Journal of Geriatric Psychiatry and Neurology最新文献_第2页

Can Cognitive Reserve Moderate the Association Between Brain Structure and Later-Life Behavioural Symptoms? 认知储备能调节脑结构与晚年行为症状的关系吗？

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-09-23 DOI: 10.1177/08919887261491948

Gurshaan Sidhu, Dylan X Guan, Maryam Ghahremani, Eric E Smith, Zahinoor Ismail

{"title":"Can Cognitive Reserve Moderate the Association Between Brain Structure and Later-Life Behavioural Symptoms?","authors":"Gurshaan Sidhu, Dylan X Guan, Maryam Ghahremani, Eric E Smith, Zahinoor Ismail","doi":"10.1177/08919887261491948","DOIUrl":"https://doi.org/10.1177/08919887261491948","url":null,"abstract":"IntroductionCognitive reserve (CR) buffers against cognitive manifestations of neurodegenerative disease; little is known about CR and neuropsychiatric symptoms (NPS). We investigated CR moderation on the relationship between AD-related cortical changes and NPS.MethodsCross-sectional data from 455 participants in COMPASS-ND were analyzed. CR score (CRS) was operationalized from education, occupation, and mentally stimulating activities; NPS were assessed using the Mild Behavioral Impairment Checklist. Logistic regression modelled the relationship between hippocampal volume/entorhinal thickness and NPS. A volume/thickness*CRS interaction term was included to assess effect modification. All models adjusted for age, sex, and cognition.ResultsCR moderated the relationship between hippocampal volume and NPS (B = -3.39, 95% CI: [-6.04, -0.84], P = .01), with greater impact at lower CR. A weaker but non-significant interaction effect was observed with lower entorhinal thickness.DiscussionGreater CR may mitigate NPS associated with lower hippocampal volume, independent of cognition, suggesting CR may preserve cognition and behaviour.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261491948"},"PeriodicalIF":2.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149030727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Value of Abnormal Expression of miR-378a-3p in Elderly Stroke Patients for Cognitive Impairment After Stroke. miR-378a-3p在老年脑卒中患者中的异常表达对脑卒中后认知功能障碍的预测价值

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-09-10 DOI: 10.1177/08919887261487671

Yan Xiao, Lei Yang, Xiuyuan Zhao, Haining Zhen, Xiaoquan Li

{"title":"Predictive Value of Abnormal Expression of miR-378a-3p in Elderly Stroke Patients for Cognitive Impairment After Stroke.","authors":"Yan Xiao, Lei Yang, Xiuyuan Zhao, Haining Zhen, Xiaoquan Li","doi":"10.1177/08919887261487671","DOIUrl":"https://doi.org/10.1177/08919887261487671","url":null,"abstract":"BackgroundPost-stroke cognitive impairment (PSCI) plays an important role in recovery and quality of life in elderly stroke patients. MicroRNAs play critical roles in the pathophysiology of PSCI.PurposeThe expression of miR-378a-3p in elderly stroke patients and its potential as a predictive biomarker for PSCI was explored.MethodsSerum samples from elderly stroke patients were collected for RT-qPCR analysis to evaluate miR-378a-3p. The Montreal Cognitive Assessment (MoCA) was performed to assess cognitive function. An oxygen-glucose deprivation (OGD) model with HT22 neuronal cells was employed to simulate ischemic injury in vitro. Functional assays, including dual-luciferase reporter assays, evaluated the direct targeting of TLR8 by miR-378a-3p. Cell viability was measured after modulation of miR-378a-3p and TLR8 expression to elucidate their roles.ResultsThe downregulation of miR-378a-3p in stroke (n = 82) compared to controls (n = 50) was observed, as well as in PSCI patients (n = 40) compared with that in post-stroke cognitively normal (n = 42). ROC curve analysis identified the potential of miR-378a-3p as a diagnostic biomarker for stroke and PSCI, yielding an area under the ROC curve (AUC) of 0.9039 (sensitivity: 89.02%; specificity: 72.00%). It was correlated positively with MoCA scores. ROC curve analysis resulted in an AUC of 0.8092 (sensitivity: 52.50%; specificity: 95.24%) for miR-378a-3p in predicting PSCI. miR-378a-3p had potential to predict PSCI occurrence. Luciferase assays confirmed direct binding between miR-378a-3p and TLR8. Overexpressing miR-378a-3p enhanced cell survival under OGD conditions, which was reversed by overexpressing TLR8.ConclusionReduced circulating miR-378a-3p associated with cognitive decline post-stroke, by negatively regulating TLR8.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261487671"},"PeriodicalIF":2.8,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148919897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dementia Carers' Perspectives on Paper- and Artificial Intelligence (AI)-Based Assessment Tools: A Qualitative Think-Aloud Study Using the COM-B Framework. 痴呆症护理人员对基于纸张和人工智能（AI）的评估工具的看法：使用COM-B框架的定性有声思考研究。

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-09-06 DOI: 10.1177/08919887261486060

Labhpreet Kaur, Alys Wyn Griffiths, Louis Stokes, Judith Harrison, Xingyi Song, Daniel Blackburn

{"title":"Dementia Carers' Perspectives on Paper- and Artificial Intelligence (AI)-Based Assessment Tools: A Qualitative Think-Aloud Study Using the COM-B Framework.","authors":"Labhpreet Kaur, Alys Wyn Griffiths, Louis Stokes, Judith Harrison, Xingyi Song, Daniel Blackburn","doi":"10.1177/08919887261486060","DOIUrl":"https://doi.org/10.1177/08919887261486060","url":null,"abstract":"ObjectivesCarer observations provide valuable longitudinal and contextual information for dementia assessment, but traditional informant-based questionnaires may limit reporting of nuanced, fluctuating changes. Artificial intelligence (AI)-based tools may offer greater flexibility to report, but their successful uptake depends on carer capability and acceptability. Despite this, little is understood about carers' views on existing informant questionnaires and emerging AI-based tools, therefore, this study explored carers' perspectives on barriers and facilitators influencing engagement with paper- and AI-based assessment tools.MethodsTen carers of people living with dementia completed think-aloud interviews, while reviewing the Cambridge Behavioural Inventory-Revised (CBI-R) and two AI-based tools, CognoSpeak™ and LUMEN (Language Usage for Monitoring Early Neurodegeneration). Using a hybrid inductive-deductive approach, themes related to barriers and facilitators to engagement were identified and subsequently mapped onto the Capability, Opportunity and Motivation-Behaviour (COM-B) framework.ResultsCarers valued the CBI-R's simplicity and breadth but found its structure, complex language and limited free-text space restrictive. Verbal, narrative responses felt more natural and less burdensome, therefore, AI-based tools were seen as more engaging and better able to collect richer narratives, with the added advantage of remote access, however, digital literacy, sensory impairments, privacy concerns could limit uptake. Participants stressed that AI should support, not replace, human-led care.ConclusionEngagement depended on individual capabilities, available opportunities and motivation; factors fundamental to successful uptake. Future tools should be co-designed to ensure accessibility, cultural sensitivity and clinical relevance.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261486060"},"PeriodicalIF":2.8,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mini-Mental State Examination Scores in Dementia and Capacity Assessment: A Narrative Review. 痴呆和能力评估的迷你精神状态考试分数：叙述性回顾。

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-09-04 DOI: 10.1177/08919887261486064

Nahum Rosenberg

{"title":"Mini-Mental State Examination Scores in Dementia and Capacity Assessment: A Narrative Review.","authors":"Nahum Rosenberg","doi":"10.1177/08919887261486064","DOIUrl":"https://doi.org/10.1177/08919887261486064","url":null,"abstract":"BackgroundThe Mini-Mental State Examination (MMSE) is widely used in older adults, but its numerical score is sometimes overinterpreted in dementia diagnosis and capacity assessment.This review examined the hypothesis that the MMSE provides screening information but cannot diagnose dementia or determine decision-specific capacity.MethodsThis narrative review synthesized PubMed-indexed evidence concerning diagnostic accuracy, dementia criteria, alternative screens, and cultural, literacy, sensory, and capacity-related influences.ResultsMMSE performance modifies diagnostic probability but does not establish a diagnosis of dementia. Accuracy varies with threshold, setting, education, language, culture, clinical stage, sensory status, and prevalence. Alternative screens sample cognition differently but require contextual interpretation. Patient agreement, voluntary participation, and standardized administration are necessary; sensory barriers or incomplete testing may render a score uninterpretable. Capacity assessment requires evaluation of understanding, appreciation, reasoning, choice, consequences, and context.ConclusionsMMSE findings should be integrated with clinical, functional, sensory, collateral, and decision-specific evidence, not used alone.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261486064"},"PeriodicalIF":2.8,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise-Induced Changes in Brain-Derived Neurotrophic Factor in Neurodegenerative Diseases: A Bayesian Network Meta-Analysis. 运动诱导的脑源性神经营养因子在神经退行性疾病中的变化：贝叶斯网络meta分析

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-09-01 Epub Date: 2025-12-20 DOI: 10.1177/08919887251409415

Zhuolin Tang, Mingyue Yin, Kai Xu, Huakun Zheng, Henghao Yan, Zexi Zhao, Qian Liu

{"title":"Exercise-Induced Changes in Brain-Derived Neurotrophic Factor in Neurodegenerative Diseases: A Bayesian Network Meta-Analysis.","authors":"Zhuolin Tang, Mingyue Yin, Kai Xu, Huakun Zheng, Henghao Yan, Zexi Zhao, Qian Liu","doi":"10.1177/08919887251409415","DOIUrl":"10.1177/08919887251409415","url":null,"abstract":"ObjectivesThis study aimed to compare the effects of different exercise interventions on brain-derived neurotrophic factor (BDNF) levels in patients with neurodegenerative diseases and to explore regulatory factors.MethodsSearched PubMed, Scopus, Web of Science Core Collection, CNKI and Cochrane Library databases up to March 15, 2025. Bayesian network meta-analysis was conducted using R software, and meta-regression analyzed the moderating effects of training period and frequency.Results42 randomized controlled trials covering 1482 patients were included. The Surface Under the Cumulative Ranking (SUCRA) indicated that stretching training (SUCRA = 78.92) and high-intensity interval training (SUCRA = 69.73) were ranked higher than other exercise modalities and exhibited more favorable effect on BDNF enhancement, although neither demonstrated statistically significant superiority over the blank control. In contrast, combined training (SUCRA = 35.58), aerobic training (SUCRA = 35.17), and resistance training (SUCRA = 12.98) showed relatively lower potential for BDNF enhancement (blank control SUCRA = 67.62). Meta-regression analysis showed that the effect of combined training was significantly and positively correlated with intervention period (P < 0.01).ConclusionsStretching training and high-intensity interval training appear promising for enhancing BDNF level in neurodegenerative diseases, while isolated aerobic or resistance training show relatively lower potential on improving BDNF. Combined training requires sustained implementation for significant benefits. These findings highlight the importance of tailored exercise prescription for improving BDNF levels.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"567-588"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145794066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinician and Client Reports of the Negative Effects of Neuropsychological Assessment for Dementia. 痴呆神经心理评估的负面影响的临床医生和客户报告。

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-09-01 Epub Date: 2025-12-26 DOI: 10.1177/08919887251407122

Nikki Miller, David J Grinter, David McGraw, Rachel Pritchett, Hamish J McLeod

{"title":"Clinician and Client Reports of the Negative Effects of Neuropsychological Assessment for Dementia.","authors":"Nikki Miller, David J Grinter, David McGraw, Rachel Pritchett, Hamish J McLeod","doi":"10.1177/08919887251407122","DOIUrl":"10.1177/08919887251407122","url":null,"abstract":"ObjectiveNeuropsychological assessment (NPA) is recommended to support differential diagnosis of dementia but little is known about its impact on clients and their experience of negative effects. This study investigated clinicians' understanding of their clients' negative experiences and explored similarities in clinician and client reports.MethodA mixed-methods approach was employed using qualitative and quantitative data. Semi-structured interviews with clinicians, and a questionnaire for clinicians and clients were collected from NHS settings across Scotland. Reflexive Thematic Analysis was used to analyse 11 clinician interviews. Descriptive statistics were reported for the 25 clinician and 12 client questionnaires and exploratory analysis investigated associations between clinician and clients reporting of negative experiences.ResultsIn the qualitative analysis, three overarching themes and 13 sub-themes were identified. The over-arching themes were: assessment can produce negative impacts for clients, indirect factors can produce harmful effects, and clinicians can take action to reduce adverse effects of NPA. For the questionnaire responses, the most endorsed negative effects were the same for clients and clinicians and included feeling stressed, worried, disappointed with their performance in assessment, frustrated, critical of themselves and worried about the outcome.ConclusionThese data provide some of the first clear empirical descriptions of the negative effects of NPA as reported by both clinicians and clients. The study also identified challenges with recruiting clients who are willing to give feedback on their experience of assessment. Future studies are needed to refine the available data capture methods and to determine if the current results are replicable.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"638-654"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upper Limb Exercises Reduce Non-motor Symptoms and Increase Cognitive Function in Parkinson's Disease: Randomized Controlled Trial. 上肢运动可减少帕金森病的非运动症状并增加认知功能：随机对照试验

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-09-01 Epub Date: 2025-12-26 DOI: 10.1177/08919887251409414

Valton Costa, Maryela Menacho, Thalita Frigo da Rocha, Felipe Fregni, Larissa Pires de Andrade, Anna Carolyna Gianlorenço

{"title":"Upper Limb Exercises Reduce Non-motor Symptoms and Increase Cognitive Function in Parkinson's Disease: Randomized Controlled Trial.","authors":"Valton Costa, Maryela Menacho, Thalita Frigo da Rocha, Felipe Fregni, Larissa Pires de Andrade, Anna Carolyna Gianlorenço","doi":"10.1177/08919887251409414","DOIUrl":"10.1177/08919887251409414","url":null,"abstract":"BackgroundPhysical exercise is a promising approach to address non-motor symptoms (NMS) in Parkinson's disease (PD), although the most effective modalities remain under investigation.ObjectiveTo compare the effects of three upper limb (UL) exercise modalities-resistance training (RES), aerobic exercise (AER), and task-specific training (TST)-on NMS in PD.MethodsThirty-seven community-dwelling individuals with PD (mean age = 62 ± 10 years; mean diagnosis duration = 7 ± 5 years; mean Hoehn & Yahr stage = 2 ± 0.4) were randomized into three intervention groups (RES, AER, TST) and a usual care control group. Interventions were performed three times per week, 40-50 minutes per session, over 8 weeks. Clinical outcomes included overall NMS (Movement Disorder Society-Unified Parkinson's Disease Rating Scale Part I, MDS-UPDRS I), global and domain-specific cognition (Mini-Mental State Examination [MMSE], Addenbrooke's Cognitive Examination-Revised [ACE-R], Trail Making Test), depression (Geriatric Depression Scale [GDS]), and anxiety (Beck Anxiety Inventory [BAI]). Intervention effects were analyzed using mixed-effects models and non-parametric factorial analyses.ResultsBetween-group analyses showed that UL exercises similarly reduced overall NMS severity and cognitive dysfunction, while maintaining baseline fatigue levels, in contrast to deterioration in the CON. RES and TST reduced anxiety (BAI), and RES also reduced apathy. Within-group improvements in cognitive domains, depression, hallucinations, and sleep problems were observed in the RES and TST groups.ConclusionsThis is the first study to demonstrate that isolated UL exercise modalities exert clinically relevant effects on NMS in PD. These modalities may be valuable additions to multidimensional rehabilitation strategies in PD care. [Brazilian Registry of Clinical Trials: RBR-7zjgnrx].","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"624-637"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients With Older-Age Bipolar Disorder (OABD) Visiting a Memory Clinic: Differentiating Underlying Pathophysiology With MRI and Cerebrospinal Fluid Markers. 老年双相情感障碍（OABD）患者访问记忆诊所：用MRI和脑脊液标志物区分潜在病理生理

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-09-01 Epub Date: 2025-12-06 DOI: 10.1177/08919887251407125

Alexandra J M Beunders, Everard G B Vijverberg, Charlotte E Teunissen, Sigfried N T M Schouws, Ralph W Kupka, Afina W Lemstra, Annemieke Dols

{"title":"Patients With Older-Age Bipolar Disorder (OABD) Visiting a Memory Clinic: Differentiating Underlying Pathophysiology With MRI and Cerebrospinal Fluid Markers.","authors":"Alexandra J M Beunders, Everard G B Vijverberg, Charlotte E Teunissen, Sigfried N T M Schouws, Ralph W Kupka, Afina W Lemstra, Annemieke Dols","doi":"10.1177/08919887251407125","DOIUrl":"10.1177/08919887251407125","url":null,"abstract":"BackgroundMany patients with bipolar disorder (BD) report cognitive problems. Pathophysiology of cognitive impairment in BD is unclear, although prevalence of dementia in BD is high. In Older-Age Bipolar Disorder (OABD) patients with cognitive complaints, neurodegeneration may play a role. This could occur in at least 2 ways: (1) BD with 'comorbid' diagnosis of dementia; (2) specific neurobiological processes can underlie a cognitive impairment that is intrinsic of BD (ie, BD-related cognitive impairment).Methods102 OABD patients were selected from the Amsterdam Dementia Cohort study. Diagnostic workup included clinical and neuropsychological assessment, CSF biomarkers and MRI visual rating scales. About half of patients had depressive symptoms. We (1) examined which neurological diagnoses were identified by the memory clinic as the main cause of cognitive complaints. Subsequently, (2) in the remaining OABD patients with an unknown cause, we performed linear regression between biomarkers of neurodegeneration and composite cognitive score.Results29 OABD patients (28.4%) received a neurological diagnosis, 6 of which Alzheimer's Disease. In the remaining 73 (71.6%) OABD patients, a lower Aβ42 CSF concentration was related to lower composite cognitive scores (B = -0.143, P = 0.034), whereas CSF T-Tau, P-Tau, and MRI markers were not.ConclusionIn most OABD patients visiting a memory clinic, a neurological cause of cognitive complaints was not identified despite extensive diagnostic work-up. Altered amyloid metabolism may be an extra biological factor in the multifactorial puzzle that is BD-related cognitive impairment. Future studies should investigate a large range of biomarkers in relation to cognition in BD, including amyloid.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"655-666"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential changes of Social Cognition According to cognitive State and Evolution in Parkinson's Disease. 帕金森病患者认知状态与进化的社会认知差异变化

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-09-01 Epub Date: 2025-12-07 DOI: 10.1177/08919887251407123

Roberto Fernández-Fernández, Clara Trompeta, Beatriz Fernández-Rodríguez, Pasqualina Guida, Guillermo Lahera, Carmen Gasca-Salas

{"title":"Differential changes of Social Cognition According to cognitive State and Evolution in Parkinson's Disease.","authors":"Roberto Fernández-Fernández, Clara Trompeta, Beatriz Fernández-Rodríguez, Pasqualina Guida, Guillermo Lahera, Carmen Gasca-Salas","doi":"10.1177/08919887251407123","DOIUrl":"10.1177/08919887251407123","url":null,"abstract":"ObjectivesSocial Cognition (SC) can be impaired in Parkinson's Disease (PD), yet its longitudinal evolution relative to cognitive status is unclear. This study examined whether SC deficits in PD patients suffers different changes based on baseline cognitive status and cognitive progression.MethodsIn this observational study 48 non-demented PD patients (32 with normal cognition [PD-CN], 16 with mild cognitive impairment [PD-MCI]), and 22 healthy controls (HC) were assessed at baseline and after three years. SC was assessed for facial emotion recognition (FER), affective and cognitive Theory of Mind (ToM), and social behavior. A comprehensive neuropsychological battery provided domain-specific z-scores. Cognitive classification followed MDS Level II criteria. Adjusted linear mixed models examined SC changes. Delta scores for SC tasks and z-score changes were correlated.ResultsAt baseline, PD-MCI patients scored lower on cognitive ToM than PD-CN and HC, with no significant group differences in affective ToM, FER, or social behavior. Over three years, PD-MCI patients experienced a significant decline in cognitive ToM compared to PD-CN and HC, while affective ToM and emotion recognition declined only relative to HC. The converters (n = 16) to a worse cognitive state (PD-CN to PD-MCI or PD-MCI to PDD) showed lower baseline cognitive ToM and steeper decline than stable patients. All SC changes correlated with visuospatial ability; affective ToM also correlated with memory, language and attention, and FER with memory and executive function.ConclusionsCognitive ToM declines in parallel with cognitive deterioration in PD, while remaining stable in PD-CN. SC measures may help identify patients at higher risk of cognitive decline.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"602-612"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement Properties of the Brazilian Portuguese Version of the PDAQ-15. 巴西葡萄牙语版PDAQ-15的测量特性。

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-09-01 Epub Date: 2025-12-22 DOI: 10.1177/08919887251408854

Núbia Isabela Macêdo Martins, Rodrigo Oliveira Mazza, Ana Elisa Lemos Silva, Daniel Weintraub, Vera Lúcia Santos de Britto, Clynton Lourenço Correa

{"title":"Measurement Properties of the Brazilian Portuguese Version of the PDAQ-15.","authors":"Núbia Isabela Macêdo Martins, Rodrigo Oliveira Mazza, Ana Elisa Lemos Silva, Daniel Weintraub, Vera Lúcia Santos de Britto, Clynton Lourenço Correa","doi":"10.1177/08919887251408854","DOIUrl":"10.1177/08919887251408854","url":null,"abstract":"BackgroundThe Penn Parkinson's Daily Activities Questionnaire (PDAQ-15) assesses the difficulty in performing cognitive instrumental activities of daily living (IADL) in people with Parkinson's disease (PD).ObjectivesTo translate, cross-culturally adapt and investigate measurement properties of the Brazilian version of the PDAQ-15 Knowledgeable Informant (KI) and Patient (PT).MethodsFollowing the translation, cross-cultural adaptation, face and content validity analyses; floor and ceiling effects, reliability (test-retest, inter-rater, internal consistency) and validity (convergent, divergent, discriminant) were evaluated in 50 persons with PD and their KI. The KI and Patient PDAQ-15 were rater-administered.ResultsThe translated and adapted KI and PT PDAQ-15 did not show floor or ceiling effects. They had appropriate internal consistency (PT = 0.825; KI = 0.923), excellent test-retest (PT = 0.97; KI = 0.99) and interrater reliability (PT = 0.92; KI = 0.99). PT and KI agreement was moderate, ICC = 0.58. The correlations with the Scales for Outcomes of Parkinson's disease - Cognition were: PT (rho = 0.50), KI (rho = 0.67); with the Direct Assessment of Functional Status: PT (rho = 0.66), KI (rho = 0.80); with Unified Parkinson's Disease Rating Scale (UPDRS) Part II: PT (rho = -0.29), KI (rho = -0.30), all P < 0.05; and with UPDRS part III: PT (rho = -0.27), KI (rho = -0.27), P > 0.05. PT and KI PDAQ-15 discriminated between the mild and moderate/severe stages of the Hoehn & Yahr Scale (P = 0.03).ConclusionThe two Brazilian versions of the PDAQ-15 have acceptable measurement properties for assessing the cognitive IADL of persons with PD. For those with suspected or diagnosed cognitive impairment, the application of both versions is suggested.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"613-623"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0