Journal of Geriatric Psychiatry and Neurology最新文献_第10页

Blood Biomarkers for the Diagnosis of Neurodegenerative Dementia: A Systematic Review. 血液生物标志物诊断神经退行性痴呆:系统综述。

IF 2.6 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-07-01 DOI: 10.1177/08919887221141651

Filipa Santos, Verónica Cabreira, Sara Rocha, João Massano

{"title":"Blood Biomarkers for the Diagnosis of Neurodegenerative Dementia: A Systematic Review.","authors":"Filipa Santos, Verónica Cabreira, Sara Rocha, João Massano","doi":"10.1177/08919887221141651","DOIUrl":"https://doi.org/10.1177/08919887221141651","url":null,"abstract":"Importance: Accurately diagnosing neurodegenerative dementia is often challenging due to overlapping clinical features. Disease specific biomarkers could enhance diagnostic accuracy. However, CSF analysis procedures and advanced imaging modalities are either invasive or high-priced, and routinely unavailable. Easily accessible disease biomarkers would be of utmost value for accurate differential diagnosis of dementia subtypes.Objective: To assess the diagnostic accuracy of blood-based biomarkers for the differential diagnosis of AD from Frontotemporal Lobar Degeneration (FTLD), or AD from Dementia with Lewy Bodies (DLB).Methods: Systematic review. Three databases (PubMed, Scopus, and Web of Science) were searched. Studies assessing blood-based biomarkers levels in AD versus FTLD, or AD versus DLB, and its diagnostic accuracy, were selected. When the same biomarker was assessed in three or more studies, a meta-analysis was performed. QUADAS-2 criteria were used for quality assessment.Results: Twenty studies were included in this analysis. Collectively, 905 AD patients were compared to 1262 FTLD patients, and 209 AD patients were compared to 246 DLB patients. Regarding biomarkers for AD versus FTLD, excellent discriminative accuracy (AUC >0.9) was found for p-tau181, p-tau217, synaptophysin, synaptopodin, GAP43 and calmodulin. Other biomarkers also demonstrated good accuracy (AUC = 0.8-0.9). For AD versus DLB distinction, only miR-21-5p and miR-451a achieved excellent accuracy (AUC >0.9).Conclusion: Encouraging results were found for several biomarkers, alone or in combination. Prospective longitudinal designs and consensual protocols, comprising larger cohorts and homogeneous testing modalities across centres, are essential to validate the clinical value of blood biomarkers for the precise etiological diagnosis of dementia.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 4","pages":"267-281"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9695546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Peripheral neuropathy and neuropathic pain in the elderly 老年人周围神经病变和神经性疼痛

IF 2.6 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-06-15 DOI: 10.53991/jgn.2023.00045

Je-Young Shin

引用次数: 0

Superficial siderosis suspected to be related to vertebral fracture and vertebroplasty 怀疑与椎体骨折和椎体成形术有关的浅表面性铁沉着

IF 2.6 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-06-15 DOI: 10.53991/jgn.2023.00031

M.-G. Choi, Dong Hyun Kim, Sung Jae Ahn, Sang-Soon Park, Seung Hyun Lee

引用次数: 0

Geriatric dizziness 老年眩晕

IF 2.6 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-06-15 DOI: 10.53991/jgn.2023.00024

Sampaio Ha

引用次数: 0

The reality and future of home visit care from an economic point of view 从经济角度看家访护理的现实与未来

IF 2.6 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-05-11 DOI: 10.53991/jgn.2023.00017

D. Oh

引用次数: 0

The Impact of the COVID-19 Pandemic on Informal Caregivers of People With Parkinson's Disease Residing in the UK: A Qualitative Study. COVID-19大流行对居住在英国的帕金森病患者的非正式照顾者的影响:一项定性研究

IF 2.6 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-05-01 DOI: 10.1177/08919887221135555

Daniel Rippon, Annette Hand, Lorelle Dismore, Roberta Caiazza

{"title":"The Impact of the COVID-19 Pandemic on Informal Caregivers of People With Parkinson's Disease Residing in the UK: A Qualitative Study.","authors":"Daniel Rippon, Annette Hand, Lorelle Dismore, Roberta Caiazza","doi":"10.1177/08919887221135555","DOIUrl":"https://doi.org/10.1177/08919887221135555","url":null,"abstract":"Informal caregivers can experience various demands when providing care and support for People with Parkinson's disease (PwP) in their own homes. The outbreak of SARS-CoV-2 and public health strategies employed to mitigate the spread of COVID-19 have presented challenges to the general populace on a global basis. The present study used a qualitative research design to explore how the COVID-19 pandemic has impacted informal caregivers in their role of providing care for PwP in their own homes. A series of 1:1 semi-structured interviews were conducted with 11 informal caregivers of PwP (M age = 72.64 years, SD = 8.94 years). A thematic analysis indicated that 1) vulnerabilities to COVID-19, 2) home maintenance & activities of daily living and 3) engagement with healthcare services were 3 themes that provided indications on how the COVID-19 pandemic impacted informal caregivers of PwP. The present study provides illustrations of how being an informal caregiver of PwP and being identified as high risk to COVID-19 can present challenges to the process of caring for loved ones who are also vulnerable to SARS-CoV-2. The results of the present study highlights the necessity to develop strategies to ensure that informal caregivers have the necessary resources to provide care for PwP in their homes and also maintain their own well-being in the post COVID-19 era.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 3","pages":"233-245"},"PeriodicalIF":2.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9618709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Family Carers of People with Dementia in Japan, Spain, and the UK: A Cross-Cultural Comparison of the Relationships between Experiential Avoidance, Cognitive Fusion, and Carer Depression. 日本、西班牙和英国痴呆症患者的家庭照顾者:经验回避、认知融合和照顾者抑郁关系的跨文化比较

IF 2.6 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-05-01 DOI: 10.1177/08919887221130269

Naoko Kishita, Hiroshi Morimoto, María Márquez-González, Samara Barrera-Caballero, Carlos Vara-García, Elien Van Hout, Milena Contreras, Andrés Losada-Baltar

{"title":"Family Carers of People with Dementia in Japan, Spain, and the UK: A Cross-Cultural Comparison of the Relationships between Experiential Avoidance, Cognitive Fusion, and Carer Depression.","authors":"Naoko Kishita, Hiroshi Morimoto, María Márquez-González, Samara Barrera-Caballero, Carlos Vara-García, Elien Van Hout, Milena Contreras, Andrés Losada-Baltar","doi":"10.1177/08919887221130269","DOIUrl":"https://doi.org/10.1177/08919887221130269","url":null,"abstract":"Objective and research design This study investigated whether the relationship between experiential avoidance and carer depression is mediated by cognitive fusion using path analysis and whether this model differs between family carers from Japan, Spain, and the UK using multi-group path analysis. Results The whole sample model (N = 745) showed a good fit to the data. The direct effect of experiential avoidance on carer depression (β = .10) and its indirect effect on carer depression through cognitive fusion (β = .15) were significant. Examined variables accounted for 45% of the variance of depression. Multi-group path analysis confirmed the same pattern of indirect path across 3 countries, while the direct path was no longer significant in Spanish and UK samples.Conclusion These findings suggest that targeting cognitive fusion may be particularly critical in culturally diverse carers and pre-emptive efforts to reduce experiential avoidance using psychological techniques may be beneficial among family carers prone to cognitive fusion regardless of cultural differences.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 3","pages":"254-264"},"PeriodicalIF":2.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9616145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Demographic and Symptom Correlates of Initial Idiopathic Psychiatric Diagnosis in Frontotemporal Dementia. 前额颞叶痴呆症患者初始特发性精神病诊断的人口统计学和症状相关性。

IF 2.9 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-05-01 Epub Date: 2022-11-07 DOI: 10.1177/08919887221130267

Corinne Sejourne, Jordan D Dworkin, Megan S Barker, Masood Manoochehri, Reena T Gottesman, Eric M Wassermann, Michael C Tierney, Edward D Huey, Jordan Grafman

{"title":"Demographic and Symptom Correlates of Initial Idiopathic Psychiatric Diagnosis in Frontotemporal Dementia.","authors":"Corinne Sejourne, Jordan D Dworkin, Megan S Barker, Masood Manoochehri, Reena T Gottesman, Eric M Wassermann, Michael C Tierney, Edward D Huey, Jordan Grafman","doi":"10.1177/08919887221130267","DOIUrl":"10.1177/08919887221130267","url":null,"abstract":"Introduction: This study aims to measure frequency and correlates of initial idiopathic psychiatric diagnosis in a cohort of 147 patients with Frontotemporal Dementia (FTD)-spectrum disorders.Methods: Participants were evaluated at the National Institutes of Health in Bethesda, Maryland. Initial participant diagnoses were determined by chart review and patient and informant interviews. Logistic regression was used to assess the relationships between diagnosis and age of symptom onset, gender, education, family history of psychiatric illness, and family history of dementia. Additional exploratory analyses investigated patients' first symptom type.Results: 25% (n=43) of all the patients reviewed were initially misdiagnosed with an idiopathic psychiatric illness, which is less than half the commonly cited 50% rate.3 Depression was the most common misdiagnosis (46.5%). Family history of dementia, family history of mental illness and an exploratory analysis of behavioral first symptoms suggested significant association with a greater likelihood of initial idiopathic psychiatric diagnosis in FTD patients.Discussion: This data confirms patterns of initial idiopathic psychiatric diagnosis in FTD and elucidates potential factors underlying misdiagnosis. Potential implications for patient outcomes, caregiver burden and healthcare costs are discussed.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 3","pages":"193-200"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11279523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9616152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of the Art Therapy Interventions on Depression Symptoms Among Older Adults: A Meta-analysis of Controlled Clinical Trials. 艺术治疗干预对老年人抑郁症状的影响:一项对照临床试验的荟萃分析

IF 2.6 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-05-01 DOI: 10.1177/08919887221130264

Ensiyeh Jenabi, Saeid Bashirian, Erfan Ayubi, Masoud Rafiee, Mozhdeh Bashirian

{"title":"The Effect of the Art Therapy Interventions on Depression Symptoms Among Older Adults: A Meta-analysis of Controlled Clinical Trials.","authors":"Ensiyeh Jenabi, Saeid Bashirian, Erfan Ayubi, Masoud Rafiee, Mozhdeh Bashirian","doi":"10.1177/08919887221130264","DOIUrl":"https://doi.org/10.1177/08919887221130264","url":null,"abstract":"Background: To our knowledge, no systematic reviews and meta-analyses have yet been published that examine the effect of art therapy (AT) interventions on depression symptoms among older adults, and this study aimed to systematically review and meta-analysis of clinical trials, summarize eligible relevant studies and provide a true effect measure for the association between AT and depression symptoms in older adults.Methods: The databases of PubMed, Web of Science, Scopus, and the Cochrane Central Register of Controlled Trials were searched until 15 February 2022. The methodological quality of the included studies was evaluated by the Delphi checklist. The heterogeneity across studies was conducted by chi-squared test and measured its quantity by the I2 statistic. We performed this meta-analysis to obtain a summary measure of the mean difference in depression scores between AT and control groups using a random-effects model. All statistical analyses were carried out at a significance level of .05 using Stata software, version 14.Results: Until 15 February 2022, 222 studies through databases and 199 studies through review of references were included in the present meta-analysis. In total, the analysis covered 8 studies. The difference in mean depression score between the intervention and control groups showed significant reductions in the AT group (MD -.78; 95% CI: -1.17, -.38; I 2 = 67.9%).Conclusion: Our findings suggest that AT can be considered an effective intervention for reducing depression symptoms among older adults and art therapists/psychotherapists can use this method to reduce the symptoms of depression among older adults.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 3","pages":"185-192"},"PeriodicalIF":2.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9618703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Psychological Factors Associated With Fear of Falling Avoidance Behavior in Parkinson's Disease: The Role of Depression, Anxiety, and Catastrophizing. 帕金森氏症患者害怕避免跌倒行为的相关心理因素:抑郁、焦虑和灾难化的作用

IF 2.6 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-05-01 DOI: 10.1177/08919887221119974

John V Rider, Jason K Longhurst, Nirmala Lekhak, James W Navalta, Daniel L Young, Merrill R Landers

{"title":"Psychological Factors Associated With Fear of Falling Avoidance Behavior in Parkinson's Disease: The Role of Depression, Anxiety, and Catastrophizing.","authors":"John V Rider, Jason K Longhurst, Nirmala Lekhak, James W Navalta, Daniel L Young, Merrill R Landers","doi":"10.1177/08919887221119974","DOIUrl":"https://doi.org/10.1177/08919887221119974","url":null,"abstract":"Purpose: The purpose of this study was to examine the relationship between psychological factors (depression, anxiety, and catastrophizing) and fear of falling avoidance behavior (FFAB) among individuals with Parkinson's disease (PD).Methods: A secondary analysis of cross-sectional data from 59 individuals with PD using hierarchical multiple regression.Results: Disease severity (Movement Disorder Society - Unified PD Rating Scale) and catastrophizing (Consequences of Falling Questionnaire (CoF)) explained approximately 48.2% of the variance in the FFAB Questionnaire scores (P < .001). Catastrophizing was the only significant psychological variable (P < .001). The damage to identity subscale of the CoF was significant in the final model (P < .001).Conclusions: Catastrophizing about the consequences of falls explained the largest portion of variability in FFAB after controlling for disease severity. Catastrophizing about the immediate consequences of falling may play a prominent role in FFAB and may be a potential treatment target for mitigating FFAB.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 3","pages":"215-224"},"PeriodicalIF":2.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9669035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1