Journal of Heart and Lung Transplantation最新文献

{"title":"Information for Readers","authors":"","doi":"10.1016/S1053-2498(25)01888-1","DOIUrl":"10.1016/S1053-2498(25)01888-1","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 5","pages":"Page A2"},"PeriodicalIF":6.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal assessment of bone mineral density changes after heart transplant: Implications for DXA screening frequency","authors":"Ronnie Sebro MD, PhD ,&nbsp;Mahmoud Elmahdy MBBS ,&nbsp;Ayanna Braxton","doi":"10.1016/j.healun.2025.01.020","DOIUrl":"10.1016/j.healun.2025.01.020","url":null,"abstract":"<div><div>We evaluated the rate of bone mineral density (BMD) loss after heart transplant using dual-energy X-ray absorptiometry (DXA) to determine the optimal DXA surveillance frequency. This retrospective study involved 153 heart transplant recipients aged 50 years or greater, followed for up to 5,614 (median 1,111) days after transplant. Mixed-effects models with random intercepts were used to evaluate BMD changes over time. We found that males had higher BMD at each site before transplant (<em>p</em> &lt; 0.05 for all). Patients with normal BMD pretransplant had a greater rate of BMD loss compared to patients who had low BMD pretransplant at the femoral neck. The rate of BMD loss was fastest at the femoral neck in patients with normal BMD pretransplant, with an estimated annual femoral neck BMD decrease of 0.00905 g/cm². The expected time for a patient to have a significant change in BMD is 1,332 days (95% confidence interval [909, 2,493] days).</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 5","pages":"Pages 823-829"},"PeriodicalIF":6.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-series tacrolimus trough level prediction using multivariate long short-term memory networks: Methodology and prospective validation","authors":"Haruki Choshi MD ,&nbsp;Kentaroh Miyoshi MD, PhD ,&nbsp;Maki Tanioka MD, PhD ,&nbsp;Shinichi Toyooka MD, PhD","doi":"10.1016/j.healun.2025.01.013","DOIUrl":"10.1016/j.healun.2025.01.013","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 5","pages":"Pages 845-847"},"PeriodicalIF":6.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning model for tacrolimus dosing: Can we validate and compare to existing options?","authors":"Michael G.S. Shashaty MD, MSCE ,&nbsp;Gary E. Weissman MD, MSHP ,&nbsp;Marc H. Scheetz PharmD, MSC ,&nbsp;Todd A. Miano PharmD, PhD","doi":"10.1016/j.healun.2024.12.021","DOIUrl":"10.1016/j.healun.2024.12.021","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 5","pages":"Pages 843-844"},"PeriodicalIF":6.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor Care Units in Heart Transplantation: The Heart of the Matter.","authors":"Ioannis Mastoris, David D'Alessandro","doi":"10.1016/j.healun.2025.03.026","DOIUrl":"https://doi.org/10.1016/j.healun.2025.03.026","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized trial of open lung protective ventilation compared to conventional mechanical ventilation in deceased organ donors.","authors":"Lorraine B Ware, Tatsuki Koyama, Ciara M Shaver, Sharon Swain, John Nguyen, Ahmad Salehi, Gundeep Dhillon, Nancy Wickersham, Julia Maheshwari, Jonathan P Singer, S Samuel Weigt, Jasleen Kukreja, Michael A Matthay","doi":"10.1016/j.healun.2025.03.027","DOIUrl":"https://doi.org/10.1016/j.healun.2025.03.027","url":null,"abstract":"<p><strong>Purpose: </strong>We conducted a randomized trial of open lung protective ventilation (OLPV) compared to conventional ventilation (CV) in deceased donors. The primary outcome was lung utilization for transplantation.</p><p><strong>Methods: </strong>Eligible donors were ≥13 years with PaO₂/FiO₂ between 150 and 400 mmHg. Donors were randomized to volume control with OLPV [tidal volume (TV) 8 ml/kg, PEEP 10 cmH₂O, protocolized recruitment maneuvers (RM)] or CV [TV 10ml/kg, PEEP 5 cm H₂O, RM only after vent disconnect] for duration of donor management. Lungs were evaluated for transplantation on standardized ventilator settings in both arms [TV 10ml/kg, PEEP 5 cm H₂O, FiO₂ 1.0].</p><p><strong>Results: </strong>153 donors were randomized (74 to OLPV, 79 to CV) and included in the final analysis. Median duration of treatment was 50 hours and did not differ by arm. Donor lung utilization was 23% in the OLPV arm and 22% in the CV arm, P = 0.85. Change in PaO₂/FiO₂ from randomization to procurement did not differ by treatment; median increase (quartiles) in OLPV versus CV was 68 mmHg (18, 127) vs 74 (-27 to 170), P = 0.72. There was no difference in need for vasopressors or serious adverse events between arms. Among 28 lung recipients in whom detailed outcomes were available, duration of mechanical ventilation, ICU stay and hospital stay were not different by treatment arm.</p><p><strong>Conclusions: </strong>An open lung protective ventilator strategy was safe but did not improve donor lung utilization or oxygenation compared to a conventional ventilator strategy in a population of US organ donors. NCT03439995.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rescue Kidneys in Lung Transplantation: A Retrospective Analysis of Recipients Who Might Have Benefitted from a Kidney Safety Net.","authors":"Jiashu Xue, Reed Jenkins, Jessica Ruck, Christian Merlo, Errol Bush","doi":"10.1016/j.healun.2025.03.025","DOIUrl":"https://doi.org/10.1016/j.healun.2025.03.025","url":null,"abstract":"<p><strong>Introduction: </strong>In 2023, a new UNOS policy established criteria for a kidney allocation safety net for lung transplant recipients (LTRs) with chronic renal dysfunction. We sought to evaluate the demographics and outcomes of past lung transplant recipients who would have been eligible for a rescue kidney under the new criteria.</p><p><strong>Methods: </strong>Using the UNOS OPTN registry, we identified lung transplant recipients from 2005-2023 who fit the eligibility for rescue kidneys. Rescue kidney eligibility was defined as recipients who had an eGFR≤20mL/min, CrCl≤20mL/min, or were receiving chronic dialysis at any point 60 to 365 days post-transplant. Baseline characteristics and survival out to 1 and 3 years were evaluated for the rescue kidney-eligible cohort compared to all other lung transplant recipients in the study period.</p><p><strong>Results: </strong>554 (2.1%) of all recipients would have been eligible for a rescue kidney under the new policy. Comparing to non-eligible group, they were older (median, 62 vs 61 years; P <.001), had higher BMI (27 vs 26; P <.001), and were more often Black (13% vs 9%; P <.001). They also had a significantly higher proportion of renal dysfunction (including CKD stage III, IV and V) at the time of transplant (17% vs 7%; P <.001) and higher likelihood of pre-transplant dialysis (7% vs 0%; P <.001). The rescue-eligible recipients had higher rates of life support (14% vs 11%; P =.031) and greater LAS at transplant (median 40 vs 39; P <.01). Compared to non-eligible recipients, rescue kidney-eligible recipients had lower survival at 1 year (42% vs. 88%, p<.001) and 3 years (28% vs. 71%, p<.001). These differences in mortality risk persisted after adjusting for donor and recipient characteristics (1-year mortality aHR 9.27; 95% CI 8.16-10.55; P <.001; 3-year aHR 5.55; 95% CI 4.97-6.20; P <.001).</p><p><strong>Conclusion: </strong>While relatively few recipients would have been eligible for a rescue kidney under the new policy, they had significantly worse survival than non-eligible recipients. This underscores the severe illness of these patients and the importance of assessing whether rescue kidneys can reduce these mortality differences.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right atrial size in PAH: Independent Marker or Just an Echo of RV Dysfunction?","authors":"Tor Skibsted Clemmensen, Mads Jønsson Andersen","doi":"10.1016/j.healun.2025.03.022","DOIUrl":"https://doi.org/10.1016/j.healun.2025.03.022","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Immersive Look into Temperature-Controlled Hypothermic Heart Preservation.","authors":"Fuyi Liao, Andrew E Gelman","doi":"10.1016/j.healun.2025.03.023","DOIUrl":"https://doi.org/10.1016/j.healun.2025.03.023","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Accuracy of the Derived Left Ventricular End-Diastolic Pressure in Impella 5.5","authors":"J.S. Hanke ,&nbsp;R. Poyanmehr ,&nbsp;D. Boethig ,&nbsp;A. Merzah ,&nbsp;J. Karsten ,&nbsp;M. Hinteregger ,&nbsp;G. Dogan ,&nbsp;J. Schmitto ,&nbsp;A. Schaefer ,&nbsp;L. Napp ,&nbsp;A. Popov ,&nbsp;A. Weymann ,&nbsp;J. Bauersachs ,&nbsp;A. Ruhparwar ,&nbsp;B. Schmack","doi":"10.1016/j.healun.2025.02.048","DOIUrl":"10.1016/j.healun.2025.02.048","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 4","pages":"Page S21"},"PeriodicalIF":6.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}