Journal of Heart and Lung Transplantation最新文献

{"title":"Impact of donor mechanism of injury on donation after circulatory death heart transplant outcomes: An analysis of the UNOS National Registry.","authors":"Tianjiao Ren, Taylor Nordan, Akinobu Itoh, Michael M Givertz","doi":"10.1016/j.healun.2026.05.036","DOIUrl":"10.1016/j.healun.2026.05.036","url":null,"abstract":"<p><p>Previous research associates explosive brain death (EBD) with inferior recipient outcomes in donation after brain death (DBD) heart transplantation. Current international guidelines recommend caution when using these organs. We investigated whether donor mechanism of injury impacts outcomes in donation after circulatory death (DCD) heart transplantation. First-time heart transplant recipients were stratified by donor mechanism of injury. No significant difference in 4-year recipient survival was detected across donor mechanism of injury categories on univariate analysis (log-rank p = 0.65). Compared with head trauma, there was no significant difference in adjusted hazard ratios among recipients of donors who experienced anoxia (aHR 0.91, 95% CI 0.65-1.28), CVA/stroke (aHR 1.32, 95% CI 0.78-2.24), or other causes (aHR 1.23, 95% CI 0.80-1.90). Severe primary graft dysfunction (PGD) was less likely in recipients of donors who experienced anoxia compared to head trauma (aOR 0.36, 95% CI 0.16-0.78, p = 0.009).</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the donor pool further-rapid recovery without pre-implant reanimation for combined heart-lung donation after circulatory death transplantation.","authors":"Amir Teimouri Dereshgi, Kevin McGann, Swaroop Bommareddi, John M Trahanas, Brian Lima, Awab Ahmad, Enock Adjei, Stephen Tapia-Ruano, Caitlin Demarest, John W Stokes, Ashish S Shah, Aaron M Williams","doi":"10.1016/j.healun.2026.04.025","DOIUrl":"10.1016/j.healun.2026.04.025","url":null,"abstract":"<p><p>Donation after circulatory death (DCD) donors have expanded the heart transplant donor pool. Current DCD recovery strategies typically require donor heart reanimation but remain limited by logistical complexity, cost, and ethical concerns. These challenges are further amplified in heart-lung transplantation. Although brain-dead donors (DBD) have historically been the primary source of heart-lung blocs, successful DCD heart-lung transplantation has recently been reported. However, most cases rely on thoracoabdominal normothermic regional perfusion (TA-NRP), which has limited global adoption and raises concerns regarding ethical considerations and lung utilization. Rapid REUP has recently emerged as an alternative strategy for DCD heart recovery without pre-implant reanimation. In this report, we describe the first application of the REUP technique in concert with direct lung procurement to recover an en bloc heart-lung, enabling successful combined heart-lung transplantation with excellent early graft function.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fifty-year pediatric heart transplant outcomes: A pediatric-adult center linked analysis","authors":"Seth A. Hollander MD ,&nbsp;Stephanie Hsiao ,&nbsp;Anubodh S. Varshney ,&nbsp;Helen Luikart ,&nbsp;Alireza Raissadati ,&nbsp;Daniel Bernstein ,&nbsp;Michael Ma ,&nbsp;Kari Wujcik ,&nbsp;Lynsey Barkoff ,&nbsp;John Dykes ,&nbsp;Donna Lee ,&nbsp;David N. Rosenthal","doi":"10.1016/j.healun.2025.10.022","DOIUrl":"10.1016/j.healun.2025.10.022","url":null,"abstract":"<div><h3>Purpose</h3><div>Long-term outcomes after pediatric heart transplant (pHT) are rarely reported owing to young programs and loss of follow-up after transition to adult care. We leveraged our program age, center volume, and linked electronic medical record to analyze 50-year outcomes after pHT, including events after adult care transfer.</div></div><div><h3>Methods</h3><div>Retrospective review of all pHT over 50 years at Stanford (August 19, 1974 to August 19, 2024). Patient characteristics and posttransplant outcomes, including death, retransplant, and subsequent kidney transplantation, were ascertained from the pediatric and adult electronic medical records, public records, and personal communication with other centers.</div></div><div><h3>Results</h3><div>There were 567 pHTs in 540 patients. Status as of August 19, 2024 was confirmed for 526 (97%),11 (2%) had partial follow-up, and 3 were missing. Over 1,888,341 follow-up days, 50 (9%) received a second heart transplant (27 pediatric, 23 adult) after a median of 9 (5, 14) years; 3 (1%) received a third heart transplant; 6 (1%) received a subsequent kidney transplant, and 212 (39%) died (172 pediatric, 40 adult). Median survival was 16.7 years; survival improved in successive eras (<em>p</em>&lt;0.001).</div></div><div><h3>Conclusion</h3><div>This linked analysis of pediatric and adult programs shows excellent long-term pHT outcomes with median survival exceeding 15 years and improving. Nearly half of retransplants occur after transfer; subsequent kidney transplant occurs infrequently.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 485-491"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145592837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric heart transplantation: We’ve come a long way but there is still a long way to go","authors":"Mary E. Teresczuk MD,&nbsp;Joseph W. Rossano MD","doi":"10.1016/j.healun.2025.11.009","DOIUrl":"10.1016/j.healun.2025.11.009","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 492-493"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond mechanics: Searching for biology in baseline lung allograft dysfunction","authors":"Jamie L. Todd MD, MHS","doi":"10.1016/j.healun.2025.11.020","DOIUrl":"10.1016/j.healun.2025.11.020","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 415-416"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between listing hemodynamics and heart transplantation waitlist outcomes: An analysis of the Scientific Registry of Transplant Recipients","authors":"Mark N. Belkin MD ,&nbsp;Molly White MS ,&nbsp;Alejandro Plana MD MS ,&nbsp;Seyed Ehsan Saffari ,&nbsp;Anthony J. Kanelidis MD ,&nbsp;Valluvan Jeevanandam MD ,&nbsp;Christopher Salerno MD ,&nbsp;Ann B. Nguyen MD ,&nbsp;Bow B. Chung MD ,&nbsp;Sara Kalantari MD ,&nbsp;Nitasha Sarswat MD ,&nbsp;Gene Kim MD ,&nbsp;Manreet Kanwar MD ,&nbsp;Sean P. Pinney MD ,&nbsp;William Parker ,&nbsp;Jonathan Grinstein MD","doi":"10.1016/j.healun.2025.10.017","DOIUrl":"10.1016/j.healun.2025.10.017","url":null,"abstract":"<div><h3>Background</h3><div>The association between invasive hemodynamics measurements at time of listing for heart transplantation and the outcome of removal from the waitlist for death or deterioration was evaluated.</div></div><div><h3>Methods</h3><div>Retrospective analysis of the Scientific Registry of Transplant Candidates, including all adults listed for heart transplant from October 2018 through December 2023 was completed. All patients with listing hemodynamics for statuses 1-4, and 6, were included, unless obtained while on mechanical circulatory support. Survival analyses was performed using competing risks regressions to assess the association between baseline hemodynamic parameters and 30-day and one-year outcomes. Results reported as sub-hazard ratios (HR) and 95% confidence intervals (CI).</div></div><div><h3>Results</h3><div>A total of 22,396 patients were listed for heart transplant, of which 14,079 patients met inclusion criteria. Aortic pulsatility index (API) &lt; 1.45 (subHR 2.14 95%CI 1.64,2.79 <em>p</em>&lt;0.001), left ventricular stroke work index (LVSWI) &lt; 20 (subHR 2.37 95%CI 1.77,3.19 <em>p</em> &lt;0.001), myocardial performance score (MPS) &lt; 0.5 (subHR 2.15 95%CI 1.64,2.81 <em>p</em>&lt;0.001), pulmonary capillary wedge pressure (PCWP) &gt; 15 mmHg (subHR 2.15 95%CI 1.67,2.85 <em>p</em>&lt;0.001), and systolic blood pressure (SBP) &lt; 90 mmHg (subHR 2.19 95%CI 1.67,2.85 <em>p</em>&lt;0.001) had the strongest association with the primary outcome. As continuous metrics, API and MPS were most strongly associated with the primary outcome.</div></div><div><h3>Conclusions</h3><div>API, LVSWI, MPS, PCWP, and SBP were the strongest predictors of transplant waitlist removal for death or deterioration of patients. The current heart transplant allocation system could be improved by incorporating more prognostic hemodynamic criteria for waitlist risk stratification.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 350-362"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary: Pregnancy after lung transplantation − a complex interplay of risk and hope","authors":"Katherine A. Young MD","doi":"10.1016/j.healun.2025.11.015","DOIUrl":"10.1016/j.healun.2025.11.015","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 428-429"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressure points: Hemodynamics and waitlist risk before heart transplant","authors":"Joseph B. Lerman MD,&nbsp;Stuart D. Russell","doi":"10.1016/j.healun.2025.11.018","DOIUrl":"10.1016/j.healun.2025.11.018","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 363-364"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited response letter","authors":"Alexander R. Berg BS,&nbsp;Aravind Krishnan MD,&nbsp;Elbert E. Heng MD,&nbsp;Ashley Y. Choi MD, MHS,&nbsp;Alyssa C. Garrison MS,&nbsp;Daniel I. Alnasir BS,&nbsp;Y. Chawannuch Ruaengsri MD,&nbsp;Yasuhiro Shudo MD, PHD,&nbsp;Y. Joseph Woo MD,&nbsp;John W. MacArthur MD","doi":"10.1016/j.healun.2025.11.025","DOIUrl":"10.1016/j.healun.2025.11.025","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 528-529"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-biased immune rewiring and the risk of cardiac allograft vasculopathy in heart transplant recipients: Initial steps in solving a complex puzzle","authors":"Tamas Alexy MD, PhD ,&nbsp;Sasa Vukelic MD, PhD","doi":"10.1016/j.healun.2025.12.006","DOIUrl":"10.1016/j.healun.2025.12.006","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"45 3","pages":"Pages 375-377"},"PeriodicalIF":6.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}