which was obtained from a so-called nosebleed during hospitalization, was analyzed and was reported to belong to the mother, confirming the diagnosis.</p></div><div><h3>Conclusions</h3><p>This case report draws attention to timely diagnoses by focusing on inconsistencies in the history and clinical signs and good clinical practices for the management of MCA, with a special emphasis on collecting evidence, including DNA samples, to confirm the diagnosis and help the legal process.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"107 ","pages":"Article 102741"},"PeriodicalIF":1.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142088641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suspicion of needle pricking/spiking in 2022 in Paris, France, an observational study from the Department of Forensic Medicine 法国巴黎 2022 年针刺/尖刺疑案,法医部的一项观察研究
IF 1.2 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-08-26 DOI: 10.1016/j.jflm.2024.102739
Clément Harmel , Marc Liautard , Marjorie Chèze , Elizabeth Alcaraz , Noémie Bergot , Catherine Dang , Saad Sarraj , Arame Mbodje , Charlotte Gorgiard , Céline Deguette , Laurène Dufayet
{"title":"Suspicion of needle pricking/spiking in 2022 in Paris, France, an observational study from the Department of Forensic Medicine","authors":"Clément Harmel ,&nbsp;Marc Liautard ,&nbsp;Marjorie Chèze ,&nbsp;Elizabeth Alcaraz ,&nbsp;Noémie Bergot ,&nbsp;Catherine Dang ,&nbsp;Saad Sarraj ,&nbsp;Arame Mbodje ,&nbsp;Charlotte Gorgiard ,&nbsp;Céline Deguette ,&nbsp;Laurène Dufayet","doi":"10.1016/j.jflm.2024.102739","DOIUrl":"10.1016/j.jflm.2024.102739","url":null,"abstract":"<div><h3>Background</h3><p>Needle pricking, the act of being intentionally pricked by an assailant, and needle spiking, the covert injection of substances using a needle, have historical precedents and recently resurfaced in Europe in 2022. This resurgence presented a challenge for emergency and forensic medicine departments.</p></div><div><h3>Methods</h3><p>We conducted a retrospective study in the forensic medicine department of Paris, France, including all patients who consulted for suspected needle pricking/spiking in 2022, following a police report. The study aimed to provide epidemiological data on victims, circumstances, and the results of toxicologic and serological analyses.</p></div><div><h3>Findings</h3><p>Of all assault victims in 2022, patients reporting or suspecting needle pricking/spiking represented 1.2 % of the total (171 cases). Most cases involved women (81.9 %) with a median age of 21.75 years. Incidents often occurred in festive contexts (84.8 %). Over a third of the patients didn't report any symptoms (37.5 %). Amnesia, nausea, and dizziness were common symptoms among those who did. Patients reporting alcohol consumption were more likely to experience symptoms (p &lt; 0.05). Over half of the patients displayed physical examinations consistent with needle pricking, with pricks mostly on their arms. Not all patients underwent toxicologic analyses (30.6 %), but all results were negative. Despite most patients not providing follow-up serology results, all received results were negative.</p></div><div><h3>Interpretation</h3><p>Overall, our data are more suggestive of needle pricking than spiking. Although women were overrepresented, there was no evidence of sexual motivation on the part of the perpetrators. It's possible that the perpetrators wanted to instill fear in the population without a specific goal. This form of violence necessitates preventive measures in festive venues and enhanced efforts to detect psychoactive substance.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"107 ","pages":"Article 102739"},"PeriodicalIF":1.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of miRNA-21 and hypoxia inducible factor-1 in predicting post mortem interval in cardiac muscles of aluminum phosphide deaths 利用磷化铝致死者心脏中的微RNA估计死后间隔时间
IF 1.2 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-08-01 DOI: 10.1016/j.jflm.2024.102726
Manar A. Ahmad , Sherien S. Ghaleb , Amr R. Zaki , Abeer O. Kamel , Amir Eid
{"title":"The role of miRNA-21 and hypoxia inducible factor-1 in predicting post mortem interval in cardiac muscles of aluminum phosphide deaths","authors":"Manar A. Ahmad ,&nbsp;Sherien S. Ghaleb ,&nbsp;Amr R. Zaki ,&nbsp;Abeer O. Kamel ,&nbsp;Amir Eid","doi":"10.1016/j.jflm.2024.102726","DOIUrl":"10.1016/j.jflm.2024.102726","url":null,"abstract":"<div><h3>Background</h3><p>The assessment of the postmortem interval (PMI) represents one of the major challenges in forensic pathology. Because of their stability, microRNAs, or miRNAs, are anticipated to be helpful in forensic research.</p></div><div><h3>Objective</h3><p>To see if estimation of PMI is possible using miRNA-21 and Hypoxia-inducible factor-1α (HIF-1α) expression levels in the heart samples from aluminum phosphide toxicity (Alpt).</p></div><div><h3>Methods</h3><p>This was a cross sectional study on 60 post-mortem samples (heart tissues) collected at different intervals during forensic autopsies. The two groups were allocated equally according to the cause of death into Group I (non-toxicated deaths, n = 30): Deaths caused by other than toxicity, and Group II (toxicated deaths, n = 30): Deaths due to Alpt. MDA (Malondialdehyde) and GSH (Glutathione), were measured in heart tissues using ELIZA. MiRNA- 21and HIF-1α expression levels were measured in heart tissues at different PMI using RT-Q PCR. ROC curve for detection of toxicated deaths using miRNA-21 and HIF was carried out.</p></div><div><h3>Results</h3><p>miRNA-21 and HIF-1α expression levels in Alp deaths were up regulated while GSH was downregulated with statistically significant difference. There was positive correlation between miRNA-21, HIF-1α and MDA with PMI while there was negative correlation between GSH and PMI in Alp deaths. In prediction of post mortem interval in Alp deaths miRNA-21 sensitivity and specificity were (75.9 %, 51.7 %, respectively) while HIF-1α sensitivity and specificity were 100 %.</p></div><div><h3>Conclusion</h3><p>PMI can be calculated using the degree to which particular miRNA-21 and HIF-1α are expressed in the heart tissue. The combination of miRNA-21 with HIF-1α in post mortem estimation is precious indicators.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"106 ","pages":"Article 102726"},"PeriodicalIF":1.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Storage of evidence and delayed reporting after sexual assault: Rates and impact factors on subsequent reporting 性侵犯后的证据储存和延迟报案:随后报案的比率和影响因素。
IF 1.2 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-08-01 DOI: 10.1016/j.jflm.2024.102731
D. Kane , J. Walshe , D. Richardson , C. Pucillo , M. Noonan , S. Maher , K. Flood , M. Eogan
{"title":"Storage of evidence and delayed reporting after sexual assault: Rates and impact factors on subsequent reporting","authors":"D. Kane ,&nbsp;J. Walshe ,&nbsp;D. Richardson ,&nbsp;C. Pucillo ,&nbsp;M. Noonan ,&nbsp;S. Maher ,&nbsp;K. Flood ,&nbsp;M. Eogan","doi":"10.1016/j.jflm.2024.102731","DOIUrl":"10.1016/j.jflm.2024.102731","url":null,"abstract":"<div><h3>Background</h3><p>Sexual assault (SA) is alarmingly prevalent, yet reporting rates remain disproportionately low. Forensic examinations (FE) play a crucial role in both immediate medical care and evidence collection, yet many victims/survivors may not report the crime initially, leading to the loss of vital forensic evidence. The storage of evidence “Option 3″ care alternative provides post-SA care including FE without initial police involvement.</p></div><div><h3>Methods</h3><p>This is a cross-sectional study analysing the attendances of people who chose to store evidence at the Dublin Sexual assault Treatment Unit (SATU) between January 1, 2017 and December 31, 2023.</p></div><div><h3>Results</h3><p>There were 238 storage of evidence FEs (‘Option 3’) performed during the study period, which represented 12.8 % of all FEs. The majority identified as female (89.1 %), with an average age of 26.6 years. 31.9 % attended within 24 h of the incident, and 51.3 % self-referred. Most assaults occurred over weekends (64.7 %), with alcohol consumption reported in 82.2 % of cases and drug-facilitated SA concerns in 20.2 %. Genital injuries were present in 17.9 % of females and 19 % of males.</p><p>Those that availed of storage of evidence (compared with those who initially reported to the police) were significantly more likely to have consumed alcohol (p &lt; 0.001) and the assault was more likely to have occurred indoors (p = 0.002). There was no significant difference in care option choice for those ‘unsure’ of the assault occurrence (p = 0.353).</p><p>Among storage of evidence cases, 20.2 % subsequently reported to the police, with females more likely to report (p = 0.02), while people who were uncertain whether an assault had occurred were less likely to report (p = 0.04). Genital injury (p = 0.822), victim-assailant relationship (p = 0.465), assault location (p = 0.487), and substance consumption (p = 0.332) did not significantly affect subsequent reporting rates.</p></div><div><h3>Conclusions</h3><p>The availability of storage of evidence has afforded people the opportunity to access prompt, responsive SATU care including collection of forensic evidence which may have significant evidential value. This approach provides further opportunity for comprehensive detection of a crime, even if reporting to the police is delayed.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"106 ","pages":"Article 102731"},"PeriodicalIF":1.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1752928X24000933/pdfft?md5=7ab6ac1fb6270c2e0936959161af4c61&pid=1-s2.0-S1752928X24000933-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forensic toxicological studies of acute glufosinate poisoning: A case series 急性草铵膦中毒的法医毒理学研究:系列病例。
IF 1.2 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-08-01 DOI: 10.1016/j.jflm.2024.102732
Shuang Zhao , Li Xiao , Yimin Sun , Zihan Jiang , Lin Yang , Jing Zhang , Yi Ye
{"title":"Forensic toxicological studies of acute glufosinate poisoning: A case series","authors":"Shuang Zhao ,&nbsp;Li Xiao ,&nbsp;Yimin Sun ,&nbsp;Zihan Jiang ,&nbsp;Lin Yang ,&nbsp;Jing Zhang ,&nbsp;Yi Ye","doi":"10.1016/j.jflm.2024.102732","DOIUrl":"10.1016/j.jflm.2024.102732","url":null,"abstract":"<div><p>Glufosinate is a widely and increasingly used non-selective, broad-spectrum herbicide. Although cases of glufosinate poisoning are frequently reported, they are rarely documented in forensic case reports, particularly in fatal instances. The present study examined six cases of glufosinate poisoning, including a fatal case involving a 25-year-old female found deceased by the roadside, with an empty 1000 mL bottle labeled \"glufosinate\" by her side. Biological specimens such as plasma or cardiac blood, gastric contents, and liver tissues were collected for quantitative analysis of glufosinate levels using LC-MS/MS. In five cases of acute glufosinate poisoning, glufosinate plasma concentrations ranged from 0.62 to 3.92 μg/mL. In the fatal case, the concentrations of glufosinate in cardiac blood, gastric contents, and liver tissues were 8.41 μg/mL, 31.25 μg/mL, and 66.1 μg/g, respectively. The pathological autopsy concluded that the cause of death was acute cardio-respiratory failure due to glufosinate poisoning, characterized by multi-organ congestion without specific pathological findings. The toxicological data provided in this study aim to serve as a critical reference for future clinical treatment and forensic validation of glufosinate poisoning-related deaths.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"106 ","pages":"Article 102732"},"PeriodicalIF":1.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viral infection and sudden non-cardiac death: A systematic review 病毒感染与非心源性猝死:系统综述。
IF 1.2 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-08-01 DOI: 10.1016/j.jflm.2024.102727
Francisco Pereira Cordeiro , Laura Cainé
{"title":"Viral infection and sudden non-cardiac death: A systematic review","authors":"Francisco Pereira Cordeiro ,&nbsp;Laura Cainé","doi":"10.1016/j.jflm.2024.102727","DOIUrl":"10.1016/j.jflm.2024.102727","url":null,"abstract":"<div><h3>Introduction</h3><p>Sudden non-cardiac death (SNCD) is a clinical entity comprising deaths lacking previous clinically significant symptoms, and in which the mechanisms of death do not involve the heart. Infection is a major cause of SNCD, particularly in children, and viruses are frequently involved in the disease process. Nevertheless, SNCD of viral infectious causes remains poorly characterized. Thus, a systematic review of the literature describing the association between viral infection and the development of SNCD was performed.</p></div><div><h3>Methods</h3><p>PRISMA statement guidelines were followed in this systematic review. A literature search was conducted across MEDLINE, Scopus and Web of Science databases. Studies considered eligible were autopsy series or cohort studies of sudden death cases, in which evidence of viral disease as a cause of death was demonstrated, along with identification of causative agents.</p></div><div><h3>Results</h3><p>Twelve studies published between 1996 and 2020 were included in this review. Selected studies were categorized into three groups according to the study population: infants and young children (up to four years of age); presumed sudden infant death syndrome patients; and older individuals (five years of age and older). SNCD with viral implication represents a minority of sudden death cases in all age groups, with infants and young children having a higher prevalence across studies. Respiratory infection was the main cause of viral SNCD, with <em>influenza</em> virus and <em>respiratory syncytial virus</em> being the most commonly identified agents in older individuals, and infants and young children respectively. Disseminated infection, gastrointestinal infection, and meningitis were other identified causes of SNCD in children.</p></div><div><h3>Conclusions</h3><p>No studies have directly assessed the frequency and causes of viral SNCD. Infants and young children show a considerable, but variable, prevalence of this clinical entity. Wider implementation of post-mortem virological molecular testing may help uncover previously unknown cases. More research into viral SNCD is needed, especially in the adult population.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"106 ","pages":"Article 102727"},"PeriodicalIF":1.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethanol concentrations in various biological specimens: Living and postmortem forensic toxicology analysis and comprehensive literature review 各种生物标本中的乙醇浓度:活体和死后法医毒理学分析及综合文献综述。
IF 1.2 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-08-01 DOI: 10.1016/j.jflm.2024.102737
Sahar Y. Issa , Amr Khattab
{"title":"Ethanol concentrations in various biological specimens: Living and postmortem forensic toxicology analysis and comprehensive literature review","authors":"Sahar Y. Issa ,&nbsp;Amr Khattab","doi":"10.1016/j.jflm.2024.102737","DOIUrl":"10.1016/j.jflm.2024.102737","url":null,"abstract":"<div><p>Alcohol use upsurges the risk for many chronic ill-health consequences such as hepatitis, malignancies, and disastrous outcomes like road traffic accidents ending in fatal injuries. Biochemical and toxicological analysis of different body fluids is crucial for identifying the cause of death and postmortem interval in many forensic cases. Blood, urine, and vitreous fluid are the most valuable body fluids for detecting alcohol during any toxicological analysis. Alcohol is responsible for widespread morbidity and mortality worldwide. Blood alcohol concentration (BAC) is a necessary toxicological test to investigate various crime and accident scenes. This study comprehensively explores the demographic characteristics, BAC distribution, and correlations of alcohol concentrations in postmortem and living cases. Postmortem cases (N = 166) reveal intriguing demographic patterns, with notable variations in year distribution, nationality, sex, age groups, occupation, smoking habits, place of death, and psychiatric history. Living cases (N = 483) exhibit distinct demographic profiles, emphasizing differences in year distribution, nationality, sex, age groups, and smoking habits.</p><p>Analysis of BAC distribution reveals diverse patterns in both postmortem and living cases, providing valuable insights into the prevalence of different BAC levels in each group. Correlation analyses unveil strong associations between alcohol concentrations in various biological samples in postmortem cases, highlighting the interdependence of blood, vitreous, and urine alcohol concentrations. Conversely, living cases display a moderate positive correlation between blood and urine alcohol concentrations.</p><p>Comparative analyses showcase significant differences in mean alcohol concentrations between postmortem and living cases, suggesting variations in alcohol metabolism and distribution. These findings underscore the importance of considering temporal factors in interpreting alcohol concentrations in forensic and clinical contexts.</p><p>In conclusion, this study enhances our understanding of alcohol-related incidents by delineating demographic profiles, BAC distributions, and correlations between different biological samples. Such insights are crucial for refining investigative and clinical approaches, contributing to the broader fields of forensic science and public health.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"106 ","pages":"Article 102737"},"PeriodicalIF":1.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reflective writing an assessment strategy for post-mortem observational activity in medical students 医学生尸体观察活动的评估策略--反思性写作。
IF 1.2 4区 医学
Journal of forensic and legal medicine Pub Date : 2024-08-01 DOI: 10.1016/j.jflm.2024.102733
Sanjay Gupta , Utsav Parekh , Daideepya Chandra Bhargava
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