Journal of Geriatric Psychiatry and Neurology最新文献_第3页

Efficacy of Brexpiprazole on Neuropsychiatric Symptoms and Impact on Caregivers: Pooled Neuropsychiatric Inventory (NPI) Analysis in Patients With Agitation Associated With Dementia due to Alzheimer's Disease. Brexpiprazole对阿尔茨海默病痴呆相关躁动患者神经精神症状的疗效及对护理人员的影响

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-09-01 Epub Date: 2025-12-24 DOI: 10.1177/08919887251407124

George T Grossberg, Marwan N Sabbagh, Sanjeda R Chumki, David Wang, Pedro Such, Zhen Zhang, Anton M Palma, Jeffrey L Cummings

{"title":"Efficacy of Brexpiprazole on Neuropsychiatric Symptoms and Impact on Caregivers: Pooled Neuropsychiatric Inventory (NPI) Analysis in Patients With Agitation Associated With Dementia due to Alzheimer's Disease.","authors":"George T Grossberg, Marwan N Sabbagh, Sanjeda R Chumki, David Wang, Pedro Such, Zhen Zhang, Anton M Palma, Jeffrey L Cummings","doi":"10.1177/08919887251407124","DOIUrl":"10.1177/08919887251407124","url":null,"abstract":"PurposeAgitation is a neuropsychiatric symptom commonly observed in Alzheimer's dementia, which causes substantial burden for patients and caregivers. In this exploratory analysis, Neuropsychiatric Inventory (NPI) data were pooled from two randomized, double-blind, fixed-dose, placebo-controlled trials of brexpiprazole in agitation associated with dementia due to Alzheimer's disease. The analysis explored the efficacy of brexpiprazole on agitation and other neuropsychiatric symptoms, including their impact on caregivers.Major FindingsBrexpiprazole 2 or 3 mg/day (N = 368) showed greater improvement vs placebo (N = 253) from baseline in NPI agitation/aggression domain score (Week 6 onwards), and in the associated occupational disruptiveness/caregiver distress score (Week 4 onwards). Improvements with brexpiprazole vs placebo also occurred on other NPI and occupational disruptiveness/caregiver distress scores, including irritability/lability, aberrant motor behavior, and anxiety.ConclusionsOver 12 weeks, brexpiprazole was associated with greater improvements vs placebo in agitation/aggression and other neuropsychiatric symptoms, and in associated caregiver disruption/distress. ClinicalTrials.gov identifiers: NCT01862640; NCT03548584.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"589-601"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145819736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Possible Impact of Montelukast in Parkinson's Disease: A Substantial Contribution. 孟鲁司特对帕金森病的可能影响：重大贡献。

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-09-01 Epub Date: 2026-01-13 DOI: 10.1177/08919887251409836

Areej Turkistani, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Duaa Eliwa, Athanasios Alexiou, Hala Alnoaman, Marios Papadakis, Gaber El-Saber Batiha

{"title":"The Possible Impact of Montelukast in Parkinson's Disease: A Substantial Contribution.","authors":"Areej Turkistani, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Duaa Eliwa, Athanasios Alexiou, Hala Alnoaman, Marios Papadakis, Gaber El-Saber Batiha","doi":"10.1177/08919887251409836","DOIUrl":"10.1177/08919887251409836","url":null,"abstract":"Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by α-synuclein aggregation and dopaminergic neuron degeneration in the substantia nigra. Evidence suggests that the leukotriene (LT) pathway contributes to PD progression through oxidative stress and neuroinflammatory mechanisms. Purpose: To evaluate the efficacy and neuroprotective potential of the leukotriene receptor antagonist montelukast in the management of PD. Research Design: A narrative review synthesizing evidence from preclinical and clinical studies investigating the effects of montelukast on PD-related neuropathology. Study Sample: Studies indexed in Scopus, Cochrane, Embase, PubMed, and CENTRAL that examined the role of montelukast in PD models or populations. Data Collection and/or Analysis: Two independent reviewers conducted database searches, screened studies for relevance, and extracted data on montelukast's effects on neuroinflammation, oxidative stress, mitochondrial function, and autophagy. Results: The reviewed evidence indicates that montelukast exhibits neuroprotective activities, including attenuation of neuroinflammation, reduction of oxidative stress, improvement of mitochondrial dysfunction, and enhancement of autophagic processes. These mechanisms collectively contribute to slowing the onset and progression of PD-related neuropathology. Conclusions: Montelukast may offer therapeutic benefits in PD by modulating key pathological processes such as inflammatory signaling, oxidative damage, mitochondrial impairment, and autophagy dysregulation. Further clinical studies are warranted to validate its potential as an adjunct or novel therapeutic option.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"551-566"},"PeriodicalIF":2.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Practice and Long-Term Developments in Multidisciplinary Dutch Memory Clinics. 多学科荷兰记忆诊所的当前实践和长期发展。

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-08-16 DOI: 10.1177/08919887261478290

Stephan Duijkers, Daphne B G Ter Huurne, Marco Blom, Hanna E Bodde, Jolanda H M Dobbe, Wiesje Van der Flier, Willemijn J Jansen, Marcel Olde Rikkert, Janne M Papma, Frans R J Verhey, Inez H G B Ramakers

{"title":"Current Practice and Long-Term Developments in Multidisciplinary Dutch Memory Clinics.","authors":"Stephan Duijkers, Daphne B G Ter Huurne, Marco Blom, Hanna E Bodde, Jolanda H M Dobbe, Wiesje Van der Flier, Willemijn J Jansen, Marcel Olde Rikkert, Janne M Papma, Frans R J Verhey, Inez H G B Ramakers","doi":"10.1177/08919887261478290","DOIUrl":"https://doi.org/10.1177/08919887261478290","url":null,"abstract":"ObjectivesMemory Clinics (MCs) have a central role in multidisciplinary diagnostics and care of cognitive disorders and dementia. This study describes current clinical practice and developments of Dutch MCs since their start in 1986.MethodsA survey was sent to all Dutch hospital-based MCs in 1998, 2004, 2009, 2017 and 2023. Topics included: organization, patient characteristics, scales and questionnaires, neuropsychological assessment, additional assessments, novel biomarkers, disclosure of diagnosis and treatment. 74 out of the total of 89 MCs completely or partially filled out the questionnaire.ResultsThe number of MCs increased to 89. The number of patients seen increased substantially (per MC/year: 1998: 130; 2023: 324; total: 1998: 1560; 2023: 28,848). The proportion of patients diagnosed with dementia decreased from 80% in 1998 to 47% in 2023. Most commonly available assessments were neuroimaging (100%), routine laboratory testing of blood (98%) and neuropsychological assessment (NPA; 98%). Thirty-one percent indicated infrastructure needed to be changed before prescribing monoclonal antibody treatments for Alzheimer's disease.ConclusionsMCs showed substantial development in number, number of patients and geographical distribution within the country. Nowadays, MCs are central care facilities for the timely and multidisciplinary diagnosis and treatment of people with cognitive disorders and dementia.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261478290"},"PeriodicalIF":2.8,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma Biomarkers and Clinical Indicators for Identifying Mild Cognitive Impairment in Older Adults With Psychiatric Disorders. 老年精神障碍患者轻度认知障碍的血浆生物标志物和临床指标

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-08-12 DOI: 10.1177/08919887261477071

Camilla Elefante, Maria Francesca Beatino, Daniela Marro, Andrea Coccoglioniti, Cosimo Lazzerini, Andrea Pacini, Ani Gasparyan, Esther Caparrós, Lucia Petrozzi, Gabriele Siciliano, Zahinoor Ismail, Lorenzo Lattanzi, Filippo Baldacci, Roberto Ceravolo, Giulio Perugi

{"title":"Plasma Biomarkers and Clinical Indicators for Identifying Mild Cognitive Impairment in Older Adults With Psychiatric Disorders.","authors":"Camilla Elefante, Maria Francesca Beatino, Daniela Marro, Andrea Coccoglioniti, Cosimo Lazzerini, Andrea Pacini, Ani Gasparyan, Esther Caparrós, Lucia Petrozzi, Gabriele Siciliano, Zahinoor Ismail, Lorenzo Lattanzi, Filippo Baldacci, Roberto Ceravolo, Giulio Perugi","doi":"10.1177/08919887261477071","DOIUrl":"10.1177/08919887261477071","url":null,"abstract":"BackgroundMild Cognitive Impairment (MCI) and Mild Behavioral Impairment (MBI) can be prodromal stages of neurodegenerative disease associated with plasma biomarkers of tau pathology and neuroaxonal damage. However, in psychiatric populations, the relationship between MCI, MBI and these plasma biomarkers remains unclear.ObjectiveThis study examined the association of MCI with plasma biomarkers of neurodegeneration (phosphorylated tau217 [p-tau217] and neurofilament light chain [NfL]), metabolic alterations, psychiatric disorder features, and MBI in older adults receiving psychiatric treatment.MethodsFifty-one non-demented patients ≥60 years, referred for mood or anxiety disorders, were enrolled and classified based on cognitive performance as MCI (n = 20) or non-MCI (n = 31). Assessments included psychiatric, cognitive, functional, and plasma biomarker measures.ResultsMCI patients exhibited higher p-tau217 (P = .003) and NfL (P = .042) levels, lower cognitive scores (P < .001), and a trend toward reduced functioning (P = .074). MCI was also associated with later onset of psychiatric symptoms (P = .033) and greater prevalence of MBI (P < .001). Logistic regression identified plasma NfL as a marker of MCI (P < .05) in this sample.ConclusionOur findings suggest that integrating cognitive, psychiatric, and biomarker assessments may improve early detection of dementia risk.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261477071"},"PeriodicalIF":2.8,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review of Effects of Cholinesterase Inhibitors and Memantine on Cognitive Domains in Alzheimer's Disease. 胆碱酯酶抑制剂和美金刚对阿尔茨海默病认知领域影响的系统综述。

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-08-11 DOI: 10.1177/08919887261470005

Anna Williams, Anish Bandalore Satheesha Reddy, Latha Velayudhan

{"title":"A Systematic Review of Effects of Cholinesterase Inhibitors and Memantine on Cognitive Domains in Alzheimer's Disease.","authors":"Anna Williams, Anish Bandalore Satheesha Reddy, Latha Velayudhan","doi":"10.1177/08919887261470005","DOIUrl":"https://doi.org/10.1177/08919887261470005","url":null,"abstract":"BackgroundAlzheimer's Disease (AD) is characterised by progressive cognitive decline. Cholinesterase inhibitors (ChEI) (donepezil, rivastigmine and galantamine) and memantine have been the mainstay treatment and have showed their effectiveness on total cognitive scores, but their effects on individual cognitive domains remain unclear. This systematic review examined their impact on individual cognitive domains.MethodPubMed, Cochrane, MEDLINE, Web of Science and PsycINFO were searched (1st January 1999 - 31st March 2025) for studies evaluating the effects of ChEI and memantine on cognitive domains using standardised cognitive scales in individuals with AD. The review followed PRISMA guidelines. Risk of bias was assessed using the Cochrane ROB1 tool and a narrative synthesis was used to report the main findings.ResultsSixteen studies were included. Rivastigmine demonstrated dose-dependent benefits across memory, language, and praxis domains, with higher-doses generally producing less cognitive decline and greater improvements than lower-dose patches or capsules. Donepezil yielded benefits in language, praxis, and visuospatial abilities. Galantamine showed significant improvements in memory, praxis, visuospatial function, and language, and was superior to donepezil in language in one comparative study. Memantine demonstrated benefits across memory, language, praxis, attention, and visuospatial domains, both as monotherapy and as an adjunct to donepezil, with adjunct therapy producing sustained improvements in language and praxis. Overall, higher treatment doses were consistently associated with greater preservation of cognitive function across domains.DiscussionChEIs and memantine provide domain-specific cognitive benefits beyond global cognitive improvement. Future studies should examine whether treatment tailored to domain-specific deficits improves patient outcome.PROSPEROCRD42024493998.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261470005"},"PeriodicalIF":2.8,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Has your Memory Been Letting you Down?" Use of Figurative Language Modulates Expression of Awareness of Impairments in Alzheimer's Disease. “你的记忆力让你失望了吗？”比喻语言的使用调节阿尔茨海默病损伤意识的表达。

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-20 DOI: 10.1177/08919887261469563

Raquel Luiza Santos de Carvalho, Luccas Abrantes Peres Dos Santos, Jamie Ferrison, Iris Bomilcar, Elodie Bertrand, Marcia Cristina Nascimento Dourado, Robin G Morris, Daniel C Mograbi

{"title":"\"Has your Memory Been Letting you Down?\" Use of Figurative Language Modulates Expression of Awareness of Impairments in Alzheimer's Disease.","authors":"Raquel Luiza Santos de Carvalho, Luccas Abrantes Peres Dos Santos, Jamie Ferrison, Iris Bomilcar, Elodie Bertrand, Marcia Cristina Nascimento Dourado, Robin G Morris, Daniel C Mograbi","doi":"10.1177/08919887261469563","DOIUrl":"https://doi.org/10.1177/08919887261469563","url":null,"abstract":"IntroductionWe compared responses of people with Alzheimer's disease (PwAD) on the Assessment Scale of Psychosocial Impact of the Diagnosis of Dementia and an adapted figurative language version. We hypothesize that figurative language improves acknowledgment of difficulties, varying by awareness object.Methods27 mild to moderate PwAD completed measures of cognition, depression and self-reported impairments. Caregivers informed about functionality, apathy and neuropsychiatric symptoms.ResultsAcknowledgment of difficulties in activities of daily living was higher in the figurative version, while acknowledgment in the emotional domain was higher in the regular version, in both cases with medium effect sizes. No significant differences emerged for total scores, acknowledgement of cognitive deficits, or changes in social relationships, all with small effect sizes.DiscussionLanguage modulation altered acknowledgment by awareness object. Findings support clear, not complex language in assessments. Future studies should define strategies to improve awareness and its predictors across clinical groups.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261469563"},"PeriodicalIF":2.8,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying the Barriers and Facilitators to Clinical Implementation of Risk Prediction Tools for Dementia Across UK Primary Care: A Stakeholder Interview Study. 识别障碍和促进痴呆风险预测工具在英国初级保健临床实施：利益相关者访谈研究。

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-02 DOI: 10.1177/08919887261464574

Emma Morgan, Pippa Bark

{"title":"Identifying the Barriers and Facilitators to Clinical Implementation of Risk Prediction Tools for Dementia Across UK Primary Care: A Stakeholder Interview Study.","authors":"Emma Morgan, Pippa Bark","doi":"10.1177/08919887261464574","DOIUrl":"https://doi.org/10.1177/08919887261464574","url":null,"abstract":"BackgroundDementia is increasingly recognised as a condition that can be prevented or delayed through modifiable lifestyle risk factors. Despite promising research into dementia risk prediction algorithms based on these risk factors, existing tools are not being integrated into UK clinical practice and policy.MethodsThis UK wide study involved 15 semi-structured interviews with GPs, dementia specialists, and policy professionals. Interviews utilised a SWOT analysis to unpick the barriers and facilitators to implementing dementia risk predictions tools.FindingsFive main themes emerged: perceptions around risk score performance; clinician acceptability; fear of dementia; clinical impact; and system integration. Overall, there was clear support for implementation, with areas of cross over and differentiation between stakeholder groups' perspectives.ConclusionsA coordinated change programme is needed which: prioritises building confidence in tool performance, secures clinician buy-in, creates a more positive narrative, shifts the focus from individual responsibility, and aligns system priorities and readiness.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"8919887261464574"},"PeriodicalIF":2.8,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delusions in Lewy Body Disease: A Cross-Sectional Study on Associated Factors and Lived Experiences. 路易体病的妄想：相关因素和生活经历的横断面研究。

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-01 Epub Date: 2025-10-31 DOI: 10.1177/08919887251392086

Caroline Sirna, Ashay Panse, Panagiotis Alexopoulos, Ella Carol, Orla Keane, Iracema Leroi

{"title":"Delusions in Lewy Body Disease: A Cross-Sectional Study on Associated Factors and Lived Experiences.","authors":"Caroline Sirna, Ashay Panse, Panagiotis Alexopoulos, Ella Carol, Orla Keane, Iracema Leroi","doi":"10.1177/08919887251392086","DOIUrl":"10.1177/08919887251392086","url":null,"abstract":"IntroductionDelusions are common in Lewy body disease (LBD), significantly impacting quality of life. This study examined clinical factors, characteristics and themes associated with delusions in LBD.MethodsClinical and demographic factors were compared between 91 individuals attending St. James's Hospital in Ireland with LBD both with and without delusions. Clinical scales include the Clinical Dementia Rating Scale (CDR), Epworth sleepiness scale (ESS), Addenbrooke's Cognitive Evaluation (ACE-III), and Neuropsychiatric Inventory-12 (NPI-12). Themes of delusions extracted from clinical descriptions were mapped onto a typology from primary psychiatric populations.ResultsIndividuals with delusions were older, had higher CDR and ESS scores, lower ACE-III performance, higher scores on the NPI-12, and demonstrated cognitive impairment at the MCI or dementia level. Misidentification delusions were most common, followed by delusions of \"being harmed, attacked, or killed\" and \"residence is not their home\".ConclusionThese findings suggest delusions are related to disease stage, sleep, distinct cognitive and neuropsychiatric patterns, and follow a unique thematic typology.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"513-533"},"PeriodicalIF":2.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mild Behavioral Impairment and Plasma Biomarkers of Neurodegeneration as Predictors of Cognitive Decline in Geriatric Patients With Psychiatric Disorders. 轻度行为障碍和血浆神经变性生物标志物作为老年精神疾病患者认知能力下降的预测因子。

IF 2.5 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-01 Epub Date: 2025-10-30 DOI: 10.1177/08919887251394747

Camilla Elefante, Maria Francesca Beatino, Chiara Fustini, Vittoria Lepri, Donatella Acierno, Alessia Scalzo, Lucia Petrozzi, Linda Giampietri, Gloria Tognoni, Filippo Baldacci, Lorenzo Lattanzi, Gabriele Siciliano, Zahinoor Ismail, Roberto Ceravolo, Giulio Perugi

{"title":"Mild Behavioral Impairment and Plasma Biomarkers of Neurodegeneration as Predictors of Cognitive Decline in Geriatric Patients With Psychiatric Disorders.","authors":"Camilla Elefante, Maria Francesca Beatino, Chiara Fustini, Vittoria Lepri, Donatella Acierno, Alessia Scalzo, Lucia Petrozzi, Linda Giampietri, Gloria Tognoni, Filippo Baldacci, Lorenzo Lattanzi, Gabriele Siciliano, Zahinoor Ismail, Roberto Ceravolo, Giulio Perugi","doi":"10.1177/08919887251394747","DOIUrl":"10.1177/08919887251394747","url":null,"abstract":"BackgroundMild Behavioral Impairment (MBI) has been increasingly recognized as a potential early clinical marker of neurodegenerative disease, while blood-based biomarkers such as phosphorylated tau 217 (p-tau217) and neurofilament light chain (NfL) are associated with Alzheimer's disease and axonal damage, respectively.ObjectiveTo investigate the role of MBI and blood-based biomarkers of neurodegeneration in the early detection of dementia.MethodsFifty-one individuals without dementia aged 60 or older with mood or anxiety disorders underwent psychiatric, neuropsychiatric, and cognitive evaluations, as well as assessment of plasma p-tau217 and NfL at baseline and at one-year follow-up.ResultsA higher proportion of males was observed in the MBI group compared to the non-MBI group (P = 0.076). MBI was significantly associated with a higher risk of conversion to dementia (P = 0.006). MBI patients showed a trend toward higher baseline p-tau217 (P = 0.096) and significantly higher NfL at follow-up (P = 0.025), suggesting active neurodegeneration. Individuals who converted to dementia had marginally higher baseline p-tau217 (P = 0.053) and NfL (P = 0.091).ConclusionMBI and blood-based biomarkers of neurodegeneration appear to be promising clinical tools for identifying dementia risk in its early stages.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"413-425"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145409221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthcare Service Utilisation of People Living With Non-Alzheimer's Dementia: A Systematic Review. 非阿尔茨海默氏痴呆症患者的医疗服务利用：一项系统综述

IF 2.8 4区医学

Journal of Geriatric Psychiatry and Neurology Pub Date : 2026-07-01 Epub Date: 2025-08-28 DOI: 10.1177/08919887251371725

Anna Tjin, Leng Leng Thang, Harsharon Kaur Sondh, Robert Stewart

{"title":"Healthcare Service Utilisation of People Living With Non-Alzheimer's Dementia: A Systematic Review.","authors":"Anna Tjin, Leng Leng Thang, Harsharon Kaur Sondh, Robert Stewart","doi":"10.1177/08919887251371725","DOIUrl":"10.1177/08919887251371725","url":null,"abstract":"IntroductionThe global rise in dementia presents significant challenges for healthcare systems. While Alzheimer's disease (AD) dominates dementia care, people with non-Alzheimer's dementias (non-AD), such as dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), vascular dementia (VD), and Parkinson's disease dementia (PDD), often have distinct and unmet healthcare needs.AimThis systematic review aimed to summarise evidence on healthcare utilisation (HCU) patterns and factors affecting care among people living with non-AD dementias.MethodsFollowing a PROSPERO-registered protocol (CRD42024568391), comprehensive searches of Embase, Ovid MEDLINE, Global Health, PsycINFO, and PubMed were conducted in February and June 2024. Peer-reviewed English-language studies reporting on HCU or its determinants in DLB, FTD, VD, or PDD were included. Reviews, case reports, grey literature, and studies without subtype-specific data were excluded. Quality was assessed using the Newcastle-Ottawa Scale.ResultsThirty-one studies (16 cohort; 10 cross-sectional, 4 case-description, and 1 chart review) were included. HCU varied by dementia subtype and was influenced by sociodemographic, cognitive, and clinical factors. Compared with AD, non-AD dementias had higher healthcare use and costs. PDD showed the highest inpatient, outpatient, and skilled nursing care use, driven by severe cognitive decline. DLB was linked to unplanned hospital admissions and frequent ambulance use, often due to falls and pneumonia. FTD resulted in extended hospital stays related to behavioural symptoms, while VD incurred high costs due to chronic comorbidities and long-term care needs.ConclusionPeople with non-AD dementias have greater and distinct healthcare needs. Future research should develop standardised measures and tailored interventions to address their complex socioeconomic and clinical requirements.","PeriodicalId":16028,"journal":{"name":"Journal of Geriatric Psychiatry and Neurology","volume":" ","pages":"355-367"},"PeriodicalIF":2.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0