轻度认知障碍和主观认知衰退个体嗅觉相关脑区结构异常。

IF 2.9 4区 医学 Q2 CLINICAL NEUROLOGY
Lujiang Zhan, Guanxiong Tan, Jia Dong, Zhengdong Deng, Yunfeng Zou, Zhiyong Dan, Ruixia Wang, Zhengli Luo, Xingxing Zhu
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引用次数: 0

摘要

背景:主观认知障碍(SCD)患者可能已经存在dolfactory损伤,并且随着阿尔茨海默病(AD)谱系的疾病严重程度而加深。然而,SCD个体嗅觉损伤的神经解剖学相关性尚未完全阐明。方法120例无痴呆的老年人(健康对照25例,SCD 45例,轻度认知障碍50例)完成嗅觉评估和磁共振成像(MRI)扫描。采用16项嗅探棒气味识别测试(SSIT)评价嗅觉功能。对8个嗅觉相关脑区的灰质体积(GMV)进行感兴趣区(ROI)分析。结果在ROI分析中,从HC、SCD组到MCI组,嗅觉相关区域GMV变小,嗅觉功能受损日益严重。HC组嗅觉损伤仅与内嗅皮质缩小相关(P < 0.05)。在SCD个体中,内嗅皮质和海马gmv的降低与嗅觉障碍相关(P < 0.05)。MCI个体梨状皮质、杏仁核、内嗅皮质、眶额皮质、海马和副海马gmv的降低与嗅觉障碍显著相关(P < 0.05)。结论HC、SCD和MCI老年人嗅觉相关脑区萎缩逐渐加重,相应的嗅觉功能逐渐下降。SCD个体与嗅觉损伤相关的嗅觉区域主要位于内嗅皮层和海马。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Structural Abnormalities of Olfactory-Related Brain Regions in Mild Cognitive Impairment and Subjective Cognitive Decline Individuals.

BackgroundOlfactory impairment might be already present at the subjective cognitive impairment (SCD) individuals, and deepens with disease severity in the Alzheimer's disease (AD) spectrum. However, the neuroanatomical correlates of olfactory impairment in SCD individuals are not fully elucidated.MethodsA hundred and twenty enrolled older adults without dementia (25 healthy controls (HCs), 45 SCD individuals and 50 mild cognitive impairment (MCI) individuals) completed olfactory assessment and structural magnetic resonance imaging (MRI) scanning. Olfactory function was evaluated by the 16-item Sniffin' Sticks odor identification test (SSIT). Region of interest (ROI) analysis was conducted for the gray matter volume (GMV) of 8 olfactory-related brain regions.ResultsIn ROI analysis, from HC, SCD to MCI group, smaller GMV of olfactory-related regions and olfactory impairment became increasingly severe. For HC group, olfactory impairment was only associated with smaller entorhinal cortex (P < 0.05). In SCD individuals, reduced GMVs of entorhinal cortex and hippocampus were associated with olfactory impairment (P < 0.05). In MCI individuals, decreased GMVs of piriform cortex, amygdala, entorhinal cortex, orbitofrontal cortex, hippocampus and parahippocampus were significantly associated with olfactory impairment (P < 0.05).ConclusionsThe atrophy of olfactory-related brain regions gradually increased and the corresponding olfactory function gradually decreased in older adults of HC, SCD and MCI. The olfactory regions associated with olfactory impairment in SCD individuals were mainly in entorhinal cortex and hippocampus.

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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
40
审稿时长
>12 weeks
期刊介绍: Journal of Geriatric Psychiatry and Neurology (JGP) brings together original research, clinical reviews, and timely case reports on neuropsychiatric care of aging patients, including age-related biologic, neurologic, and psychiatric illnesses; psychosocial problems; forensic issues; and family care. The journal offers the latest peer-reviewed information on cognitive, mood, anxiety, addictive, and sleep disorders in older patients, as well as tested diagnostic tools and therapies.
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