Journal of forensic and legal medicine最新文献_第10页

A method of identifying the high-risk mutations of sudden cardiac death at KCNQ1 and KCNH2 genes 一种识别 KCNQ1 和 KCNH2 基因心源性猝死高危突变的方法

IF 1.2 4区医学

Journal of forensic and legal medicine Pub Date : 2024-06-15 DOI: 10.1016/j.jflm.2024.102707

Jiaqi Wang , Zidong Liu , Yuxin Zhang , Mingming Zhang , Deqing Chen , Gengqian Zhang

{"title":"A method of identifying the high-risk mutations of sudden cardiac death at KCNQ1 and KCNH2 genes","authors":"Jiaqi Wang , Zidong Liu , Yuxin Zhang , Mingming Zhang , Deqing Chen , Gengqian Zhang","doi":"10.1016/j.jflm.2024.102707","DOIUrl":"10.1016/j.jflm.2024.102707","url":null,"abstract":"<div><p>Sudden Cardiac Death (SCD) often shows negative anatomy results after a systemic autopsy and the gene mutations of potassium channel play a key role in the etiology of SCD. We established a feasible system to detect SCD-related mutations and investigated the mutations at KCNQ1 and KCNH2 genes in the Chinese population. We established a mutation detection system combined with multiplex PCR, SNaPshot technique, and capillary electrophoresis. We genotyped 101 putative mutations at KCNQ1 and KCNH2 genes in 60 SCD of negative anatomy and 50 controls using the established assay and compared Odd Ratio (OR). Four coding variants were identified in the KCNQ1 gene: S546S, I145I, P448R, and G643S. The mutations of I145I and S546S did not differ significantly in the SCD compared with controls. 21 SCD individuals (35 %) and 1 control individual (2 %) showed a genotype of C/G at P448R (OR = 17.5, 95 % CI [2.40–127.82]). 24 SCD individuals (40 %) and 1 control individual (2 %) showed a genotype of C/G at G643S (OR = 20.0, 95 % CI [2.75–145.25]). We established a robust assay for rapid screening the putative SCD-related mutations in KCNQ1 and KCNH2 genes. The new assay in our study is easily amenable to the majority of laboratories without the need for new specialized equipment. Our method will meet the increasing requirement of mutation screening for SCD in regular DNA laboratories and will help screen mutations in those dead of SCD and their relatives.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"105 ","pages":"Article 102707"},"PeriodicalIF":1.2,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141390459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hunger strikes and force feeding in detention: Clinical and ethical challenges 绝食和强制喂食：临床和伦理挑战

IF 1.5 4区医学

Journal of forensic and legal medicine Pub Date : 2024-06-10 DOI: 10.1016/j.jflm.2024.102706

Fabiola Molina , Sumaiya Sayeed , John J. Andrews , Katherine C. McKenzie

引用次数: 0

Sexual dimorphism of the twelfth thoracic vertebra for sex determination in the Central Thai population 泰国中部人群第十二胸椎的性别二形性，用于性别鉴定

IF 1.5 4区医学

Journal of forensic and legal medicine Pub Date : 2024-05-01 DOI: 10.1016/j.jflm.2024.102688

Paleenan Srithawee , Duangnate Pipatsatitpong , Narumol Parasompong , Nutcha Poolkasem , Palita Watthanaworasakul , Pairoa Praihirunkit

{"title":"Sexual dimorphism of the twelfth thoracic vertebra for sex determination in the Central Thai population","authors":"Paleenan Srithawee , Duangnate Pipatsatitpong , Narumol Parasompong , Nutcha Poolkasem , Palita Watthanaworasakul , Pairoa Praihirunkit","doi":"10.1016/j.jflm.2024.102688","DOIUrl":"https://doi.org/10.1016/j.jflm.2024.102688","url":null,"abstract":"<div><p>Analyzing skeletal remains is crucial for identifying individuals, and forensic anthropologists use this analysis to determine biological characteristics, particularly sex, aiding criminal investigations. Among thoracic vertebrae, the twelfth thoracic vertebra (T12) is highly sexually dimorphic in various populations. This study aims to establish a discriminant function equation (DFE) for sex determination based on T12 in the Central Thai population. A total of 15 parameters of T12 were examined in 69 bone samples (43 males and 26 females). Among the 15 parameters, 14 were significantly different between males and females. The discriminant function equation (DFE) was generated as DFE = −19.578 + 0.376(i) BDsm + 0.254(l) PW + 0.081TDm, with a cutoff value of −0.296 for males and females, showing 92.8 % accuracy. The evaluation of the DFE using 10 blind samples showed 90 % accuracy. These findings may offer an additional method for sex determination through T12, complementing the examination of other skeletal elements.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"104 ","pages":"Article 102688"},"PeriodicalIF":1.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140824041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forensic medicine in (West-Bank) Palestine visions and obstacles 巴勒斯坦法医学的愿景与障碍

IF 1.5 4区医学

Journal of forensic and legal medicine Pub Date : 2024-05-01 DOI: 10.1016/j.jflm.2024.102696

Hafsah Ghanem

{"title":"Forensic medicine in (West-Bank) Palestine visions and obstacles","authors":"Hafsah Ghanem","doi":"10.1016/j.jflm.2024.102696","DOIUrl":"10.1016/j.jflm.2024.102696","url":null,"abstract":"<div><p>Forensic medicine in Palestine is a new branch of medicine compared with other medical specialties and is still at a nascent stage. Only 6 medical doctors specializing in forensic medicine are currently practicing in Palestine, including only one female specialist (the author). Palestine has adopted a system that combines clinical forensic medicine and forensic pathology. Forensic doctors can deal with both the living and the dead and deal with cases of physical and sexual assault, gender-based violence, and domestic violence.</p><p>In different courts, such as civil, military, and shariah, Palestinian judicial decisions depend primarily on forensic medical reports and the testimonies that forensic doctors provide for the court to explain their reports. Forensic medicine has a significant role and crucial impact on achieving justice for victims of all types of abuse, either dead or alive. However, the role of forensic medicine in achieving justice for victims, and hence fighting and eradicating violence, is underestimated and not fully understood by the general population.</p><p>This paper introduces to the reader the status of forensic medicine in Palestine, focusing on the challenges and obstacles faced by both the victims and forensic doctors. Meeting these challenges and overcoming obstacles is essential for fighting all types of violence, including violence against women in Palestinian society.</p><p>The current provision of forensic medical services in Palestine is less than satisfactory, being considerably hampered by the lack of legislation and regulations.</p><p>Palestine is in great need of continued international support for forensic medicine and forensic services. Two projects supported by the United Nations put the country on the road, but there are still many miles to go toward the aim.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"104 ","pages":"Article 102696"},"PeriodicalIF":1.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141136875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bite marks: To opine or not to opine? 咬痕发表意见还是不发表意见？

IF 1.5 4区医学

Journal of forensic and legal medicine Pub Date : 2024-05-01 DOI: 10.1016/j.jflm.2024.102689

Maria Nittis , Richard Bassed

引用次数: 0

Male rape in Brazil: A descriptive analysis from 2010 to 2022 巴西的男性强奸案：2010 年至 2022 年的描述性分析

IF 1.5 4区医学

Journal of forensic and legal medicine Pub Date : 2024-05-01 DOI: 10.1016/j.jflm.2024.102684

Edmilson Ozorio dos Santos, Ivan Dieb Miziara

{"title":"Male rape in Brazil: A descriptive analysis from 2010 to 2022","authors":"Edmilson Ozorio dos Santos, Ivan Dieb Miziara","doi":"10.1016/j.jflm.2024.102684","DOIUrl":"10.1016/j.jflm.2024.102684","url":null,"abstract":"<div><p>Male rape is a relatively under-discussed topic in scientific literature, despite its significant relevance and prevalence worldwide, including in Brazil. To inform public health and safety policies, this study aimed to analyze cases of male rape using data from SINAN, the Information System for Notifiable Diseases, a division of the Brazilian Ministry of Health, for the years 2010–2022. Our findings reveal a 469 % increase in male rape cases in the country over the study period, with a predominance of cases in the state of São Paulo. Also, a higher prevalence of cases was observed among individuals aged 5–9 years. Furthermore, we identified a correlation between the occurrence of rape and certain factors, including individuals with less than 4 years of formal education if they were over the age of 50, and those who had a history of being sexually abused between the ages of 5 and 14. Additionally, this study reinforces the prevalence of rape cases occurring within domestic environments and perpetrated by individuals closely related to the victims. This study contributes to filling the gap in research on male rape in Brazil, laying the foundation for the development of strategies to prevent and combat rape in the country.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"104 ","pages":"Article 102684"},"PeriodicalIF":1.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute upper airway obstruction due to cervical hematoma after cervicofacial liposuction 颈面部吸脂术后颈部血肿导致急性上呼吸道阻塞

IF 1.5 4区医学

Journal of forensic and legal medicine Pub Date : 2024-05-01 DOI: 10.1016/j.jflm.2024.102697

Shutaro Nagano , Kana Unuma , Yohsuke Makino , Hiroki Mori , Koichi Uemura

{"title":"Acute upper airway obstruction due to cervical hematoma after cervicofacial liposuction","authors":"Shutaro Nagano , Kana Unuma , Yohsuke Makino , Hiroki Mori , Koichi Uemura","doi":"10.1016/j.jflm.2024.102697","DOIUrl":"10.1016/j.jflm.2024.102697","url":null,"abstract":"<div><p>Liposuction is a surgical procedure performed worldwide. Although many fatal complications of liposuction have been reported, to our knowledge, no cases of fatal liposuction complications specifically related to the face region have been reported. Here, we present a case of a woman in her 30s who developed a cervical hematoma and upper airway obstruction following facial liposuction. We present this unique case to highlight the rare occurrence of fatal complications specific to facial liposuction.</p><p>The patient underwent liposuction during surgery at a cosmetic surgical clinic and awoke from anesthesia after the procedure. Two hours later, she developed a neck swelling and dyspnea. While the anesthesiologist managed her airway, she went into cardiopulmonary arrest. She was then transferred to the emergency room but died on day 7 of hospitalization. The autopsy revealed swelling of the right cheek and mandible, a subcutaneous hematoma in the same area, and laryngeal edema. A damaged facial artery branch was identified, which was consistent with the computed tomography (CT) findings on admission. CT also showed that the hematoma compressed the right internal jugular vein, suggesting that venous outflow impairment caused by the hematoma may have exacerbated the airway obstruction.</p><p>This case reveals that cervical hematoma caused by facial liposuction can cause fatal upper airway obstruction and the onset of the hematoma may be gradual.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"104 ","pages":"Article 102697"},"PeriodicalIF":1.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141028457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examination of bone fractures in women exposed to domestic violence (Tokat-Turkey) 检查遭受家庭暴力妇女的骨折情况（土耳其托卡特）

IF 1.5 4区医学

Journal of forensic and legal medicine Pub Date : 2024-05-01 DOI: 10.1016/j.jflm.2024.102687

Ugur Demir , Yasin Etli , Mahmut Asirdizer

{"title":"Examination of bone fractures in women exposed to domestic violence (Tokat-Turkey)","authors":"Ugur Demir , Yasin Etli , Mahmut Asirdizer","doi":"10.1016/j.jflm.2024.102687","DOIUrl":"https://doi.org/10.1016/j.jflm.2024.102687","url":null,"abstract":"<div><h3>Background</h3><p>Fractures are an important symptom of physical violence that will negatively affect the woman's quality of life in the coming years. However, there is limited information in the literature about fractures in women exposed to domestic violence (DV). The aim of this study was to compare fracture development rates and age distributions in women exposed to DV and intimate partner violence (IPV), a component of DV, and women exposed to other physical violence (OV), to determine the incidence of DV cases with and without fractures, and to determine fracture locations in DV cases and to identify diagnostic lesions accompanying fractures.</p></div><div><h3>Methods</h3><p>A retrospective review was made of patients injured as a result of IPV, other domestic violence (ODV) and OV. The data of cases with fracture were analyzed in terms of age groups of the victims and according to location and types of fractures.</p></div><div><h3>Results</h3><p>Of the 854 female patients aged >18 years who were admitted to the hospital due to violence, 55.2% were exposed to DV. Most DV victims (87.9%) were assaulted by intimate partners. The incidence of fractures in IPV cases (7.2%), was nearly twice that of ODV and OV cases. The mean age of IPV cases with fractures (42.1 ± 12.1 years) was significantly higher than that of IPV cases without fractures (33.1 ± 11.8 years) (p < 0.05). Most IPV cases (61.8%) were aged <35 years. Most DV cases with fractures (75%) were aged <50 years. Facial/neck injuries (41.5%) and facial fractures (52.6%) were prominent in DV cases.</p></div><div><h3>Conclusion</h3><p>The results of this study of the presence of facial fractures, especially in women aged <50 years, is an important finding that can alert doctors to potential cases of domestic violence.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"104 ","pages":"Article 102687"},"PeriodicalIF":1.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140901053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a standardized peer review and oversight process in cases of suspected child physical abuse 针对疑似虐待儿童案件制定标准化同行审查和监督程序

IF 1.5 4区医学

Journal of forensic and legal medicine Pub Date : 2024-05-01 DOI: 10.1016/j.jflm.2024.102698

Aisling R. Geoghegan , William RM. Weiler , Frances Yeung , Emma J. Cory

{"title":"Development of a standardized peer review and oversight process in cases of suspected child physical abuse","authors":"Aisling R. Geoghegan , William RM. Weiler , Frances Yeung , Emma J. Cory","doi":"10.1016/j.jflm.2024.102698","DOIUrl":"https://doi.org/10.1016/j.jflm.2024.102698","url":null,"abstract":"<div><p>Peer review of medical opinions provided in cases of suspected child physical abuse is generally considered to be best practice for pediatricians engaged in this field. However, there are no published standardized guidelines on how pediatricians should undertake physical abuse peer review including case selection and process. Due to the high-stakes nature in the field of child abuse pediatrics, rigorous quality assurance practices and oversight mechanisms are essential to safeguard children, families, health care providers, and intersecting systems. The Suspected Child Abuse and Neglect program at The Hospital for Sick Children, Toronto, Canada developed a structured peer review process for cases of suspected physical abuse. Included in the process is an approach for the evaluation of institutional complaints received related to a child abuse pediatrician's medical opinion. This quality assurance process is presented so that other child abuse pediatricians and programs may replicate or adapt the protocol for their own local context.</p></div>","PeriodicalId":16098,"journal":{"name":"Journal of forensic and legal medicine","volume":"104 ","pages":"Article 102698"},"PeriodicalIF":1.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141091084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suicide by a construction nail fired from a pistol 用手枪发射建筑钉自杀

IF 1.5 4区医学

Journal of forensic and legal medicine Pub Date : 2024-04-01 DOI: 10.1016/j.jflm.2024.102682

M.A. Kislov , M. Chauhan , A.N. Prikhodko , R.V. Bespamyatnov , K.V. Natarova

引用次数: 0