Journal of Infection and Public Health最新文献

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Unraveling influenza sentinel surveillance in Pakistan 2008-2024: Epidemiological insights during the pre and post pandemic period of COVID-19. 解读 2008-2024 年巴基斯坦流感哨点监测:COVID-19 大流行前后的流行病学见解。
IF 4.7 3区 医学
Journal of Infection and Public Health Pub Date : 2024-11-16 DOI: 10.1016/j.jiph.2024.102595
Nazish Badar, Muhammad Salman, Nadia Nisar, Hamza Ahmed Mirza, Abdul Ahad, Faisal Ahmad, Bisma Daud
{"title":"Unraveling influenza sentinel surveillance in Pakistan 2008-2024: Epidemiological insights during the pre and post pandemic period of COVID-19.","authors":"Nazish Badar, Muhammad Salman, Nadia Nisar, Hamza Ahmed Mirza, Abdul Ahad, Faisal Ahmad, Bisma Daud","doi":"10.1016/j.jiph.2024.102595","DOIUrl":"https://doi.org/10.1016/j.jiph.2024.102595","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus pandemic has substantially influenced the transmission pattern of other respiratory viruses. However, screening and detecting other respiratory pathogens was unheeded during this time to combat the COVID-19 pandemic. High virulence and re assortment factors intensify the importance of influenza virus surveillance for effective disease management. Therefore, the present surveillance study was designed to determine the influenza positivity rate from 2008-24. This study will provide integral support in depicting a panoramic representation of two respiratory-pandemic periods, 2010-11 and 2019-2021, for influenza and COVID-19 pandemics, respectively.</p><p><strong>Methods: </strong>An inferential cross-sectional study was conducted from 2008 to 2024 by collecting influenza surveillance data from twelve sentinel sites in Pakistan. Clinical and demographic data was recorded at sample collection time. Specimens were collected through nasopharyngeal/throat swabs and stored in viral transport medium (VTM) at the sentinel site laboratory at 2-4 °C. Viral RNA was isolated from the samples using KingFisher TM Flex Purification System and MagMAX™ Viral/Pathogen Nucleic Acid Extraction Kit.</p><p><strong>Results: </strong>Within 16 years, 78118 samples were tested for influenza, of which 7999 (10.2 %) appeared positive. The positivity rate appeared very low in recent years, with only a 3.5 % positivity rate observed in 2020. Influenza A strain H1N1pdm09 seemed to be the prominent strain (n = 3407, 42.6 %), followed by influenza B (n = 2125, 26.6 %).</p><p><strong>Conclusion: </strong>The positivity of influenza samples was 10.2 % and recorded in patients where typical clinical representation of influenza was absent. Fewer samples were reported during the coronavirus pandemic, which might be because influenza screening was hindered and overlooked to combat the SARS-CoV-2 virus, and the patient threshold was very high for COVID-19 virus screening.</p>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 12","pages":"102595"},"PeriodicalIF":4.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emergence of multidrug-resistant E. coli ST8346 isolates carrying three distinct plasmids with NDM-5, KPC-2, and OXA-181. 出现携带 NDM-5、KPC-2 和 OXA-181 三种不同质粒的耐多药大肠杆菌 ST8346 分离物。
IF 4.7 3区 医学
Journal of Infection and Public Health Pub Date : 2024-11-16 DOI: 10.1016/j.jiph.2024.102596
Ping-Yuan Chen, Yu-Chin Chen, Che-Ming Chiang, Chi-Chung Chen, Chih-Cheng Lai, Chia-Hung Tsai, Chung-Han Ho, Po-Yu Chen, Hung-Jen Tang, Julie Chi Chow, Tu-Hsuan Chang
{"title":"Emergence of multidrug-resistant E. coli ST8346 isolates carrying three distinct plasmids with NDM-5, KPC-2, and OXA-181.","authors":"Ping-Yuan Chen, Yu-Chin Chen, Che-Ming Chiang, Chi-Chung Chen, Chih-Cheng Lai, Chia-Hung Tsai, Chung-Han Ho, Po-Yu Chen, Hung-Jen Tang, Julie Chi Chow, Tu-Hsuan Chang","doi":"10.1016/j.jiph.2024.102596","DOIUrl":"https://doi.org/10.1016/j.jiph.2024.102596","url":null,"abstract":"<p><strong>Background: </strong>E. coli ST8346 is a unique strain associated with the potential carriage of multiple carbapenemases. Three unique E. coli ST8346 isolates were identified, each concurrently harboring multiple carbapenemases, including bla<sub>NDM-5</sub>, bla<sub>KPC-2</sub>, and/or bla<sub>OXA-181</sub>. This study aimed to characterize the genetic and plasmid structures of these isolates to understand their transmission and resistance mechanisms.</p><p><strong>Methods: </strong>Antibiotic resistance profiles, genetic relatedness, and plasmid structures were determined using antibiotic susceptibility testing, multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE), S1 nuclease PFGE, and long-read sequencing.</p><p><strong>Results: </strong>All the strains were carbapenem resistant. PFGE revealed close genetic relationships among the isolates, despite the lack of geographical or epidemiological connections. bla<sub>NDM-5</sub>, bla<sub>KPC-2</sub>, and bla<sub>OXA-181</sub> were located on separate plasmids. Plasmids harboring bla<sub>NDM-5</sub> showed genetic similarities to bla<sub>NDM-5</sub>-bearing IncF plasmids in the United Kingdom. The IncA/C plasmids harboring bla<sub>KPC-2</sub> had identical sequences resembling a plasmid from a K. pneumoniae strain in Taiwan, except for the bla<sub>KPC-2</sub> region, which matched a strain from China, indicating a hybrid plasmid.</p><p><strong>Conclusion: </strong>This study is the first to identify and characterize the coexistence of bla<sub>NDM-5</sub>, bla<sub>KPC-2</sub>, and bla<sub>OXA-181</sub> in E. coli ST8346 isolates. The spread appears to be due to independent acquisition events. We identified the putative origins of these plasmids and detected a possible recombination event in a novel IncA/C plasmid. These findings emphasize the importance of ongoing surveillance and further investigations.</p>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 12","pages":"102596"},"PeriodicalIF":4.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotic residues in poultry products and bacterial resistance: A review in developing countries 家禽产品中的抗生素残留与细菌耐药性:发展中国家综述。
IF 4.7 3区 医学
Journal of Infection and Public Health Pub Date : 2024-11-12 DOI: 10.1016/j.jiph.2024.102592
Chantal Abou-Jaoudeh , Jeanne Andary , Rony Abou-Khalil
{"title":"Antibiotic residues in poultry products and bacterial resistance: A review in developing countries","authors":"Chantal Abou-Jaoudeh ,&nbsp;Jeanne Andary ,&nbsp;Rony Abou-Khalil","doi":"10.1016/j.jiph.2024.102592","DOIUrl":"10.1016/j.jiph.2024.102592","url":null,"abstract":"<div><div>Antimicrobial resistance (AMR) is a growing global concern, particularly in poultry farming, where antibiotics are widely used for both disease prevention and growth promotion. This review examines the misuse of antibiotics in poultry production, especially in developing countries, and its contribution to the emergence of antibiotic-resistant bacteria. The findings highlight that factors such as increasing demand for poultry protein, the availability of inexpensive antibiotics, and weak regulatory oversight have led to widespread misuse, accelerating the spread of resistance genes. Although evidence links poultry farming to AMR, significant data gaps remain, especially regarding resistance transmission from poultry to humans. The review underscores the urgent need for stronger regulatory frameworks, phased-out use of antimicrobial growth promoters, and enhanced awareness campaigns to address this issue. Improving the capacity of regulatory bodies and developing more robust national data monitoring systems are essential steps to mitigate the threat of AMR in poultry farming and to protect both animal and human health.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 12","pages":"Article 102592"},"PeriodicalIF":4.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular characterization of colistin-resistant Klebsiella pneumoniae isolates and their conjugative mcr-carrying plasmids. 耐秋水仙碱肺炎克雷伯氏菌分离物及其共轭 mcr 携带质粒的分子特征。
IF 4.7 3区 医学
Journal of Infection and Public Health Pub Date : 2024-11-07 DOI: 10.1016/j.jiph.2024.102588
Cheng-Yen Kao, Pei-Yun Kuo, Chih-Chieh Lin, Ya-Yu Cheng, Ming-Cheng Wang, Yu-Chen Chen, Wei-Hung Lin
{"title":"Molecular characterization of colistin-resistant Klebsiella pneumoniae isolates and their conjugative mcr-carrying plasmids.","authors":"Cheng-Yen Kao, Pei-Yun Kuo, Chih-Chieh Lin, Ya-Yu Cheng, Ming-Cheng Wang, Yu-Chen Chen, Wei-Hung Lin","doi":"10.1016/j.jiph.2024.102588","DOIUrl":"https://doi.org/10.1016/j.jiph.2024.102588","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to characterize colistin-resistant K. pneumoniae (CoRKp) strains isolated from patients with urinary tract infections and bacteremia between 1999 and 2022 at a tertiary teaching hospital in Taiwan.</p><p><strong>Methods: </strong>A total of 1966 K. pneumoniae isolates were collected, among which 21 strains were identified as CoRKp. The antimicrobial susceptibility of these CoRKp strains to 19 antibiotics was assessed. The genome characteristics of 21 CoRKp strains were determined by Nanopore-Illumina hybrid whole genome sequencing. Additionally, conjugation assays were conducted to determine the transferability of plasmids carrying mcr genes to K. pneumoniae ATCC BAA-1706 and E. coli C600. The larvae infection model was used to analyze the differences in virulence between transconjugants and recipient strains.</p><p><strong>Results: </strong>Among the 21 CoRKp, 12 were multidrug-resistant, and four were extensively drug-resistant. The distribution of sequence types (STs) and K types among the CoRKp strains was quite diverse, and ST307 (5 strains) and K64 (3 strains) dominated in CoRKp. The insertion elements IS903B and ISVsa5, were found to inactivate mgrB of 1 and 2 CoRKp isolates, respectively. Moreover, 1, 4, 6, and 1 missense mutations of PhoQ, PmrA, PmrB, and MgrB, were identified in 21 CoRKp. Only two isolates SC-KP169 and SC-KP585 carried mcr-1 and mcr-8, respectively. The plasmid pSC-KP169-1 could be transferred inter- and intra-genus and contributed to the virulence of K. pneumoniae to larvae. In contrast, the plasmid pSC-KP585-1 could be transferred to E. coli but could not affect its virulence to larvae.</p><p><strong>Conclusions: </strong>We identified 21 CoRKp from 1966 isolates and found a conjugative plasmid carrying mcr-1 gene that contributed to the virulence of K. pneumoniae to larvae.</p>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 12","pages":"102588"},"PeriodicalIF":4.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological and typing features of HPV co-infections in MSM with mpox: A hospital-based prospective study. 患有疱疹的男男性行为者HPV合并感染的流行病学和分型特征:一项基于医院的前瞻性研究。
IF 4.7 3区 医学
Journal of Infection and Public Health Pub Date : 2024-11-07 DOI: 10.1016/j.jiph.2024.102586
Tianyang Liu, Siwei Zhang, Liuqing Yang, Ling Peng, Shanshan Tang, Wanlin Li, Zengchen Liu, Xichao Zhu, Tingdan Gong, Siyu Duan, Yunyan Tang, Yao Wang, Yun Peng, Rui Li, Shiyan Feng, Chuming Chen, Mengli Cao, Siran Huang, Yang Yang, Fuxiang Wang, Hongzhou Lu, Lanlan Wei
{"title":"Epidemiological and typing features of HPV co-infections in MSM with mpox: A hospital-based prospective study.","authors":"Tianyang Liu, Siwei Zhang, Liuqing Yang, Ling Peng, Shanshan Tang, Wanlin Li, Zengchen Liu, Xichao Zhu, Tingdan Gong, Siyu Duan, Yunyan Tang, Yao Wang, Yun Peng, Rui Li, Shiyan Feng, Chuming Chen, Mengli Cao, Siran Huang, Yang Yang, Fuxiang Wang, Hongzhou Lu, Lanlan Wei","doi":"10.1016/j.jiph.2024.102586","DOIUrl":"https://doi.org/10.1016/j.jiph.2024.102586","url":null,"abstract":"<p><strong>Objectives: </strong>Recent mpox outbreaks highlight diverse transmission modes, with sexual behavior prominent in China's IIb strain. Nevertheless, despite HPV being a common sexually transmitted pathogen, there is a paucity of research into its coexistence and genotype distribution within this patients population.</p><p><strong>Methods: </strong>We conducted a study at the Third People's Hospital of Shenzhen from May to September 2023. We collected information on mpox patients, including their sociodemographic and clinical characteristics. Anal swabs were collected for HPV genotyping.</p><p><strong>Results: </strong>Among 73 MSM mpox cases, HIV positivity was 56.2 % (41/73) and HPV positivity 80.4 % (41/51). Multiple HPV infections were prevalent (56.9 %, 29/51), especially among HIV-positive (93 %, 27/29). HPV16 (29.3 %, 12/41) was the most common high-risk genotype, followed by HPV59 (26.8 %, 10/41), HPV42 (19.5 %, 8/41), HPV6 (14.6 %, 6/41), and HPV54 (14.6 %, 6/41). HPV infection was significantly associated with HIV infection (p = 0.001). Additionally, HIV infection (p = 0.001) and PCR-detected positive sites for mpox (p = 0.047) were associated with high-risk HPV infection.</p><p><strong>Conclusions: </strong>In this study, most of the mpox patients were found to be infected with HPV, mostly with high-risk types and multiple infections. Therefore, it is strongly recommended that mpox-infected individuals intensify HPV-related screening, prevention, and treatment measures.</p>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 12","pages":"102586"},"PeriodicalIF":4.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seroprevalence and detection of Human herpesvirus-8 (HHV-8) among healthy blood donors residing in Qatar 居住在卡塔尔的健康献血者中人类疱疹病毒-8(HHV-8)的血清流行率和检测结果。
IF 4.7 3区 医学
Journal of Infection and Public Health Pub Date : 2024-11-07 DOI: 10.1016/j.jiph.2024.102590
Hadeel T. Zedan , Alaa Elkhider , Asalet Hicazi , Fathima Amanullah , Duaa W. Al-Sadeq , Parveen B. Nizamuddin , Farah M. Shurrab , Maria K. Smatti , Asmaa A. Althani , Laith J. Abu Raddad , Gheyath K. Nasrallah , Hadi M. Yassine
{"title":"Seroprevalence and detection of Human herpesvirus-8 (HHV-8) among healthy blood donors residing in Qatar","authors":"Hadeel T. Zedan ,&nbsp;Alaa Elkhider ,&nbsp;Asalet Hicazi ,&nbsp;Fathima Amanullah ,&nbsp;Duaa W. Al-Sadeq ,&nbsp;Parveen B. Nizamuddin ,&nbsp;Farah M. Shurrab ,&nbsp;Maria K. Smatti ,&nbsp;Asmaa A. Althani ,&nbsp;Laith J. Abu Raddad ,&nbsp;Gheyath K. Nasrallah ,&nbsp;Hadi M. Yassine","doi":"10.1016/j.jiph.2024.102590","DOIUrl":"10.1016/j.jiph.2024.102590","url":null,"abstract":"<div><h3>Background</h3><div>Human herpesvirus 8 (HHV-8) is a critical causative agent behind Kaposi sarcoma (KS), an oncogenic disease with profound consequences in immunocompromised individuals. Studies suggested HHV-8 seroprevalence in healthy populations is uncommon, but comprehensive investigations within the Middle East region remain scarce. This study aimed to bridge this knowledge gap by meticulously assessing HHV-8 seroprevalence among healthy blood donors in Qatar, leveraging serological methodologies and PCR.</div></div><div><h3>Methods</h3><div>We used sera samples collected from 621 healthy blood donors (median age = 36 years, IQR 30–43) from different nationalities residing in Qatar, mainly from the MENA region and Southeast Asia. All sera samples were tested for total anti-HHV-8 IgG antibodies using ELISA. The presence of lytic HHV-8 antibodies was confirmed by an immunofluorescence assay (IFA). Further, HHV-8 DNA was tested and quantitated by qRT-PCR.</div></div><div><h3>Results</h3><div>ELISA detected anti-HHV-8 IgG total antibodies in 6.9 % [43/621, 95 %CI 5.2–9.2] of the tested samples. Subsequent testing by IFA revealed that 14 % [6/43, 95 %CI 3.6–24.3] of these anti-HHV-8 IgG were classified as HHV-8 lytic antibodies. This suggests that 0.97 % [6/621, 95 %CI 0.2–1.7] of these donors had a recent or ongoing active infection and viral replication. Only one seronegative Qatari blood donor had detectable HHV-8 DNA in his blood. No significant difference was observed between HHV-8 seropositivity and the demographic characteristics of the donors.</div></div><div><h3>Conclusion</h3><div>Our study showed that HHV-8 prevalence in Qatar aligns closely with global reports. Moreover, our findings raise considerations regarding HHV-8’s potential transmission via transfusion, which suggests the value of routine HHV-8 screening, particularly for immunocompromised patients vulnerable to KS.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 12","pages":"Article 102590"},"PeriodicalIF":4.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the Bangladeshi antibiotic market: Implications of the WHO AWaRe classification and dosage form availability on antimicrobial resistance 孟加拉国抗生素市场评估:世界卫生组织 AWaRe 分类和剂型供应对抗菌药耐药性的影响。
IF 4.7 3区 医学
Journal of Infection and Public Health Pub Date : 2024-11-06 DOI: 10.1016/j.jiph.2024.102587
Joya Rani , Sudipta Saha , Fahmi Ferdous , Md. Ajijur Rahman
{"title":"Assessment of the Bangladeshi antibiotic market: Implications of the WHO AWaRe classification and dosage form availability on antimicrobial resistance","authors":"Joya Rani ,&nbsp;Sudipta Saha ,&nbsp;Fahmi Ferdous ,&nbsp;Md. Ajijur Rahman","doi":"10.1016/j.jiph.2024.102587","DOIUrl":"10.1016/j.jiph.2024.102587","url":null,"abstract":"<div><h3>Background</h3><div>Availability of antibiotics without prescription contributes to the rising threat of antibiotic resistance due to widespread self-medication and improper use. In this study, we aimed to assess the antibiotic market in Bangladesh according to the WHO AWaRe (Access, Watch, Reserve) classification system to better understand how the unregulated access of antibiotics may influence self-medication practices and the emergence of antibiotic resistance in the country.</div></div><div><h3>Methods</h3><div>Data on AWaRe class antibiotics, their strengths, and dosage forms were collected from Bangladeshi drug indexing smartphone applications, the Bangladesh National Formulary (BDNF), and the Directorate General of Drug Administration (DGDA) website. Sales data were analyzed using IQVIA data to determine the market value and compound annual growth rates (CAGR) of antibiotics. The analysis focused on categorizing antibiotics according to the WHO AWaRe classification and examining their availability in various dosage forms and strengths including child-appropriate formulations.</div></div><div><h3>Results</h3><div>Of the 81 antibiotics available in Bangladesh, 54.32 % belong to the Watch class, 30.86 % to Access, 8.64 % to Reserve, and 6.17 % were unclassified. In terms of ATC classifcation, the majority (91.35 %) belonged to the J01 class. Most antibiotics were available in multiple dosage forms and strengths, with tablets (54.87 %), injections (48.78 %), and capsules (30.48 %) being the most common. Additionally, 35.8 % of antibiotics were available as child-appropriate formulations. Oral formulations were prevalent, with 88.0 % of Access, 75.0 % of Watch, and 28.57 % of Reserve class antibiotics were available in oral dosage forms. A total of 56 antibiotic combinations were identified, including six WHO-recommended and two WHO-not-recommneded fixed-dose combinations. Watch class antibiotics dominated the market in terms of sales value and CAGR.</div></div><div><h3>Conclusion</h3><div>The widespread availability of Watch class antibiotics, particularly in oral and child-appropriate formulations suggest a need for stricter regulation and public health interventions to curb self-medication, inappropriate marketing and use of antibiotics to mitigate the risks of resistance.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 12","pages":"Article 102587"},"PeriodicalIF":4.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The unprecedented surge of dengue in the Americas: Strategies for effective response 美洲登革热空前肆虐:有效应对战略。
IF 4.7 3区 医学
Journal of Infection and Public Health Pub Date : 2024-11-06 DOI: 10.1016/j.jiph.2024.102585
Ashutosh Pareek, Runjhun Singhal, Aaushi Pareek, Anil Chuturgoon, Alfonso J. Rodriguez-Morales
{"title":"The unprecedented surge of dengue in the Americas: Strategies for effective response","authors":"Ashutosh Pareek,&nbsp;Runjhun Singhal,&nbsp;Aaushi Pareek,&nbsp;Anil Chuturgoon,&nbsp;Alfonso J. Rodriguez-Morales","doi":"10.1016/j.jiph.2024.102585","DOIUrl":"10.1016/j.jiph.2024.102585","url":null,"abstract":"","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 12","pages":"Article 102585"},"PeriodicalIF":4.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circulating inflammatory cytokines predict severity disease in hospitalized COVID-19 patients: A prospective multicenter study of the European DRAGON consortium 循环炎性细胞因子可预测 COVID-19 住院患者的病情严重程度:欧洲 DRAGON 联盟的一项前瞻性多中心研究。
IF 4.7 3区 医学
Journal of Infection and Public Health Pub Date : 2024-11-06 DOI: 10.1016/j.jiph.2024.102589
Barbara Polese , Marie Ernst , Monique Henket , Benoit Ernst , Marie Winandy , Makon-Sébastien Njock , Céline Blockx , Stéphanie Kovacs , Florence Watar , Anna Julie Peired , Sara Tomassetti , Cosimo Nardi , Stéphanie Gofflot , Souad Rahmouni , James PR Schofield , Rebekah Penrice-Randal , Paul J. Skipp , Fabio Strazzeri , Erika Parkinson , Gilles Darcis , Julien Guiot
{"title":"Circulating inflammatory cytokines predict severity disease in hospitalized COVID-19 patients: A prospective multicenter study of the European DRAGON consortium","authors":"Barbara Polese ,&nbsp;Marie Ernst ,&nbsp;Monique Henket ,&nbsp;Benoit Ernst ,&nbsp;Marie Winandy ,&nbsp;Makon-Sébastien Njock ,&nbsp;Céline Blockx ,&nbsp;Stéphanie Kovacs ,&nbsp;Florence Watar ,&nbsp;Anna Julie Peired ,&nbsp;Sara Tomassetti ,&nbsp;Cosimo Nardi ,&nbsp;Stéphanie Gofflot ,&nbsp;Souad Rahmouni ,&nbsp;James PR Schofield ,&nbsp;Rebekah Penrice-Randal ,&nbsp;Paul J. Skipp ,&nbsp;Fabio Strazzeri ,&nbsp;Erika Parkinson ,&nbsp;Gilles Darcis ,&nbsp;Julien Guiot","doi":"10.1016/j.jiph.2024.102589","DOIUrl":"10.1016/j.jiph.2024.102589","url":null,"abstract":"<div><h3>Background</h3><div>COVID-19 has put a huge strain on the healthcare systems worldwide, requiring unprecedented intensive care resources. There is still an unmet clinical need for easily available biomarkers capable of predicting the risk for severe disease. The main goal of this prospective multicenter study was to identify biomarkers that could predict ICU admission and in-hospital mortality.</div></div><div><h3>Methods</h3><div>We prospectively recruited COVID-19 PCR positive patients in two hospitals, in Belgium and Italy. Blood samples were collected at hospital admission and 20 potential biomarkers were measured with the Luminex technology. Logistic regression models were performed to identify the biomarkers that, alone or together, were associated with patient disease severity.</div></div><div><h3>Results</h3><div>Our study demonstrates that elevated levels of circulating inflammatory cytokines were associated with disease severity in COVID-19 hospitalized patients. CXCL10, IL-4, IL-6 and MCP-1 values were predictive of ICU admission. Elevated levels of IL-6 and MCP-1 were also associated with in hospital death in COVID-19 hospitalized patients.</div></div><div><h3>Conclusion</h3><div>Altogether, elevated and correlated inflammatory cytokines in the blood of COVID-19 patients at hospital admission are predictive of disease severity and suggest a dysregulated inflammation induced by SARS-CoV-2 infection.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 12","pages":"Article 102589"},"PeriodicalIF":4.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healthcare workers’ knowledge and preparedness for unprecedented foodborne botulism outbreak in Saudi Arabia 沙特阿拉伯医护人员对史无前例的食源性肉毒杆菌疫情的了解和准备情况。
IF 4.7 3区 医学
Journal of Infection and Public Health Pub Date : 2024-11-05 DOI: 10.1016/j.jiph.2024.102584
Abdullah Alhuzaimi , Fatimah S. Alshahrani , Fadi Aljamaan , Fatema H. AL-Ajwad , Ibraheem Altamimi , Abdullah Bukhari , Lama Al-Eyadhy , Sarah Al-Subaie , Nasser S. Alharbi , Mazin Barry , Yamen Shayah , Amr Jamal , Alaa A. Alanteet , Khalid Alhasan , Sameera M. Aljuhani , Jaffar A. Al-Tawfiq , Mohamad-Hani Temsah
{"title":"Healthcare workers’ knowledge and preparedness for unprecedented foodborne botulism outbreak in Saudi Arabia","authors":"Abdullah Alhuzaimi ,&nbsp;Fatimah S. Alshahrani ,&nbsp;Fadi Aljamaan ,&nbsp;Fatema H. AL-Ajwad ,&nbsp;Ibraheem Altamimi ,&nbsp;Abdullah Bukhari ,&nbsp;Lama Al-Eyadhy ,&nbsp;Sarah Al-Subaie ,&nbsp;Nasser S. Alharbi ,&nbsp;Mazin Barry ,&nbsp;Yamen Shayah ,&nbsp;Amr Jamal ,&nbsp;Alaa A. Alanteet ,&nbsp;Khalid Alhasan ,&nbsp;Sameera M. Aljuhani ,&nbsp;Jaffar A. Al-Tawfiq ,&nbsp;Mohamad-Hani Temsah","doi":"10.1016/j.jiph.2024.102584","DOIUrl":"10.1016/j.jiph.2024.102584","url":null,"abstract":"<div><h3>Background</h3><div>The recent unprecedented foodborne botulism outbreak in Saudi Arabia necessitated an assessment of healthcare workers' (HCWs) knowledge, attitudes, and practices (KAP). This study assessed healthcare workers' knowledge regarding the transmission, contagiousness, presentation, and diagnosis of foodborne botulism, as well as their management practices, including contacting public health authorities, administering antitoxin, preparedness to respond to botulism cases and consulting generative Artificial Intelligent (AI)-chatbots, like ChatGPT.</div></div><div><h3>Methods</h3><div>A cross-sectional online survey targeting Saudi HCWs was conducted from May 6–19, 2024, following the first foodborne botulism outbreak. The survey, developed by infectious disease and public health experts according to the Saudi Public Health Authority (SPHA) botulism guidelines, covered several sections: demographics, knowledge about foodborne botulism, attitudes and perceptions, intended practices, and worry level. Statistical analysis included descriptive statistics, multivariable linear regression to assess factors influencing knowledge, and multivariable logistic binary regression to evaluate factors affecting confidence in handling botulism.</div></div><div><h3>Results</h3><div>Among the 1058 participants, the knowledge score was 9.69/20 (48.4 % correct ± 18 %), with higher scores among HCWs working in tertiary centers, older than 34 years, reading SPHA botulism protocol, and using scientific journals as main information sources. HCWs consulting ChatGPT had significantly lower knowledge scores (p-value &lt; 0.001). HCWs displayed highly intended practices in managing botulism, with a mean score of 4.10/5. The self-rated management confidence was moderate (2.84 ± 1.05 out of 5-points). Multivariable logistic binary regression showed that previous experience with botulism and reading SPHA protocol were the most significant factors associated with a higher management confidence.</div></div><div><h3>Conclusions</h3><div>This study highlights significant HCWs’ knowledge gaps during unprecedented foodborne botulism outbreak. Previous experience with botulism cases and reading recent guidelines were associated with higher knowledge and confidence, while reliance on ChatGPT was linked to lower scores. This study emphasizes the importance of timely publishing local guidelines to favorably affect both knowledge and confidence to deal with infectious outbreaks. Future research should evaluate long-term effectiveness of educational interventions.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"17 12","pages":"Article 102584"},"PeriodicalIF":4.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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