Journal of Heart and Lung Transplantation最新文献_第2页

Highly sensitized patients listed for heart after liver transplantation with or without domino. 肝脏移植后，高度敏感的患者在使用或不使用多米诺的情况下被列入心脏移植名单。

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-01-01 Epub Date: 2024-08-31 DOI: 10.1016/j.healun.2024.08.024

Shin Lin, Ioannis Dimarakis, Elina Minami, Ramasamy Bakthavatsalam, Renuka Bhattacharya, April Stempien-Otero, Yiing Lin, Aris Karatasakis, Maziar Khorsandi, Elaine Chou-Wu, Idoia Gimferrer, Mariya Y Golub, Daniel Fishbein, Richard K Cheng, Ryutaro Hirose, Mark Sturdevant, Jay D Pal

引用次数: 0

The outcome of restrictive cardiac allograft physiology in severe coronary allograft vasculopathy. 严重冠状动脉异体移植物血管病变中心脏异体移植物生理学受限的结果。

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-01-01 Epub Date: 2024-10-05 DOI: 10.1016/j.healun.2024.09.029

Masaki Tsuji, Jignesh K Patel, Michelle M Kittleson, David H Chang, Evan P Kransdorf, Andriana P Nikolova, Lily K Stern, Nayana Bhatnagar, Jon A Kobashigawa

{"title":"The outcome of restrictive cardiac allograft physiology in severe coronary allograft vasculopathy.","authors":"Masaki Tsuji, Jignesh K Patel, Michelle M Kittleson, David H Chang, Evan P Kransdorf, Andriana P Nikolova, Lily K Stern, Nayana Bhatnagar, Jon A Kobashigawa","doi":"10.1016/j.healun.2024.09.029","DOIUrl":"10.1016/j.healun.2024.09.029","url":null,"abstract":"Background: Microvascular dysfunction after heart transplantation leads to restrictive cardiac allograft physiology (RCP), which is classified as severe coronary allograft vasculopathy (CAV); however, the prognosis of RCP remains unclear. Therefore, in this study, we aimed to elucidate the prognosis of RCP in comparison with that of severe angiographic CAV.Methods: We assessed 116 patients with severe CAV who underwent heart transplantation between 2004 and 2023. RCP was defined as symptomatic heart failure with restrictive hemodynamic values (mean right atrial pressure >12 mm Hg, pulmonary capillary wedge pressure >25 mm Hg, and cardiac index <2.0 liter/min/m2). The primary outcome was death or retransplantation.Results: Of the 116 patients with severe CAV, 42 had RCP (RCP-CAV group) and 74 had severe angiographic CAV without RCP (Angio-CAV group). A significantly shorter time from heart transplantation to diagnosis and lower subsequent percutaneous catheter intervention after diagnosis were seen in the RCP-CAV group than in the Angio-CAV group (both p < 0.001). Freedom from death or retransplantation at 5 years was significantly worse in the RCP-CAV group compared to the Angio-CAV group (18.4% vs 35.4%, p = 0.001). In the Cox proportional hazard model, RCP was independently associated with an increased risk of death or retransplantation (hazard ratio 2.08, 95% confidence intervals 1.26-3.44, p = 0.004).Conclusions: The prognosis of patients with RCP was significantly worse than that of patients with severe angiographic CAV. The early detection of microvascular dysfunction and retransplantation listing may improve the prognosis of patients with RCP.","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":"57-63"},"PeriodicalIF":6.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term air pollution exposure and the risk of primary graft dysfunction after lung transplantation. 肺移植术后长期暴露于空气污染与原发性移植物功能障碍的风险。

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-01-01 Epub Date: 2024-07-15 DOI: 10.1016/j.healun.2024.07.003

Tatsuki Koyama, Zhiguo Zhao, John R Balmes, Carolyn S Calfee, Michael A Matthay, John P Reilly, Mary K Porteous, Joshua M Diamond, Jason D Christie, Edward Cantu, Lorraine B Ware

{"title":"Long-term air pollution exposure and the risk of primary graft dysfunction after lung transplantation.","authors":"Tatsuki Koyama, Zhiguo Zhao, John R Balmes, Carolyn S Calfee, Michael A Matthay, John P Reilly, Mary K Porteous, Joshua M Diamond, Jason D Christie, Edward Cantu, Lorraine B Ware","doi":"10.1016/j.healun.2024.07.003","DOIUrl":"10.1016/j.healun.2024.07.003","url":null,"abstract":"Background: Primary graft dysfunction (PGD) contributes substantially to both short- and long-term mortality after lung transplantation, but the mechanisms that lead to PGD are not well understood. Exposure to ambient air pollutants is associated with adverse events during waitlisting for lung transplantation and chronic lung allograft dysfunction, but its association with PGD has not been studied. We hypothesized that long-term exposure of the lung donor and recipient to high levels of ambient air pollutants would increase the risk of PGD in lung transplant recipients.Methods: Using data from 1428 lung transplant recipients and their donors enrolled in the Lung Transplant Outcomes Group observational cohort study, we evaluated the association between the development of PGD and zip-code-based estimates of long-term exposure to 6 major air pollutants (ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide, particulate matter 2.5, and particulate matter 10) in both the lung donor and the lung recipient. Exposure estimates used daily EPA air pollutant monitoring data and were based on the geographic centroid of each subject's residential zip code. Associations were tested in both univariable and multivariable models controlling for known PGD risk factors.Results: We did not find strong associations between air pollutant exposures in either the donor or the recipient and PGD.Conclusions: Exposure to ambient air pollutants, at the levels observed in this study, may not be sufficiently harmful to prime the donor lung or the recipient to develop PGD, particularly when considering the robust associations with other established PGD risk factors.","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":"64-74"},"PeriodicalIF":6.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141633728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hospital volume does not mitigate the impact of area socioeconomic deprivation on heart transplantation outcomes. 医院规模并不能减轻社会经济贫困地区对心脏移植结果的影响。

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-01-01 Epub Date: 2024-09-30 DOI: 10.1016/j.healun.2024.08.012

Sara Sakowitz, Syed Shahyan Bakhtiyar, Saad Mallick, Amulya Vadlakonda, Nikhil Chervu, Richard Shemin, Peyman Benharash

{"title":"Hospital volume does not mitigate the impact of area socioeconomic deprivation on heart transplantation outcomes.","authors":"Sara Sakowitz, Syed Shahyan Bakhtiyar, Saad Mallick, Amulya Vadlakonda, Nikhil Chervu, Richard Shemin, Peyman Benharash","doi":"10.1016/j.healun.2024.08.012","DOIUrl":"10.1016/j.healun.2024.08.012","url":null,"abstract":"Background: While structural socioeconomic inequity has been linked with inferior health outcomes, some have postulated reduced access to high-quality care to be the mediator. We assessed whether treatment at high-volume centers (HVC) would mitigate the adverse impact of area deprivation on heart transplantation (HT) outcomes.Methods: All HT recipients ≥18 years were identified in the 2005-2022 Organ Procurement and Transplantation Network. Neighborhood socioeconomic deprivation was assessed using the previously validated Area Deprivation Index. Recipients with scores in the highest quintile were considered Most Deprived (others: Less Deprived). Hospitals in the highest quartile by cumulative center volume (≥21 transplants/year) were classified as HVC. The primary outcome was post-transplant survival.Results: Of 38,022 HT recipients, 7,579 (20%) were considered Most Deprived. Following risk adjustment, Most Deprived demonstrated inferior survival at 3 (hazard ratio [HR] 1.14, 95% confidence interval [CI] 1.06-1.21) and 5 years following transplantation (HR 1.13, CI 1.07-1.20). Similarly, Most Deprived faced greater graft failure at 3 (HR 1.14, CI 1.06-1.22) and 5 years (HR 1.13, CI 1.07-1.20). Evaluating patients transplanted at HVC, Most Deprived continued to face greater mortality at 3 (HR 1.10, CI 1.01-1.21) and 5 years (HR 1.10, CI 1.01-1.19). The interaction between Most Deprived status and care at HVC was not significant, such that transplantation at HVC did not ameliorate the survival disparity between Most and Less Deprived.Conclusions: Area socioeconomic disadvantage is independently associated with inferior survival. Transplantation at HVC did not eliminate this inequity. Future efforts are needed to increase engagement with longitudinal follow-up care and address systemic root causes to improve outcomes.","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":"33-43"},"PeriodicalIF":6.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in heart transplant outcomes for patients over the age of 70 years in the United States: An analysis of the scientific registry of transplant recipients database. 美国 70 岁以上患者心脏移植结果趋势：移植受者科学登记数据库分析》。

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-01-01 Epub Date: 2024-08-08 DOI: 10.1016/j.healun.2024.08.001

Erik J Henricksen, Brian Wayda, Jeffrey J Teuteberg, Helen Luikart, Joyce Njoroge, Brandon A Guenthart, Kiran K Khush

{"title":"Trends in heart transplant outcomes for patients over the age of 70 years in the United States: An analysis of the scientific registry of transplant recipients database.","authors":"Erik J Henricksen, Brian Wayda, Jeffrey J Teuteberg, Helen Luikart, Joyce Njoroge, Brandon A Guenthart, Kiran K Khush","doi":"10.1016/j.healun.2024.08.001","DOIUrl":"10.1016/j.healun.2024.08.001","url":null,"abstract":"Background: Patients of advanced age are often considered to be poor candidates for heart transplant (HT). As the U.S. population continues to age, it is important for clinicians to understand how best to select patients for advanced therapies.Methods: This was a retrospective analysis of the U.S. Scientific Registry of Transplant Recipients data from 2006 to August 2022 in adult recipients. Patients were excluded if they were multiorgan transplant, re-do transplants, or less than 1 year post transplant.Results: Recipients ≥70 had a 1-year survival of 87.5%, compared to 91.1% for <60%, and 88.4% for 60-69 years (p < 0.001). Survival improved numerically, but not significantly, as transplant eras progressed for those ≥70 years. Survival by Kaplan-Meier analysis was greatest at 5 years for <60 years (80.6%), compared to 60-69 years (78.2%) and ≥70 years (77.1%). When comparing 60-69 years to ≥70 years by this same metric, there was significant difference (p = 0.12). One year survival for those ≥70 years has improved from 2000-2009 (80.7%) to 88.5% since October 2018 (p < 0.001). As recipients increased in age, they were more likely to be male, and less likely to be Black or Hispanic/Latino (p < 0.001).Conclusion: Overall, HT outcomes are excellent for carefully selected patients ≥70 years, and transplanting patients in this age cohort can be considered.","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":"75-81"},"PeriodicalIF":6.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Therapeutic Agents for Cardiometabolic Risk Mitigation in Heart Transplant Recipients.

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2024-12-17 DOI: 10.1016/j.healun.2024.12.006

Ananya Gorrai, Maryjane Farr, Patrick Ohara, Hadi Beaini, Nicholas Hendren, Christopher Wrobel, E Ashley Hardin, Darren McGuire, Amit Khera, Thomas Wang, Mark Drazner, Sonia Garg, Matthias Peltz, Lauren K Truby

引用次数: 0

Goodnight Moon: The (not so) mystical effect of folklore and superstitions on cardiac transplantation. 晚安月亮民间传说和迷信对心脏移植的（不那么）神秘影响。

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2024-12-13 DOI: 10.1016/j.healun.2024.12.007

Michaela Asher, Amit Iyengar, David Rekhtman, Joyce Jiang, Cindy Song, Noah Weingarten, Max Shin, Lindsay Nitsche, Constantine D Mavroudis

{"title":"Goodnight Moon: The (not so) mystical effect of folklore and superstitions on cardiac transplantation.","authors":"Michaela Asher, Amit Iyengar, David Rekhtman, Joyce Jiang, Cindy Song, Noah Weingarten, Max Shin, Lindsay Nitsche, Constantine D Mavroudis","doi":"10.1016/j.healun.2024.12.007","DOIUrl":"https://doi.org/10.1016/j.healun.2024.12.007","url":null,"abstract":"Background: The effect of Friday the 13th and Full Moons on cardiac transplantation is unknown. We investigated the impact of these superstitious events on recipient and donor qualities, complications, survival, and volume.Methods: All adult transplants from 2013-2023 in the United Network for Organ Sharing database were retrospectively reviewed. Friday the 13th recipients were compared to Adjacent Friday recipients and all other recipients. Full Moon recipients were compared to New Moon recipients and all other transplants. Recipient and donor characteristics were statistically compared, and outcomes including transplant volume, frequency, complications, and survival were assessed between groups before, and after, the 2018 allocation change.Results: One thousand and twenty transplants occurred on a Full Moon, and 134 occurred on a Friday the 13th. No differences between donors, recipients, or outcomes and volume across eras were found in the Lunar analysis (all p > 0.05). Compared to Adjacent Friday recipients, but not to the control group, Friday the 13th recipients had higher rates of severe functional impairment (44% vs 41%), longer admissions before transplant (4 vs 1 day), and a higher prevalence of intensive care unit placement (40% vs 35%) (all p < 0.05). However, no differences were found in donor characteristics, outcomes, survival, or volume in either era (all p > 0.05).Conclusions: There is likely no substantial adverse or unlucky influence of the Full Moon or Friday the 13th on cardiac transplantation. However, perceived stress has demonstrated effects on medical outcomes and health system functioning. Therefore, further research should investigate the persistence of these beliefs in health care settings.","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary graft dysfunction, dysbiosis, and innate immune activation after lung transplantation.

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2024-12-11 DOI: 10.1016/j.healun.2024.11.043

Adam G Stewart, Daniel C Chambers

引用次数: 0

Dosing of Apixaban with Left Ventricular Assist Devices: A Need for Greater Clarity.

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2024-12-11 DOI: 10.1016/j.healun.2024.12.003

Ajith Nair, Palak Shah

引用次数: 0

"Surveillance without scars": The quest for noninvasive detection of cardiac allograft rejection.