Journal of Infection and Public Health最新文献

{"title":"Immune response against the SARS-CoV-2 spike protein in cancer patients after COVID-19 vaccination during the Omicron wave: a prospective study","authors":"María José Muñoz-Gómez ,&nbsp;Pablo Ryan ,&nbsp;Marta Quero-Delgado ,&nbsp;María Martin-Vicente ,&nbsp;Guillermo Cuevas ,&nbsp;Jorge Valencia ,&nbsp;Eva Jiménez ,&nbsp;Natalia Blanca-López ,&nbsp;Miguel Ángel Lara-Álvarez ,&nbsp;José Ángel Hernández-Rivas ,&nbsp;Gerardo Redondo ,&nbsp;Vicente Mas ,&nbsp;Daniel Sepúlveda-Crespo ,&nbsp;Mónica Vázquez ,&nbsp;Juan Torres-Macho ,&nbsp;Isidoro Martínez ,&nbsp;Salvador Resino","doi":"10.1016/j.jiph.2024.102473","DOIUrl":"10.1016/j.jiph.2024.102473","url":null,"abstract":"<div><h3>Background</h3><p>Cancer patients often have weakened immune systems, resulting in a lower response to vaccines, especially those receiving immunosuppressive oncological treatment (OT). We aimed to assess the impact of OT on the humoral and T-cell response to the B.1 lineage and Omicron variant following COVID-19 vaccination in patients with solid and hematological neoplasms.</p></div><div><h3>Methods</h3><p>We conducted a prospective study on cancer patients, stratified into OT and non-OT groups, who received a two-dose series of the COVID-19 mRNA vaccine and a booster six months later. The outcomes measured were the humoral (anti-SARS-CoV-2 S IgG titers and ACE2-S interaction inhibition capacity) and cellular (SARS-CoV-2 S-specific T-cell spots per million PBMCs) responses against the B.1 lineage and Omicron variant. These responses were evaluated four weeks after the second dose (n = 98) and eight weeks after the booster dose (n = 71).</p></div><div><h3>Results</h3><p>The humoral response after the second vaccine dose against the B.1 lineage and Omicron variant was significantly weaker in the OT group compared to the non-OT group (q-value&lt;0.05). A booster dose of the mRNA-1273 vaccine significantly improved the humoral response in the OT group, making it comparable to the non-OT group. The mRNA-1273 vaccine, designed for the original Wuhan strain, elicited a weaker humoral response against the Omicron variant compared to the B.1 lineage, regardless of oncological treatment or vaccine dose. In contrast, T-cell responses against SARS-CoV-2, including the Omicron variant, were already present after the second vaccine dose and were not significantly affected by oncological treatments.</p></div><div><h3>Conclusions</h3><p>Cancer patients, particularly those receiving immunosuppressive oncological treatments, should require booster doses and adapted COVID-19 vaccines for new SARS-CoV-2 variants like Omicron. Future studies should evaluate the durability of the immune response and the efficacy of individualized regimens.</p></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 7","pages":"Article 102473"},"PeriodicalIF":6.7,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876034124002077/pdfft?md5=a6ebf6ee6f401095455250652182c641&pid=1-s2.0-S1876034124002077-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling therapeutic dynamics: An in-depth comparative analysis of neutralizing monoclonal antibodies and favipiravir in alleviating COVID-19 outpatients impacts among middle-aged and special populations (MA-FAST)","authors":"Taweegrit Siripongboonsitti ,&nbsp;Kriangkrai Tawinprai ,&nbsp;Thachanun Porntharukcharoen ,&nbsp;Supamas Sirisreetreerux ,&nbsp;Thitapha Thongchai ,&nbsp;Kamonwan Soonklang ,&nbsp;Nithi Mahanonda","doi":"10.1016/j.jiph.2024.102471","DOIUrl":"10.1016/j.jiph.2024.102471","url":null,"abstract":"<div><h3>Background</h3><p>Neutralizing monoclonal antibodies (NMabs) are recognized for their efficacy against non-severe COVID-19. However, spike protein mutations may confer resistance. This study evaluates the effectiveness of favipiravir (FPV) versus NMabs in preventing severe COVID-19 in special populations.</p></div><div><h3>Methods</h3><p>A retrospective cohort was conducted on middle-aged, elderly, diabetic, or obese patients with COVID-19 treated with either FPV or NMabs. Propensity score matching (PSM) was used for analysis.</p></div><div><h3>Results</h3><p>The study included 1410 patients, resulting in four cohorts: middle-aged (36), elderly (48), diabetic (46), and obese (28) post-PSM. No significant differences were noted in 28-day emergency department (ED) visits across all groups between NMabs and FPV treatments, despite lower immunity in the FPV group. However, the diabetic group treated with FPV had higher 28-day hospitalization and oxygen supplemental, with no differences in the other groups. Intensive care unit (ICU) admissions, invasive mechanical ventilation, and mortality rates were similar between the two treatments.</p></div><div><h3>Conclusions</h3><p>Early dose-adjusted FPV showed no difference from NMabs in preventing ED visits, ICU admissions, ventilator needs, or mortality among patients with major comorbidities. Diabetic patients on FPV experienced higher hospitalizations and oxygen needs, with no observed differences in other groups. FPV may be a viable alternative, especially in settings with limited resources.</p></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 7","pages":"Article 102471"},"PeriodicalIF":6.7,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876034124002053/pdfft?md5=f2b1104ae8991dc418c3268bbbcf876b&pid=1-s2.0-S1876034124002053-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of malaria in Gabon: A systematic review and meta-analysis from 1980 to 2023","authors":"Yann Vital Sima-Biyang ,&nbsp;Steede Seinnat Ontoua ,&nbsp;Neil Michel Longo-Pendy ,&nbsp;Clark Mbou-Boutambe ,&nbsp;Patrice Makouloutou-Nzassi ,&nbsp;Cyr Kinga Moussadji ,&nbsp;Jean-Bernard Lekana-Douki ,&nbsp;Larson Boundenga","doi":"10.1016/j.jiph.2024.05.047","DOIUrl":"10.1016/j.jiph.2024.05.047","url":null,"abstract":"<div><p>The objective of this were conducted to elucidate spatiotemporal variations in malaria epidemiology in Gabon since 1980. For that, five databases, were used to collect and identify all studies published between 1980 and 2023 on malaria prevalence, antimalarial drug resistance, markers of antimalarial drug resistance and insecticide resistance marker. The findings suggest that Gabon continues to face malaria as an urgent public health problem, with persistently high prevalence rates. Markers of resistance to CQ persist despite its withdrawal, and markers of resistance to SP have emerged with a high frequency, reaching 100 %, while ACTs remain effective. Also, recent studies have identified markers of resistance to the insecticides Kdr-w and Kdr-e at frequencies ranging from 25 % to 100 %. Ace1R mutation was reported with a frequency of 0.4 %. In conclusion, the efficacy of ACTs remains above the threshold recommended by the WHO. Organo-phosphates and carbamates could provide an alternative for vector control.</p></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 7","pages":"Article 102459"},"PeriodicalIF":6.7,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876034124001886/pdfft?md5=e654ac50694ebb79bf2cd1667a2b06d3&pid=1-s2.0-S1876034124001886-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141275635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and antibiotic susceptibility patterns of acinetobacter implicated in wound infections","authors":"Hanan S. Alghamdi,&nbsp;Hesham A. Malak,&nbsp;Hussein H. Abulreesh","doi":"10.1016/j.jiph.2024.05.022","DOIUrl":"10.1016/j.jiph.2024.05.022","url":null,"abstract":"","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 6","pages":"Page 1152"},"PeriodicalIF":6.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S187603412400162X/pdfft?md5=d7701db69338b6c612cba3d71ff015cb&pid=1-s2.0-S187603412400162X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141231395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shorter versus longer courses of antibiotics for bloodstream infections caused by carbapenemase-producing klebsiella pneumoniae: Multicenter study in Saudi Arabia","authors":"Ahlam Alghamdi ,&nbsp;Hajar Alghatani ,&nbsp;Nada Alkhani ,&nbsp;Afrah Alkazemi ,&nbsp;Majed Almajed","doi":"10.1016/j.jiph.2024.05.010","DOIUrl":"10.1016/j.jiph.2024.05.010","url":null,"abstract":"","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 6","pages":"Page 1148"},"PeriodicalIF":6.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876034124001503/pdfft?md5=f3ab89d0438f40e66ed52272ac3e0878&pid=1-s2.0-S1876034124001503-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is YouTube a reliable source of information on antimicrobial resistance in the Arab world?","authors":"Raghad Y. Bajaba,&nbsp;Shahad S. Aljerrari,&nbsp;Aroob E. Al-Bukhari,&nbsp;Mashael H. Qadah,&nbsp;Abrar K. Thabit","doi":"10.1016/j.jiph.2024.05.017","DOIUrl":"https://doi.org/10.1016/j.jiph.2024.05.017","url":null,"abstract":"","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 6","pages":"Page 1150"},"PeriodicalIF":6.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876034124001576/pdfft?md5=501b193aba06eda4c038642bc5d1a458&pid=1-s2.0-S1876034124001576-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141239108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality in Norway and Sweden during the COVID-19 pandemic","authors":"Staffan Björck ,&nbsp;Ola Stenqvist","doi":"10.1016/j.jiph.2024.03.017","DOIUrl":"10.1016/j.jiph.2024.03.017","url":null,"abstract":"","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 6","pages":"Page 1142"},"PeriodicalIF":6.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876034124000777/pdfft?md5=a390cdaabbd52fe8b8edbaeb4775ed5a&pid=1-s2.0-S1876034124000777-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140204366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of knowledge and attitudes of college of medicine medical interns toward HIV positive l subjects at Jeddah, Saudi Arabia","authors":"Israa Abdullah Malli,&nbsp;Alhanoof Aljahdali,&nbsp;Amal Almutairi,&nbsp;Raghad Jar,&nbsp;Reham Alzahrani,&nbsp;Muhammad Anwar Khan","doi":"10.1016/j.jiph.2024.05.034","DOIUrl":"10.1016/j.jiph.2024.05.034","url":null,"abstract":"","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 6","pages":"Page 1156"},"PeriodicalIF":6.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876034124001746/pdfft?md5=c58fa0e3ed9672e9869595887321ed4d&pid=1-s2.0-S1876034124001746-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141231507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ralstonia species infection: relevance and clinical response, single center experience","authors":"Mooza Almannaei ,&nbsp;Abdullatif Al Rashed ,&nbsp;Manal Atta ,&nbsp;Yamama AlJishi","doi":"10.1016/j.jiph.2024.05.019","DOIUrl":"10.1016/j.jiph.2024.05.019","url":null,"abstract":"","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 6","pages":"Page 1151"},"PeriodicalIF":6.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S187603412400159X/pdfft?md5=cf7a756de191021e854ecdae3b763b76&pid=1-s2.0-S187603412400159X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141234851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of calcitriol on geriatric COVID-19 patients: A systematic review","authors":"Ibrahim Omer,&nbsp;Ali Saleh Alsudais,&nbsp;Bassam Alrajhi,&nbsp;Zahra Alsayed,&nbsp;Ghadeer Khan,&nbsp;Najla Nassar","doi":"10.1016/j.jiph.2024.05.037","DOIUrl":"https://doi.org/10.1016/j.jiph.2024.05.037","url":null,"abstract":"","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 6","pages":"Page 1157"},"PeriodicalIF":6.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876034124001771/pdfft?md5=f02f66bf645ecf255e018f6ddff67f8c&pid=1-s2.0-S1876034124001771-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141239263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}