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Journal of Heart and Lung Transplantation最新文献

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They're doing cartwheels-I'm just trying to drink my coffee: Direct procurement DCD lung retrieval remains viable with abdominal normothermic regional perfusion. 他们在做侧手翻——我只是想喝我的咖啡：直接获取DCD肺回收在腹部常温区域灌注下仍然可行。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2025-05-27 DOI: 10.1016/j.healun.2025.04.017
Michael T Cain, Sandra Lindstedt
{"title":"They're doing cartwheels-I'm just trying to drink my coffee: Direct procurement DCD lung retrieval remains viable with abdominal normothermic regional perfusion.","authors":"Michael T Cain, Sandra Lindstedt","doi":"10.1016/j.healun.2025.04.017","DOIUrl":"https://doi.org/10.1016/j.healun.2025.04.017","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Obesity on Long Term Post Heart Transplantation Outcomes. 肥胖对心脏移植术后长期预后的影响。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2025-05-27 DOI: 10.1016/j.healun.2025.04.021
Darae Kim, In-Cheol Kim, Jong-Chan Youn, Woo-Sung Chang, Jin-Jin Kim, Mi-Hyang Jung, Jin-Oh Choi, Daniel Seong Kyu Kim, Mason Lee, Evan P Kransdorf, David H Chang, Michelle M Kittleson, Jignesh K Patel, Fardad Esmailian, Jon A Kobashigawa
{"title":"Impact of Obesity on Long Term Post Heart Transplantation Outcomes.","authors":"Darae Kim, In-Cheol Kim, Jong-Chan Youn, Woo-Sung Chang, Jin-Jin Kim, Mi-Hyang Jung, Jin-Oh Choi, Daniel Seong Kyu Kim, Mason Lee, Evan P Kransdorf, David H Chang, Michelle M Kittleson, Jignesh K Patel, Fardad Esmailian, Jon A Kobashigawa","doi":"10.1016/j.healun.2025.04.021","DOIUrl":"https://doi.org/10.1016/j.healun.2025.04.021","url":null,"abstract":"<p><strong>Background: </strong>Obesity is an ongoing pandemic, and the rising trend of body mass index (BMI) in heart transplant (HTx) recipients is well known. However, the long term post-HTx outcomes of obese patients are not clearly documented.</p><p><strong>Aims: </strong>We aimed to investigate long term post-transplant outcomes in obese patients.</p><p><strong>Methods: </strong>Among 1,787 consecutively enrolled adult HTx recipients between September 1990 and June 2022, patients were categorized into BMI groups: underweight (<18 kg/m²), normal weight (18.0-24.9 kg/m²), overweight (25-29.9 kg/m²), and obese (≥ 30 kg/m²). The primary outcome was post-HTx mortality, with secondary outcomes including primary graft dysfunction, treated rejection, coronary allograft vasculopathy, retransplant, and nonfatal major adverse cardiac event.</p><p><strong>Results: </strong>Over time, there was a significant increase in obese recipients (BMI ≥ 30 kg/m²) and they were more likely to have comorbidities such as diabetes and hypertension, experience significantly longer wait times, and more frequently received undersized donors compared to those with normal weight. During the median follow up duration of 6 years after HTx, obese recipients showed significantly higher incidence of treated rejection (P =0.027) and lower post-HTx survival compared to those with normal weight (P=0.009). In multivariable analysis, obese patients had a significantly higher risk of post-transplant mortality, primary graft dysfunction, and any treated rejection even after adjusting relevant clinical variables.</p><p><strong>Conclusions: </strong>Obese HTx recipients demonstrated a significantly higher risk of death, primary graft dysfunction, and any treated rejection. Our findings highlight the need for proactive, multidisciplinary management of obesity prior to HTx.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Fc gamma-binding protein rs1464897604 polymorphism with bronchiolitis obliterans syndrome in lung transplant recipients. Fc γ结合蛋白rs1464897604多态性与肺移植受者闭塞性细支气管炎综合征的关系
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2025-05-27 DOI: 10.1016/j.healun.2025.05.001
Junho Kang, Yun Hak Kim, Eunjeong Choi, Hee Yun Seol, Seong Hoon Yoon, Eunjeong Son, Seung Eun Lee, Woo Hyun Cho, Hyun-Ji Lee, Seung Hwan Oh, Hye Ju Yeo
{"title":"Association of Fc gamma-binding protein rs1464897604 polymorphism with bronchiolitis obliterans syndrome in lung transplant recipients.","authors":"Junho Kang, Yun Hak Kim, Eunjeong Choi, Hee Yun Seol, Seong Hoon Yoon, Eunjeong Son, Seung Eun Lee, Woo Hyun Cho, Hyun-Ji Lee, Seung Hwan Oh, Hye Ju Yeo","doi":"10.1016/j.healun.2025.05.001","DOIUrl":"https://doi.org/10.1016/j.healun.2025.05.001","url":null,"abstract":"<p><strong>Background: </strong>Bronchiolitis obliterans syndrome (BOS) is a major challenge after lung transplantation (LT) and hematopoietic stem cell transplantation (HSCT), sharing pathological similarities but lacking identified common genetic mutations.</p><p><strong>Methods: </strong>We conducted a comparative analysis of whole-genome sequencing data from lung tissue samples of patients with BOS after LT and HSCT to identify shared and distinct genetic alterations. Common variants were validated using Sanger sequencing of peripheral blood samples. We then evaluated the association between validated variants and clinical outcomes in an independent LT cohort.</p><p><strong>Results: </strong>Single nucleotide polymorphisms (SNPs) were the most prevalent variants in both cohorts, with a mean of 731 SNPs in post-LT BOS patients and 990 SNPs in post-HSCT BOS patients. Five candidate SNPs-FCGBP rs1464897604, KMT2C rs146238849, LINC01410 rs28440808, PABPC3 rs781717999, and POM121 rs1307236009-were selected based on their higher detection frequencies in BOS tissues compared to the general population. Sanger sequencing of blood samples confirmed that FCGBP rs1464897604 and POM121 rs1307236009 were germline variants. Among these, FCGBP rs1464897604 was prioritized for further analysis due to its relatively low minor allele frequency (MAF) in the Korean population (0.0038) and markedly higher frequency in the BOS cohort (MAF 0.4444). FCGBP rs1464897604 was significantly associated with adverse transplant outcomes, including higher rates of acute rejection, increased incidence of de novo donor-specific antibody formation within two years, and greater BOS occurrence in independent LT cohorts.</p><p><strong>Conclusion: </strong>The common genetic variant FCGBP, identified in patients with post-HSCT and post-LT BOS, was associated with poor clinical outcomes following LT.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ensuring Access to Novel Donor Heart Preservation Modalities. 确保获得新的供体心脏保存方式。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2025-05-27 DOI: 10.1016/j.healun.2025.04.018
Joseph B Lerman, Katherine D Marapese, Amber R Johnson, Ian R Jamieson, Jeffrey E Keenan, Jacob N Schroder, Adam D DeVore, Chetan B Patel
{"title":"Ensuring Access to Novel Donor Heart Preservation Modalities.","authors":"Joseph B Lerman, Katherine D Marapese, Amber R Johnson, Ian R Jamieson, Jeffrey E Keenan, Jacob N Schroder, Adam D DeVore, Chetan B Patel","doi":"10.1016/j.healun.2025.04.018","DOIUrl":"https://doi.org/10.1016/j.healun.2025.04.018","url":null,"abstract":"<p><p>Despite improvements in managing earlier stage heart disease, the population of patients needing heart transplants continues to increase in the United States. Fortunately, novel methods of procuring and preserving donor hearts, including the use of ex-vivo heart perfusion (EVHP) and controlled hypothermic preservation, have enabled a rise in heart transplantation. In particular, EVHP has contributed to increased utilization of donation after circulatory death (DCD), as well as enhanced use of donor hearts from increased geographic distances and extended criteria (marginal) donors. The use of such preservation technologies, however, has coincided with a significant increase in the cost of donor heart procurement and the advent of a donor organ procurement services industry. We aim to provide an overview on the rising costs of heart donation, explore the causes of such increase, and discuss potential solutions to drive both cost savings and increased access to heart transplantation.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An open letter to the ISHLT and its global lung transplantation community. 致ISHLT及其全球肺移植社区的公开信。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2025-05-26 DOI: 10.1016/j.healun.2025.05.006
Paul A Corris, Maria M Crespo, Robin Vos, Sangeeta Bhorade, Scott Palmer, Daniel Chambers
{"title":"An open letter to the ISHLT and its global lung transplantation community.","authors":"Paul A Corris, Maria M Crespo, Robin Vos, Sangeeta Bhorade, Scott Palmer, Daniel Chambers","doi":"10.1016/j.healun.2025.05.006","DOIUrl":"https://doi.org/10.1016/j.healun.2025.05.006","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re: Optimizing the Handling of Missing Data in the UNOS Database. Re：优化UNOS数据库丢失数据的处理。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2025-05-26 DOI: 10.1016/j.healun.2025.04.026
William L Baker, Timothy Moore, Eric Baron, Michelle Kittleson, William F Parker, Abhishek Jaiswal
{"title":"Re: Optimizing the Handling of Missing Data in the UNOS Database.","authors":"William L Baker, Timothy Moore, Eric Baron, Michelle Kittleson, William F Parker, Abhishek Jaiswal","doi":"10.1016/j.healun.2025.04.026","DOIUrl":"https://doi.org/10.1016/j.healun.2025.04.026","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maribavir: Double edged sword 马里巴韦：双刃剑
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2025-05-19 DOI: 10.1016/j.healun.2025.01.011
Yoichiro Natori MD, MPH , Mohammed Raja MD , Shweta Anjan MD , Jose F. Camargo MD
{"title":"Maribavir: Double edged sword","authors":"Yoichiro Natori MD, MPH ,&nbsp;Mohammed Raja MD ,&nbsp;Shweta Anjan MD ,&nbsp;Jose F. Camargo MD","doi":"10.1016/j.healun.2025.01.011","DOIUrl":"10.1016/j.healun.2025.01.011","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 6","pages":"Pages 1007-1008"},"PeriodicalIF":6.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Information for Readers 读者资讯
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2025-05-19 DOI: 10.1016/S1053-2498(25)01946-1
{"title":"Information for Readers","authors":"","doi":"10.1016/S1053-2498(25)01946-1","DOIUrl":"10.1016/S1053-2498(25)01946-1","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 6","pages":"Page A2"},"PeriodicalIF":6.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Information for Readers 读者信息
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2025-04-11 DOI: 10.1016/S1053-2498(25)01888-1
{"title":"Information for Readers","authors":"","doi":"10.1016/S1053-2498(25)01888-1","DOIUrl":"10.1016/S1053-2498(25)01888-1","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 5","pages":"Page A2"},"PeriodicalIF":6.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal assessment of bone mineral density changes after heart transplant: Implications for DXA screening frequency 心脏移植后骨密度变化的纵向评估：对DXA筛查频率的影响
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2025-04-11 DOI: 10.1016/j.healun.2025.01.020
Ronnie Sebro MD, PhD , Mahmoud Elmahdy MBBS , Ayanna Braxton
{"title":"Longitudinal assessment of bone mineral density changes after heart transplant: Implications for DXA screening frequency","authors":"Ronnie Sebro MD, PhD ,&nbsp;Mahmoud Elmahdy MBBS ,&nbsp;Ayanna Braxton","doi":"10.1016/j.healun.2025.01.020","DOIUrl":"10.1016/j.healun.2025.01.020","url":null,"abstract":"<div><div>We evaluated the rate of bone mineral density (BMD) loss after heart transplant using dual-energy X-ray absorptiometry (DXA) to determine the optimal DXA surveillance frequency. This retrospective study involved 153 heart transplant recipients aged 50 years or greater, followed for up to 5,614 (median 1,111) days after transplant. Mixed-effects models with random intercepts were used to evaluate BMD changes over time. We found that males had higher BMD at each site before transplant (<em>p</em> &lt; 0.05 for all). Patients with normal BMD pretransplant had a greater rate of BMD loss compared to patients who had low BMD pretransplant at the femoral neck. The rate of BMD loss was fastest at the femoral neck in patients with normal BMD pretransplant, with an estimated annual femoral neck BMD decrease of 0.00905 g/cm<sup>2</sup>. The expected time for a patient to have a significant change in BMD is 1,332 days (95% confidence interval [909, 2,493] days).</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 5","pages":"Pages 823-829"},"PeriodicalIF":6.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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