Journal of Heart and Lung Transplantation最新文献

{"title":"Proteomic and Metabolomic Profiling Nominates Druggable Targets and Biomarkers for Pulmonary Arterial Hypertension-Associated Myopathy and Exercise Intolerance in Male Monocrotaline Rats.","authors":"Phablo Abreu, Ryan Moon, Jenna B Mendelson, Todd Markowski, LeeAnn Higgins, Kevin Murray, Candace Guerrero, Jeffrey Blake, Sasha Z Prisco, Kurt W Prins","doi":"10.1016/j.healun.2025.06.034","DOIUrl":"10.1016/j.healun.2025.06.034","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary arterial hypertension (PAH) is a rare but debilitating condition that causes exercise intolerance and ultimately death. Skeletal muscle derangements contribute to depressed exercise capacity in PAH, but the mechanisms underlying muscle dysfunction including the changes in muscle biology based on fiber type are understudied.</p><p><strong>Methods: </strong>We evaluated exercise capacity, muscle histopathology, mitochondrial density, mitochondrial proteomics, and metabolomics/lipidomics of quadriceps (predominately fast fibers) and soleus (predominately slow fibers) muscles in the monocrotaline (MCT) rat model of PAH.</p><p><strong>Results: </strong>MCT rats exhibited impaired exercise capacity. Surprisingly, there were divergent atrophic and metabolic remodeling in the quadriceps and soleus muscles of MCT rats. In the quadriceps, there was a mild atrophic response only in type II fibers. In contrast, both type I and II fibers atrophied in the soleus. Both muscles exhibited fibrotic infiltration, but mitochondrial density was reduced in the quadriceps only. Mitochondrial proteomics and tissue metabolomics/lipidomics profiling demonstrated the two muscles exhibited distinct responses as the quadriceps had impairments in oxidative phosphorylation/fat metabolism and storage of triacylglycerides. However, the soleus showed signs of proteasome deficiencies and alterations in phosphatidylcholine/phosphatidylethanolamine homeostasis. Finally, profiling of metabolites/lipids in the serum identified potential novel biomarkers of exercise intolerance in PAH including the dimethylarginine pathway, cysteine, and triacylglycerides.</p><p><strong>Conclusion: </strong>Our data suggest differential cachectic and metabolic responses occur in PAH-induced myopathy. We nominate mitochondrial biogenesis and proteasome activation as potential druggable targets for PAH-myopathy.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144618581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACUTE PULMONARY EMBOLISM IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION, TWO CLINICAL CASES","authors":"A.-M. Claveau ,&nbsp;M.J. Eisenberg ,&nbsp;A.O. Abualsaud","doi":"10.1016/j.healun.2024.04.022","DOIUrl":"10.1016/j.healun.2024.04.022","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S22"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFICACY OF PRECEDING BALLOON PULMONARY ANGIOPLASTY BEFORE PULMONARY ENDARTERECTOMY FOR HIGH-RISK CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION PATIENTS","authors":"J. Yamashita ,&nbsp;R. Ito ,&nbsp;S. Suzuki ,&nbsp;K. Satomi ,&nbsp;Y. Shimahara","doi":"10.1016/j.healun.2024.04.031","DOIUrl":"10.1016/j.healun.2024.04.031","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S25"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MICROCIRCULATORY RESISTANCE IN THE RIGHT CORONARY ARTERY OF PATIENTS WITH CTEPH","authors":"I.M. Lang,&nbsp;C. Gerges,&nbsp;M. Stojanovic","doi":"10.1016/j.healun.2024.04.009","DOIUrl":"10.1016/j.healun.2024.04.009","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S16"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INITIAL CHARACTERISTICS OF PATIENTS WITH AND WITHOUT RESIDUAL PULMONARY HYPERTENSION AFTER PULMONARY THROMBOENDARTERECTOMY","authors":"S. Gratsianskaya,&nbsp;Z. Valieva,&nbsp;K. Mershin,&nbsp;T. Martynyuk","doi":"10.1016/j.healun.2024.04.038","DOIUrl":"10.1016/j.healun.2024.04.038","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S28"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARISON OF THE RESPONSE TO SELECTIVE PULMONARY VASODILATOR IN CTEPH PATIENTS WITH OR WITHOUT MYELOPROLIFERATIVE NEOPLASM","authors":"M. Hirose ,&nbsp;S. Adachi ,&nbsp;Y. Nakano ,&nbsp;I. Nishiyama ,&nbsp;T. Adachi ,&nbsp;H. Kondo ,&nbsp;T. Murohara","doi":"10.1016/j.healun.2024.04.028","DOIUrl":"10.1016/j.healun.2024.04.028","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S24"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SAME DAY DISCHARGE FOLLOWING BALLOON PULMONARY ARTERY ANGIOPLASTY","authors":"S. Bartolome,&nbsp;T. Shah,&nbsp;J. Chidester,&nbsp;T. Koshy","doi":"10.1016/j.healun.2024.04.050","DOIUrl":"10.1016/j.healun.2024.04.050","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S33"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDENTIFICATION OF POTENTIAL PATHOGENIC GENES FUNCTIONING IN THE DEVELOPMENT FROM PE TO CTEPH BY INTEGRATED BIOINFORMATICS ANALYSIS AND MACHINE LEARNING","authors":"Y. Li ,&nbsp;X. Li ,&nbsp;J. Liu ,&nbsp;S. Ma ,&nbsp;Z. Zhai ,&nbsp;W. Xie ,&nbsp;C. Wang","doi":"10.1016/j.healun.2024.04.008","DOIUrl":"10.1016/j.healun.2024.04.008","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Pages S15-S16"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PULMONARY ENDARTERECTOMY IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION: KAZAKHSTAN EXPERIENCE","authors":"A. Kuzhakhmetova ,&nbsp;M. Mukarov ,&nbsp;T. Lesbekov","doi":"10.1016/j.healun.2024.04.044","DOIUrl":"10.1016/j.healun.2024.04.044","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S31"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SAFETY AND FEASIBILITY OF A PULMONARY ENDARTERECTOMY TRAINING PROGRAM: EXPERIENCE FROM THE UK NATIONAL PROGRAMME","authors":"S. Chiu,&nbsp;A. Chia,&nbsp;P. Appenzeller,&nbsp;F. Taghavi,&nbsp;S. Tsui,&nbsp;D. Jenkins,&nbsp;C. Ng","doi":"10.1016/j.healun.2024.04.047","DOIUrl":"10.1016/j.healun.2024.04.047","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S32"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}