Journal of Infection and Public Health最新文献

{"title":"Rare infantile sepsis and meningitis caused by Pasteurella multocida: A case report","authors":"Ming-ming Ni ,&nbsp;Wen-xin Lin ,&nbsp;Yang Li ,&nbsp;Jin-chun Qiu ,&nbsp;Chun-feng Wu","doi":"10.1016/j.jiph.2025.102822","DOIUrl":"10.1016/j.jiph.2025.102822","url":null,"abstract":"<div><div>This case report highlights a rare instance of <em>Pasteurella multocida</em> meningitis in a 2-month-old infant, complicated by subdural empyema. The pathogen was identified using next-generation sequencing (NGS), despite negative bacterial cultures, underscoring the diagnostic challenges. The strain was predicted to be resistant to meropenem and ampicillin, necessitating a tailored treatment approach. The strain was likely transmitted through a neighbor's dog, emphasizing the complexity of <em>P. multocida</em> transmission. This case underscores the importance of advanced diagnostic techniques and personalized therapy for managing rare, antibiotic-resistant infections.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 8","pages":"Article 102822"},"PeriodicalIF":4.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superspreading potential of SARS-CoV-2 across multiple infection generations","authors":"Hee Kyoung Kim ,&nbsp;Jun-Sik Lim ,&nbsp;Seonghui Cho ,&nbsp;Eun Woo Lee ,&nbsp;Minje Lee ,&nbsp;Dong Wook Kim ,&nbsp;Kyungnam Kim ,&nbsp;Achangwa Chiara ,&nbsp;Sang-Eun Lee ,&nbsp;Sukhyun Ryu","doi":"10.1016/j.jiph.2025.102808","DOIUrl":"10.1016/j.jiph.2025.102808","url":null,"abstract":"<div><h3>Background</h3><div>Early during the coronavirus disease 2019 pandemic, the first patients to be identified as the source of infection in the clustered outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were labeled superspreaders in South Korea. However, the extent to which superspreading potential varies across different infection generations remains unclear. This study aims to estimate SARS-CoV-2 superspreading potentials across different infection generations from the largest clustered outbreak of the SARS-CoV-2 wild type in Seoul, South Korea, 2020.</div></div><div><h3>Methods</h3><div>We retrieved the infector–infectee line list data on an outbreak occurred between May 6 and June 5, 2020. To evaluate the superspreading potential (<span><math><mi>k</mi></math></span>), we fitted the offspring distributions that had been acquired by counting the number of observed secondary infections for each case and each generation into negative binomial distributions.</div></div><div><h3>Results</h3><div>The outbreak yielded a <span><math><mi>k</mi></math></span> value of 0.18 (95 % confidence interval [CI]: 0.13–0.27) and similar superspreading potentials across the different infection generations. Regarding the superspreading potential in each generation (i.e., individuals’ heterogeneity across different generations), <span><math><mi>k</mi></math></span> was estimated to be 0.27 (95 % CI: 0.15–0.51), 0.14 (0.03–0.23), 0.10 (0.01–0.17), 0.55 (0.12–5.80 ×10⁵), and 0.19 (0.07–0.73) for the first, second, third, fourth, and fifth or more generations, respectively.</div></div><div><h3>Conclusions</h3><div>Our findings revealed no significant variations in the superspreading potential of SARS-CoV-2 across cases from different infection generations in the clustered outbreak. Assessing superspreading potential during the epidemic is necessary to refine epidemic modeling and enhance public health understanding of the transmission dynamic of epidemics.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 8","pages":"Article 102808"},"PeriodicalIF":4.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Papillomavirus (HPV) prevalence in population younger than 12 years old: A meta-analysis and systematic review","authors":"Mona Sadat Larijani ,&nbsp;Amir Javadi ,&nbsp;Amirabbas Faridpour ,&nbsp;Mohammad Banifazl ,&nbsp;Fatemeh Ashrafian ,&nbsp;Anahita Bavand ,&nbsp;Ladan Moradi ,&nbsp;Amitis Ramezani","doi":"10.1016/j.jiph.2025.102814","DOIUrl":"10.1016/j.jiph.2025.102814","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of HPV in children has been studied in different populations; however, the heterogeneity between the investigations is remarkable, and the total prevalence of HPV infection in this population is not well understood.</div></div><div><h3>Methods</h3><div>The conducted studies on the prevalence of HPV infection in the population &lt; 12 years old were explored and analyzed through a systematic review and meta-analysis approach. The studies which investigated HPV detection in oropharyngeal, nasopharyngeal and/or anogenital samples were included. HPV prevalence, sample type and age were considered as the inclusion criteria for the meta-analysis.</div></div><div><h3>Results</h3><div>Fifteen published studies between 1994 and 2021 with a total number of 2638 children aged from 1 day to 12 years, were analyzed. The total HPV prevalence in this population is estimated to be 14.7 % with the highest rate in kids over 1 year old, accounting for 25.4 %. Furthermore, the type of samples showed that buccal swabs had the highest rate of infection. The ratio of HPV-positive children born to HPV-positive mothers varied from 3 % to 55 % (median: 17.5 %), while this ratio decreased to 0–19.7 % (median 5.55 %) in HPV-positive kids born to HPV-negative mothers.</div></div><div><h3>Conclusion</h3><div>According to the present analysis, the prevalence of HPV in children is relatively high and requires further prospective studies and monitoring HPV acquisition in the young population, specifically in those born to HPV-positive mothers. Follow-up studies to assess the persistency rate of HPV after infancy are needed in order to highlight any possible implications for HPV vaccination programs and policy-making.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 8","pages":"Article 102814"},"PeriodicalIF":4.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143946736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particle filtration efficiency of respirators during the COVID-19 pandemic","authors":"Jackson Williams,&nbsp;Lucan Baillie,&nbsp;Wayne Clancy,&nbsp;Travis Dodd,&nbsp;Kelly Tsang,&nbsp;Katie Burns,&nbsp;Lisa Kerr,&nbsp;Amanda Craig","doi":"10.1016/j.jiph.2025.102811","DOIUrl":"10.1016/j.jiph.2025.102811","url":null,"abstract":"<div><h3>Background</h3><div>Respirators are an essential medical device vital to prevent the transmission of airborne illness between persons. This study presents an investigation conducted by the Therapeutic Goods Administration (TGA) into the particle filtration efficiency (PFE) performance of respirators supplied in Australia that were included as medical devices in the Australian Register of Therapeutic Goods (ARTG) throughout the COVID-19 pandemic or supplied to the TGA from other jurisdictions for compliance testing.</div></div><div><h3>Methods</h3><div>A total of 400 real-world batches of respirators were tested against a rapid-screen PFE method developed by the TGA. The TGA analysed a respirator’s ability to meet its claimed filtration efficiency with a statistical power analysis differentiated by the claimed PFE standard, country of manufacture, time of inclusion into the ARTG and respirators with surgical against non-surgical claims.</div></div><div><h3>Findings</h3><div>Of the tested batches of respirators (n = 400), 70 % were compliant with the pre-set compliance criteria. The results indicate statistically significant PFE differences (p &lt; 0.05) between respirators claiming the standards 42 CFR Part 84, AS 1716:2012, GB 19083: 2010 and EN 149:2001+ A1:2009 when tested against respirators claiming GB 2626:2006. There were no observed significant differences between the PFE of surgical and non-surgical respirators (p &gt; 0.05).</div></div><div><h3>Interpretation</h3><div>The findings of this study highlight the importance of ensuring respirators meet their claimed PFE level based on their claimed standard prior to manufacturer release. Further studies should be focussed on investigating the effect of respiratory protection devices and their claimed efficiency in clinical settings such as hospitals against aerosolised particulates using a range of respiratory protection devices.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 8","pages":"Article 102811"},"PeriodicalIF":4.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional challenges in Brazil's decision-making process of vaccines adoption: The case of childhood pneumococcal conjugate vaccines","authors":"Ana Marli Christovam Sartori ,&nbsp;Patrícia Coelho de Soárez ,&nbsp;Hillegonda Maria Dutilh Novaes ,&nbsp;Thayssa Veiga da Fonseca Victer ,&nbsp;Ana Catarina de Melo Araujo ,&nbsp;Greice Madeleine Ikeda do Carmo ,&nbsp;Marcelo Yoshito Wada ,&nbsp;Eder Gatti Fernandes","doi":"10.1016/j.jiph.2025.102812","DOIUrl":"10.1016/j.jiph.2025.102812","url":null,"abstract":"<div><div>The objective of this paper was to examine the process of adopting new vaccines in a middle-income country.</div></div><div><h3>Methods</h3><div>We used an intrinsic explanatory case study to analyze the recent decision-making process of switching 10-valent Pneumococcal Conjugate Vaccine (PCV10) to PCV13 in the Brazilian childhood immunization schedule. We analyzed Conitec (<em>Comissão Nacional de Incorporação de Tecnologias no Sistema Único de Saúde) official documents.</em></div></div><div><h3>Results</h3><div>In November 2022, the Conitec plenary recommended, at first, switching from PCV10 to PCV13, considering PCV13 non-inferiority and similar safety profile to PCV10, the price proposed by Wyeth/Pfizer, below the currently practiced, and the scenario of possible resource savings observed in an economic analysis conducted by Wyeth/Pfizer. In a second meeting, in April 2023, Conitec final decision was not to introduce PCV13 at that moment, based on additional scientific, administrative and technical data presented by the National Immunization Program, mainly epidemiological data showing no recent increase of pneumococcal disease (PD), the need to increase vaccination coverage to better control PD and to implement a sentinel surveillance of vaccine-preventable bacterial diseases with nationwide representation to better evaluate PD burden and serotypes replacement, and the country technological development and self-sufficiency in vaccine production.</div></div><div><h3>Conclusions</h3><div>Our case showed the decision-making process of adopting new vaccines is country-specific and involve many levels of political prioritization and complex technical aspects, and depends on the presence of strong public health institutions.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 8","pages":"Article 102812"},"PeriodicalIF":4.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pertussis hospitalizations in France (2008–2020): A real-world retrospective analysis of incidence and costs based on the French National Health Data System","authors":"Juan C. Vargas-Zambrano ,&nbsp;Mickael Arnaud ,&nbsp;Ana Antunes ,&nbsp;Khalil Karzazi ,&nbsp;Johanna Despres ,&nbsp;Regis Verdier ,&nbsp;Florence Boisnard ,&nbsp;Jerome Jund ,&nbsp;Cecile Janssen ,&nbsp;Didier Pinquier ,&nbsp;Denis Macina","doi":"10.1016/j.jiph.2025.102801","DOIUrl":"10.1016/j.jiph.2025.102801","url":null,"abstract":"<div><h3>Background</h3><div>Assessing pertussis burden and the impact of the 2013 vaccination schedule update (3 + 1 to 2 + 1 schedule) in France is hindered by non-mandatory reporting. We aimed to estimate the cumulative incidence and hospitalization costs due to pertussis in France between 2008 and 2020.</div></div><div><h3>Methods</h3><div>This observational retrospective cohort study was conducted using claims data from the French National Health Data System (SNDS) (January 2008–December 2020). Cumulative incidence of pertussis-hospitalizations, cumulative incidence ratios, and economic burden were analyzed. Cumulative incidences were estimated as the total pertussis-hospitalizations recorded annually from SNDS with respect to the French population, and expressed per 100,000 inhabitants. Cumulative incidence ratios were estimated using a negative binomial regression adjusted on the cyclical pattern of pertussis disease.</div></div><div><h3>Results</h3><div>Overall, 10,893 patients were hospitalized for pertussis (severe cases: 36.7 % [n = 3997]; <em>Bordetella pertussis</em> disease: 93.3 % [n = 10,158]). Outbreaks were reported in 2009 (n = 1276), 2012–2013 (n = 2762), and 2017–2018 (n = 1727). The age group with the highest proportion of cases was 2–5 months (34.7 %), followed by 0–1 month (18.0 %) and ≥65 years (13.6 %). Cumulative incidence of hospitalization due to <em>Bordetella pertussis</em> disease was similar among infants aged &lt;2 and 2–5 months (cumulative incidence ratio [CIR]=0.96 [0.90–1.02]; comparator: &lt;2 months) and quite low in children aged ≥1 year (CIR≤0.01). Among adults, CIRs increased with age and peaked at ≥65 years (CIR=2.95 [2.57–3.38]; comparator: 18–25 years). CIRs decreased post schedule change (CIR=0.61 [0.43–0.84]; comparator: 3 + 1) and post-implementation of mandatory vaccination policy (CIR=0.68 [0.43–1.08]; comparator: before mandatory vaccination policy) across all age groups. Median overall costs were €3259 (all cases), with higher costs for severe cases and highest costs (€4880) for infants aged &lt;2 months.</div></div><div><h3>Conclusion</h3><div>Results reemphasized the persistent public health challenge of pertussis, especially in infants aged 0–5 months. Findings may guide future vaccination policies in Europe.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 8","pages":"Article 102801"},"PeriodicalIF":4.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women’s perceptions and preferences toward HPV self-sampling in France: A questionnaire within the French CapU4 Trial","authors":"Hélène De Pauw ,&nbsp;Alexandra Ducancelle ,&nbsp;Marc Arbyn ,&nbsp;Adeline Pivert ,&nbsp;Anne-Sophie Le Duc Banaszuk ,&nbsp;Juliette Noyelle ,&nbsp;Johane Le Goff ,&nbsp;Franck Rexand-Galais ,&nbsp;Gilbert Donders ,&nbsp;Caroline Lefeuvre","doi":"10.1016/j.jiph.2025.102809","DOIUrl":"10.1016/j.jiph.2025.102809","url":null,"abstract":"<div><h3>Background</h3><div>Despite organised screening efforts since 2018 targeting under-screened women, cervical cancer (CC) screening coverage remains moderate (60 %) in France. The target age for HPV-based screening is women aged 30–65. Vaginal self-sampling (VSS) has recently been introduced for women who have not been screened. This study assesses women’s perceptions and preferences toward HPV self-sampling among women enrolled in the CapU4 trial.</div></div><div><h3>Methods</h3><div>CapU4 is a randomised controlled trial with two experimental arms (mailing either a urine self-sampling (USS) or VSS kit) and a control arm (mailing of a conventional invitation letter). The trial invited 15,000 women aged 30–65, who had no screening test recorded since more than four years and who did not respond to an invitation letter within 12 months before. Half of the women in each arm were randomly selected to receive a supplementary questionnaire (sent in March 2023, with responses collected until August 2023).</div></div><div><h3>Results</h3><div>In total, 682 completed questionnaires were analysed (9.1 % response rate). Most women found self-sampling instructions clear (VSS 87.4 %, USS 90.7 %) and procedures easy (VSS 85.9 %, USS 90.3 %). About 23.5 % of VSS users and 4.9 % of USS users found the process unpleasant. Around 80 % of participants in both SS arms preferred taking a specimen at home rather than going to a health care professional for cervical screening. They also indicated a preference for using self-sampling kit to collect a sample for their next CC screening instead of visiting a health care professional (VSS 82.6 %, USS 89.1 %).</div></div><div><h3>Conclusion</h3><div>Self-sampling appears to be a well-received alternative in women not attending routine CC screening programme.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 8","pages":"Article 102809"},"PeriodicalIF":4.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of mutations in immunodominant regions of SARS-CoV-2 variants on recognition by CD8+ T cell: An in silico analysis","authors":"Greice Carolina Santos da Silva ,&nbsp;Victoria Cruz Paraná ,&nbsp;Filipe Ferreira de Almeida Rego ,&nbsp;Mariana Maciel Portela ,&nbsp;Mariana Barros Queiroz ,&nbsp;Raimundo Coutinho Junior ,&nbsp;Carlos Gustavo Regis da Silva ,&nbsp;Luana Leandro Gois ,&nbsp;Maria Fernanda Rios Grassi","doi":"10.1016/j.jiph.2025.102803","DOIUrl":"10.1016/j.jiph.2025.102803","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate whether mutations in the immunodominant regions of the S, M, and N proteins of the Gamma, Delta, and Omicron SARS-CoV-2 variants that circulated in Brazil affect the recognition of viral antigens by Brazilian HLA-I-restricted CD8+ T cell epitopes, using an <em>in silico</em> approach.</div></div><div><h3>Methods</h3><div>Sequences of the Gamma (n = 36,174), Delta (n = 35,129), and Omicron (n = 336) variants were retrieved using GISAID. Consensus sequences were generated using Geneious software with NC045512 as a reference. Epitopes for the S, M, and N proteins of both the original and variant sequences were predicted using NetCTLpan 1.1, NetMHCpan 4.0, and VaxiJen v2.0. The positions occupied by these epitopes, with high probability of presentation, affinity to HLA molecules, and antigenicity, were identified as potentially immunodominant regions.</div></div><div><h3>Results</h3><div>The S protein of the reference sequence (NC045512) and its variants contained 17 immunodominant regions. Delta showed the highest conservation (94.1 %, 16), followed by Gamma (82.3 %, 14) and Omicron (70.5 %, 12). Omicron exhibited the greatest mutational variability and had regions of increased antigenicity and two novel immunodominant regions with broader human leukocyte antigen (HLA) recognition. Additionally, Omicron lost two previously identified immunodominant regions and had one region of reduced antigenicity that did not affect HLA recognition. Gamma had mutations in three regions that increased both antigenicity and HLA recognition. Delta had only one mutated region with lower antigenicity, which did not affect HLA recognition. Notably, new immunodominant regions for the M and N proteins appeared in the Omicron variant.</div></div><div><h3>Conclusions</h3><div>Brazilian HLA-I-restricted CD8+ T cell epitopes from SARS-CoV-2 immunodominant regions are partially conserved in the Gamma, Delta, and Omicron variants circulating in Brazil, suggesting effective a cross-protective immune response that may help reduce COVID-19 severity and mortality.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 8","pages":"Article 102803"},"PeriodicalIF":4.7,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Molecular and serological evidence of chikungunya virus among dengue suspected patients in Sri Lanka” [J Infect Public Health 2025;18(5):102709]","authors":"Mya Myat Ngwe Tun ,&nbsp;Maurine Mumo Mutua ,&nbsp;Shingo Inoue ,&nbsp;Yuki Takamatsu ,&nbsp;Satoshi Kaneko ,&nbsp;Takeshi Urano ,&nbsp;Rohitha Muthugala ,&nbsp;Lakkumar Fernando ,&nbsp;Menaka Hapugoda ,&nbsp;YINS Gunawardene ,&nbsp;Kouichi Morita","doi":"10.1016/j.jiph.2025.102806","DOIUrl":"10.1016/j.jiph.2025.102806","url":null,"abstract":"","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 7","pages":"Article 102806"},"PeriodicalIF":4.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis of the global prevalence of human enteric adenovirus infections","authors":"Mary E. Wikswo ,&nbsp;Anita K. Kambhampati ,&nbsp;Claire P. Mattison ,&nbsp;Preeti Chhabra ,&nbsp;Oluwatosin Olojo ,&nbsp;Taha Rana ,&nbsp;Jan Vinjé ,&nbsp;Carl D. Kirkwood ,&nbsp;Umesh D. Parashar ,&nbsp;Sara A. Mirza","doi":"10.1016/j.jiph.2025.102800","DOIUrl":"10.1016/j.jiph.2025.102800","url":null,"abstract":"<div><div>Human adenovirus (HAdV), especially HAdV species F (HAdV-F) is recognized as a cause of acute gastroenteritis (AGE) worldwide. To assess the global prevalence of HAdV in case-patients of all ages with AGE, we conducted a systematic literature search for studies published in English during 2015–2022. We generated pooled prevalence estimates using generalized linear mixed models. Using data from 147 included articles, the overall pooled prevalence among AGE case-patients of any species of HAdV (pan-HAdV) was 5.8 % and 6.0 % for HAdV-F. The prevalence of HAdV was significantly higher among case-patients &lt; 5 years of age compared with case-patients ≥ 5 years of age (pan-HAdV: 6.6 % vs. 2.0 %, p &lt; 0.0001; HAdV-F: 8.7 % vs. 2.3 %, p = 0.04). Prevalence was significantly higher in high mortality developing countries and lowest in developed countries (pan-HAdV: 9.4 % vs. 4.0 %, p &lt; 0.0001; HAdV-F: 11.6 % vs. 3.2 %, p = 0.0003). Understanding the burden of HAdV-associated AGE may be useful for targeted interventions, including future vaccine development.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 7","pages":"Article 102800"},"PeriodicalIF":4.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}