Journal of Geriatric Psychiatry and Neurology最新文献

{"title":"Brain Structures Associated with Depression in Older Adults in the National Alzheimer's Coordinating Center Uniform Data Set.","authors":"Shanna L Burke, Adrienne Grudzien, Tan Li, Natalie Goulett, Christopher P Barnes, Kevin Hanson, Steven T DeKosky","doi":"10.1177/08919887251361101","DOIUrl":"10.1177/08919887251361101","url":null,"abstract":"<p><p>PurposeThis study examined relations between four late-life depression subgroups (recent, >2 years ago, chronic, no depression) and regional brain volumes using structural MRI data from the National Alzheimer's Coordinating Center (n=1,551).Data AnalysisMultiple linear regressions evaluated the effects of depression on 30 MRI biomarkers, while moderation analyses assessed how APOE ε4 and depression shape the connections between cognitive status and brain structure volumes.ResultsAfter adjusting for covariates and applying Hochberg's method, recent depression (< 2 years) was associated with reduced total cerebrum cranial volume and left frontal lobe cortical gray matter volume. Chronic depression correlated with larger right lateral ventricle volume.ConclusionThese findings suggest that recent depression is linked to brain atrophy across specific regions and ventricular enlargement. Future research should investigate age-related impacts on these associations and whether restoration of brain volume occurs after depressive symptoms subside.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"207-224"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Utility of a Clinical Staging Approach and the DSM-5 in Diagnosing Personality Disorders Among Older Adults.","authors":"Jelle de Jong, Sebastiaan P J van Alphen, Jeroen A P Conjaerts, Roel Schepman, Machteld A Ouwens, Arjan C Videler","doi":"10.1177/08919887251358413","DOIUrl":"10.1177/08919887251358413","url":null,"abstract":"<p><p>Clinical staging may provide a valuable alternative to the limitations of categorical diagnostic models like the DSM-5 for mental disorders. However, research on the clinical utility of staging models on mental disorders is limited, particularly in comparison to the DSM-5, which hinders the implementation of staging models in clinical practice. The limitations of categorical models are even more pronounced in older adults, as personality disorders (PDs) may manifest differently later in life, potentially leading to over- or underdiagnosis when relying on the DSM-5.AimThis study compared the clinical utility of a clinical staging model (CSM) with the DSM-5 for diagnosing PDs in older adults from the perspective of clinicians.MethodThirty-four Dutch participants, including psychiatrists, geriatricians, psychologists, and psychiatric nurse practitioners (PNP), completed an online questionnaire featuring an introduction to the CSM and the assessment of 2 fictional vignettes. Each vignette represented different stages of PDs and was evaluated using both the CSM and the DSM-5. Participants rated their experiences across 6 domains for both models.ResultsThe clinicians rated the clinical utility of the CSM significantly higher than that of the DSM-5 across all domains, with 55.9% preferring the CSM, 32.8% opting for both models, and 11.8% preferring the DSM-5 in clinical practice.ConclusionsThese findings suggest that the CSM may be a valuable addition to the diagnosis of PDs in older adults. This highlights the need for further research into its clinical application and the general utility of staging models.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"161-170"},"PeriodicalIF":2.5,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motivation, Worries and Digital Affinity in Cognitive Screening - Qualitative Findings From the CogScreen Study.","authors":"Paulina Tegethoff, Robert Perneczky, Marleen Taute, Amy Deckert, Michael Hornbecker, Sophia Rutt, Anna Hufnagel, Soeren Mattke, Carolin Kurz","doi":"10.1177/08919887261429558","DOIUrl":"https://doi.org/10.1177/08919887261429558","url":null,"abstract":"<p><p><b>Background:</b> Subjective cognitive decline is considered one of the earliest signs of Alzheimer's disease (AD), making early detection crucial for disease-modifying treatments to have the greatest impact. The CogScreen study, supported by the Davos Alzheimer's Collaborative Healthcare System Preparedness Program, evaluates tools for community-based screening of AD in its early stages. This study investigates subjective experiences, focusing on motivations, concerns, and potential improvements regarding digital tools used in cognitive assessments.<b>Methods:</b> Semi-structured qualitative interviews were conducted with a random selection of 28 participants with subjective cognitive decline or healthy controls. Interviews were transcribed and analyzed using conventional content analysis (MAXQDA, VERBI Software, 2024). <b>Results:</b> Analysis identified emergent themes related to the usability of digital tools, the importance of clear communication, and the desire for a more personalized research experience. Participants highlighted motivations and concerns regarding the implementation of digital assessments. <b>Discussion:</b> Findings support the feasibility of integrating digital assessments in aging populations and underscore the importance of addressing participants' motivations, concerns, and digital affinity when introducing innovative tools into clinical practice. <b>Conclusion:</b> Insights from this study contribute to future participant engagement strategies and the development of early detection methods for cognitive impairment. <b>Trial Registration:</b> CogScreen is registered at ClinicalTrials.gov (NCT06191952).</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261429558"},"PeriodicalIF":2.5,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Longevity is Associated With Reduced Risk but an Earlier Onset of Alzheimer's Disease in Offspring.","authors":"Miguel Tábuas-Pereira, Francisco Mano, Catarina Bernardes, João Durães, Marisa Lima, Kaitlyn DenHaan, Kimberly Paquette, Célia Kun-Rodrigues, Susana Carmona, Teresa Tábuas, Pedro Faustino, Mariana Ruth Coelho, Anuschka Silva-Spínola, Diana Duro, Maria Rosário Almeida, João Malva, Inês Baldeiras, José Brás, Rita Guerreiro, Isabel Santana","doi":"10.1177/08919887261424534","DOIUrl":"https://doi.org/10.1177/08919887261424534","url":null,"abstract":"<p><p>IntroductionWhile human longevity has increased significantly over the last 2 centuries, the time spent in good physical and cognitive health has not risen proportionately. The incidence of Alzheimer's disease (AD) increases with age, but parental longevity is often associated with better offspring health and lower AD risk. This study aimed to investigate the relationship between parental longevity and AD.MethodsWe included patients with AD and cognitively healthy subjects (over 75 years), collecting family history data, namely maternal and paternal age at death. We performed a logistic regression to evaluate the association of parental longevity and AD risk and linear regression models for the association with age of onset and CSF biomarkers, adjusting for confounders.ResultsWe analyzed 3069 participants from a Portuguese cohort, including 893 AD patients and 2176 cognitively healthy controls. Maternal longevity was inversely associated with AD risk (OR: 0.989, 95%CI = [0.982, 0.997], <i>P</i> = 0.005). In AD patients, higher maternal age of death was associated with an earlier disease onset (β = -0.081, 95%CI = [-0.148, -0.013], <i>P</i> = 0.019). No associations were found between parental longevity and CSF biomarkers.DiscussionMaternal longevity appears protective against AD risk but is linked to an earlier onset in patients. This may indicate that protective factors for AD could become detrimental once AD is triggered. These findings highlight the complex interplay of genetic, environmental, and potentially epigenetic influences on AD.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261424534"},"PeriodicalIF":2.5,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral Blood Epigenetic Age Acceleration is Associated With Psychosis in Female APOE4 Carriers With Mild Cognitive Impairment and Alzheimer's Disease: A Pilot Study.","authors":"Dylan Kwan, Neda Rashidi-Ranjbar, Joseph E Marinas, Andrew Namasivayam, Nathan Churchill, Luis R Fornazzari, Zahinoor Ismail, Vincenzo DeLuca, Tom A Schweizer, David G Munoz, Corinne E Fischer","doi":"10.1177/08919887261424535","DOIUrl":"https://doi.org/10.1177/08919887261424535","url":null,"abstract":"<p><p>ObjectivePsychosis is a significant neuropsychiatric symptom in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI). While female APOE4 homozygotes are at the highest risk of psychosis, mechanisms underlying this association remain unclear. We investigated whether epigenetic age acceleration (EAA) is associated with psychosis in individuals with AD and MCI, and whether this association varies by sex and APOE4 status.MethodsParticipants with clinical MCI or AD were drawn from the Alzheimer's Disease Neuroimaging Initiative database. EAA was calculated from DNA methylation data using the PhenoAge epigenetic clock, with the Horvath and Hannum clocks included for comparison. Psychosis status was defined as experiencing hallucinations or delusions at any time, based on the Neuropsychiatric Inventory Questionnaire. Logistic regression models were used to assess associations between EAA and psychosis, including three-way interactions with sex and APOE4 carrier status.ResultsAmong 418 total participants (54 with psychosis, 84 female APOE4 carriers), EAA was not associated with psychosis for any of the 3 clocks utilized. However, a significant three-way interaction between sex, APOE4 carrier status, and PhenoAge EAA in predicting psychosis was observed (<i>P</i> = 0.013). Elevated PhenoAge EAA was associated with higher odds of psychosis in female APOE4 carriers (OR = 1.76 per 5-year, <i>P</i> = .025), whereas no associations were observed for other subgroups or clocks.ConclusionsPhenoAge EAA may serve as a novel biomarker of psychosis among female APOE4 carriers. These findings highlight the potential of second-generation epigenetic clocks for early risk stratification and biological investigations into psychosis in AD and MCI.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261424535"},"PeriodicalIF":2.5,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Descriptive Statistical Analysis of Neuropsychiatric Symptom Pair Prevalence.","authors":"Timofey L Galankin, Jina Swartz, Hans J Moebius, Anton Y Bespalov","doi":"10.1177/08919887251341574","DOIUrl":"10.1177/08919887251341574","url":null,"abstract":"<p><p>Neuropsychiatric symptoms (NPS) are very common and associated with high levels of distress, both in dementia patients and their caregivers. Especially at more advanced dementia disease stages, NPS rarely occur in isolation and the presence of two or more NPS may affect disease severity as well as the response to therapy. There is limited quantitative information on prevalence of specific symptom combinations in the general population, as well as in the populations recruited for symptom-specific investigations. We performed cross-sectional analyses of data from two longitudinal studies (Aging, Demographics, and Memory Study (ADAMS) and the National Alzheimer's Coordinating Center data (NACC)). In both studies and all Mini Mental State Examination (MMSE) strata, we observed every possible pair combination, from commonly recognized and discussed associations (e.g., hallucinations and delusions) to what might be seen as rather counter-intuitive patterns (e.g., apathy and agitation). In conclusion, prevalence of symptom pairs cannot be readily predicted based on prevalence of individual symptoms. Further, the presence of cognitive deficit and degree of cognitive impairment is associated with increased prevalence of all symptoms and symptom pairs, albeit to different degrees. The present study illustrates that, while there is the possibility of any combination of neuropsychiatric symptoms presenting during the course of dementia, their co-occurrence cannot be readily predicted based on the prevalence of individual symptoms. Thus, our study results serve as a source of reference information to inform the design and recruitment strategies for future clinical studies and epidemiological research on neuropsychiatric symptoms in people with dementia.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"90-103"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Better Assessment of Illness Study (BASIL) II for Delirium Severity: Study Design, Variables, and Methods.","authors":"Tammy T Hshieh, Benjamin A Chapin, Wingyun Mak, Guoquan Xu, Eva M Schmitt, Edward R Marcantonio, Hannah Shanes, Cole Heine, Jordan Helfand, Catherine Price, Kenneth S Boockvar, Eran D Metzger, Tamara G Fong, Richard N Jones, Sharon K Inouye","doi":"10.1177/08919887251343604","DOIUrl":"10.1177/08919887251343604","url":null,"abstract":"<p><p>PurposeDelirium is a common yet preventable complication of hospitalization, surgery and illness that is associated with poor outcomes. Older adults with Alzheimer's Disease and Related Dementias (ADRD) are especially vulnerable to delirium and experience greater delirium severity, yet no existing assessment tool is specifically designed to evaluate this vulnerable population. This study will validate two new delirium severity instruments, the Delirium Severity (DEL-S) rating for all older adults and the Delirium Severity Rating in ADRD (DEL-S-AD) for patients with dementia.Design/Setting and ParticipantsThe Better ASsessment of ILlness II (BASIL II) study is an innovative prospective cohort study that measures cognitive function, delirium, delirium severity, demographics, clinical and functional variables and clinical outcomes. Participants include older adults from 3 unique yet complementary clinical sites: medical inpatients, elective surgery inpatients, or skilled nursing facility residents.MethodsPerformance of DEL-S and DEL-S-AD items in older adults with cognition ranging from no impairment to moderate impairment will be determined. Analyses will include psychometric characteristics of DEL-S and DEL-S-AD items, harmonization of the two scales and validation against reference standard diagnoses.Conclusions and ImplicationsResults from this study will help accurately measure delirium severity, a critically important, graded outcome. The DEL-S-AD instrument holds broad applications in persons with and without ADRD to monitor delirium severity in clinical settings, and as an outcome measure in future clinical treatment trials and pathophysiologic studies. Ultimately, the DEL-S and DEL-S-AD have the potential to improve health care for the vulnerable, growing population of older adults with cognitive impairment worldwide.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"79-89"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Violent Behaviors in Frontotemporal Dementia.","authors":"Othman Mounir Alaoui, Alexandra Fayel, Emmanuel Morain, Dominique De Blanchard, Claire Paquet, Emmanuel Cognat","doi":"10.1177/08919887251348933","DOIUrl":"10.1177/08919887251348933","url":null,"abstract":"<p><p>BackgroundThis study assessed the prevalence, characteristics, and contributing factors of violent behaviors in patients with frontotemporal dementia (FTD) as reported by their caregivers.MethodsA nationwide survey was conducted in France targeting caregivers of FTD patients. The survey was disseminated online between July and September 2022 through the French FTD association communications channels. It collected data on the frequency, types and targets of violent behaviors, and associated behavioral and psychological symptoms of dementia (BPSD). Associations between violent behaviors, BPSD, and demographic factors were explored.Results167 answers were analyzed. Violent behaviors were reported in 56.29% of patients with FTD, predominantly verbal (83.2%), often directed at caregivers (68.1%). Factors associated with violence included higher proxy NPI, delusions, agitation/aggression, and irritability scores. Violent behaviors were underreported, with only 48.8% of caregivers having disclosed them to health professionals.ConclusionsViolent behaviors in patients suffering from FTD appear often underreported. Systematic screening during medical appointments is recommended to ensure early intervention and better management.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"104-112"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twelve Weeks of Resistance Training is Equally as Effective at Improving Cardiovascular Risk Factors in Older Women With and Without History of Depression: A Cross-Over Trial.","authors":"Paolo M Cunha, André O Werneck, Felipe B Schuch, Liye Zou, Jin Kuang, Edilaine Fungari Cavalcante, Luís Alves de Lima, Letícia Trindade Cyrino, Pâmela de Castro-E-Souza, Max D Oliveira, Décio S Barbosa, Danielle Venturini, Brendon Stubbs, Edilson S Cyrino","doi":"10.1177/08919887251343603","DOIUrl":"10.1177/08919887251343603","url":null,"abstract":"<p><p>BackgroundWe aimed to evaluate the effects of 12 weeks of resistance training (RT) on cardiovascular disease (CVD) risk factors in older women with and without history of depression.MethodsWe included 79 older women, 52 without depression and 27 with a history of depression. 79 participants formed the waitlist control group and were instructed to maintain their habitual routine. The participants were reevaluated and attended 12 weeks of RT. The Beck Anxiety Inventory (BAI) and Patient Health Questionnaire-9 (PHQ-9). The serum levels of high-sensitivity C-reactive protein (CRP), glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density cholesterol (LDL-c), and triglycerides (TG) were used as cardiovascular risk factors. The Linear Mixed Model (LMM) was used to compare between groups.ResultsThe average age of the sample was 69.3 ± 5.7 and the body mass index was 28.5 ± 4.5. The 12 weeks of RT resulted in a reduction in BAI (-3.9 [-7.1; -0.6], <i>P</i> < 0.05) and PHQ-9 scores (-1.4 [-3.2; -0.5] <i>P</i> < 0.05) in the Training group with depressive disorders. In the training group with depressive disorders, it was observed an improvement in TG (-17.1 [-43.0; -8.8]), TC (-18.6 [-35.9; -1.3]), LDL-c (-10.3 [-26.8; -6.2]), and CRP (-0.4 [-1.3; -0.5]). Similar results were found for TG, TC, and LDL-c in the Training group without depressive symptoms. No difference between RT groups was observed.ConclusionOur results suggest that RT is effective in improving CVD risk factors, anxiety, and depressive symptoms in older women with history of depression.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"24-36"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subjective Memory Complaints in Older Adults: The Role of Polypharmacy and Anticholinergic Burden.","authors":"Betül Gülsüm Yavuz Veizi, Ekin Oktay Oğuz, Mehmet Ilkin Naharci","doi":"10.1177/08919887251339837","DOIUrl":"10.1177/08919887251339837","url":null,"abstract":"<p><p>BackgroundSubjective memory complaints (SMC) are common in older adults and may indicate an increased risk of cognitive decline. Polypharmacy and anticholinergic burden have been associated with cognitive impairment, but their specific contribution to SMC remains unclear. The aim of this study was to investigate the association between polypharmacy, anticholinergic burden and SMC in community-dwelling older adults.MethodsThis cross-sectional study included 652 participants aged 65 years and older from geriatric outpatient clinics. SMC was assessed via a structured clinician-administered question, and cognitive function was evaluated using the Mini-Mental State Examination (MMSE). Polypharmacy was defined as the concomitant use of five or more medications, while anticholinergic burden was determined using the Anticholinergic Burden Classification (ABC). Logistic regression models were used to examine the independent effects of polypharmacy and anticholinergic burden on SMC, adjusting for demographic variables, comorbidities and depressive symptoms.ResultsSMC was reported by 48% of participants. Polypharmacy (OR = 2.10, 95% CI: 1.43-3.08, <i>P</i> < 0.001) and higher anticholinergic burden (OR = 2.39, 95% CI: 1.72-3.32, <i>P</i> < 0.001) were independently associated with increased SMC. Chronic obstructive pulmonary disease (COPD) was also identified as a significant predictor (OR = 2.90, 95% CI: 1.41-5.98, <i>P</i> = 0.004).ConclusionPolypharmacy and anticholinergic burden are significant risk factors for SMC in older adults. Reducing unnecessary medication use and minimizing anticholinergic burden may help to alleviate cognitive complaints. Future longitudinal studies are needed to determine causal relationships and possible interventions.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"69-78"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}