Journal of Geriatric Psychiatry and Neurology最新文献

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Barriers and Facilitators for the Adaptation and Implementation of Cognitive Stimulation Therapy: A Systematic Review. 认知刺激疗法适应和实施的障碍和促进因素:系统综述。
IF 2.8 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-11-01 Epub Date: 2026-01-09 DOI: 10.1177/08919887261416029
Valentina Herrera Montoya, Raquel Luiza Santos de Carvalho, Elodie Bertrand, Renata Naylor, Aimee Spector, Daniel C Mograbi
{"title":"Barriers and Facilitators for the Adaptation and Implementation of Cognitive Stimulation Therapy: A Systematic Review.","authors":"Valentina Herrera Montoya, Raquel Luiza Santos de Carvalho, Elodie Bertrand, Renata Naylor, Aimee Spector, Daniel C Mograbi","doi":"10.1177/08919887261416029","DOIUrl":"10.1177/08919887261416029","url":null,"abstract":"<p><p>Cognitive Stimulation Therapy is a group-based psychosocial intervention for people living with dementia with a solid evidence base. Although Cognitive Stimulation Therapy provision is expanding, its access remains limited, particularly in low- and middle-income countries. To foster dissemination of this intervention, the purpose of the current article is to conduct a systematic review to identify barriers and facilitators that different countries experienced during the adaptation and/or implementation of Cognitive Stimulation Therapy. This was done to understand both shared and context-specific difficulties during these processes. We followed Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Studies describing cultural adaptation and implementation of Cognitive Stimulation Therapy in different countries were included. The databases used for this research were PubMed, Science Direct and PsycInfo. Social connection, emotional support, and spirituality were key facilitators. Stigma, caregiver burden, and lack of awareness about dementia were significant barriers, highlighting the need for culturally sensitive strategies. Cultural influences across different social contexts were crucial for the adaptation and exploration of the efficacy of the program. Lack of knowledge and stigma about dementia reinforce the importance of implementing and enhancing strategies to increase dementia awareness, subsequently encouraging greater uptake of psychosocial interventions.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"700-714"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145944631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Mobility Loss on Independence and Psychosocial Wellbeing in People With Parkinson's Disease and Carers: A Meta-Ethnography. 活动能力丧失对帕金森病患者及其照护者的独立性和社会心理健康的影响:一项元民族志。
IF 2.8 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-11-01 Epub Date: 2026-01-07 DOI: 10.1177/08919887251414664
Megan Hanrahan, Cameron Wilson, Lynn Rochester, Alison Keogh, Ríona Mc Ardle, Katie Brittain
{"title":"Impact of Mobility Loss on Independence and Psychosocial Wellbeing in People With Parkinson's Disease and Carers: A Meta-Ethnography.","authors":"Megan Hanrahan, Cameron Wilson, Lynn Rochester, Alison Keogh, Ríona Mc Ardle, Katie Brittain","doi":"10.1177/08919887251414664","DOIUrl":"10.1177/08919887251414664","url":null,"abstract":"<p><p>BackgroundMobility impairments in Parkinson's disease (PD) significantly impact individuals' physical health, independence, and psychosocial wellbeing. In this review, mobility loss is used to refer to altered or impaired mobility (eg, reduced gait, balance difficulties, freezing of gait), rather than a complete loss of mobility. These changes affect daily functioning and quality of life. Carers also experience significant burden as they manage mobility issues. Understanding the implications of mobility loss in PD is essential for improving support for both people with PD and carers. This review explores impact of mobility loss on perceived independence and psychosocial wellbeing in people with PD and carers, providing deeper insight into the broader emotional and social consequences of the condition.MethodsA systematic search of six health databases (Medline, Embase, PsycInfo, CINAHL, Scopus, Web of Science) was conducted using key terms related to mobility loss, independence, and psychosocial wellbeing in PD. Studies were included if they employed qualitative methods to explore experiences of mobility from people with PD and/or carers. The methodological quality of studies was assessed using the NICE qualitative checklist, and reporting adhered to PRISMA guidelines. A meta-ethnographic approach was used to extract key themes and construct a comprehensive understanding of the findings.ResultsFive key themes emerged: the struggle for independence and associated self-esteem, navigating personal relationships, perceived stigmatisation and social isolation, resilience and adaptation, and impact of mobility on carer wellbeing.DiscussionFindings highlight the need for comprehensive support systems that address the challenges of mobility loss in PD. Wearable technology presents a promising solution for personalised interventions. Future research should explore diverse populations of people with PD and include formal carers to develop a more holistic perspective of mobility-related challenges in PD caregiving.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"683-699"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Role of Portable Accelerometers for Assessment of Gait Instability in Idiopathic Normal Pressure Hydrocephalus: A Systematic Review. 便携式加速度计在特发性常压脑积水步态不稳定评估中的新作用:系统综述。
IF 2.8 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-11-01 Epub Date: 2026-01-28 DOI: 10.1177/08919887261421222
Ryan J Davis, Emanuella M Brito, Julia L Armstrong, Roberto Martin, Jehan Bista, Bryan A Lieber, Regina M Graham
{"title":"Emerging Role of Portable Accelerometers for Assessment of Gait Instability in Idiopathic Normal Pressure Hydrocephalus: A Systematic Review.","authors":"Ryan J Davis, Emanuella M Brito, Julia L Armstrong, Roberto Martin, Jehan Bista, Bryan A Lieber, Regina M Graham","doi":"10.1177/08919887261421222","DOIUrl":"https://doi.org/10.1177/08919887261421222","url":null,"abstract":"<p><p>BackgroundIdiopathic normal pressure hydrocephalus (iNPH) is a reversible cause of gait disturbance, cognitive decline, and urinary incontinence in older adults. Early detection with shunt surgery can significantly improve symptoms.MethodsA systematic review following PRISMA guidelines evaluated the role of portable and smartphone-based accelerometers in quantifying gait parameters in iNPH.ResultsAcross 32 studies, 22 different accelerometers were used, ranging from wearable inertial sensors to smartphone applications. The Three-Dimensional Pose Tracker for Gait Test (TDPT-GT) app was the most frequently utilized, enabling detection of pathological gait features such as shuffling, short steps, and wide-based walking. The G-Walk device was commonly used in clinical assessments, including before and after CSF tap tests. Several studies integrated accelerometry with machine-learning models, improving differentiation of iNPH from other neurological gait disorders.ConclusionPortable accelerometry offers an accessible, objective tool for diagnosis, monitoring, and prognostication in iNPH, with growing potential for routine clinical integration.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":"39 6","pages":"715-726"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subjective Cognitive Complaints and Somatic Symptoms in Cognitively Healthy Older Adults - Network Analysis Perspective. 认知健康老年人的主观认知主诉和躯体症状——网络分析视角。
IF 2.8 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-11-01 Epub Date: 2026-02-08 DOI: 10.1177/08919887261418713
Simona Krakovská, Petra Brandoburová, Jakub Januška, Anton Heretik, Michal Hajdúk
{"title":"Subjective Cognitive Complaints and Somatic Symptoms in Cognitively Healthy Older Adults - Network Analysis Perspective.","authors":"Simona Krakovská, Petra Brandoburová, Jakub Januška, Anton Heretik, Michal Hajdúk","doi":"10.1177/08919887261418713","DOIUrl":"10.1177/08919887261418713","url":null,"abstract":"<p><p>ObjectiveSubjective cognitive complaints (SCC) are often conceptualized as a risk factor for objective cognitive decline predominantly due to neurodegenerative diseases, however, they can be associated also with other psychiatric or somatic conditions. The study on healthy older adults aims to examine complex associations between SCC, cognitive performance, somatic, and psychiatric symptoms, using network analysis.Method154 participants older than 65 years (mean age 74.47 SD = 6.76, 58% females) were assessed with a comprehensive neuropsychological battery, including self-report measures on SCC, somatic symptoms, symptoms of anxiety, and depression. SCC were measured by the Multifactorial Memory Questionnaire (MMQ). Data were analyzed using a network analysis. Gaussian Graphical Modelling was used for network visualization.ResultsMMQ subscale Ability was negatively associated with cardiopulmonary, gastrointestinal and fatigue symptoms, whereas Satisfaction subscale was associated with pain. All subscales were associated with the measure of anxiety symptoms. Depression was negatively associated with the Satisfaction and Ability scale, the first association being stronger.ConclusionThe study provides novel insights by taking into account different aspects of SCC and analyzing mutual relationships of several variables. SCC formulated as memory failures are associated with higher levels of somatic symptoms. Negative emotions towards the memory are associated with depression symptoms. The explanation behind these complex relationships may include pathophysiological mechanisms. Differentiation between different forms of SCC may help to navigate the further diagnostic procedures in clinical practice.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"671-682"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of Cognitive Reserve Index Questionnaire for Community-Dwelling Older Adults With Cognitive Frailty. 认知储备指数问卷对社区居住老年人认知衰弱的验证。
IF 2.8 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-11-01 Epub Date: 2025-12-24 DOI: 10.1177/08919887251410236
Wanrui Wei, Kairong Wang, Huan Zhang, Shuaifang Wei, Zheng Li
{"title":"Validation of Cognitive Reserve Index Questionnaire for Community-Dwelling Older Adults With Cognitive Frailty.","authors":"Wanrui Wei, Kairong Wang, Huan Zhang, Shuaifang Wei, Zheng Li","doi":"10.1177/08919887251410236","DOIUrl":"10.1177/08919887251410236","url":null,"abstract":"<p><p>ObjectiveCognitive reserve is a resilience construct that mitigates the impact of brain aging and disease on cognition, yet validated instruments remain scarce in older adults with cognitive frailty. This study aimed to translate, culturally adapt, and evaluate the psychometric properties of the Chinese version of the Cognitive Reserve Index questionnaire (C-CRIq) among community-dwelling older adults with cognitive frailty.MethodsA methodological study was conducted. The C-CRIq was translated using a modified Brislin back-translation model, and translation validity was examined. Psychometric testing followed COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN), assessing content validity, convergent validity, known-groups validity, and test-retest reliability. Partial Least Squares regression was applied to confirm the measurement model.ResultsA total of 231 participants with cognitive frailty were recruited. Translation validity index reached 100%. Item-level and scale-level content validity indices were high (0.875-1.00; 0.82; 0.98). Convergent validity exceeded 0.60, known-groups validity demonstrated sex differences, and test-retest reliability was strong (intraclass correlation coefficient = 0.85).ConclusionsThe C-CRIq is a valid, reliable, and feasible instrument for assessing cognitive reserve in older adults with cognitive frailty, supporting neuropsychiatric care, risk stratification, and cross-cultural geriatric research.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"757-768"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145819711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular Medications and Dementia Risk in Older Adults: A Literature Review and Disproportionality Analysis Using OpenVigil FAERS Data. 老年人心血管药物和痴呆风险:文献综述和使用OpenVigil FAERS数据的不均衡分析
IF 2.8 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-11-01 Epub Date: 2026-01-03 DOI: 10.1177/08919887251415199
Jehath Syed, Amruta Potdar, Sri Harsha Chalasani
{"title":"Cardiovascular Medications and Dementia Risk in Older Adults: A Literature Review and Disproportionality Analysis Using OpenVigil FAERS Data.","authors":"Jehath Syed, Amruta Potdar, Sri Harsha Chalasani","doi":"10.1177/08919887251415199","DOIUrl":"10.1177/08919887251415199","url":null,"abstract":"<p><p>BackgroundCardiovascular medications are commonly prescribed to older adults; however, their potential association with cognitive decline remains poorly understood.ObjectiveThis study aimed to systematically evaluate the relationship between cardiovascular drugs and the risk of dementia.Methods(1) A retrospective disproportionality analysis of the FDA Adverse Event Reporting System data, accessed via OpenVigil 2.1, which examined 97 cardiovascular drugs across 14 therapeutic categories in patients aged ≥60 years, and (2) a literature review of case-reports of drug-induced cognitive impairment.ResultsOf the 97 drugs analyzed, disproportionate reporting signals (indicating more frequent reporting than expected by chance) were identified for 38 (39.2%) across four types of dementia: dementia (13.4%), Alzheimer's disease (16.5%), vascular dementia (18.6%), and dementia with Lewy-bodies (6.2%). ACE inhibitors exhibited the highest signal rate (75.0%). Thirteen case-reports were identified, primarily involving statins (53.8%). Discontinuation of the drug resulted in cognitive improvement in 12/13 cases.ConclusionsThis study identifies disproportionate dementia-related adverse event reporting for nearly 40% of cardiovascular drugs examined, with ACE inhibitors and ARBs showing the highest signal rates. However, these findings are preliminary and require validation through future pharmacoepidemiological studies.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"727-738"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing Dementia Care Units: Predictors of Length of Psychiatric Hospitalization for Persons With Dementia and Neuropsychiatric Symptoms. 优化痴呆护理单位:痴呆和神经精神症状患者精神病住院时间的预测因子
IF 2.8 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-11-01 Epub Date: 2026-01-03 DOI: 10.1177/08919887251413787
James M Wilkins, Brent P Forester
{"title":"Optimizing Dementia Care Units: Predictors of Length of Psychiatric Hospitalization for Persons With Dementia and Neuropsychiatric Symptoms.","authors":"James M Wilkins, Brent P Forester","doi":"10.1177/08919887251413787","DOIUrl":"10.1177/08919887251413787","url":null,"abstract":"<p><p>BackgroundDementia care units offer specialized inpatient psychiatric treatment for persons living with dementia (PLWD). Given increasing numbers of PLWD and limited availability of dementia care units, it is crucial to clarify how these units can be used most efficiently.MethodsThe sample included data from 75 unique inpatient psychiatric hospitalizations for PLWD. Data were collected via retrospective chart review. Mixed random and fixed effects longitudinal analyses were run to identify significant predictors of length of psychiatric hospitalization.ResultsPredictors showing significant association included a change in living environment at time of discharge; an ED send out/admission to a general medical hospital; legal pursuits; and diagnostic evaluations pursued during the psychiatric hospitalization.ConclusionsDementia care units are effective in reducing neuropsychiatric symptoms for PLWD. This study highlights avenues for optimization of this care environment to allow for the maximum number of PLWD to receive specialized dementia care treatment.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"748-756"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge and Attitudes Toward Dementia Among Healthcare Professionals in the MENA Region: A Multinational Survey. 中东和北非地区医疗保健专业人员对痴呆症的知识和态度:一项跨国调查。
IF 2.8 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-11-01 Epub Date: 2025-12-30 DOI: 10.1177/08919887251414658
Ahmed Dahshan, Rehab Magdy Hassan, Ebtehal S Doma, Dalia Abdelfatah, Marwa Ibrahim Mahfouz Khalil, Nasiru Mohammed Abdullahi, Taliaa Mohsen Al-Yafeai, Tarek M Selim, Basma Salameh, Ismael Ahmad Khalil Al-Nawaja'a, Nadia Mohamed Ibrahim Wahba, Asmaa Hammooz, Hosny Maher Sultan, Wissam Mohammed Kareem, Walaa Mansour Ahmed, Alaa Hamza Hermis, Mohammed Musaed Al-Jabri, Adam Mahmoud Salameh Khraisat, Nada Ab Hweissa, Abdulrahman AlGhaithi, Eman Tarhuni, Ammar Abdulhamza, Fatima Hallaj, Nawara Khirallah Abd El Fatah Abd El Ghany, Enas Fouad Sayed Mousa, Ola Ezzat Eltohamy Mohamed, Walaa Mowafy Abd El-Halim El-Lawaty, Diana Khedr
{"title":"Knowledge and Attitudes Toward Dementia Among Healthcare Professionals in the MENA Region: A Multinational Survey.","authors":"Ahmed Dahshan, Rehab Magdy Hassan, Ebtehal S Doma, Dalia Abdelfatah, Marwa Ibrahim Mahfouz Khalil, Nasiru Mohammed Abdullahi, Taliaa Mohsen Al-Yafeai, Tarek M Selim, Basma Salameh, Ismael Ahmad Khalil Al-Nawaja'a, Nadia Mohamed Ibrahim Wahba, Asmaa Hammooz, Hosny Maher Sultan, Wissam Mohammed Kareem, Walaa Mansour Ahmed, Alaa Hamza Hermis, Mohammed Musaed Al-Jabri, Adam Mahmoud Salameh Khraisat, Nada Ab Hweissa, Abdulrahman AlGhaithi, Eman Tarhuni, Ammar Abdulhamza, Fatima Hallaj, Nawara Khirallah Abd El Fatah Abd El Ghany, Enas Fouad Sayed Mousa, Ola Ezzat Eltohamy Mohamed, Walaa Mowafy Abd El-Halim El-Lawaty, Diana Khedr","doi":"10.1177/08919887251414658","DOIUrl":"10.1177/08919887251414658","url":null,"abstract":"<p><p>BackgroundDementia is an escalating public health challenge in the MENA region, where primary healthcare professionals' (HCPs) knowledge and preparedness remain underexplored. Understanding their knowledge and attitudes is vital for early diagnosis, quality care, and effective awareness strategies.MethodsWe conducted a cross-sectional study of 1224 HCPs across several Arab countries, primarily in primary care settings. Data were collected via an online survey using two validated instruments: the Dementia Knowledge Assessment Scale (DKAS) and the Dementia Attitudes Scale (DAS).ResultsMost participants demonstrated moderate knowledge (68.5%), while 19.9% demonstrated poor knowledge and 11.5% demonstrated good knowledge. Attitudes were largely neutral to positive (44.1%). Multivariate analysis revealed that higher age predicted better knowledge (OR = 1.04, 95% CI: 1.02-1.06, <i>P</i> < .001), while positive attitudes were significantly associated with older age (OR = 1.02, 95% CI: 1.01-1.04, <i>P</i> = .002), female gender (OR = 1.44, 95% CI: 1.14-1.84, <i>P</i> = .003), and higher knowledge scores (OR = 1.23, 95% CI: 1.17-1.28, <i>P</i> < .001).Conclusionmoderate knowledge and generally positive attitudes, important gaps persist. Tailored education, particularly for younger and male HCPs, is needed to improve dementia literacy and care.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"769-780"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145856883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating Physical Frailty as a Marker of Cognitive Health in Older Adults without Dementia. 评估身体虚弱作为无痴呆老年人认知健康的标志。
IF 2.8 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-11-01 Epub Date: 2026-01-27 DOI: 10.1177/08919887261421225
Youngmin Cho, Jing Huang, Sofia Liu, Nada Lukkahatai, Jessica Gill, Junxin Li
{"title":"Evaluating Physical Frailty as a Marker of Cognitive Health in Older Adults without Dementia.","authors":"Youngmin Cho, Jing Huang, Sofia Liu, Nada Lukkahatai, Jessica Gill, Junxin Li","doi":"10.1177/08919887261421225","DOIUrl":"10.1177/08919887261421225","url":null,"abstract":"<p><p>Physical frailty is associated with adverse health outcomes in older adults, including cognitive decline; however, the underlying biological and pathophysiological mechanisms linking frailty to neuropathological biomarkers remain underexplored, particularly in older adults without dementia. This study examined associations between physical frailty and cognitive performance and biomarkers based on the amyloid, tau, and neurodegeneration (ATN) framework in a sample of community-dwelling older adults without dementia. Using baseline data from a randomized controlled trial, we conducted a secondary cross-sectional analysis of 137 sedentary adults aged 60-85 years with insomnia symptoms and Montreal Cognitive Assessment scores above 17. Frailty was measured using the Johns Hopkins Frailty Assessment Tool. Cognitive performance was assessed with the CogState computerized battery, and plasma biomarkers-including amyloid beta 42/40 ratio (Aβ42/Aβ40), total tau (t-tau), and neurofilament light chain (NfL)-were quantified using Single Molecule Array (Simoa) technology in a subsample (n = 98). In adjusted models, frail participants demonstrated significantly lower global cognition, processing speed, and attention compared to robust individuals. Prefrail participants did not show significant differences in cognitive performance. For biomarkers, prefrail individuals had significantly lower Aβ42/Aβ40 ratios in unadjusted models, and frail individuals showed significantly higher NfL levels in adjusted models. No significant associations were found for t-tau. These findings suggest that physical frailty is linked to both cognitive impairment and early neurobiological changes in older adults without dementia. Incorporating frailty assessments alongside biomarker evaluation may enhance early detection of Alzheimer's-related changes and guide timely interventions to mitigate cognitive decline.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"739-747"},"PeriodicalIF":2.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146064292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating a Two-Step Approach: Combining Brief Risk Indicators and Short Cognitive Assessments for Improving Early Detection of Cognitive Impairment. 评估两步方法:结合简短的风险指标和简短的认知评估以提高认知障碍的早期发现。
IF 2.8 4区 医学
Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-10-19 DOI: 10.1177/08919887261498437
Hanna K Hausman, Samantha M Roop, Jeremy J Davis, Jeffrey N Keller, Robin C Hilsabeck
{"title":"Evaluating a Two-Step Approach: Combining Brief Risk Indicators and Short Cognitive Assessments for Improving Early Detection of Cognitive Impairment.","authors":"Hanna K Hausman, Samantha M Roop, Jeremy J Davis, Jeffrey N Keller, Robin C Hilsabeck","doi":"10.1177/08919887261498437","DOIUrl":"https://doi.org/10.1177/08919887261498437","url":null,"abstract":"<p><p>BackgroundScalable approaches for early detection of cognitive impairment are urgently needed. A two-step screening approach, in which short cognitive assessments are administered only to individuals at risk, offers an efficient alternative to universal screening. This study evaluated combinations of brief self-report risk indicators and short cognitive assessments to identify models that accurately classify cognitive impairment.MethodsParticipants aged 60+ from dementia specialty settings were classified as cognitively normal (CN; n = 87) or cognitively impaired (CI; n = 66). All completed three risk indicators, a modified self-report Brief Dementia Screening Indicator (BDSI), self-report of personal memory concerns, self-report of memory concerns expressed by others (other concern), and two short cognitive assessments (Quick Mild Cognitive Impairment screen [Qmci] and Speeded Matching [SM]). Logistic regressions using continuous variables and composite binary predictors predicted cognitive status.ResultsModels significantly predicted cognitive status (<i>P</i> < .001; AUCs = 0.84-0.91 for continuous models and 0.59-0.79 for composite models). Among risk indicators, the BDSI was least informative, while other concern was the strongest predictor. Qmci and SM performed comparably as continuous variables. The best-performing composite predictor derived from other concern and Qmci yielded OR = 28.70 (<i>P</i> < .001), sensitivity = 63.6%, specificity = 94.3%.ConclusionA two-step approach using brief self-report risk indicators and short cognitive assessments shows promise for efficient detection of cognitive impairment, providing initial validation in dementia specialty settings to support evaluation in primary care.</p>","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261498437"},"PeriodicalIF":2.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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