Journal of Human Reproductive Sciences最新文献

{"title":"Does Serum Estradiol Prior to Progesterone Administration in Programmed Frozen Embryo Transfer Cycle Impacts Live Birth Rate: A Prospective Cohort Study.","authors":"Neeta Singh, Bakkireddy Saisree, Neena Malhotra, Supriya Kumari, Reeta Mahey, Nisha, Monika Saini","doi":"10.4103/jhrs.jhrs_76_24","DOIUrl":"10.4103/jhrs.jhrs_76_24","url":null,"abstract":"<p><strong>Background: </strong>There is a paucity of data on the optimal threshold of oestradiol (E2) levels required for successful implantation as this is a valid question to be answered, considering that significant number of <i>in vitro</i> fertilisation cycles are deferred for FET cycles.</p><p><strong>Aim: </strong>The aim of this study is to investigate the serum E2 levels before starting exogenous progesterone in artificial autologous frozen thawed embryo transfers on pregnancy outcomes.</p><p><strong>Settings and design: </strong>This was a cohort study wherein clinical data of 213 artificial autologous programmed hormone-regulated frozen embryo transfer (HR-FET) cycles were collected.</p><p><strong>Materials and methods: </strong>The HR-FET cycles were divided into three groups based on the E2 levels before starting progesterone: Group A: E2 ≤300 pg/mL, Group B: E2 301-500 pg/mL and Group C: E2 >500 pg/mL. After adequate endometrial stripe was appreciated by transvaginal ultrasonography, single blastocyst transfer was performed in all the cycles.</p><p><strong>Statistical analysis used and results: </strong>The clinical pregnancy rate (CPR) in Groups A, B and C were 41.8%, 73.5% and 0.95%, respectively (<i>P</i> = 0.0001). The live birth rate (LBR) in Groups A, B and C was 18.1%, 62.2% and 0%, respectively (<i>P</i> = 0.0001). The miscarriage rate (MR) was significantly lower (15.3%) when E2 was between 301 and 500 pg/mL (<i>P</i> = 0.001). At both the extremes of serum E2 values, the rate of miscarriage increased. If serum E2 levels were ≤300 pg/mL or >500 pg/mL, the rate of miscarriage was 56.5% and 100%, respectively.</p><p><strong>Conclusion: </strong>Serum E2 levels in the range of 301-500 pg/mL before starting progesterone in programmed FET cycle are associated with an improved CPR and LBR and also decreased MR as compared to the extreme values of E2 ≤300 pg/mL or >500 pg/mL.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 3","pages":"193-199"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Burden of Fatigue on Work Performance among Women with Polycystic Ovarian Syndrome.","authors":"Aakanksha Bajpai, Digvijay Sharma, Gunjan Nagpal, Kalpana Verma","doi":"10.4103/jhrs.jhrs_124_24","DOIUrl":"10.4103/jhrs.jhrs_124_24","url":null,"abstract":"","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 3","pages":"221-222"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated Levels of Gonadotrophic Hormones and Antioxidant Biomarker in Male Rats Following Administration of Hydromethanol Leaf Extract of Justicia secunda in Response to 2,4-Dinitrophenylhydrazine Induction","authors":"S. K. Mobisson, U. L. Iyanyi, B. E. Ehigiator, F. U. Ibe, J. B. Monye, A. O. Obembe","doi":"10.4103/jhrs.jhrs_13_24","DOIUrl":"https://doi.org/10.4103/jhrs.jhrs_13_24","url":null,"abstract":"ABSTRACT\u0000 \u0000 \u0000 \u0000 2,4-Dinitrophenylhydrazine induces testicular toxicity and can result in reproductive dysfunction in male rats.\u0000 \u0000 \u0000 \u0000 This study investigated the effects of hydromethanolic leaf extract of Justicia\u0000 secunda on phenylhydrazine (PHZ)-induced reproductive dysfunction in male Wistar rats.\u0000 \u0000 \u0000 \u0000 Twenty rats (90–170 g) were grouped into five (A-E) (n = 4) with the approval of the research ethics committee.\u0000 \u0000 \u0000 \u0000 Group A (control) received 0.5 mL of normal saline, Groups B to E received PHZ, PHZ + Astymin (0.5 mL), PHZ + J. secunda (0.2 mg/kg) and PHZ + J. secunda (0.5 mg/kg), respectively. All animals in Groups B to E received 2 mg/kg PHZ intraperitoneally for 2 days, and thereafter, administration of Astymin and J. secunda commenced in Groups C, D and E for 14 days using gavage.\u0000 \u0000 \u0000 \u0000 The data were analysed using a one-way analysis of variance and the Bonferroni post\u0000 hoc test.\u0000 \u0000 \u0000 \u0000 Follicle-stimulating hormone (FSH) decreased significantly in PHZ, PHZ + Astymin and PHZ + J. secunda (0.2 mg/kg) and increased significantly in PHZ + J. secunda (0.5 mg/kg) than control. Luteinising hormone (LH) and testosterone significantly (P < 0.001) reduced in treated groups than control. Total cholesterol, triglyceride, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol and very-low-density lipoprotein-cholesterol were significantly reduced in the treated groups than the control. Tumour necrosis factor alpha (TNF-α) significantly (P < 0.001) increased in treated groups than in control. Testicular glutathione (GSH), glutathione peroxidase, catalase and malondialdehyde significantly increased in extract-treated groups compared to control. Superoxide dismutase significantly decreased in PHZ-treated group than in the control.\u0000 \u0000 \u0000 \u0000 PHZ administration caused testicular toxicity and altered biochemical markers, astymin treatment reduced male reproductive hormones, while J. secunda (0.5 mg/kg) increased FSH and LH, decreased TNFα levels and altered the concentration of testicular antioxidant markers. These alterations may be linked to the toxic effect of PHZ and could negatively affect spermatogenesis.\u0000","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141364858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Fibroblast Growth Factor-1 Promoter Polymorphism and its Serum Concentrations with Repeated Implantation Failure after <i>In vitro</i> Fertilisation: A Cross-sectional Study.","authors":"Afshin Kharamani, Farhad Mashayekhi, Zivar Salehi","doi":"10.4103/jhrs.jhrs_68_24","DOIUrl":"10.4103/jhrs.jhrs_68_24","url":null,"abstract":"<p><strong>Background: </strong>Fibroblast growth factors (FGFs) play a key role in embryo implantation and support endometrial trophoblastic interaction.</p><p><strong>Aim: </strong>The aim of the study was to evaluate the association between FGF-1 (rs34011) gene variety and its serum concentration with repeated implantation failure (RIF).</p><p><strong>Setting and design: </strong>The design of the study was a cross-sectional study.</p><p><strong>Materials and methods: </strong>Four hundred infertile women with a history of RIF and 400 healthy women undergoing the first <i>in vitro</i> fertilisation-embryo transfer attempt with successful delivery (controls) were enrolled in the study. Genomic DNA was extracted from peripheral blood leucocytes and genotyped by Tetra-Primer Amplification Refractory Mutation System-Polymerase Chain Reaction. Serum FGF-1 concentration was evaluated with enzyme-linked immunosorbent assay.</p><p><strong>Statistical analysis used: </strong>The ANOVA test was used to analyse the difference between the means of the groups.</p><p><strong>Results: </strong>In RIF group, the genotype frequencies of the GG, GA and AA were 59%, 33.5% and 7.5%, respectively, whereas in controls were 72.5%, 24% and 3.5%, respectively. The G and A allele frequencies in the RIF group were 75.75% and 24.25%, while in controls were 84.5% and 15.5%, respectively (<i>P</i> < 0.0001). We have also shown that serum FGF-1 concentration in RIF and control groups was 17 ± 3.55 and 23.62 ± 4.91 pg/mL, respectively (<i>P</i> = 0.008). We have also shown that AA genotype is significantly associated with decreased serum FGF-1 concentration in RIF (AA, GA and GG serum levels were 9.55 ± 2.65, 14 ± 3.35 and 22.55 ± 7.26 pg/mL, and in controls were 12.22 ± 2.27, 18.44 ± 5.98 and 26.66 ± 8.29 pg/mL, respectively).</p><p><strong>Conclusion: </strong>The current study suggests that a significant association between FGF-1 (rs34011) promoter polymorphism and its serum concentration with RIF. The study also suggests that AA genotype is linked to lower FGF-1 serum levels and may play a risk factor for RIF.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 2","pages":"121-127"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient Complete Asthenozoospermia.","authors":"Artenisa Kulla, Basil Mirza, Kevin James Campbell","doi":"10.4103/jhrs.jhrs_28_24","DOIUrl":"10.4103/jhrs.jhrs_28_24","url":null,"abstract":"<p><p>Limited research exists on the mechanisms underlying asthenozoospermia associated with acquired ciliary dyskinesia. Primary ciliary dyskinesia links respiratory pathology with infertility and provides a basis for a potential mechanism. The aetiology of asthenozoospermia is often unclear and may be secondary to direct or indirect effects on sperm motility. Here, we report a case - with a brief clinical review - of recovering sperm motility after diagnosis of complete asthenozoospermia coinciding with resolution of chronic respiratory infections. The patient is a 36-year-old male, with initial semen analysis demonstrating 100% immotile sperm. Following the resolution of chronic respiratory infection, subsequent analysis demonstrated functional improvement with 76 million sperm/mL, 8% progressive motility and 4% strict morphology. Our case reinforces a potentially underappreciated role of environmental risk factors in infertility, with a focus on the patient's history of infections and other risk factors for acquired ciliary dyskinesia, which should be kept in mind when treating patients with asthenozoospermia.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 2","pages":"133-135"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semen Washing and Intrauterine Insemination for Reducing the Risk of Human Immunodeficiency Virus Transmission in Serodiscordant Couples: A Cross-sectional Study.","authors":"Duru Shah, Raj Harjani, Vishesha Yadav","doi":"10.4103/jhrs.jhrs_11_24","DOIUrl":"10.4103/jhrs.jhrs_11_24","url":null,"abstract":"<p><strong>Background: </strong>Antiretroviral therapy has helped human immunodeficiency virus (HIV)-infected people live an enhanced quality of life and attempt for a pregnancy, without placing their partner at risk. Although periconceptional pre-exposure prophylaxis for the uninfected partner and consistent antiretroviral therapy for the HIV-infected partner are important to prevent HIV transmission, semen washing could be a great option to further reduce the semen viral load.</p><p><strong>Aim: </strong>The aim of this study were as follows: to determine if semen washing with intrauterine insemination provides an added safety net to HIV-serodiscordant couples when the male partner is HIV-infected and virally suppressed and to determine if the U = U concept (undetectable = untransmittable) holds true in virally suppressed HIV-infected males.</p><p><strong>Settings and design: </strong>This was an observational study conducted in seropositive HIV men under treatment with highly active antiretroviral therapy (HAART) in collaboration with Metropolis Laboratory, a CAP recognised private Healthcare Laboratory in Mumbai, India.</p><p><strong>Materials and methods: </strong>Blood and semen samples were collected from a total of 110 adult HIV-1-infected males virally suppressed on HAART. These samples were processed to assess the viral load in plasma as well as raw and processed semen fractions.</p><p><strong>Statistical analysis used: </strong>Descriptive statistics were used to analyse the data.</p><p><strong>Results: </strong>Only men with plasma viral loads < 1000 copies were selected in our study. Out of the 110 HIV-infected individuals, 102 (92.73%) patients had undetectable (<20 copies/ml) plasma viral load while 8 (7.27%) patients had a detectable (>20 copies/ml) viral load, who were excluded from the study. In the virally suppressed 102 men, the raw semen samples of 100 men showed an undetectable viral load, while 2 samples showed detectable contamination, even though their plasma samples from the blood showed a viral load of <20 copies/ml. The semen was then separated into the sperm and the seminal plasma samples. The seminal plasma had <20 copies/ml in 95 samples (93.14%) but a detectable viral load in 7 (6.86%) samples. After subjecting all the 102 processed (post-wash) sperm samples to quantitative analysis, an undetectable viral load of <20 copies/ml was found in all the samples. Thus, the raw sample (prewashed),seminal plasma and processed (postwash) samples were evaluated. The post-wash sperm sample showing zero contamination was frozen for intrauterine insemination (IUI) in the uninfected female partner.</p><p><strong>Conclusions: </strong>Semen washing with IUI should be advocated as a safe, efficacious way to increase the safety net and to further reduce the minimal risk of HIV transmission in serodiscordant couples in addition to the U = U concept.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 2","pages":"94-101"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Cinnamaldehyde's Potency on Heat Stress-induced Testicular Impairments in Wistar Rats.","authors":"Pazhanisankar Muthusamy, Dapkupar Wankhar, Jeyakumari Paul, Nivetha Ravishankar, Ravindran Rajan","doi":"10.4103/jhrs.jhrs_27_24","DOIUrl":"10.4103/jhrs.jhrs_27_24","url":null,"abstract":"<p><strong>Background: </strong>Male sterility results from high testicular temperatures, which affect mammalian spermatogenesis. High testicular temperatures affect sperm motility, morphology and fertility according to their magnitude and duration.</p><p><strong>Aim: </strong>The aim of the current study is to examine the effects of heat-induced oxidative stress and cinnamaldehyde on Wistar rat testicular structure and function.</p><p><strong>Settings and design: </strong>The rats used in this experiment were Wistar albino rats.</p><p><strong>Materials and methods: </strong>This research has six animals per group. Male Wistar albino rats of 2.5-3 months old and 275-300 g. (I) control, (II) heat stress (HS) in a closed chamber at 41°C for 14 days and (III) HS with cinnamaldehyde (CA) 50 mg/kg body weight for 14 days. (IV) CA alone. After the study, the animals were euthanised, and test samples were taken for sperm count, morphology, haematoxylin and eosin stain for normal cellular morphology, antioxidants and DNA integrity assessments.</p><p><strong>Statistical analysis used: </strong>The data were analysed statistically using one- and two-way ANOVA tests for comparisons between groups.</p><p><strong>Results: </strong>The stress group had significantly lower sperm counts and poor sperm morphology. The stress group's antioxidant capacity is much lower than that of the control group. Animals under stress have fragmented DNA. Treatment with cinnamaldehyde increased overall antioxidant capacity and seminal parameters, and rats behaved most like controls.</p><p><strong>Conclusion: </strong>CA restores malondialdehyde levels, total antioxidant capacity, sperm characteristics and mitigates testicular damage in rats exposed to experimental HS.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 2","pages":"102-111"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Zinc Levels in Women with Polycystic Ovarian Syndrome are Lower as Compared to Those without Polycystic Ovarian Syndrome: A Cohort Study.","authors":"Swati Dhar, Reena Yadav, Akash Tomar","doi":"10.4103/jhrs.jhrs_81_24","DOIUrl":"10.4103/jhrs.jhrs_81_24","url":null,"abstract":"","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 2","pages":"138-139"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Zinc Levels in Women with Polycystic Ovarian Syndrome Are Lower as Compared to Those without Polycystic Ovarian Syndrome: A Cohort Study.","authors":"Mahmood Dhahir Al-Mendalawi","doi":"10.4103/jhrs.jhrs_61_24","DOIUrl":"10.4103/jhrs.jhrs_61_24","url":null,"abstract":"","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 2","pages":"136-137"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Imaging Evaluation of Wolffian Duct Anomalies - OHVIRA and OSVIRA.","authors":"Lukshay Bansal, Suryansh Arora, Akhila Prasad","doi":"10.4103/jhrs.jhrs_19_24","DOIUrl":"10.4103/jhrs.jhrs_19_24","url":null,"abstract":"<p><p>Herlyn-Werner-Wunderlich syndrome in females, also known as obstructed haemivagina and ipsilateral renal agenesis (OHVIRA), and Zinner's syndrome, also known as OSVIRA in males, are two rare congenital syndromes affecting the urogenital tract. OHVIRA is obstructed haemivagina and ipsilateral renal agenesis and OSVIRA abbreviation stands for obstructed seminal vesicle and ipsilateral renal agenesis. For a long, these syndromes were considered different entities, owing to our poor understanding of underlying embryopathogenesis; however, in light of the recent acceptance of the Wolffian origin of the vagina in its entirety, these two syndromes are considered to be cut from the same cloth. In this case series, we present magnetic resonance imaging features of two cases each of OHVIRA and OSVIRA and discuss the similarities in embryopathogenesis behind them while debunking the old concepts. A deep understanding of embryopathogenesis allows a clinician and radiologist to predict the disease manifestation, and its outcome and also acts as a guide to screen for potential subtle defects, which would otherwise have been missed.</p>","PeriodicalId":15975,"journal":{"name":"Journal of Human Reproductive Sciences","volume":"17 2","pages":"128-132"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}