Journal of Geriatric Psychiatry and Neurology最新文献

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Attitudes Towards Dementia Among a Diverse Group of Refugees Resettled in the United States. 在美国定居的不同难民群体对痴呆症的态度。
IF 2.9 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-03-01 Epub Date: 2024-09-03 DOI: 10.1177/08919887241280891
Dahlia A Kaki, Lana Bridi, Purity Mwendwa, Maryam Aso, Rawnaq Behnam, Nissma Bencheikh, Behnan Albahsahli, Xara Khan, Raghad Aljenabi, Alissa Bernstein Sideman, Alison Moore, Tala Al-Rousan
{"title":"Attitudes Towards Dementia Among a Diverse Group of Refugees Resettled in the United States.","authors":"Dahlia A Kaki, Lana Bridi, Purity Mwendwa, Maryam Aso, Rawnaq Behnam, Nissma Bencheikh, Behnan Albahsahli, Xara Khan, Raghad Aljenabi, Alissa Bernstein Sideman, Alison Moore, Tala Al-Rousan","doi":"10.1177/08919887241280891","DOIUrl":"10.1177/08919887241280891","url":null,"abstract":"<p><strong>Background: </strong>Forced migration results in exposure to trauma, interrupted access to healthcare, and loss of social support and may increase dementia risk. Literature on refugees' knowledge of dementia and its risk factors is scant. This study investigates refugee perspectives on dementia and their access to cognitive healthcare in the United States (US).</p><p><strong>Methods: </strong>We conducted 6 focus groups and 30 individual in-depth interviews (total of 69 participants) with Arab, African, and Afghan refugees resettled in San Diego, California. Data was coded using inductive thematic analysis.</p><p><strong>Results: </strong>Organized by the socioecological model of health, the following themes emerged: (1) mental trauma due to migration was linked to dementia (individual); (2) fear of dementia and burdening caregivers due to limited support systems (interpersonal); (3) reliance on <i>virtual communities</i> for dementia information and the stress of <i>local community loss</i> increasing dementia risk (community); (4) healthcare providers, both in the US and in refugee camps, didn't address cognitive health concerns (institutions); and (5) discriminatory immigration and healthcare policies as barriers to healthy aging (policy).</p><p><strong>Discussion: </strong>Despite being a heterogeneous group, refugees share specific experiences, knowledge gaps, and barriers to healthy aging. Tailored interventions and policies are needed to address this population's cognitive health needs. This includes addressing their mental health and social support concerns as well as training clinicians to screen for/discuss dementia with aging refugee patients.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"132-142"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142120028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pyridostigmine for the Management of Neurogenic Orthostatic Hypotension: A Systemic Review. 吡啶斯的明治疗神经源性正张力性低血压:系统回顾。
IF 2.9 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-03-01 Epub Date: 2024-07-23 DOI: 10.1177/08919887241266800
Amanda C Holder, Angela Dylewski, Jamie N Brown
{"title":"Pyridostigmine for the Management of Neurogenic Orthostatic Hypotension: A Systemic Review.","authors":"Amanda C Holder, Angela Dylewski, Jamie N Brown","doi":"10.1177/08919887241266800","DOIUrl":"10.1177/08919887241266800","url":null,"abstract":"<p><strong>Background: </strong>Pyridostigmine is hypothesized to improve neurogenic orthostatic hypotension (nOH) symptoms without causing or exacerbating supine hypertension. The objective of this review was to evaluate the safety and efficacy of pyridostigmine for management of nOH.</p><p><strong>Methods: </strong>A literature search of PubMed, Embase, and CENTRAL was performed in December 2023 for prospective trials with a placebo or active comparator.</p><p><strong>Results: </strong>Four randomized and two non-randomized studies were reviewed. Three studies utilizing a single dose, crossover design found significant differences of orthostatics using adjunctive pyridostigmine. Two studies assessing longer-term endpoints demonstrated conflicting efficacy of pyridostigmine with one trial finding significant improvement in orthostatics and symptoms after three months of therapy. Use of pyridostigmine did not lead to supine hypertension with most adverse effects being cholinergic.</p><p><strong>Conclusion: </strong>Pyridostigmine may be considered as an adjunctive medication in individuals with nOH refractory to standard treatment options as it carries a favorable safety profile with low risk for supine hypertension.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"85-93"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Associations of Sensory Impairment With 10-Year Risk of Dementia and Alzheimer's Disease: The Health and Retirement Study, 2010-2020. 感官障碍与痴呆症和阿尔茨海默病 10 年风险的关系:2010-2020 年健康与退休研究》。
IF 2.9 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-03-01 Epub Date: 2024-08-26 DOI: 10.1177/08919887241275042
Kun Li, Rahul Ghosal, Donglan Zhang, Yike Li, Matthew C Lohman, Monique J Brown, Anwar T Merchant, Chih-Hsiang Yang, Jean Neils-Strunjas, Daniela B Friedman, Jingkai Wei
{"title":"The Associations of Sensory Impairment With 10-Year Risk of Dementia and Alzheimer's Disease: The Health and Retirement Study, 2010-2020.","authors":"Kun Li, Rahul Ghosal, Donglan Zhang, Yike Li, Matthew C Lohman, Monique J Brown, Anwar T Merchant, Chih-Hsiang Yang, Jean Neils-Strunjas, Daniela B Friedman, Jingkai Wei","doi":"10.1177/08919887241275042","DOIUrl":"10.1177/08919887241275042","url":null,"abstract":"<p><strong>Background: </strong>Studies have examined the association between dual sensory impairment and late-life cognitive outcomes in the U.S with inconsistent findings.</p><p><strong>Objective: </strong>To examine the associations between sensory impairment and 10-year risk of dementia or Alzheimer's disease among U.S. adults aged ≥ 50.</p><p><strong>Methods: </strong>A prospective cohort study based on the Health and Retirement Study from 2010 to 2020. Individuals aged ≥ 50 years without self-reported dementia and Alzheimer's disease in 2010 were included in the analysis. Self-reported visual and hearing impairments were measures in 2010. Main failure events included self-reported incident dementia and Alzheimer's disease over a 10-year follow-up period. Participants were categorized as having no visual or hearing impairment, visual impairment only, hearing impairment only, and dual sensory impairment. Fine-Gray competing risk regression model was applied to estimate the associations of sensory impairment with incident dementia and Alzheimer's disease, adjusted for demographic characteristics, health behaviors, and health conditions at baseline.</p><p><strong>Results: </strong>Of 20,248 identified individuals, 14.6% had visual impairment only, 11.2% had hearing impairment only, and 9.1% had dual impairment at baseline. After adjusting for all covariates, dual sensory impairment was associated with higher risk of dementia (HR = 1.46, 95% CI: 1.23-1.73) and Alzheimer's disease (HR = 1.35, 95% CI: 1.03-1.76). Visual impairment only was also associated with incident dementia and Alzheimer's disease among individuals <65 years.</p><p><strong>Conclusion: </strong>Older adults in the U.S. with visual and hearing impairments simultaneously had a particularly greater risk of dementia and Alzheimer's disease, indicating the needs of targeted screening for timely treatment and further prevention of dementia and Alzheimer's disease.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"94-105"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Socioenvironmental Factors are Associated With Dopamine Transporter Availability in Healthy Individuals but not in Parkinson's Disease. 社会环境因素与健康人多巴胺转运体的可用性有关,但与帕金森病无关。
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-03-01 Epub Date: 2024-09-07 DOI: 10.1177/08919887241281062
Salih Cayir, Melike Tezel, David Matuskey
{"title":"Socioenvironmental Factors are Associated With Dopamine Transporter Availability in Healthy Individuals but not in Parkinson's Disease.","authors":"Salih Cayir, Melike Tezel, David Matuskey","doi":"10.1177/08919887241281062","DOIUrl":"10.1177/08919887241281062","url":null,"abstract":"<p><strong>Objective: </strong>Social factors can influence the brain's dopaminergic function. This study investigated the relationship between socioenvironmental factors and dopamine transporter (DaT) availability in healthy individuals (n = 74) and those with Parkinson's disease (PD) (n = 240).</p><p><strong>Methods: </strong>All single photon emission computed tomography (SPECT) DaT data and clinical data used in this study were obtained from the Parkinson's Progression Markers Initiative (PPMI) dataset. Socioenvironmental data was obtained from Social Explorer analyses of the American Community Survey (2014-2018) using the residential ZIP codes of the subjects available in the PPMI dataset.</p><p><strong>Results: </strong>Participants resided in 302 ZIP code tabulation areas across 38 U.S. states. In healthy individuals<b>,</b> DaT signals were significant and negatively correlated in the caudate with median household income (r = -0.27, <i>P</i> = 0.02) and educational level of the living area (r = -0.23, <i>P</i> = 0.04), but not significant in the putamen (r = -0.21, <i>P</i> = 0.08; r = -0.11, <i>P</i> = 0.37 respectively). Also, there was a significant positive correlation between DaT signals in caudate and poverty rates (r = 0.29, <i>P</i> = 0.01), but not in the putamen (r = 0.16, <i>P</i> = 0.19) in healthy subjects. No significant associations were observed in the PD group for any variables.</p><p><strong>Conclusion: </strong>The study findings suggest that socioenvironmental factors, such as median household income, education level, and poverty rate, are significantly associated with DaT availability in the caudate of healthy individuals but not in those with PD. This indicates that PD might disrupt the connection between the social environment and dopaminergic function. These results underscore the importance of considering socioenvironmental variables when studying dopaminergic function in the human brain.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"143-149"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12473387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modifiable and Non-Modifiable Risk Factors for Dementia Among Non-Hispanic White and Black Populations Aged 50-64 in the United States, 2006-2016. 2006-2016 年美国 50-64 岁非西班牙裔白人和黑人中痴呆症的可改变和不可改变风险因素。
IF 2.9 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-03-01 Epub Date: 2024-07-22 DOI: 10.1177/08919887241267315
Jingkai Wei, Matthew C Lohman, Monique J Brown, James W Hardin, Chih-Hsiang Yang, Anwar T Merchant, Daniela B Friedman
{"title":"Modifiable and Non-Modifiable Risk Factors for Dementia Among Non-Hispanic White and Black Populations Aged 50-64 in the United States, 2006-2016.","authors":"Jingkai Wei, Matthew C Lohman, Monique J Brown, James W Hardin, Chih-Hsiang Yang, Anwar T Merchant, Daniela B Friedman","doi":"10.1177/08919887241267315","DOIUrl":"10.1177/08919887241267315","url":null,"abstract":"<p><strong>Background and objectives: </strong>Non-Hispanic Black populations (NHB) have a significantly higher prevalence of dementia than non-Hispanic Whites in the U.S., and the underlying risk factors may play a role in this racial disparity. We aimed to calculate risk scores for dementia among non-Hispanic White (NHW) and non-Hispanic Black populations aged 50-64 years over a period of 10 years, and to estimate potential differences of scores between NHW and NHB.</p><p><strong>Research design and methods: </strong>The Health and Retirement Study from 2006 to 2016 was used to calculate the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) risk score, a validated score for predicting dementia risk. Weighted average CAIDE score, as well as CAIDE score for modifiable factors hypertension, obese, hypercholesterolemia, physical inactivity), and non-modifiable factors (age, sex, education) were calculated for adults aged 50-64 years with normal cognition for 2006-2008, 2010-2012, 2014-2016. The associations of race with CAIDE score and elevated CAIDE score were examined.</p><p><strong>Results: </strong>A total of 10,871 participants were included in the analysis. The CAIDE score showed declining trends for NHB from 2006 to 2016, while NHB consistently had a higher total CAIDE score and CAIDE score for modifiable factors from 2006 to 2016, but not for non-modifiable factors.</p><p><strong>Discussion and implications: </strong>NHB had a higher level of dementia risk factors than NHW among adults aged 50-64 years in the U.S. from 2006 to 2016, and the difference is attributable to modifiable risk factors, which holds promise for risk reduction of dementia.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"106-114"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementing Arts on Prescription at Home for People Living With Dementia: A Hybrid-Effectiveness Feasibility Study. 在家中为痴呆症患者实施处方艺术:混合效果可行性研究。
IF 2.9 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-03-01 Epub Date: 2024-07-23 DOI: 10.1177/08919887241267335
Claire Mc O'Connor, Roslyn G Poulos, Michelle Heldon, Costanza Preti, Elizabeth Beattie, Christopher J Poulos
{"title":"Implementing Arts on Prescription at Home for People Living With Dementia: A Hybrid-Effectiveness Feasibility Study.","authors":"Claire Mc O'Connor, Roslyn G Poulos, Michelle Heldon, Costanza Preti, Elizabeth Beattie, Christopher J Poulos","doi":"10.1177/08919887241267335","DOIUrl":"10.1177/08919887241267335","url":null,"abstract":"<p><p>Arts on prescription at home (AoP@Home) is a participatory art-based approach involving a professional artist engaging a person with dementia (and their family carer) in art-making in their own home. This study evaluated the implementation of AoP@Home within a real-world community aged care context. A hybrid effectiveness-implementation design was used to simultaneously test both the AoP@Home intervention and the implementation process. AoP@Home program outcomes included person with dementia and family carer (dyad) health and wellbeing, and personal goal attainment. Implementation outcomes were evaluated according to feasibility, fidelity, acceptability, uptake, and costs via routinely collected data, artist notes, and interviews with program managers, artists, and participant dyads. Four dyads completed an AoP@Home program during the study period. All participants with dementia reported improvements in their overall health and wellbeing, and wellbeing scores improved for all carers from baseline to post-program. Implementation was feasible using existing government funding mechanisms, and programs were acceptable to all stakeholders. It is possible to deliver participatory arts programs for community-dwelling people with dementia and their family, in their home, using sustainable and available funding models. Programs such as AoP@Home should be made more accessible alongside broader allied health and care services.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"115-131"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin D Deficiency in the Acute Phase of Stroke May Predict Post-stroke Depression: A Systematic Review and Meta-Analysis. 中风急性期维生素 D 缺乏可预测中风后抑郁:系统回顾与元分析》。
IF 2.9 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-03-01 Epub Date: 2024-08-23 DOI: 10.1177/08919887241275044
Yongjun Tan, Xiaojun Jing, Jiani Wang, Li Zhou, Yilin Wang, Hua Zhang, Qin Yang
{"title":"Vitamin D Deficiency in the Acute Phase of Stroke May Predict Post-stroke Depression: A Systematic Review and Meta-Analysis.","authors":"Yongjun Tan, Xiaojun Jing, Jiani Wang, Li Zhou, Yilin Wang, Hua Zhang, Qin Yang","doi":"10.1177/08919887241275044","DOIUrl":"10.1177/08919887241275044","url":null,"abstract":"<p><strong>Objective: </strong>To conduct the association between vitamin D levels in the acute phase of stroke and post-stroke depression (PSD) in stroke patients.</p><p><strong>Methods: </strong>Five international databases (PubMed, Web of Science, Embase, Ovid MEDLINE(R), Cochrane Library) and one Chinese database (Wanfang Data) were searched for observational studies in any language reporting on PSD and vitamin D levels tested in the acute phase of stroke in stroke patients from inception to May 2024. Data extraction and study quality assessment were conducted by two authors independently. Qualitative and quantitative analyses of data were performed. The meta-analysis was registered in the PROSPERO database (CRD42023398581).</p><p><strong>Results: </strong>We included 7 studies containing 3537 participants in the systematic review and meta-analysis. All studies that met the inclusion and exclusion criteria were conducted in China. Vitamin D levels in the acute phase of stroke were lower in PSD patients compared with non-PSD patients (weighted mean difference = -14.97 nmol/L; 95% confidence interval = -19.54, -10.40). Stroke patients with vitamin D deficiency (<50 nmol/L) had an increased risk of PSD compared with stroke patients with vitamin D sufficiency (≥75 nmol/L) (odds ratio = 3.59; 95% confidence interval = 2.05, 6.27). However, the association between vitamin D insufficiency (50-75 nmol/L) and PSD were not statistically significant (odds ratio = 4.15; 95% confidence interval = 0.87, 19.78).</p><p><strong>Conclusion: </strong>Vitamin D deficiency in the acute phase of stroke may be a risk factor for PSD.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"75-84"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuropsychiatric Comorbidities and Psychotropic Medication Use in Medicare Beneficiaries With Dementia by Sex and Race. 按性别和种族分列的痴呆症医疗保险受益人的神经精神并发症和精神药物使用情况。
IF 2.9 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-01-01 Epub Date: 2024-05-20 DOI: 10.1177/08919887241254470
Kim G Johnson, Cassie Ford, Amy G Clark, Melissa A Greiner, Jay B Lusk, Cody Perry, Richard O'Brien, Emily C O'Brien
{"title":"Neuropsychiatric Comorbidities and Psychotropic Medication Use in Medicare Beneficiaries With Dementia by Sex and Race.","authors":"Kim G Johnson, Cassie Ford, Amy G Clark, Melissa A Greiner, Jay B Lusk, Cody Perry, Richard O'Brien, Emily C O'Brien","doi":"10.1177/08919887241254470","DOIUrl":"10.1177/08919887241254470","url":null,"abstract":"<p><strong>Background: </strong>Neuropsychiatric symptoms affect the majority of dementia patients. Past studies report high rates of potentially inappropriate prescribing of psychotropic medications in this population. We investigate differences in neuropsychiatric diagnoses and psychotropic medication prescribing in a local US cohort by sex and race.</p><p><strong>Methods: </strong>We utilize Medicare claims and prescription fill records in a cohort of 100% Medicare North and South Carolina beneficiaries ages 50 and above for the year 2017 with a dementia diagnosis. We identify dementia and quantify diagnosis of anxiety, depression and psychosis using validated coding algorithms. We search Medicare claims for antianxiety, antidepressant and antipsychotic medications to determine prescriptions filled.</p><p><strong>Results: </strong>Anxiety and depression were diagnosed at higher rates in White patients; psychosis at higher rates in Black patients. (<i>P</i> < .001) Females were diagnosed with anxiety, depression and psychosis at higher rates than males (<i>P</i> < .001) and filled more antianxiety and antidepressant medications than males. (<i>P</i> < .001) Black and Other race patients filled more antipsychotic medications for anxiety, depression and psychosis than White patients. (<i>P</i> < .001) Antidepressants were prescribed at higher rates than antianxiety or antipsychotic medications across all patients and diagnoses. Of patients with no neuropsychiatric diagnosis, 11.4% were prescribed an antianxiety medication, 22.8% prescribed an antidepressant and 7.6% prescribed an antipsychotic.</p><p><strong>Conclusions: </strong>The high fill rate of antianxiety (benzodiazepine) medications in dementia patients, especially females is a concern. Patients are prescribed psychotropic medications at high rates. This practice may represent potentially inappropriate prescribing. Patient/caregiver education with innovative community outreach and care delivery models may help decrease medication use.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"44-52"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Greater Apathy Associated With Selective Serotonin Reuptake Inhibitor Use in Parkinson's Disease. 帕金森病患者使用选择性羟色胺再摄取抑制剂会导致更严重的冷漠。
IF 2.9 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-01-01 Epub Date: 2024-05-23 DOI: 10.1177/08919887241254471
Rachel N Schade, Connor B Etheridge, Lauren E Kenney, Adrianna M Ratajska, Katie Rodriguez, Francesca V Lopez, Joshua Gertler, Alyssa Ray, Lauren Santos, Christopher Hess, Dawn Bowers
{"title":"Greater Apathy Associated With Selective Serotonin Reuptake Inhibitor Use in Parkinson's Disease.","authors":"Rachel N Schade, Connor B Etheridge, Lauren E Kenney, Adrianna M Ratajska, Katie Rodriguez, Francesca V Lopez, Joshua Gertler, Alyssa Ray, Lauren Santos, Christopher Hess, Dawn Bowers","doi":"10.1177/08919887241254471","DOIUrl":"10.1177/08919887241254471","url":null,"abstract":"<p><strong>Objective: </strong>Apathy, a motivational disorder, is common in Parkinson's disease (PD) and often misdiagnosed as depression. Use of selective serotonin reuptake inhibitors (SSRIs) has been associated with increased apathy in adolescents and adults with depression. Based on observations that serotonin may downregulate dopaminergic systems, we examined the relationship between apathy and SSRI use in individuals with PD.</p><p><strong>Methods: </strong>Medications, mood/motivation scales, and clinical data were collected from a convenience sample of 400 individuals with PD. Depression and apathy were measured using the Beck Depression Inventory-II (BDI-Il) and the Apathy Scale (AS). Antidepressant medications were grouped by mechanism type.</p><p><strong>Results: </strong>Of the 400 PD patients, 26% were on SSRIs. On standard mood/motivation scales, 38% of the sample exceeded clinical cut-offs for apathy and 28% for depression. Results of hierarchical regression analyses revealed that SSRIs were the only antidepressant that were significantly associated with higher apathy scores (β = .1, <i>P</i> = .02). Less education (β = -.1, <i>P</i> = .01) worse cognition (β = -.1, <i>P</i> = .01), and greater depressive symptoms (β = .5, <i>P</i> < .001) were also significant predictors of apathy.</p><p><strong>Conclusion: </strong>These findings suggest that use of SSRIs, but not other antidepressants, is associated with greater apathy in PD. Given the interactive relationship between serotonin and dopamine, the current findings highlight the importance of considering apathy when determining which antidepressants to prescribe to individuals with PD. Similarly, switching a SSRI for an alternative antidepressant in individuals with PD who are apathetic may be a potential treatment for apathy that needs further study.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"13-22"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparison of Test-Retest Reliability and Practice Effects of Short Portable Mental State Questionnaire and Montreal Cognitive Assessment in Patients with Stroke. 脑卒中患者的便携式精神状态短问卷与蒙特利尔认知评估的测试-重测可靠性和实践效果比较。
IF 4.6 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-01-01 Epub Date: 2024-07-24 DOI: 10.1177/08919887241266793
Ta-Cheng Chen, Ya-Chen Lee, Yi-Ching Wang, Ton-Lin Hsieh, Mei-Hsiang Chen
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