Journal of Geriatric Psychiatry and Neurology最新文献

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Impact of PTSD and Obstructive Sleep Apnea on Cognition in Older Adult Veterans. 创伤后应激障碍和阻塞性睡眠呼吸暂停对老年退伍军人认知的影响。
IF 2.6 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-09-01 Epub Date: 2023-01-02 DOI: 10.1177/08919887221149132
Madeline D W Noland, Emily W Paolillo, Art Noda, Laura C Lazzeroni, Jon-Erik C Holty, Ware G Kuschner, Jerome Yesavage, Lisa M Kinoshita
{"title":"Impact of PTSD and Obstructive Sleep Apnea on Cognition in Older Adult Veterans.","authors":"Madeline D W Noland,&nbsp;Emily W Paolillo,&nbsp;Art Noda,&nbsp;Laura C Lazzeroni,&nbsp;Jon-Erik C Holty,&nbsp;Ware G Kuschner,&nbsp;Jerome Yesavage,&nbsp;Lisa M Kinoshita","doi":"10.1177/08919887221149132","DOIUrl":"10.1177/08919887221149132","url":null,"abstract":"<p><p><b>Background:</b> Posttraumatic stress disorder (PTSD) and obstructive sleep apnea (OSA) are highly prevalent and comorbid among older adult male veterans. Both PTSD and OSA are independently associated with cognitive deficits in older adults, but little research regarding the impact of comorbid PTSD and OSA among older adults exists. <b>Purpose:</b> The current study aimed to examine the independent and interactive effects of PTSD and OSA on cognitive functioning in older adult veterans. <b>Study Sample:</b> Older adult male veterans with (<i>n</i> = 106) and without PTSD (<i>n</i> = 69), ranging in age from 55 to 89 (<i>M</i> = 63.35). <b>Data Collection:</b> Participants underwent polysomnography evaluation to assess severity of OSA symptoms and comprehensive neuropsychological evaluation to assess cognitive functioning in 3 domains: attention and processing speed, learning and memory, and executive functioning. <b>Results:</b> Multiple regression analyses showed that the interaction between PTSD and OSA did not predict cognitive performance. However, PTSD significantly predicted poorer attention and processing speed, and increased OSA severity predicted poorer learning and memory. <b>Conclusions:</b> While PTSD and OSA did not have a synergistic detrimental impact on cognition, each independently predicted poorer cognitive functioning within certain domains, suggesting that older adults with these comorbid conditions may experience a wider array of cognitive difficulties.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 5","pages":"386-396"},"PeriodicalIF":2.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9890808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caregiver Experiences Navigating the Diagnostic Journey in a Rapidly Progressing Dementia. 照顾者在快速进展的痴呆症诊断过程中的经历。
IF 2.9 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-07-01 Epub Date: 2022-11-22 DOI: 10.1177/08919887221135552
Alissa Bernstein Sideman, Joni Gilissen, Krista L Harrison, Sarah B Garrett, Michael J Terranova, Christine S Ritchie, Michael D Geschwind
{"title":"Caregiver Experiences Navigating the Diagnostic Journey in a Rapidly Progressing Dementia.","authors":"Alissa Bernstein Sideman, Joni Gilissen, Krista L Harrison, Sarah B Garrett, Michael J Terranova, Christine S Ritchie, Michael D Geschwind","doi":"10.1177/08919887221135552","DOIUrl":"10.1177/08919887221135552","url":null,"abstract":"<p><strong>Introduction: </strong>People with suspected Alzheimer's disease and related dementias (ADRD) and their families experience a burdensome process while seeking a diagnosis. These challenges are problematic in the most common dementia syndromes, but they can be even more distressing in rarer, atypical syndromes such as rapidly progressive dementias (RPDs), which can be fatal within months from onset. This study is an examination of the diagnostic journey experience from the perspective of caregivers of people who died from the prototypic RPD, sporadic Creutzfeldt-Jakob Disease (sCJD).</p><p><strong>Methods: </strong>eIn this mixed-methods study, qualitative data were drawn from interviews with former caregivers of 12 people who died from sCJD. Chart review data were drawn from research and clinical chart data about the person with sCJD. Data were analyzed by a multidisciplinary research team using qualitative and descriptive statistical analysis.</p><p><strong>Results: </strong>We identified 4 overarching themes that characterized the experience of the diagnostic journey in sCJD: clinician knowledge, clinician communication, experiences of uncertainty, and the caregiver as advocate. We also identified 4 phases along the diagnostic journey: recognition, the diagnostic workup, diagnosis, and post-diagnosis. Sub-themes within each phase include struggles to recognize what is wrong, complex processes of testing and referrals, delay and disclosure of diagnosis, and access to resources post-diagnosis.</p><p><strong>Conclusions: </strong>Findings suggest that more work is needed to improve clinician diagnostic knowledge and communication practices. Furthermore, caregivers need better support during the diagnostic journey. What we learn from studying sCJD and other RPDs is likely applicable to other more common dementias.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 4","pages":"282-294"},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10265278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9695547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breakfast Skipping and Declines in Cognitive Score Among Community-Dwelling Older Adults: A Longitudinal Study of the HEIJO-KYO Cohort. 在社区居住的老年人中不吃早餐和认知评分下降:一项对平州-京队列的纵向研究。
IF 2.6 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-07-01 DOI: 10.1177/08919887221135551
Rika Ishizuka, Naoto Otaki, Yoshiaki Tai, Yuki Yamagami, Kunihiko Tanaka, Masayuki Morikawa, Masayuki Iki, Norio Kurumatani, Keigo Saeki, Kenji Obayashi
{"title":"Breakfast Skipping and Declines in Cognitive Score Among Community-Dwelling Older Adults: A Longitudinal Study of the HEIJO-KYO Cohort.","authors":"Rika Ishizuka,&nbsp;Naoto Otaki,&nbsp;Yoshiaki Tai,&nbsp;Yuki Yamagami,&nbsp;Kunihiko Tanaka,&nbsp;Masayuki Morikawa,&nbsp;Masayuki Iki,&nbsp;Norio Kurumatani,&nbsp;Keigo Saeki,&nbsp;Kenji Obayashi","doi":"10.1177/08919887221135551","DOIUrl":"https://doi.org/10.1177/08919887221135551","url":null,"abstract":"<p><p>Previous studies outlined the correlation of adverse effects of breakfast skipping with cognitive function. However, the majority of these studies have focused on the short-term effects; to date, the long-term effect of breakfast skipping on cognitive function among older adults remains unclear. In this prospective cohort study of 712 older adults (mean age, 70.8 years), breakfast skipping was defined as skipping breakfast one or more times per week, and declines in cognitive score was defined as decreases in Mini-Mental State Examination (MMSE) score of two or more in the observed period. During follow-up (median, 31 months), 135 of 712 participants developed declines in cognitive score. Poisson regression models revealed that the incidence rate for declines in cognitive score was significantly higher in breakfast skipper (n = 29) than breakfast eaters (n = 683) [incidence rate ratio (IRR), 2.10; 95% CI, 1.28-3.44]. Additional propensity score adjustments related to breakfast skipping from baseline parameters (age, gender, smoking and drinking status, BMI, household income, educated level, depressive symptoms, hypertension, diabetes, sleep medication, physical activity, caloric intake, and baseline cognition) produced consistent results (IRR, 2.21; 95% CI, 1.33-3.68). Sensitivity analysis, when the cut-off value of decreases in MMSE score was changed to three points, suggested a significant and stronger association (IRR, 3.03; 95% CI, 1.72-5.35). Regarding daily intakes of food groups, breakfast skippers consumed a significantly lower amount of vegetables, fruits, and fish than breakfast eaters. In conclusion, our findings suggest that breakfast skipping is longitudinally associated with declines in cognitive score among older adults.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 4","pages":"316-322"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9645485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High frequency of Depressive Disorders and Suicidal Phenomena in Late-Stage Parkinson´s Disease - A Cross-Sectional Study. 晚期帕金森病患者抑郁障碍和自杀现象的高频率-一项横断面研究
IF 2.6 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-07-01 DOI: 10.1177/08919887221135556
Inês Chendo, Margherita Fabbri, Catarina Godinho, Rita Moiron Simões, Catarina Severiano Sousa, Miguel Coelho, Valerie Voon, Joaquim J Ferreira
{"title":"High frequency of Depressive Disorders and Suicidal Phenomena in Late-Stage Parkinson´s Disease - A Cross-Sectional Study.","authors":"Inês Chendo,&nbsp;Margherita Fabbri,&nbsp;Catarina Godinho,&nbsp;Rita Moiron Simões,&nbsp;Catarina Severiano Sousa,&nbsp;Miguel Coelho,&nbsp;Valerie Voon,&nbsp;Joaquim J Ferreira","doi":"10.1177/08919887221135556","DOIUrl":"https://doi.org/10.1177/08919887221135556","url":null,"abstract":"<p><strong>Background: </strong>Depressive disorders (DD) are widely recognized as one of the most frequent neuropsychiatric disorders in Parkinson´s disease. Patients with late-stage Parkinson´s disease (LSPD) continue to be a neglected population, and little is known about DD frequency in LSPD.</p><p><strong>Objectives: </strong>To determine the frequency of DD in LSPD patients through a clinical diagnostic interview (CDI) and according to diagnostic DSM- 5 criteria. Secondary objectives were to determine the predictive ability of depressive scales to detect DD, to identify potential predictors of DD in LSPD and, to evaluate suicidal phenomena in LSPD.</p><p><strong>Methods: </strong>A cross-sectional study including LSPD patients (≥7 years from symptom onset and Hoehn and Yahr scale score >3 or a Schwab and England scale score <50% in the ON condition) was conducted. Patients were subjected to psychiatric, neurological, and neuropsychological evaluations. Six depression scales were applied.</p><p><strong>Results: </strong>92 LSPD patients were included. 59.78% of LSPD patients had a current diagnosis of DD according to CDI, 38.04% patients had a diagnosis of major depressive disorder, and 21.72% non-major depressive disorder. Suicidal ideation was present in 36.96% of patients. All applied scales were able to detect depressive disorders.</p><p><strong>Conclusions: </strong>More than half of LSPD patients met DD diagnostic criteria and over one-third were diagnosed with major depressive disorder. Overall, the LSPD population seem to have a unique clinical phenotype regarding the frequency and features of DD, whose early identification and treatment could improve the quality of life of patients and caregivers.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 4","pages":"336-346"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9642456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Understanding Clinician's Experiences with Implementation of a Younger Onset Dementia Telehealth Service. 了解临床医生实施年轻发病痴呆症远程医疗服务的经验。
IF 2.6 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-07-01 DOI: 10.1177/08919887221141653
Aimee D Brown, Wendy Kelso, Dennis Velakoulis, Sarah Farrand, Renerus J Stolwyk
{"title":"Understanding Clinician's Experiences with Implementation of a Younger Onset Dementia Telehealth Service.","authors":"Aimee D Brown,&nbsp;Wendy Kelso,&nbsp;Dennis Velakoulis,&nbsp;Sarah Farrand,&nbsp;Renerus J Stolwyk","doi":"10.1177/08919887221141653","DOIUrl":"https://doi.org/10.1177/08919887221141653","url":null,"abstract":"<p><p>The successful implementation of telehealth services depends largely on clinician acceptance of telehealth as a viable healthcare option and their adoption of telehealth methods into their clinical practice. While growing research supports the feasibility of telehealth services, no research has evaluated clinicians' experiences during the implementation of a younger onset dementia telehealth service. Semi-structured group interviews were conducted with 7 metropolitan (hub) clinicians and 16 rural (spoke) clinicians during the pre-and post-implementation phases of a novel Younger onset dementia (YOD) telehealth service. Reflexive thematic analysis identified five themes at pre-implementation: <i>clinical need, previous experiences and views, potential telehealth barriers, solutions to potential telehealth barriers,</i> and <i>potential clinical outcomes</i>. At post-implementation, nine themes were identified: <i>clinical need, clinical relationships, concerns about the future of rural healthcare, clinical practice and resourcing factors, patient suitability, difficulties with technology, service quality, the way forward</i>, and <i>the impact of</i> <i>COVID-19</i>. Most clinicians held positive views regarding the service, particularly the ability to provide more options to rural-dwelling patients. However, some concerns about threats to rural healthcare and the validity of telehealth assessments remained. Overall, this study has identified service implementation barriers and facilitators and contributes to the long-term sustainability of current and future telehealth YOD services.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 4","pages":"295-308"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9642457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visuoconstructional Abilities of Patients With Subjective Cognitive Decline, Mild Cognitive Impairment and Alzheimer's Disease. 主观认知能力下降、轻度认知障碍和阿尔茨海默病患者的视觉建构能力
IF 2.6 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-07-01 DOI: 10.1177/08919887221135549
Paula Knechtl, Johann Lehrner
{"title":"Visuoconstructional Abilities of Patients With Subjective Cognitive Decline, Mild Cognitive Impairment and Alzheimer's Disease.","authors":"Paula Knechtl,&nbsp;Johann Lehrner","doi":"10.1177/08919887221135549","DOIUrl":"https://doi.org/10.1177/08919887221135549","url":null,"abstract":"<p><strong>Background: </strong>Via the Vienna Visuoconstructional Test 3.0 (VVT 3.0) delayed recall we combined the assessment of visuoconstructive abilities and memory and investigated the test's potential to support diagnostic processes, including staging and the elaboration of a cognitive profile.</p><p><strong>Methods: </strong>We retrospectively analysed the data of 368 patients of the Department of Neurology, Medical University of Vienna, between 04/2014 and 10/2020 that had performed the VVT 3.0. Our sample involved 70 healthy controls (HC), 29 patients with subjective cognitive decline (SCD), 154 patients with mild cognitive impairment (MCI) and 115 patients with Alzheimer's disease (AD). We investigated the differences in the VVT 3.0 scores, as well as the VVT's ability to differentiate between AD and nonAD by calculating receiver-operating-characteristic (ROC) curves, ideal cut-offs and a logistic regression model.</p><p><strong>Results: </strong>Results stated that the VVT 3.0 delayed recall scores were able to differentiate between all diagnostic groups, respectively, except HC-SCD and SCD-MCI. The ROC analyses determined an AUC of 0.890, 95% CI [0.855; 0.925], P < .001, and the ideal cut-off at 29.5 points that maximised sensitivity at 0.896 and specificity at 0.81. The logistic regression model classified 83.4% of AD patients correctly and delivered a significant Cohen's Kappa of 0.619 (P < .001).</p><p><strong>Conclusion: </strong>As the VVT 3.0 revealed satisfactory values of diagnostic accuracy in our sample, it could enrich clinical diagnosing. However, for more clarity about its informative value in other populations, there remains a need for future studies with other samples.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 4","pages":"323-335"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ea/03/10.1177_08919887221135549.PMC10265306.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9639778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of a Suicide Prevention Gatekeeper Training Program for Nursing Home Staff. 疗养院工作人员自杀预防看门人训练计划之评估。
IF 2.6 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-07-01 DOI: 10.1177/08919887221149142
Alice Demesmaeker, Nicolas Baelde, Ali Amad, Jean Roche, Marie Playe, Guillaume Vaiva, Alina Amariei, Wanda Blervaque, Marguerite Marie Defebvre, Brigitte Caron, Francois Puisieux, Laurent Plancke
{"title":"Assessment of a Suicide Prevention Gatekeeper Training Program for Nursing Home Staff.","authors":"Alice Demesmaeker,&nbsp;Nicolas Baelde,&nbsp;Ali Amad,&nbsp;Jean Roche,&nbsp;Marie Playe,&nbsp;Guillaume Vaiva,&nbsp;Alina Amariei,&nbsp;Wanda Blervaque,&nbsp;Marguerite Marie Defebvre,&nbsp;Brigitte Caron,&nbsp;Francois Puisieux,&nbsp;Laurent Plancke","doi":"10.1177/08919887221149142","DOIUrl":"https://doi.org/10.1177/08919887221149142","url":null,"abstract":"<p><strong>Introduction: </strong>Older adults have one of the highest age-specific suicide rates in France, and the risk of suicide is higher for those living in nursing homes. The aim of our study was to assess the effectiveness of gatekeeper training for nursing home staff on the knowledge and stigmas towards suicidal crisis and the impact on suicidal behaviour rates.</p><p><strong>Method: </strong>A total of 427 nursing or administrative staff from 110 nursing homes received gatekeeper training in the Hauts-de-France French region between September 2016 and June 2018. First, knowledge and stigmas on suicidal crisis were assessed through a pretest and posttest survey. Second, a retrospective survey was conducted to determine suicide behaviour rates before and after training in nursing homes. Then, changes between pre- and posttraining scores and suicide rates were evaluated with a paired samples T test and rate difference calculation (<i>P</i> value of <0.05 was considered statistically significant).</p><p><strong>Results: </strong>A total of 315 trainees completed the questionnaires on knowledge and stigmas related to suicidal crisis, and we found a significant difference in the total scores (<i>P</i> < 0.01). Moreover, we found a significant decrease in the incidence of suicide attempts (SAs) after training (<i>P</i> = 0.002), but the incidence of deaths by suicide was not significantly different prior to and after the training course (<i>P</i> = 0.46).</p><p><strong>Conclusion: </strong>We highlighted an improvement in knowledge and stigmas after training and a reduction in the rates of SAs with our gatekeeper suicide prevention program. Future research is needed to improve suicide prevention for nursing home residents.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 4","pages":"309-315"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9642469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood Biomarkers for the Diagnosis of Neurodegenerative Dementia: A Systematic Review. 血液生物标志物诊断神经退行性痴呆:系统综述。
IF 2.6 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-07-01 DOI: 10.1177/08919887221141651
Filipa Santos, Verónica Cabreira, Sara Rocha, João Massano
{"title":"Blood Biomarkers for the Diagnosis of Neurodegenerative Dementia: A Systematic Review.","authors":"Filipa Santos,&nbsp;Verónica Cabreira,&nbsp;Sara Rocha,&nbsp;João Massano","doi":"10.1177/08919887221141651","DOIUrl":"https://doi.org/10.1177/08919887221141651","url":null,"abstract":"<p><strong>Importance: </strong>Accurately diagnosing neurodegenerative dementia is often challenging due to overlapping clinical features. Disease specific biomarkers could enhance diagnostic accuracy. However, CSF analysis procedures and advanced imaging modalities are either invasive or high-priced, and routinely unavailable. Easily accessible disease biomarkers would be of utmost value for accurate differential diagnosis of dementia subtypes.</p><p><strong>Objective: </strong>To assess the diagnostic accuracy of blood-based biomarkers for the differential diagnosis of AD from Frontotemporal Lobar Degeneration (FTLD), or AD from Dementia with Lewy Bodies (DLB).</p><p><strong>Methods: </strong>Systematic review. Three databases (PubMed, Scopus, and Web of Science) were searched. Studies assessing blood-based biomarkers levels in AD versus FTLD, or AD versus DLB, and its diagnostic accuracy, were selected. When the same biomarker was assessed in three or more studies, a meta-analysis was performed. QUADAS-2 criteria were used for quality assessment.</p><p><strong>Results: </strong>Twenty studies were included in this analysis. Collectively, 905 AD patients were compared to 1262 FTLD patients, and 209 AD patients were compared to 246 DLB patients. Regarding biomarkers for AD versus FTLD, excellent discriminative accuracy (AUC >0.9) was found for p-tau181, p-tau217, synaptophysin, synaptopodin, GAP43 and calmodulin. Other biomarkers also demonstrated good accuracy (AUC = 0.8-0.9). For AD versus DLB distinction, only miR-21-5p and miR-451a achieved excellent accuracy (AUC >0.9).</p><p><strong>Conclusion: </strong>Encouraging results were found for several biomarkers, alone or in combination. Prospective longitudinal designs and consensual protocols, comprising larger cohorts and homogeneous testing modalities across centres, are essential to validate the clinical value of blood biomarkers for the precise etiological diagnosis of dementia.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"36 4","pages":"267-281"},"PeriodicalIF":2.6,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9695546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Peripheral neuropathy and neuropathic pain in the elderly 老年人周围神经病变和神经性疼痛
IF 2.6 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-06-15 DOI: 10.53991/jgn.2023.00045
Je-Young Shin
{"title":"Peripheral neuropathy and neuropathic pain in the elderly","authors":"Je-Young Shin","doi":"10.53991/jgn.2023.00045","DOIUrl":"https://doi.org/10.53991/jgn.2023.00045","url":null,"abstract":"Neuropathic pain is a common symptom in the elderly and tends to increase according to the frequency of related underlying disease. In older patients, cognitive decline and accompanying medical conditions may make early diagnosis difficult. Therefore, a detailed history taking, neurological examination, and laboratory tests should be performed. Diabetic peripheral neuropathy, entrapment neuropathy, radiculopathy, postherpetic neuralgia, and chemotherapy-induced peripheral neuropathy are the major causes of peripheral neuropathy in the elderly. When treating elderly patients, the dose of drug should be adjusted in consideration of its side effects. An accurate diagnosis and treatment of neuropathic pain is essential to improve the quality of life of elderly patients.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"66 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76953774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Superficial siderosis suspected to be related to vertebral fracture and vertebroplasty 怀疑与椎体骨折和椎体成形术有关的浅表面性铁沉着
IF 2.6 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2023-06-15 DOI: 10.53991/jgn.2023.00031
M.-G. Choi, Dong Hyun Kim, Sung Jae Ahn, Sang-Soon Park, Seung Hyun Lee
{"title":"Superficial siderosis suspected to be related to vertebral fracture and vertebroplasty","authors":"M.-G. Choi, Dong Hyun Kim, Sung Jae Ahn, Sang-Soon Park, Seung Hyun Lee","doi":"10.53991/jgn.2023.00031","DOIUrl":"https://doi.org/10.53991/jgn.2023.00031","url":null,"abstract":"Superficial siderosis (SS) of the central nervous system is a rare disorder caused by chronic or recurrent hemorrhages into the subarachnoid space, and subsequent deposition of hemosiderin in the subpial layers of the brain and spinal cord lead to the development of neuronal damage. The diagnosis of SS is typically made by brain imaging and management may include identifying and treating the underlying cause of the bleeding, as well as symptomatic treatment. We present the case of a 79-year-old female with chronic progressive gait ataxia and dysarthria. She was eventually diagnosed with SS probably due to lumbar compression fracture treated with vertebroplasty 6 years ago.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"964 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77072725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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