Journal of Geriatric Psychiatry and Neurology最新文献

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Delusions in Lewy Body Disease: A Cross-Sectional Study on Associated Factors and Lived Experiences. 路易体病的妄想:相关因素和生活经历的横断面研究。
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-01 Epub Date: 2025-10-31 DOI: 10.1177/08919887251392086
Caroline Sirna, Ashay Panse, Panagiotis Alexopoulos, Ella Carol, Orla Keane, Iracema Leroi
{"title":"Delusions in Lewy Body Disease: A Cross-Sectional Study on Associated Factors and Lived Experiences.","authors":"Caroline Sirna, Ashay Panse, Panagiotis Alexopoulos, Ella Carol, Orla Keane, Iracema Leroi","doi":"10.1177/08919887251392086","DOIUrl":"10.1177/08919887251392086","url":null,"abstract":"<p><p>IntroductionDelusions are common in Lewy body disease (LBD), significantly impacting quality of life. This study examined clinical factors, characteristics and themes associated with delusions in LBD.MethodsClinical and demographic factors were compared between 91 individuals attending St. James's Hospital in Ireland with LBD both with and without delusions. Clinical scales include the Clinical Dementia Rating Scale (CDR), Epworth sleepiness scale (ESS), Addenbrooke's Cognitive Evaluation (ACE-III), and Neuropsychiatric Inventory-12 (NPI-12). Themes of delusions extracted from clinical descriptions were mapped onto a typology from primary psychiatric populations.ResultsIndividuals with delusions were older, had higher CDR and ESS scores, lower ACE-III performance, higher scores on the NPI-12, and demonstrated cognitive impairment at the MCI or dementia level. Misidentification delusions were most common, followed by delusions of \"being harmed, attacked, or killed\" and \"residence is not their home\".ConclusionThese findings suggest delusions are related to disease stage, sleep, distinct cognitive and neuropsychiatric patterns, and follow a unique thematic typology.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"513-533"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healthcare Service Utilisation of People Living With Non-Alzheimer's Dementia: A Systematic Review. 非阿尔茨海默氏痴呆症患者的医疗服务利用:一项系统综述
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-01 Epub Date: 2025-08-28 DOI: 10.1177/08919887251371725
Anna Tjin, Leng Leng Thang, Harsharon Kaur Sondh, Robert Stewart
{"title":"Healthcare Service Utilisation of People Living With Non-Alzheimer's Dementia: A Systematic Review.","authors":"Anna Tjin, Leng Leng Thang, Harsharon Kaur Sondh, Robert Stewart","doi":"10.1177/08919887251371725","DOIUrl":"10.1177/08919887251371725","url":null,"abstract":"<p><p>IntroductionThe global rise in dementia presents significant challenges for healthcare systems. While Alzheimer's disease (AD) dominates dementia care, people with non-Alzheimer's dementias (non-AD), such as dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), vascular dementia (VD), and Parkinson's disease dementia (PDD), often have distinct and unmet healthcare needs.AimThis systematic review aimed to summarise evidence on healthcare utilisation (HCU) patterns and factors affecting care among people living with non-AD dementias.MethodsFollowing a PROSPERO-registered protocol (CRD42024568391), comprehensive searches of Embase, Ovid MEDLINE, Global Health, PsycINFO, and PubMed were conducted in February and June 2024. Peer-reviewed English-language studies reporting on HCU or its determinants in DLB, FTD, VD, or PDD were included. Reviews, case reports, grey literature, and studies without subtype-specific data were excluded. Quality was assessed using the Newcastle-Ottawa Scale.ResultsThirty-one studies (16 cohort; 10 cross-sectional, 4 case-description, and 1 chart review) were included. HCU varied by dementia subtype and was influenced by sociodemographic, cognitive, and clinical factors. Compared with AD, non-AD dementias had higher healthcare use and costs. PDD showed the highest inpatient, outpatient, and skilled nursing care use, driven by severe cognitive decline. DLB was linked to unplanned hospital admissions and frequent ambulance use, often due to falls and pneumonia. FTD resulted in extended hospital stays related to behavioural symptoms, while VD incurred high costs due to chronic comorbidities and long-term care needs.ConclusionPeople with non-AD dementias have greater and distinct healthcare needs. Future research should develop standardised measures and tailored interventions to address their complex socioeconomic and clinical requirements.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"355-367"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mild Behavioral Impairment and Plasma Biomarkers of Neurodegeneration as Predictors of Cognitive Decline in Geriatric Patients With Psychiatric Disorders. 轻度行为障碍和血浆神经变性生物标志物作为老年精神疾病患者认知能力下降的预测因子。
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-01 Epub Date: 2025-10-30 DOI: 10.1177/08919887251394747
Camilla Elefante, Maria Francesca Beatino, Chiara Fustini, Vittoria Lepri, Donatella Acierno, Alessia Scalzo, Lucia Petrozzi, Linda Giampietri, Gloria Tognoni, Filippo Baldacci, Lorenzo Lattanzi, Gabriele Siciliano, Zahinoor Ismail, Roberto Ceravolo, Giulio Perugi
{"title":"Mild Behavioral Impairment and Plasma Biomarkers of Neurodegeneration as Predictors of Cognitive Decline in Geriatric Patients With Psychiatric Disorders.","authors":"Camilla Elefante, Maria Francesca Beatino, Chiara Fustini, Vittoria Lepri, Donatella Acierno, Alessia Scalzo, Lucia Petrozzi, Linda Giampietri, Gloria Tognoni, Filippo Baldacci, Lorenzo Lattanzi, Gabriele Siciliano, Zahinoor Ismail, Roberto Ceravolo, Giulio Perugi","doi":"10.1177/08919887251394747","DOIUrl":"10.1177/08919887251394747","url":null,"abstract":"<p><p>BackgroundMild Behavioral Impairment (MBI) has been increasingly recognized as a potential early clinical marker of neurodegenerative disease, while blood-based biomarkers such as phosphorylated tau 217 (p-tau217) and neurofilament light chain (NfL) are associated with Alzheimer's disease and axonal damage, respectively.ObjectiveTo investigate the role of MBI and blood-based biomarkers of neurodegeneration in the early detection of dementia.MethodsFifty-one individuals without dementia aged 60 or older with mood or anxiety disorders underwent psychiatric, neuropsychiatric, and cognitive evaluations, as well as assessment of plasma p-tau217 and NfL at baseline and at one-year follow-up.ResultsA higher proportion of males was observed in the MBI group compared to the non-MBI group (<i>P</i> = 0.076). MBI was significantly associated with a higher risk of conversion to dementia (<i>P</i> = 0.006). MBI patients showed a trend toward higher baseline p-tau217 (<i>P</i> = 0.096) and significantly higher NfL at follow-up (<i>P</i> = 0.025), suggesting active neurodegeneration. Individuals who converted to dementia had marginally higher baseline p-tau217 (<i>P</i> = 0.053) and NfL (<i>P</i> = 0.091).ConclusionMBI and blood-based biomarkers of neurodegeneration appear to be promising clinical tools for identifying dementia risk in its early stages.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"413-425"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145409221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intranasal Oxytocin for Managing Agitation in a Patient of Mixed Dementia With Multiple Pathologies, Particularly With a History of Repetitive Head Injuries. 鼻内催产素对合并多种病理,特别是有重复性头部损伤史的混合性痴呆患者躁动的控制
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-01 Epub Date: 2025-09-19 DOI: 10.1177/08919887251382495
Naresh Jadav, Sümeyye Kuş, James Ellison, David Weisman, Mijail D Serruya
{"title":"Intranasal Oxytocin for Managing Agitation in a Patient of Mixed Dementia With Multiple Pathologies, Particularly With a History of Repetitive Head Injuries.","authors":"Naresh Jadav, Sümeyye Kuş, James Ellison, David Weisman, Mijail D Serruya","doi":"10.1177/08919887251382495","DOIUrl":"10.1177/08919887251382495","url":null,"abstract":"<p><p>BackgroundAgitation is common in persons living with dementia (major neurocognitive disorder) and worsens with disease progression. Brexpiprazole is the sole FDA-approved drug for agitation in persons with Alzheimer's dementia, but requires daily dosing over weeks. Limited pharmacologic options exist for acute agitation management.PurposeTo show the efficacy of oxytocin for acute agitation management in dementia patients.CaseWe report a 70-year-old former professional wrestler with repetitive head trauma who developed dementia and severe agitation. He showed remarkable, rapid improvement with as-needed intranasal oxytocin 30 IU until his death. Post-mortem examination revealed mixed pathology: Alzheimer's disease (Intermediate stage), Lewy Body disease (Limbic/Transitional stage), cerebrovascular disease with multiple infarcts, and chronic traumatic encephalopathy.ConclusionThis case demonstrates the potential efficacy of intranasal oxytocin for acute agitation management in persons living with mixed dementia and may inspire further investigation.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"426-430"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Caring on Psychological Wellbeing: A Qualitative Study in Carers of People Living With Behavioural-Variant Frontotemporal Dementia. 关怀对心理健康的影响:行为变异额颞叶痴呆患者照护者的质性研究
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-01 Epub Date: 2025-11-21 DOI: 10.1177/08919887251401262
Isabella M Ocampo, Jemma Todd, Grace Wei, Fiona Kumfor
{"title":"The Impact of Caring on Psychological Wellbeing: A Qualitative Study in Carers of People Living With Behavioural-Variant Frontotemporal Dementia.","authors":"Isabella M Ocampo, Jemma Todd, Grace Wei, Fiona Kumfor","doi":"10.1177/08919887251401262","DOIUrl":"10.1177/08919887251401262","url":null,"abstract":"<p><p><b>Background:</b> Informal carers of people living with dementia can experience increased burden, stress and a decline in mental health and wellbeing. Growing evidence suggests these impacts are greater for those caring for individuals living with behavioural-variant frontotemporal dementia. However, little is known about their psychological needs and how these carers access psychological support. <b>Objective:</b> This study aimed to understand the impact of caring on psychological wellbeing and the experiences and needs of carers in seeking psychological support. <b>Methods:</b> Twelve carers participated in either a group or individual semi-structured interview. Data were analysed qualitatively using thematic analysis. <b>Results:</b> Five themes emerged: (1) <i>The job of being a carer</i>, (2) <i>The carer and person living with bvFTD as a unit</i>: <i>Reciprocal wellbeing & Care for the carers</i>, (3) <i>Feeling seen, Feeling heard, and Being connected</i>, (4) <i>The power of information</i> and (5) <i>Meaning and purpose through caring</i>. These themes captured the challenges, supports and meaningful aspects of the caring experience, and their impact on psychological wellbeing. While carers reported both positive and negative impacts of caregiving on their psychological wellbeing, they also highlighted a lack of tailored services in the context of behavioural-variant frontotemporal dementia. <b>Conclusions:</b> Psychological support services for carers should address common barriers to accessibility and flexibility and be developed in collaboration with carers to optimise feasibility and efficacy.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"534-548"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145573644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of the Psychosis and Hallucinations Questionnaire in Lewy Body Dementia. 路易体痴呆患者精神病和幻觉问卷的验证。
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-01 Epub Date: 2025-11-07 DOI: 10.1177/08919887251395314
Chaminda Withanachchi Gunawardana, Peter G R Burke, Elie Matar, Simon J G Lewis
{"title":"Validation of the Psychosis and Hallucinations Questionnaire in Lewy Body Dementia.","authors":"Chaminda Withanachchi Gunawardana, Peter G R Burke, Elie Matar, Simon J G Lewis","doi":"10.1177/08919887251395314","DOIUrl":"10.1177/08919887251395314","url":null,"abstract":"<p><p>BackgroundPsychotic symptoms are common in patients with Parkinson's Disease Dementia and Dementia with Lewy Bodies, known collectively as the Lewy Body Dementias (LBD). It is important to identify these symptoms early and accurately. However, these symptoms are challenging to identify and quantify in clinical practice. The Psychosis and Hallucinations Questionnaire (PsycH-Q) was developed as a self-report tool using patient-friendly language to assess hallucinations and related phenomena and has been previously validated in Parkinson's Disease patients without dementia and their caregivers.ObjectivesThis study aimed to evaluate the utility of the PsycH-Q in patients diagnosed with a Lewy Body Dementia.MethodsA total of 33 LBD patients, assisted by their caregivers, completed the PsycH-Q, along with the Scales for Outcomes in Parkinson's Disease-Psychiatric Complications (SCOPA-PC) and the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). Items relating to hallucinations and psychotic phenomena from the SCOPA-PC and MDS-UPDRS were then compared with analogous ratings on the PsycH-Q.ResultsScores on the PsycH-Q were significantly correlated with SCOPA-PC Questions 1 and 3, as well as the MDS-UPDRS question 1.2 (Spearman's rho of 0.65, 0.73, and 0.47, respectively; p < 0.01 for all three correlations).ConclusionsThese results support the PsycH-Q as a patient-friendly questionnaire that accurately identifies hallucinatory phenomena and their features in LBD patients via self-report completed by patients with their caregivers. Future use of the PsycH-Q in clinical practice and research could improve early detection of psychotic symptoms in LBD patients, leading to improved management.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"368-379"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145471098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive Function and Insomnia Symptoms are Associated With Subjective-Objective Sleep Discrepancies in Older Adults Without Dementia. 无痴呆老年人认知功能和失眠症状与主客观睡眠差异相关
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-01 Epub Date: 2025-12-10 DOI: 10.1177/08919887251403581
Russell Calderon, Sofia Liu, Jing Huang, Miranda V McPhillips, Michelle Liu, Jiaying Li, Junxin Li
{"title":"Cognitive Function and Insomnia Symptoms are Associated With Subjective-Objective Sleep Discrepancies in Older Adults Without Dementia.","authors":"Russell Calderon, Sofia Liu, Jing Huang, Miranda V McPhillips, Michelle Liu, Jiaying Li, Junxin Li","doi":"10.1177/08919887251403581","DOIUrl":"10.1177/08919887251403581","url":null,"abstract":"<p><p>BackgroundAccurate sleep assessment is key to promoting healthy aging, yet self-reported measures often diverge from actigraphy. The factors driving these discrepancies in older adults remain unclear.MethodsThis cross-sectional secondary analysis examined the prevalence and correlates of subjective-objective sleep discrepancies in 195 community-dwelling older adults (69.84 ± 6.83 years old, 78.97% women) without dementia using baseline data from two clinical trials. Time in bed (TIB), sleep onset latency (SOL), total sleep time (TST), and sleep efficiency were collected via ≥3 days of actigraphy, sleep diaries, and the Pittsburgh Sleep Quality Index (PSQI). Discrepancies were calculated as self-reported minus actigraphy values, using ±15 min (±15% for sleep efficiency) as thresholds. Validated scales assessed insomnia, sleepiness, pain, and depression. Computerized batteries assessed processing speed, attention, executive function, working memory, and episodic memory.ResultsDiscrepancies greater than ±15 min (or ±15%) were prevalent: 88.50% for TST, 81.25% for TIB (PSQI), 45.71% for TIB (diary), 45.87% for SOL, and 42.20% for sleep efficiency. Adjusted multinomial logistic regression revealed that more severe insomnia symptoms were significantly associated with reduced odds of over-reporting sleep efficiency on the PSQI (OR = 0.82, 95% CI [0.72, 0.94]). Although no longer significant after correcting for multiple comparisons, better verbal episodic memory was associated with greater odds of over-reporting sleep efficiency (OR = 2.11, 95% CI [1.10, 4.07]) and lower odds of under-reporting diary-based TIB (OR = 0.32, 95% CI [0.13, 0.76]).ConclusionCognitive function and insomnia are linked to sleep discrepancies and may affect perceived sleep quality, warranting careful interpretation of self-reported sleep in older adults.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"453-470"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145724024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Usability of the Rhode Island Mobile Cognitive Assessment Tool for Self-Administration in Detecting Cognitive Impairment in Older Adults. 罗德岛移动认知评估工具在检测老年人认知障碍中的自我管理的可用性。
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-01 Epub Date: 2025-08-30 DOI: 10.1177/08919887251375475
Sydney C Sullivan, Melissa G Zammitti, Taylor Maynard, Kunal Mankodiya, Nicholas Constant, Laura E Korthauer, Brian R Ott, Charles Denby, Alyssa N De Vito, Geoffrey Tremont
{"title":"Usability of the Rhode Island Mobile Cognitive Assessment Tool for Self-Administration in Detecting Cognitive Impairment in Older Adults.","authors":"Sydney C Sullivan, Melissa G Zammitti, Taylor Maynard, Kunal Mankodiya, Nicholas Constant, Laura E Korthauer, Brian R Ott, Charles Denby, Alyssa N De Vito, Geoffrey Tremont","doi":"10.1177/08919887251375475","DOIUrl":"10.1177/08919887251375475","url":null,"abstract":"<p><p>ObjectiveThis study evaluated the usability of the Rhode Island Mobile Cognitive Assessment Tool (RIMCAT), a proctored digital cognitive screening measure to assess its potential for self-administration.Methods100 participants (Healthy Controls [HC] <i>n</i> = 50; Cognitively Impaired [CI] <i>n</i> = 50) were recruited, and 90 completed the RIMCAT twice, with verbal prompts when necessary. Participants then completed an exit survey regarding their experience.ResultsAll HC completed the RIMCAT, but four CI individuals could not. Most finished in under 30 min. HC (M = 2.18, SD = 1.93) required significantly fewer prompts during the first RIMCAT administration compared to the CI group (M = 3.82, SD = 2.87). Both groups needed fewer prompts on the second visit, with prompts often related to input methods, button use, and instruction comprehension.ConclusionsThe RIMCAT shows promise for self-administration, particularly with minor modifications that could improve clarity, interface design, and user experience for optimal usability and self-administration.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"488-498"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-Care Experiences and Behaviours in People With Parkinson's Disease: A Meta-Synthesis. 帕金森病患者的自我照顾经验和行为:一项综合研究。
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-01 Epub Date: 2025-11-13 DOI: 10.1177/08919887251392139
Monica Petralito, Chiara Tedesco, Ercole Vellone, Silvia Cilluffo, Maura Lusignani, Stefano Terzoni, Andrea Zanichelli, Rosario Caruso, Gianluca Pucciarelli
{"title":"Self-Care Experiences and Behaviours in People With Parkinson's Disease: A Meta-Synthesis.","authors":"Monica Petralito, Chiara Tedesco, Ercole Vellone, Silvia Cilluffo, Maura Lusignani, Stefano Terzoni, Andrea Zanichelli, Rosario Caruso, Gianluca Pucciarelli","doi":"10.1177/08919887251392139","DOIUrl":"10.1177/08919887251392139","url":null,"abstract":"<p><p>BackgroundParkinson's disease (PD) is the fastest-growing neurodegenerative condition globally, significantly impairing self-care capacity due to its complex motor and nonmotor symptoms. Caregiver involvement is often essential.ObjectiveThis review aims to synthesise qualitative evidence on self-care behaviours and experiences in individuals with PD, from both patient and caregiver perspectives.MethodsA qualitative meta-synthesis was conducted using Sandelowski and Barroso's methodology. Fifty-two eligible studies were analysed. Thematic categories were mapped onto Riegel's self-care framework: maintenance, monitoring, and management.ResultsSelf-care maintenance emerged as the most frequently reported dimension. Across all three dimensions, caregiver support played a central role in enabling effective symptom control and treatment adherence.ConclusionsThe synthesis highlights the critical importance of supporting self-care-especially maintenance behaviours-in PD management. It also emphasizes the vital role caregivers play in reinforcing self-care, pointing to the need for integrated support structures in clinical and research contexts.RegistrationThis review was registered in PROSPERO (https://www.crd.york.ac.uk/PROSPERO/view/CRD42024598072).</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"380-412"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145504728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of Baseline Pathological, Neuroimaging and Clinical Markers for Prognosis in Early Parkinson's Disease. 基线病理、神经影像学和临床指标在早期帕金森病预后中的应用
IF 2.5 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-01 Epub Date: 2025-11-13 DOI: 10.1177/08919887251397641
Angus McNamara, Benjamin Paul Ellul, Irina Baetu, Mark Jenkinson, Stephan Laurenz, Lyndsey Collins-Praino
{"title":"Utility of Baseline Pathological, Neuroimaging and Clinical Markers for Prognosis in Early Parkinson's Disease.","authors":"Angus McNamara, Benjamin Paul Ellul, Irina Baetu, Mark Jenkinson, Stephan Laurenz, Lyndsey Collins-Praino","doi":"10.1177/08919887251397641","DOIUrl":"10.1177/08919887251397641","url":null,"abstract":"<p><p>BackgroundCurrently, prognosis of Parkinson's Disease (PD) is limited. Emerging literature highlights potential of multi-modal biomarkers and neuroimaging to provide critical insight into clinical progression, potentially improving prediction of long-term outcomes.MethodsData were extracted from the Parkinson's Progression Markers Initiative (PPMI). Hierarchical clustering was applied to Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) scores at year-five follow-up, identifying two clusters. Differences in progression, as well as retrospective assessment of baseline differences, between clusters were explored for pathological biomarkers, neuroimaging, and prodromal measures. Additionally, logistic regression, receiver operating characteristic curve analyses and machine learning were employed to determine utility of variables at baseline as predictors of cluster membership.ResultsThe more impaired cluster demonstrated worse motor and non-motor outcomes, including higher rates of dementia and cognitive complaints at year-five, as well as more profound rigidity than cluster one. Further, retrospective comparisons showed cluster two performing worse in all prodromal measures and demonstrated lower striatal dopamine transporter and cognitive ability. Logistic regression determined that membership in this cluster was predicted by higher autonomic dysfunction and p-tau, along with reduced smell and alpha-syn, predicting 49.1% of variance (AUC = 0.92). This was significantly higher (<i>p</i> < 0.001) than the model including MDS-UPDRS scores alone, only accounting for 27.4% of variance (AUC = 0.74). Findings were corroborated by machine learning, whereby multi-modal assessment corresponded to 74% classification accuracy, compared to 60% with MDS-UPDRS alone.ConclusionPrediction of more marked impairment at year-five was substantially improved via multi-modal assessment, specifically, pathological biomarkers, suggesting that incorporating biomarkers into clinical criteria could enhance long-term prognosis.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"471-487"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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