Journal of Human Reproductive Sciences最新文献

{"title":"Exploring the Factors Associated with Attrition in a Lifestyle Intervention Trial amongst Women with Polycystic Ovarian Syndrome Desiring Fertility - An Interview based Study.","authors":"Mary Ann, Chinta Parimala, Parisuddharao Koduri, Aleyamma Thayparmbil Kunjummen, Mohan Shashikant Kamath","doi":"10.4103/jhrs.jhrs_173_24","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_173_24","url":null,"abstract":"<p><strong>Background: </strong>Previous studies exploring the barriers to weight management have suggested psychological, social and logistical barriers were important reasons for high attrition and non-adherence.</p><p><strong>Aim: </strong>The aim of this study was to assess the possible reasons for high attrition and non-adherence to lifestyle interventions in a trial setting amongst women with polycystic ovarian syndrome (PCOS) who wish to conceive.</p><p><strong>Setting and design: </strong>The study was conducted in a tertary level hospital and employed a qualitative study paradigm.</p><p><strong>Materials and methods: </strong>The study was nested within a feasibility study that explored the possibility of conducting lifestyle interventional trials in women with PCOS who wish to conceive. Eligible participants who refused participation in the trial were interviewed under three major categories: refusal before randomisation, refusal after randomisation and non-adherence.</p><p><strong>Statistical analysis used: </strong>Thematic analysis was used to analyse textual data.</p><p><strong>Results: </strong>The participants considered PCOS as a 'fairly common' condition and did not perceive the need to address the impact of PCOS on their health. The second recurring theme was the perception of being overweight as 'healthy' and 'normal' and downplaying lifestyle changes to focus only on fertility treatment for achieving pregnancy. Finally, the decision to pursue weight loss or to discontinue it seems to be a shared decision making among family memebers which limits the ability of the clinicians and healthcare practitioners to effectively deliver appropriate advice on lifestyle interventions.</p><p><strong>Conclusion: </strong>The current findings would help in planning and designing adequately powered randomised controlled trials to evaluate the impact of lifestyle intervention in women with PCOS.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"18 1","pages":"23-31"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Anxiety and Perceived Stress with <i>In vitro</i> Fertilization Outcomes in Infertile Women: A Cross-sectional Study.","authors":"Sara Abdoli, Amir Hossein Gholami, Seyedeh Zahra Masoumi, Roya Najafi-Vosough, Mozhdeh Azimi, Ensiyeh Jenabi, Sahar Aliabadi, Ali Reza Soltanian, Ali Ghaleiha, Shamim Pilehvari","doi":"10.4103/jhrs.jhrs_168_24","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_168_24","url":null,"abstract":"<p><strong>Background: </strong>The studies have shown that the effects of psychological distress on the outcome of <i>in vitro</i> fertilization (IVF) treatment are unclear, and there is still no conclusive empirical evidence that lower anxiety levels lead to better outcomes in assisted reproductive technique treatments.</p><p><strong>Aim: </strong>the present study was conducted to investigate the impact of perceived anxiety and stress on the outcome of IVF in infertile women in Western Iran.</p><p><strong>Settings and design: </strong>The current study is a cross-sectional study.</p><p><strong>Materials and methods: </strong>This study was conducted on infertile women who were candidates for IVF and visited the infertility center at Fatemiyeh Hospital in Hamadan City in the west of Iran from 8 July 2023, to 15 March 2024. The questionnaires were demographic and midwifery characteristics, the Spielberger State-Trait Anxiety Inventory and Perceived Stress Scale-14.</p><p><strong>Statistical analysis used: </strong>All statistical analyses were performed in SPSS software at a significance level of 0.05.</p><p><strong>Results: </strong>The stress was significantly associated with metaphase II eggs (<i>r</i> = -0.487), and the number of transferred embryos based on grade (<i>r</i> = -0.562), duration of marriage (<i>r</i> = 0.628), duration of infertility (<i>r</i> = 0.595) and duration of treatment (<i>r</i> = 0.595). There was no significant association between stress and endometrial thickness (<i>P</i> = 0.189). In addition, the anxiety was significantly associated with age (<i>r</i> = 0.509), husband›s age (<i>r</i> = 0.436), endometrial thickness (<i>r</i> = -0.173), metaphase II eggs (<i>r</i> = -0.570), and the number of ‎transferred embryos based on grade (<i>r</i> = -0.610), duration of marriage (<i>r</i> = 0.604), duration of infertility (<i>r</i> = 0.592) and duration of treatment (<i>r</i> = 0.604).</p><p><strong>Conclusion: </strong>Mean stress and anxiety in infertile women were significantly lower in infertile women with successful IVF. Stress was significantly associated with age, spouse's age, metaphase stage oocytes, embryo grade, duration of marriage and infertility and duration of treatment.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"18 1","pages":"16-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Commentary.","authors":"Mohan S Kamath","doi":"10.4103/jhrs.jhrs_191_24","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_191_24","url":null,"abstract":"","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 4","pages":"223"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Integrative Approach to Precision Pre-implantation Genetic Diagnosis by Investigating Single-cell Sequencing, Polygenic Risk Assessment, Artificial Intelligence-guided Embryo Selection and Genome Editing in Embryos with COL4A1 c.1537G>A Mutation.","authors":"Muhammed Ali Siham","doi":"10.4103/jhrs.jhrs_145_24","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_145_24","url":null,"abstract":"","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 4","pages":"292-293"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of Long Non-coding RNA FAS-AS1/FAS/Caspase3 Axis in Endometriosis: A Cross-sectional Study.","authors":"Amir Hossein Shayanfard, Zivar Salehi, Farhad Mashayekhi, Ziba Zahiri","doi":"10.4103/jhrs.jhrs_92_24","DOIUrl":"10.4103/jhrs.jhrs_92_24","url":null,"abstract":"<p><strong>Background: </strong>An increasing number of studies have demonstrated that excessive proliferation and apoptosis play a pivotal role in the development of endometriosis.</p><p><strong>Aim: </strong>The aim of the study was to evaluate the expression of long non-coding RNA (lncRNA) FAS-AS1, FAS, soluble Fas (sFas) and caspase-3 in patients with different stages of endometriosis.</p><p><strong>Setting and design: </strong>The design of the study was a cross-sectional study.</p><p><strong>Materials and methods: </strong>The relative expression of lncRNA FAS-AS1 and FAs gene was evaluated by the quantitative real-time polymerase chain reaction in 60 ectopic endometrial samples from women with endometriosis in relation to 85 normal endometrial tissues from healthy women, whereas the protein level of sFAs in the peritoneal fluid samples and cleaved caspase-3 in ectopic and normal endometrial tissue samples were determined using the enzyme-linked immunosorbent assay and western blot, respectively. Furthermore, <i>in silico</i> analyses were performed to investigate protein-protein interactions as well as molecular function and cellular location of selected proteins.</p><p><strong>Statistical analysis used: </strong>The student's <i>t</i>-test was used to analyse the difference between the means of the two groups.</p><p><strong>Results: </strong>The expression of FAS and sFas increased in endometriosis tissues as compared to the control group (<i>P</i> < 0.05). However, lncRNA FAS-AS1 and cleaved caspase-3 decreased in ectopic endometrial tissues compared to normal endometrial tissues and low lncRNA FAS-AS1 expression was correlated with disease stages. In addition, the <i>in silico</i> analysis revealed the importance of FAS/caspase3 in the biological processes involved in the development of endometriosis.</p><p><strong>Conclusion: </strong>The current study suggests that lncRNA FAS-AS1 may function as an ectopic endometriotic suppressor. Moreover, the results showed that severity of endometriosis is also closely correlated with the expression of lncRNA FAS-AS1 and sFAS.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 4","pages":"246-254"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Predictors of Response to Ovulation Induction Using Letrozole in Women with Polycystic Ovary Syndrome: A Prospective Cohort Study.","authors":"Shanti Tholiya, Archana Kumari, Reeta Mahey, Mani Kalaivani, Hem Chandra Sati, Mona Sharma, Aarthi K Jayraj, Neena Malhotra","doi":"10.4103/jhrs.jhrs_133_24","DOIUrl":"10.4103/jhrs.jhrs_133_24","url":null,"abstract":"<p><strong>Background: </strong>Ovulation induction (OI) in patients with polycystic ovary syndrome (PCOS) remains challenging, and several biomarkers have been evaluated for their ability to predict ovulation. The predictive ability of candidate biomarkers, particularly with letrozole-based therapy in infertile PCOS women, remains inconclusive as it is yet to be evaluated in a prospective study.</p><p><strong>Aim: </strong>To assess the role of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinising hormone (LH)/FSH ratio, testosterone and free androgen index (FAI) as predictors of ovarian response to letrozole-based OI therapy during OI cycles in infertile women with PCOS from North India.</p><p><strong>Settings and design: </strong>A prospective cohort study was conducted in a tertiary care hospital in north India.</p><p><strong>Materials and methods: </strong>The study enrolled 80 infertile women with PCOS, diagnosed according to the Rotterdam criteria. OI was conducted using letrozole with or without human menopausal gonadotropin. Baseline endocrine and metabolic parameters, including serum AMH, FSH, LH, testosterone and FAI levels, were measured using ELISA or chemiluminescence methods on day 2 of the menstrual cycle. Follicular response to OI was monitored by transvaginal ultrasonography.</p><p><strong>Statistical analysis used: </strong>Descriptive and inferential statistical analyses were conducted, including Mann-Whitney, Kruskal-Wallis, Independent <i>t</i>-test, analysis of variance, Fisher's exact test and receiver operating characteristic curve analysis. Data were processed using Microsoft Excel and analysed with SPSS software, version 25.0. <i>P</i> < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Of 80 women enrolled, 74 responded to letrozole-based OI, while six were non-responders. Body mass index (BMI), serum testosterone and pre-treatment AMH levels significantly correlated with follicular response, with higher values linked to reduced responsiveness. The likelihood ratio+ (95% confidence interval) was 3.32 (2.45-5.06) for AMH, 1.97 (1.03-3.78) for BMI and 1.93 (1.22-3.08) for testosterone. The odds ratio for AMH was 2.88 (1.01-8.21) and 1.25 (1.02-1.53) for BMI. An AMH cut-off of ≤16.43 ng/mL predicted ovarian response with an AUC of 0.88.</p><p><strong>Conclusions: </strong>Pre-treatment AMH levels, along with BMI and serum testosterone, are significant predictors of ovarian response to letrozole-based OI in infertile women with PCOS.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 4","pages":"240-245"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-trimester Doppler Ultrasound for Predicting Successful Management of Pregnancy with Recurrent Pregnancy Losses Due to Antiphospholipid Syndrome and Thrombophilia: A Cohort Study.","authors":"Muhammad Adrianes Bachnas, Uki Retno Budihastuti, Eriana Melinawati, Nutria Widya Purna Anggraini, Robert Ridwan, Lini Astetri, Agung Sari Wijayanti, Atthahira Amalia Hafiizha, Muhammad Denny Gagah Pradana, Aliffudin Nur, Muhammad Alamsyah Azis, Wiryawan Permadi, Luthfi Rahman, Jimmy Yanuar Annas, Daniel Jonathan Mangapul Siagian, Neissya Nastiti Firmanto, Gilang Rizqy Perdana Aries Rohman, Muhammad Ilham Aldika Akbar","doi":"10.4103/jhrs.jhrs_137_24","DOIUrl":"10.4103/jhrs.jhrs_137_24","url":null,"abstract":"<p><strong>Background: </strong>Recurrent pregnancy loss (RPL) often stems from a hypercoagulable state that exacerbates conditions such as antiphospholipid syndrome (APS) and thrombophilia, leading to early placental issues. Although treatments such as low-molecular-weight heparin (LMWH) and low-dose aspirin (LDA) are used, outcomes vary. This study proposes using first-trimester Doppler ultrasound - specifically, uterine radial artery resistance index (URa-RI) at 8 weeks and uterine artery pulsatility index (Ut-PI) with pre-diastolic notching (Ut-notch) at 11-13 weeks - to better predict successful pregnancies and reduce risks of adverse outcomes.</p><p><strong>Aim: </strong>The aim of this study was to evaluate URa-RI, Ut-PI and Ut-notch between successful pregnancy and not successful and between pregnancy with adverse events and without.</p><p><strong>Settings and design: </strong>The study was conducted in a clinical setting, using a retrospective cohort design on a sample of 72 patients with a history of two or more RPL episodes.</p><p><strong>Materials and methods: </strong>Data on URa-RI measured at 8 weeks and Ut-PI and Ut-notch measured at 11-13 weeks were collected. Maternal characteristics - including age, BMI, number of pregnancy losses, etiopathology and immuno-inflammatory response - were considered in the analysis.</p><p><strong>Statistical analysis used: </strong>Comparative statistical analysis was performed on URa-RI, Ut-PI and Ut-notch data, evaluating their associations with pregnancy success and adverse outcomes. Variables were statistically compared between successful and unsuccessful pregnancies and also analysed for adverse events. Analysis was performed using SPSS (IBM, 27^th edition). Chi-square tests were applied to nominal categories and multivariate logistic regression adjusted for age, body mass index (BMI), previous pregnancy losses, etiopathology and antinuclear antibody positivity. Primary outcomes (URa-RI, Ut-PI and Ut-notch) were reported with odds ratios and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Low URa-RI (<0.45) at 8 weeks gives a 16.4 times higher chance for the management to be successful and result in a healthy take-home baby (95% CI = 4.4-61, <i>P</i> < 0.0001). The mean URa-RI was also significantly higher in unsuccessful pregnancy (0.50 ± 0.09 vs. 0.38 ± 0.04, <i>P</i> < 0.0001). High Ut-PI and positive Ut-notch result in a significant increase of adverse event risk, which are 19.4 times and 8.1 times, respectively (95% CI = 4.2-51.6 and 3.12-20.5, <i>P</i> < 0.0001).</p><p><strong>Conclusion: </strong>This study demonstrates the utility of first-trimester Doppler ultrasound (URa-RI, Ut-PI and Ut-notch) in predicting pregnancy success and adverse events in patients with RPL, particularly those managed with LMWH and LDA. These ultrasound markers may provide valuable guidance in managing and anticipating outcomes in RPL cases related to thrombophilia and APS.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 4","pages":"261-268"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Lactoferrin and Iron in Seminal Plasma and Their Possible Relation to Semen Parameters and Infertility in Varicocele: A Cross-sectional Study.","authors":"Ali Mohamed Mahran, Marilyn Sameh Abd-Almalak, Fatma Mohammed Helbawi, Marwa Mohammad Mekkawy","doi":"10.4103/jhrs.jhrs_153_24","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_153_24","url":null,"abstract":"<p><strong>Background: </strong>Male infertility emerges as an important cause during the evaluation of infertile couples. Varicocele is a well-known cause of male infertility. The role of seminal lactoferrin, an iron-binding glycoprotein, in male fertility is unclear and needs further investigation. Recently, it has been linked to some sperm abnormalities and subfertility.</p><p><strong>Aim: </strong>This study aims to detect seminal lactoferrin levels in infertile men with varicocele and their relation to semen parameters and fertility status. We investigated a possible link between seminal lactoferrin and iron.</p><p><strong>Settings and design: </strong>A cross-sectional study was conducted through the outpatient clinic.</p><p><strong>Materials and methods: </strong>Seventy-five individuals were included in 3 groups (33 infertile men with varicocele, 25 infertile men without varicocele and 17 fertile participants without varicocele). Conventional semen analysis was conducted, and seminal plasma was obtained in all groups to detect lactoferrin and iron levels.</p><p><strong>Statistical analysis used: </strong>Statistical analysis was performed by SPSS version 24.</p><p><strong>Results: </strong>In infertile men with varicocele, seminal lactoferrin (155.92 ± 8.4 ng/ml, <i>P</i> = 0.296) and iron levels (260.71 ± 38.3 μg/dl, <i>P</i> = 0.409) were not significantly different from other groups. There was a positive correlation between seminal lactoferrin, iron levels and sperm concentrations and counts. Seminal iron and lactoferrin were significant independent predictors of sperm concentration. A negative correlation was reported between seminal lactoferrin levels and age. Lactoferrin in seminal plasma was not correlated with seminal iron.</p><p><strong>Conclusion: </strong>Infertile men with varicocele have seminal lactoferrin levels comparable to other infertile men and possibly fertile individuals. Iron concentrations are not linked to lactoferrin levels in seminal plasma.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 4","pages":"284-291"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sperm Morphology of Post-wash Sample and Its Association with Clinical Pregnancy among the Couples Undergoing Intrauterine Insemination: A Cohort Study.","authors":"Syamala Prathyusha, N S Kubera, Srimathi Murugesan, Jitendar Kumar Sharma, Sujatha Venkatraman, Anusuya Ram","doi":"10.4103/jhrs.jhrs_158_24","DOIUrl":"10.4103/jhrs.jhrs_158_24","url":null,"abstract":"<p><strong>Background: </strong>Intrauterine insemination (IUI) is an effective and inexpensive method of managing patients with unexplained and male factor infertility. It is attempted before proceeding to more invasive assisted reproductive techniques such as <i>in vitro</i> fertilisation and intracytoplasmic sperm injection. Numerous semen parameters have been assessed to indicate successful outcomes with IUI. It is debatable to what extent morphological parameters influence the IUI success.</p><p><strong>Aim: </strong>We aimed to study the association of sperm morphology and other semen parameters in post-wash inseminated samples with clinical pregnancy rate (CPR) among the couples undergoing IUI.</p><p><strong>Settings and design: </strong>This was a prospective cohort study conducted between March 2022 and January 2024 in the Department of Obstetrics and Gynaecology, Women and Children's Hospital, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry.</p><p><strong>Materials and methods: </strong>A total of 127 couples presenting with infertility (underwent 246 IUI cycles) were included after written informed consent from study participants, semen collection was done and pre-wash and post-wash semen were analysed as per the World Health Organization Sixth Edition Laboratory Manual for sperm morphology.</p><p><strong>Statistical analysis used: </strong>Demographic data, semen analysis parameters and CPR results were compared and analysed using SPSS version 19.0.</p><p><strong>Results: </strong>Among 246 IUI cycles, post-wash sperm morphology was normal in 47.6% and teratozoospermia was noted in 52.4%. Clinical pregnancy was reported in 10.6% (<i>n</i> = 26) of couples, of which 6.1% (<i>n</i> = 15) had post-wash normal sperm morphology and 4.5% (<i>n</i> = 11) had post-wash teratozoospermia. When categorised by strict morphology ≤1%, 2%-3%, 4%-5% and ≥5%, the CPR was 0.0%, 12.0%, 12.6% and 12.9%, respectively. Even though clinical pregnancy was noted only with >1% sperm morphology, there was no significant association between sperm morphology and CPR.</p><p><strong>Conclusion: </strong>No significant differences in CPR were noted following IUI in couples with post-wash normal and abnormal sperm morphology. Hence, the current study findings suggest that sperm morphology should not be a criterion to exclude couples from undergoing IUI.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 4","pages":"255-260"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilisation of Cryopreserved Gametes in Cancer Patients who Underwent Fertility Preservation.","authors":"Devika Gunasheela, N Ashwini, Yoshita Saneja, D Deepthi","doi":"10.4103/jhrs.jhrs_134_24","DOIUrl":"10.4103/jhrs.jhrs_134_24","url":null,"abstract":"<p><strong>Background: </strong>Cancer treatments such as chemotherapy and radiotherapy often compromise fertility by damaging gonadal function, creating a critical need for fertility preservation options. Despite advancements in fertility preservation techniques, there is a significant lack of research focused on their application in Asian cancer patients and their utilisation remains underexplored in this population.</p><p><strong>Aim: </strong>This study aims to evaluate the utilisation rates and outcomes of cryopreserved gametes in cancer patients who underwent fertility preservation before their cancer treatment.</p><p><strong>Settings and design: </strong>This retrospective study was conducted at our hospital from January 2003 to May 2023. It investigated the utilisation of cryopreserved gametes in 557 male patients aged 15-50 years and 39 female patients aged 15-40 years who opted for fertility preservation before chemotherapy or radiotherapy.</p><p><strong>Materials and methods: </strong>Data were retrospectively collected, including patient demographics and fertility preservation outcomes. Various fertility preservation methods were employed based on patient suitability and availability. Participants were surveyed to identify reasons for non-utilisation of cryopreserved gametes. All data were collected and analysed following institutional ethical guidelines.</p><p><strong>Statistical analysis used: </strong>Descriptive statistics were used to calculate utilisation rates and report clinical pregnancy and live birth rates. Reasons for non-usage were categorised into mortality, spontaneous pregnancies, financial constraints and social factors.</p><p><strong>Results: </strong>Out of 596 participants, only 11 utilised their cryopreserved gametes, yielding a utilisation rate of 1.8%. Among those who used their gametes, clinical pregnancy rates were 66.66% for males and 50% for females, with live birth rates of 33.33% for males and 50% for females. Non-usage was primarily due to mortality, spontaneous pregnancies, financial constraints and social issues.</p><p><strong>Conclusion: </strong>The utilisation rate of cryopreserved gametes was low at 1.8%. Challenges such as mortality, financial constraints and social factors highlight the need for improved counselling and a refined approach to fertility preservation, ensuring services better align with patients' future needs.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 4","pages":"232-239"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}