Journal of Heart and Lung Transplantation最新文献

{"title":"Signals amid the noise: Parsing dd-cfDNA and MMDx in cardiac transplant surveillance","authors":"David M. Elliott MD, PhD, Chetan B. Patel MD","doi":"10.1016/j.healun.2025.05.005","DOIUrl":"10.1016/j.healun.2025.05.005","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 9","pages":"Pages 1394-1395"},"PeriodicalIF":6.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S1053-2498(25)02168-0","DOIUrl":"10.1016/S1053-2498(25)02168-0","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 9","pages":"Page A4"},"PeriodicalIF":6.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the handling of missing data in the UNOS database","authors":"Hanwen Yang MD, Yangkai Fu MD, Zhili Ji MD","doi":"10.1016/j.healun.2025.04.004","DOIUrl":"10.1016/j.healun.2025.04.004","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 9","pages":"Page 1525"},"PeriodicalIF":6.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pendulum is swinging: Be like water","authors":"Ahmet Kilic MD","doi":"10.1016/j.healun.2025.05.003","DOIUrl":"10.1016/j.healun.2025.05.003","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 9","pages":"Pages 1418-1419"},"PeriodicalIF":6.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine perfusion across different donor pathways in heart transplantation: A systematic review and network meta-analysis.","authors":"Dong-Young Kim, Minseok Kang, Jaeyoung Kim, Dongho Choi, Sook-Jin Lee","doi":"10.1016/j.healun.2025.08.013","DOIUrl":"10.1016/j.healun.2025.08.013","url":null,"abstract":"<p><strong>Background: </strong>The shortage of donor hearts significantly limits heart transplantation. Innovative machine perfusion strategies have emerged to address the shortcomings of traditional static cold storage after brain death (SCS-DBD), potentially enhancing outcomes and broadening donor eligibility. We performed a systematic review and network meta-analysis to compare the effectiveness of heart transplantation using machine perfusion techniques with conventional SCS-DBD.</p><p><strong>Methods: </strong>The MEDLINE, Embase, and PubMed databases were systematically searched for articles published between January 2024 and March 2025. Additional relevant studies from 2014-2023 were identified through previous systematic reviews and reference lists. Included were randomized clinical trials and nonrandomized studies evaluating outcomes of heart transplantation methods utilizing hearts from donors after brain death (DBD) and donors after circulatory death (DCD). Meta-analysis was performed examining 30-day and 1-year survival, acute rejection, and primary graft dysfunction.</p><p><strong>Results: </strong>From 1,758 screened records, 19 studies involving 22,029 patients met the inclusion criteria. No significant differences in 30-day mortality were observed between preservation methods. At 1 year, direct procurement with perfusion of DCD (risk ratio [RR] 0.63 [95% credible interval [CrI] 0.45-0.89]; high certainty) and normothermic regional perfusion of DCD (RR 0.68 [CrI 0.47-0.96]; low certainty) significantly reduced mortality compared with SCS-DBD. Among DBD groups, no mortality differences emerged. Hypothermic oxygenated machine perfusion of DBD significantly reduced severe primary graft dysfunction compared with SCS-DBD (0.27 [0.10-0.63]; high certainty), but acute rejection rates were similar across all methods.</p><p><strong>Conclusions: </strong>Outcomes of machine perfusion strategies appear noninferior to those of the conventional SCS, proving its potential to broaden the donor pool.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The International Society for Heart and Lung Transplantation Guidelines for the Management of Pediatric Heart Failure (Update From 2014)","authors":"Claire Irving ,&nbsp;Estela Azeka ,&nbsp;Rachele Adorisio ,&nbsp;Elizabeth D. Blume ,&nbsp;Carmel Bogle ,&nbsp;Henry Chubb ,&nbsp;Jennifer Conway ,&nbsp;Melissa K. Cousino ,&nbsp;Jonathan Edelson ,&nbsp;Katrina Ford ,&nbsp;Paula Holinski ,&nbsp;Jan Janousek ,&nbsp;Ashwin Lal ,&nbsp;Teresa Lee ,&nbsp;Angela Lorts ,&nbsp;Stephanie Nakano ,&nbsp;David N. Rosenthal ,&nbsp;Joseph Rossano ,&nbsp;Shelley D. Miyamoto","doi":"10.1016/j.healun.2025.06.003","DOIUrl":"10.1016/j.healun.2025.06.003","url":null,"abstract":"<div><div>Pediatric heart failure (HF) secondary to cardiomyopathies, acquired heart disease, and congenital heart disease is associated with significant morbidity and mortality. These guidelines represent an update from the International Society for Heart and Lung Transplantation guidelines for the management of pediatric HF that were published in 2014 and incorporate interval advancements in medical therapies and new approaches in the evaluation and management of children with HF.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 10","pages":"Pages e21-e71"},"PeriodicalIF":6.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the ideal driveline design for a Left Ventricular Assist Device?","authors":"Michele Gallo, Mark S Slaughter","doi":"10.1016/j.healun.2025.07.035","DOIUrl":"https://doi.org/10.1016/j.healun.2025.07.035","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncoupling walking tests.","authors":"Louise Fuller","doi":"10.1016/j.healun.2025.07.038","DOIUrl":"https://doi.org/10.1016/j.healun.2025.07.038","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex matters at JHLT.","authors":"Joseph G Rogers","doi":"10.1016/j.healun.2025.07.028","DOIUrl":"https://doi.org/10.1016/j.healun.2025.07.028","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-year outcomes in the direct oral anticoagulant apixaban in left ventricular assist devices (DOAC LVAD) study.","authors":"Aditya Mehta, Pramita Bagchi, Mary Looby, Matthew Dimond, Iyad Isseh, Allman Rollins, Ahmad Abdul-Aziz, Jamie L W Kennedy, Daniel Tang, Wendy Sheaffer, Meredith Snipes, Bhruga Shah, Shashank S Sinha, Christopher M O'Connor, Palak Shah","doi":"10.1016/j.healun.2025.08.012","DOIUrl":"10.1016/j.healun.2025.08.012","url":null,"abstract":"<p><p>Anticoagulation with apixaban was previously demonstrated to be feasible without excess hemocompatibility-related adverse events (HRAEs) at 6 months but longer-term data on use of apixaban is lacking. We report 2-year outcomes of patients enrolled into the DOAC LVAD (Evaluation of the Hemocompatibility of the Direct Oral Anti-Coagulant Apixaban in Left Ventricular Assist Devices) study. The primary study outcome was death or major HRAE (stroke, device thrombosis, major bleeding, aortic root thrombus, and/or arterial non-central nervous system thromboembolism). Patients were randomized to treatment with apixaban (5 mg twice daily, without dose adjustment) as compared to warfarin (INR goal of 2.0 to 2.5). A total of 30 patients were randomized (16 to apixaban, 14 to warfarin). At 2-years, the primary outcome occurred in 2 patients (12.5%) in the apixaban group compared to 6 patients (43%) in the warfarin group (p = 0.087). In the apixaban group, HRAEs occurred in 1 patient (6.3%, major bleeding), compared to 5 HRAEs with warfarin (35.7%, 1 hemorrhagic stroke, 3 major bleeds, and 1 right ventricular thrombus formation, p = 0.07). All bleeding episodes were gastrointestinal. These findings support the long-term feasibility of apixaban anticoagulation in patients with a LVAD and underscore the need for larger randomized trials to confirm these findings.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}