Journal of Geriatric Psychiatry and Neurology最新文献

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Conversion to Mild Cognitive Impairment and Alzheimer's Disease Dementia Related to Apathy, APOE Genotype and Antidepressant Use. 转化为轻度认知障碍和阿尔茨海默病痴呆相关的冷漠,APOE基因型和抗抑郁药的使用。
IF 2.8 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-11-01 Epub Date: 2025-04-14 DOI: 10.1177/08919887251335002
Rubina Malik, Miguel Restrepo Martinez, Isis So, Elizabeth Finger
{"title":"Conversion to Mild Cognitive Impairment and Alzheimer's Disease Dementia Related to Apathy, <i>APOE</i> Genotype and Antidepressant Use.","authors":"Rubina Malik, Miguel Restrepo Martinez, Isis So, Elizabeth Finger","doi":"10.1177/08919887251335002","DOIUrl":"10.1177/08919887251335002","url":null,"abstract":"<p><p>ObjectiveApathy and <i>APOE</i> ε4 genotype are risk factors for developing Alzheimer's disease dementia (ADD). Antidepressant use is known to induce apathy. This study aimed to examine associations between <i>APOE</i> ε4, apathy, and antidepressant use with progression from cognitively normal (CN) to mild cognitive impairments (MCI), and MCI to ADD.MethodsParticipants aged 55-90 were recruited from the Alzheimer's Disease Neuroimaging Initiative. Participants were CN or had MCI at baseline and had completed at least 3 consecutive study visits. The NPI and NPI-Q apathy subscales were used to index the presence of apathy. Antidepressants used by participants included SSRIs, SNRIs, and AYTADs. Cox proportional hazards analyses examined the combined effects of apathy, <i>APOE</i> ε4 genotype, and antidepressant use on conversion from CN to MCI and from MCI to ADD.ResultsApathy and <i>APOE</i> ε4 were associated with increased risk of conversion along the CN-MCI-ADD continuum. Antidepressant use was associated with progression from MCI to ADD, and progression from CN to MCI in non-apathetic <i>APOE</i> ε4 carriers.ConclusionOur findings support apathy and <i>APOE</i> ε4 as robust predictors of conversion to MCI and ADD, and demonstrate novel associations between antidepressant use and conversion. Future research should explore whether antidepressant use in MCI and ADD causes apathetic symptoms or serves to index apathy/depression severity.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"484-497"},"PeriodicalIF":2.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Oldest Old" Attending Psychiatric Emergency Services: A Monocentric Retrospective Study. “最老的老人”参加精神科急诊服务:一项单中心回顾性研究
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-11-01 Epub Date: 2025-04-16 DOI: 10.1177/08919887251334992
Hugo Tiercelin, Mathilde Gras, Jérôme Silva, David Barruel, Raphaël Gourevitch, Nicolas Hoertel, Alexandra Pham-Scottez
{"title":"\"Oldest Old\" Attending Psychiatric Emergency Services: A Monocentric Retrospective Study.","authors":"Hugo Tiercelin, Mathilde Gras, Jérôme Silva, David Barruel, Raphaël Gourevitch, Nicolas Hoertel, Alexandra Pham-Scottez","doi":"10.1177/08919887251334992","DOIUrl":"10.1177/08919887251334992","url":null,"abstract":"<p><p>\"Oldest old\", although increasingly numerous, remain insufficiently described in mental health services. By studying those who visit the busiest Psychiatric Emergency Services (PES) in France, our primary objective was to describe the \"oldest old\" seeking psychiatric care and, secondly, to identify predictive factors of hospitalization. We chose a cut-off age of 80 years and recruited all patients who visited our monocentric PES over a five-year period between 2018 and 2022. This retrospective observational study relied on clinical assessments and medical records. A total of 306 visits from 274 distinct patients were analyzed. Patients were mostly women, living alone at home, with a psychiatric history and using psychotropic medications. The majority were diagnosed with mood disorders and did not appear to have cognitive impairment. Patients were primarily referred to either inpatient or outpatient psychiatric care. These results enhance our understanding of the psychiatric needs of the \"oldest-old\".</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"498-506"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural Abnormalities of Olfactory-Related Brain Regions in Mild Cognitive Impairment and Subjective Cognitive Decline Individuals. 轻度认知障碍和主观认知衰退个体嗅觉相关脑区结构异常。
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-11-01 Epub Date: 2025-04-16 DOI: 10.1177/08919887251336464
Lujiang Zhan, Guanxiong Tan, Jia Dong, Zhengdong Deng, Yunfeng Zou, Zhiyong Dan, Ruixia Wang, Zhengli Luo, Xingxing Zhu
{"title":"Structural Abnormalities of Olfactory-Related Brain Regions in Mild Cognitive Impairment and Subjective Cognitive Decline Individuals.","authors":"Lujiang Zhan, Guanxiong Tan, Jia Dong, Zhengdong Deng, Yunfeng Zou, Zhiyong Dan, Ruixia Wang, Zhengli Luo, Xingxing Zhu","doi":"10.1177/08919887251336464","DOIUrl":"10.1177/08919887251336464","url":null,"abstract":"<p><p>BackgroundOlfactory impairment might be already present at the subjective cognitive impairment (SCD) individuals, and deepens with disease severity in the Alzheimer's disease (AD) spectrum. However, the neuroanatomical correlates of olfactory impairment in SCD individuals are not fully elucidated.MethodsA hundred and twenty enrolled older adults without dementia (25 healthy controls (HCs), 45 SCD individuals and 50 mild cognitive impairment (MCI) individuals) completed olfactory assessment and structural magnetic resonance imaging (MRI) scanning. Olfactory function was evaluated by the 16-item Sniffin' Sticks odor identification test (SSIT). Region of interest (ROI) analysis was conducted for the gray matter volume (GMV) of 8 olfactory-related brain regions.ResultsIn ROI analysis, from HC, SCD to MCI group, smaller GMV of olfactory-related regions and olfactory impairment became increasingly severe. For HC group, olfactory impairment was only associated with smaller entorhinal cortex (<i>P</i> < 0.05). In SCD individuals, reduced GMVs of entorhinal cortex and hippocampus were associated with olfactory impairment (<i>P</i> < 0.05). In MCI individuals, decreased GMVs of piriform cortex, amygdala, entorhinal cortex, orbitofrontal cortex, hippocampus and parahippocampus were significantly associated with olfactory impairment (<i>P</i> < 0.05).ConclusionsThe atrophy of olfactory-related brain regions gradually increased and the corresponding olfactory function gradually decreased in older adults of HC, SCD and MCI. The olfactory regions associated with olfactory impairment in SCD individuals were mainly in entorhinal cortex and hippocampus.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"467-474"},"PeriodicalIF":2.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Educational Heterogeneity in the Relationship Between Internet Use and Episodic Memory Among Older Adults. 老年人网络使用与情景记忆关系的教育异质性。
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-09-01 Epub Date: 2025-04-01 DOI: 10.1177/08919887251330311
Xiaohang Zhao, Skylar Biyang Sun
{"title":"Educational Heterogeneity in the Relationship Between Internet Use and Episodic Memory Among Older Adults.","authors":"Xiaohang Zhao, Skylar Biyang Sun","doi":"10.1177/08919887251330311","DOIUrl":"10.1177/08919887251330311","url":null,"abstract":"<p><p>ObjectiveThis study aims to examine educational heterogeneity in the relationship between internet use and episodic memory among older adults in China, within the context of advancing Chinese modernization.MethodsData from the 2018 and 2020 waves of China Health and Retirement Longitudinal Study (CHARLS) were used for analysis. By employing a longitudinal study design with lagged predictors and the inverse probability of treatment weighting (IPTW) approach alongside its extension-the marginal structural model (MSM) for sufficient cause interactions-this study mitigated potential reverse causality and self-selection biases related to internet use and educational attainment.ResultsThe findings indicate a significant positive longitudinal association between internet use and delayed word recall in older women, incorporating delayed and immediate recall scores at baseline as covariates for predicting propensity scores of internet use. Additionally, the preservation of delayed word recall linked to internet use was more pronounced among older women with less than an elementary school education. Doubly robust estimation results further confirmed the reliability of the core findings. Furthermore, we investigated the longitudinal associations between specific online activities and episodic memory. The results show that posting on social media and engaging in online chatting positively correlated with episodic memory in older women, whereas browsing news online was positively associated with episodic memory in older men.ConclusionThese findings support the cognitive enrichment hypothesis, which asserts that internet use serves as a mentally stimulating activity that may help delay cognitive aging, especially among individuals with limited cognitive stimuli.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"362-377"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Views of Healthcare Professionals on iFall, a Smartphone Application for Falls Reporting in Parkinson's Disease: A Qualitative Study. 医疗保健专业人员对iFall的看法,一个智能手机应用程序跌倒报告帕金森病:一个定性研究。
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-09-01 Epub Date: 2025-02-01 DOI: 10.1177/08919887251317728
Michael C Kelly, Jenni Naisby, Jill Wales, Elaine Webster, Gerry Standerline, Gill Barry, Annee Amjad, Jason Moore, Natasha Ratcliffe, Alan Godfrey, Rosie Morris
{"title":"The Views of Healthcare Professionals on iFall, a Smartphone Application for Falls Reporting in Parkinson's Disease: A Qualitative Study.","authors":"Michael C Kelly, Jenni Naisby, Jill Wales, Elaine Webster, Gerry Standerline, Gill Barry, Annee Amjad, Jason Moore, Natasha Ratcliffe, Alan Godfrey, Rosie Morris","doi":"10.1177/08919887251317728","DOIUrl":"10.1177/08919887251317728","url":null,"abstract":"<p><p><b>Background:</b> Accurate falls reporting is important in the management of Parkinson's disease. One way in which to improve accuracy is by providing a smartphone app to log fall events. This qualitative study sought to gain insights from healthcare professionals based in the United Kingdom on a novel smartphone application co-developed by people with Parkinson's (PwP) disease for falls reporting. <b>Research Methods:</b> A purposive sample of n=11 healthcare professionals with expertise in Parkinson's were recruited to take part in a focus group to explore their views on the smartphone app. Framework analysis was utilised to interpret the data. <b>Results:</b> Participants discussed the applications role in clinical practice, research, and provided recommendations for future improvements. Within the overarching theme of implementation of iFall in clinical and research practice, three subthemes emerged: (1) applicability to clinical practice, (2) the future of iFall in research and (3) future developments. The application was viewed positively, exhibiting potential to address important contemporary issues within falls reporting and research, whilst being clear, simple and easy to use. Implementation challenges of the application, such as IT integration were highlighted, while enhancements such as voice recognition were suggested. <b>Conclusions:</b> Incorporating suggestions from healthcare professionals and piloting of the application with PwP will increase the likelihood of successful implementation of the iFall app into clinical practice and research.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"405-416"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Novel Continuous Subcutaneous Levodopa Infusion Therapies ND0612 and ABBV-951 for Parkinson's Disease: A Systematic Review. 新型左旋多巴持续皮下输注疗法ND0612和ABBV-951治疗帕金森病的疗效和安全性:系统评价
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-09-01 Epub Date: 2025-04-20 DOI: 10.1177/08919887251335011
Matheus de Medeiros Fernandes, Luis Otávio Souza Nogueira, Isabella Soares Marques Rabelo, Louise Dalla Corte Dallé, Angela Maria Sandini Corso, Fernanda Medeiros Santos, Roberta Arb Saba Rodrigues Pinto, Vanderci Borges, Henrique Ballalai Ferraz, Dayany Leonel Boone
{"title":"Efficacy and Safety of Novel Continuous Subcutaneous Levodopa Infusion Therapies ND0612 and ABBV-951 for Parkinson's Disease: A Systematic Review.","authors":"Matheus de Medeiros Fernandes, Luis Otávio Souza Nogueira, Isabella Soares Marques Rabelo, Louise Dalla Corte Dallé, Angela Maria Sandini Corso, Fernanda Medeiros Santos, Roberta Arb Saba Rodrigues Pinto, Vanderci Borges, Henrique Ballalai Ferraz, Dayany Leonel Boone","doi":"10.1177/08919887251335011","DOIUrl":"10.1177/08919887251335011","url":null,"abstract":"<p><p>IntroductionRecent research in Parkinson's disease (PD) has highlighted the potential therapies of continuous subcutaneous infusions (CSCI) of levodopa/carbidopa (ND0612) and foslevodopa/foscarbidopa (ABBV-951). This systematic review aims to explore their effectiveness and safety for PD.MethodsGuided by the PRISMA statement, we systematically searched 3 electronic databases: MEDLINE, Embase, and Cochrane Central. We combined quantitative and qualitative data for synthesis and descriptive analysis. Quality assessment and risk of bias were evaluated by ROBINS-1 and Rob-2 criteria.ResultsWe included 6 records with a total of 698 patients. CSCI therapies reduced motor symptoms in PD patients with levodopa-related motor fluctuations and clinical improvements. Infusions-site reactions were the main adverse event recorded.ConclusionsND0612 and ABBV-951 are promising options for enhancing motor control and quality of life in PD patients. However, further research is needed to assess long-term efficacy, safety, and comparisons with oral levodopa and device-aided treatments.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"326-338"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential Risk Factors for Psychosis in Parkinson's Disease: A Review of Cohort and Case-Control Studies. 帕金森病精神病的潜在危险因素:队列和病例对照研究综述
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-09-01 Epub Date: 2025-02-10 DOI: 10.1177/08919887251319558
Dimitry S Davydow, Michael S Okun, Gregory M Pontone
{"title":"Potential Risk Factors for Psychosis in Parkinson's Disease: A Review of Cohort and Case-Control Studies.","authors":"Dimitry S Davydow, Michael S Okun, Gregory M Pontone","doi":"10.1177/08919887251319558","DOIUrl":"10.1177/08919887251319558","url":null,"abstract":"<p><p>BackgroundAmong neuropsychiatric sequelae of Parkinson's disease (PD), psychosis may have the most adverse impacts on prognosis and quality of life.ObjectivesTo summarize and critically review the literature on potential risk factors for psychosis in PD, with particular focus on potentially modifiable risk factors.MethodsWe conducted a literature review using PubMed and EMBASE. We included articles if: (1) the study population was comprised of patients with PD, (2) the presence of psychosis was systematically ascertained through clinician diagnosis, clinical outcome assessments and/or administrative data, and (3) potential risk factors were examined prior to the onset of psychosis.ResultsTwenty-six studies (15 prospective cohort, 10 retrospective cohort, 1 retrospective case-control) of 21 patient cohorts (n = 15,535 unique patients) were included in the review. Ten studies included minor phenomena in their definition of psychosis. The most consistent potential risk factors for psychosis were sleep disturbances, particularly rapid eye movement sleep behavior disorder and autonomic dysfunction. Potentially modifiable risk factors for psychosis included excessive daytime sleepiness and exposure to anticholinergic medications and levodopa. Possible biomarkers for psychosis in PD included reduced striatal dopamine transporter binding on imaging and mutations in the <i>GBA</i> gene.ConclusionsSeveral studies have identified potentially modifiable risk factors for the development of psychosis in PD. Future studies should utilize consistent, validated definitions of psychosis and focus on increasing understanding of, and developing interventions for, potentially modifiable risk factors for psychosis in patients with PD.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"311-325"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Validation of the Parkinson's Disease Specific Anxiety Inventory (PDSAI). 帕金森病特异性焦虑量表(PDSAI)的开发和验证。
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-09-01 Epub Date: 2025-04-08 DOI: 10.1177/08919887251332660
Nadeeka N Dissanayaka, Dana Pourzinal, Gerard Byrne, Nancy A Pachana, John D O'Sullivan, Elizabeth White, Tiffany Au, Jihyun Yang, Alejandro Interian, Kailyn Rodriguez, Roseanne D Dobkin
{"title":"Development and Validation of the Parkinson's Disease Specific Anxiety Inventory (PDSAI).","authors":"Nadeeka N Dissanayaka, Dana Pourzinal, Gerard Byrne, Nancy A Pachana, John D O'Sullivan, Elizabeth White, Tiffany Au, Jihyun Yang, Alejandro Interian, Kailyn Rodriguez, Roseanne D Dobkin","doi":"10.1177/08919887251332660","DOIUrl":"10.1177/08919887251332660","url":null,"abstract":"<p><p>BackgroundAnxiety is poorly recognized and inadequately treated in persons with Parkinson's disease (PD).ObjectiveThe present study aimed to develop and validate a new clinical screening and research outcome measure to identify triggers and manifestations of anxiety specific to PD, the Parkinson's disease Specific Anxiety Inventory (PDSAI).MethodData from PDSAI derived from 172 people with PD across Australia and the United States was used to assess the reliability and validity of the inventory. Construct validity was assessed.ResultsFrequency analyses revealed low rates of missing data across the 40 items. The inventory demonstrated high reliability (Cronbach's a = 0.93, split-half = 0.68) and mid to high concurrent validity between the PDSAI and (i) Hamilton Anxiety Scale (r = 0.51), (ii) Liebowitz Social Anxiety Scale (r = 0.697) and Parkinson's Anxiety Scale (r = 0.747).ConclusionsThe PDSAI is a valid and reliable tool designed to capture PD specific triggers and manifestations of anxiety in people with PD.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"353-361"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to Break Stubborn Association Between Hearing Loss and Cognitive Impairment: A Systematic Review and Meta-Analysis of Moderators and Mediators. 如何打破听力损失与认知障碍之间的顽固联系:调节因子和调节因子的系统回顾和荟萃分析。
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-09-01 Epub Date: 2025-03-19 DOI: 10.1177/08919887251328880
Zeyi Zhang, Tingting Wang, Heng Cao, Longshan Yang, Xue Chen, Yu Han
{"title":"How to Break Stubborn Association Between Hearing Loss and Cognitive Impairment: A Systematic Review and Meta-Analysis of Moderators and Mediators.","authors":"Zeyi Zhang, Tingting Wang, Heng Cao, Longshan Yang, Xue Chen, Yu Han","doi":"10.1177/08919887251328880","DOIUrl":"10.1177/08919887251328880","url":null,"abstract":"<p><p>BackgroundHearing loss has been related to impaired cognition among older adults. The cost effectiveness of existing hearing support tools is controversial. Other potential modifying strategies that could effectively intervene in this prevalent and far-reaching association between hearing loss and cognitive decline remain unclear. This study aimed to narratively and quantitatively synthesize the mediators and moderators involved in the link between hearing loss and cognitive impairment from a psycho-social and physical point of view.MethodWe searched 6 databases for articles exploring mediating or moderating associations of hearing loss-cognition association from inception to March, 2024. Data were synthesized narratively and quantitatively by meta-analytic approaches.ResultsThe search yielded 63 included studies. Social (social engagement, social support, age, sex, ethnicity, cognitive reserve)-psycho (depression, anxiety, loneliness, resilience)-physical (cardiovascular diseases and risk factors, perceived health, disability, APOE carrier, vision impairment, gait speed) variables mediated or moderated the relationship between hearing loss and cognitive impairment to varying degrees. Subgroup analyses identified susceptible populations at greater risk for cognitive decline, including women, younger elders with hearing loss, and older adults with dual sensory loss.ConclusionCombined interventions targeting these modifiable variables across psycho-social and physical dimensions may be more cost-effective for intervening in the ensemble of hearing loss-cognitive impairment in older adults.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"339-352"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contributors to Gender Disparities in Parkinson's Disease Caregiving. 帕金森氏症护理中的性别差异。
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2025-09-01 Epub Date: 2025-03-21 DOI: 10.1177/08919887251329957
Sarah Horn, Yunfeng Dai, Samuel S Wu, Nabila Dahodwala
{"title":"Contributors to Gender Disparities in Parkinson's Disease Caregiving.","authors":"Sarah Horn, Yunfeng Dai, Samuel S Wu, Nabila Dahodwala","doi":"10.1177/08919887251329957","DOIUrl":"10.1177/08919887251329957","url":null,"abstract":"<p><p>BackgroundWomen with Parkinson's disease (PD) are less likely to have a caregiver.ObjectiveTo determine factors contributing to gender disparities in PD caregiving.MethodsWe conducted a cross-sectional survey of people with PD and caregivers participating in the Parkinson's Foundation Parkinson's Outcomes Project and compared patient and caregiver characteristics by gender.ResultsAmong PD patients, 20.7% of 1663 women and 14.2% of 3005 men had no caregiver (<i>P</i> < 0.001). Women without caregivers were older (69.1 vs 66.3, <i>P</i> < 0.001), less likely to be married (30.4% vs 54.7%, <i>P</i> < 0.001), and more likely to be taking an antidepressant (41.8% vs 30.9%, <i>P</i> = 0.002) than men. Using stepwise logistic regression models, gender differences in access to caregiving were explained by marital status. Among caregivers, women reported more strain (<i>P</i> < 0.001) and had less time for other family members (<i>P</i> < 0.001).ConclusionFewer women with PD have caregivers because they are less likely to have a spouse.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"394-404"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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