Journal of Heart and Lung Transplantation最新文献

{"title":"PREDICTORS OF DEATH IN PATIENTS WITH ANTIPHOSPHOLIPID ANTIBODY SYNDROME (APS) IN PULMONARY ENDARTERECTOMY IN CTPEH","authors":"N. Zayas, M.A. Diaz Pastrana, R. Zebadua Torres, B. Urueta Chavez, J.C. Gomez Rodríguez, J.C. Lopez Reyes, N.L. Chavez Gomez, J.F. Canul Tamay","doi":"10.1016/j.healun.2024.04.058","DOIUrl":"10.1016/j.healun.2024.04.058","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S37"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TREATMENT APPROACH IN THE MULTIMODAL ERA (TEAM) REGISTRY IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION (CTEPH) OR CHRONIC THROMBOEMBOLIC PULMONARY DISEASE (CTEPD)","authors":"N.H. Kim , D.P. Jenkins , A. Kavaliunas , V. Gressin , M. Delcroix","doi":"10.1016/j.healun.2024.04.015","DOIUrl":"10.1016/j.healun.2024.04.015","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S18"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of chronic thromboembolic pulmonary hypertension","authors":"Xavier Jais MD ,&nbsp;Victor Tapson MD ,&nbsp;Timothy M. Fernandes MD ,&nbsp;Elie Fadel MD ,&nbsp;Seth Kligerman MD ,&nbsp;Joanna Pepke-Zaba MD ,&nbsp;Kim M. Kerr MD ,&nbsp;Peter F. Fedullo MD ,&nbsp;Jenny Z. Yang MD ,&nbsp;Michael M. Madani MD ,&nbsp;Irene M. Lang MD ,&nbsp;Nick H. Kim MD","doi":"10.1016/j.healun.2025.02.1688","DOIUrl":"10.1016/j.healun.2025.02.1688","url":null,"abstract":"<div><div>Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe complication of acute pulmonary embolism (PE), affecting approximately 2.7% of PE survivors. CTEPH results from persistent obstruction of the proximal pulmonary arteries by organized fibrotic clots, in combination with a secondary microvasculopathy, leading to increased pulmonary vascular resistance and progressive right heart failure. The mechanisms precluding a complete resolution of PE are not yet fully understood and include chronic inflammation, impaired fibrinolysis and coagulation abnormalities. Chronic thromboembolic pulmonary disease is the broader term for symptomatic patients with mismatched perfusion defects and signs of chronic thrombi on pulmonary vascular imaging, after at least 3 months of therapeutic anticoagulation, with CTEPH specifically referring to those with pulmonary hypertension. In patients with persistent dyspnea after PE or with PH, the diagnosis of CTEPH is suspected when ventilation/perfusion lung scan shows mismatched perfusion defects and is confirmed by comprehensive right heart catheterization and imaging with CT pulmonary angiography and/or digital subtraction angiography, which ought to be performed at centers with CTEPH expertise. Indeed, early referral to expert centers with experienced multidisciplinary teams ensures accurate diagnosis and tailored treatment, ultimately improving outcomes for CTEPH patients.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Pages S1-S7"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"USE OF PULMONARY ARTERIAL HYPERTENSION-TARGETED MEDICATIONS IS ASSOCIATED WITH A DELAY IN REFERRAL FOR PULMONARY THROMBOENDARTERECTOMY","authors":"M. Stinson ,&nbsp;J. Yang ,&nbsp;D. Papamatheakis ,&nbsp;K. Kerr ,&nbsp;D. Poch ,&nbsp;M. Alotaibi ,&nbsp;V. Pretorius ,&nbsp;M. Madani ,&nbsp;N.H. Kim ,&nbsp;T. Fernandes","doi":"10.1016/j.healun.2024.04.053","DOIUrl":"10.1016/j.healun.2024.04.053","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S35"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSOCIATION BETWEEN CEREBRAL OXIMETRY AND POSTOPERATIVE DELIRIUM IN PATIENTS WITH CHRONIC THROMBEMBOLIC PULMONARY HYPERTENSION UNDERGOING PULMONARY ENDARTERECTOMY","authors":"D. Kuschka MD ,&nbsp;P. Tsimpoura MD ,&nbsp;C. Torregroza MD, PhD ,&nbsp;R. M'Pembele MD ,&nbsp;S. Roth MD ,&nbsp;M. Adameit MD ,&nbsp;E. Mayer MD ,&nbsp;R. Huhn MD, PhD ,&nbsp;C. Wiedenroth MD ,&nbsp;S. Guth MD","doi":"10.1016/j.healun.2024.04.024","DOIUrl":"10.1016/j.healun.2024.04.024","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S22"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of patients supported on Impella 5.5 for more than 14 days: A Cardiogenic Shock Working Group registry analysis","authors":"Manreet K. Kanwar MD ,&nbsp;Nir Uriel MD ,&nbsp;Anthony Carnicelli MD ,&nbsp;Kevin John MD ,&nbsp;Song Li MD ,&nbsp;Chloe Kong MA ,&nbsp;Elric Zweck MD ,&nbsp;Shashank S. Sinha MD MSc ,&nbsp;Van Khue Ton MD ,&nbsp;Arthur R. Garan MD ,&nbsp;Rachna Kataria MD ,&nbsp;Jacob Abraham MD ,&nbsp;Jaime Hernandez-Montfort MD ,&nbsp;Daniel Burkhoff MD, PhD ,&nbsp;CSWG Academic Research Consortium ,&nbsp;Navin K. Kapur MD","doi":"10.1016/j.healun.2025.05.017","DOIUrl":"10.1016/j.healun.2025.05.017","url":null,"abstract":"<div><h3>Background</h3><div>The Impella 5.5 (ABIOMED, Danvers, MA) is a micro-axial pump that is currently approved for up to 14 days of support in the United States. However, in clinical practice it is being used for longer durations of time, especially as a bridge to heart replacement therapies (HRT). We aimed to define patient characteristics and outcomes (mortality and serious adverse events/SAE) in patients supported on Impella 5.5 for &gt;14 days in a large, multi-center registry.</div></div><div><h3>Methods</h3><div>The Cardiogenic Shock<span> Working Group (CSWG) registry enrolling consecutive patients in heart failure (HF) or myocardial infarction related CS (MI-CS) from 34 international sites between 2022 and 2024 was analyzed. Patients supported with Impella 5.5 &gt;14 days were compared to those supported for ≤14 days for baseline characteristics. In-hospital outcomes were further classified as ‘‘favorable’’ (heart recovery, successful bridge to HRT and discharged alive) or ‘‘unfavorable’’ (death, need for escalation to veno-arterial extracorporeal membrane oxygenation [VA-ECMO]). Predictors of favorable outcomes were assessed using uni- and multi-variable analysis.</span></div></div><div><h3>Results</h3><div>A total of 927 patients were supported on Impella 5.5 of whom 381 had the device for &gt;14 days. Median time of support in the 2 groups (&gt; or ≤14 days) was 23.9 [21.2] and 7.1 [IQR 5.7] days, respectively. Patients with Impella 5.5 &gt;14 days were younger (mean age 57 vs 61 years, <em>p</em> &lt; 0.001), more likely to have HF-CS vs MI-CS (78% vs 61%; <em>p</em><span> &lt; 0.001) and have a dilated left ventricle (left ventricular end diastolic dimension [LVEDD] 6.4 vs 5.9 cm, </span><em>p</em><span> = 0.002) and chronic kidney disease (38% vs 30%, </span><em>p</em><span> = 0.03) as compared to those supported ≤14 days. Baseline Society for Cardiovascular Angiography and Interventions (SCAI) stage, lactate, and vital signs were not significantly different. Unadjusted survival was higher (80% vs 68%, </span><em>p</em> &lt; 0.001) in those supported for &gt;14 days, with a significantly higher HRT for those supported for &gt;14 days, compared to the ≤14 days cohort (58% vs 38%, <em>p</em> &lt; 0.001). Less than a fourth (19.1%) had an SAE, with highest rates seen in MI-CS supported for ≤14 days. The majority (75%) of patients on support for &gt;14 days had favorable outcomes with no linear increments in rates of SAE with prolonged duration of support.</div></div><div><h3>Conclusion</h3><div>Patients supported with Impella 5.5 beyond the Food and Drug Administration (FDA) approved duration of 14 days had high rates of favorable outcomes, especially as bridge to HRT. Use of Impella 5.5 for longer durations needs to be further investigated in prospective studies.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 10","pages":"Pages 1583-1594"},"PeriodicalIF":6.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144533293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extending the bridge, bridging the gap","authors":"Miguel Alvarez Villela MD,&nbsp;Snehal R. Patel MD","doi":"10.1016/j.healun.2025.06.021","DOIUrl":"10.1016/j.healun.2025.06.021","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 10","pages":"Pages 1595-1596"},"PeriodicalIF":6.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct application of a drug delivery platform improves heart transplantation: On the path from innovation to implementation","authors":"Brisa Peña ,&nbsp;Benjamin J. Kopecky","doi":"10.1016/j.healun.2025.06.020","DOIUrl":"10.1016/j.healun.2025.06.020","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 10","pages":"Pages 1635-1637"},"PeriodicalIF":6.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lessons in longevity and collaboration","authors":"Neha Bansal MD ,&nbsp;Daphne T. Hsu MD","doi":"10.1016/j.healun.2025.06.022","DOIUrl":"10.1016/j.healun.2025.06.022","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 10","pages":"Pages 1610-1611"},"PeriodicalIF":6.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lumpers vs. splitters: The search for treatable traits in post-transplant BOS","authors":"Eric D. Morrell M.D. ,&nbsp;Guang-Shing Cheng","doi":"10.1016/j.healun.2025.06.010","DOIUrl":"10.1016/j.healun.2025.06.010","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 10","pages":"Pages 1567-1568"},"PeriodicalIF":6.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}