Journal of Heart and Lung Transplantation最新文献_第3页

The effect of CTLA4-Ig on fibrotic progression in a murine model of chronic lung allograft dysfunction. CTLA4-Ig对慢性同种异体肺移植功能障碍小鼠模型纤维化进展的影响。

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-05-28 DOI: 10.1016/j.healun.2025.05.002

Katsutaka Mineura, Satona Tanaka, Yasufumi Goda, Itsuki Yuasa, Yumeta Shimazu, Yoshito Yamada, Yojiro Yutaka, Akihiro Ohsumi, Daisuke Nakajima, Toshi Menju, Atsuyasu Sato, Hiroshi Date

{"title":"The effect of CTLA4-Ig on fibrotic progression in a murine model of chronic lung allograft dysfunction.","authors":"Katsutaka Mineura, Satona Tanaka, Yasufumi Goda, Itsuki Yuasa, Yumeta Shimazu, Yoshito Yamada, Yojiro Yutaka, Akihiro Ohsumi, Daisuke Nakajima, Toshi Menju, Atsuyasu Sato, Hiroshi Date","doi":"10.1016/j.healun.2025.05.002","DOIUrl":"10.1016/j.healun.2025.05.002","url":null,"abstract":"Co-stimulatory blockade has emerged as a promising strategy for preventing acute and chronic rejection in solid organ transplantation. This study investigates the efficacy of cytotoxic T-lymphocyte-associated protein-4-Ig (CTLA4-Ig), a T-cell co-stimulation blocker, in mitigating chronic lung allograft dysfunction (CLAD). Using a murine CLAD model, we demonstrated that CTLA4-Ig treatment significantly reduced fibrotic progression and cellular rejection when initiated immediately after transplantation compared to IgG1 Fc-isotype. CTLA4-Ig treatment resulted in a decreased number of intragraft CD3+ T cells, whereas B cell numbers and the CD4+/CD8+ ratio in the grafts remained unaffected. In contrast, when administered after the onset of acute rejection, CTLA4-Ig was less effective in preventing allograft fibrosis and was associated with a reduced Foxp3+ regulatory T cell population. These findings suggest that CTLA4-Ig plays a role in modulating T-cell responses and highlight the importance of early initiation of treatment in preventing CLAD.","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of occult HFpEF and age-specific efficacy of passive leg raise in pulmonary hypertension. 肺动脉高压患者隐匿性HFpEF患病率及被动抬腿治疗的年龄特异性疗效。

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-05-28 DOI: 10.1016/j.healun.2025.04.020

Chiho Nakata, Ayumi Goda, Kaori Takeuchi, Shinsuke Takeuchi, Hanako Kikuchi, Takumi Inami, Kyoko Soejima, Takashi Kohno

{"title":"Prevalence of occult HFpEF and age-specific efficacy of passive leg raise in pulmonary hypertension.","authors":"Chiho Nakata, Ayumi Goda, Kaori Takeuchi, Shinsuke Takeuchi, Hanako Kikuchi, Takumi Inami, Kyoko Soejima, Takashi Kohno","doi":"10.1016/j.healun.2025.04.020","DOIUrl":"10.1016/j.healun.2025.04.020","url":null,"abstract":"Background: Occult heart failure with preserved ejection fraction (HFpEF), characterized by elevated pulmonary arterial wedge pressure during exercise (PAWPexercise), has gained attention in the context of pulmonary hypertension (PH). This study aimed to evaluate the prevalence of occult HFpEF and assess the diagnostic efficacy of passive leg raise (PLR) in patients with confirmed or suspected PH.Methods: A total of 619 patients with normal resting PAWP underwent symptom-limited exercise testing using a supine cycle ergometer in conjunction with right heart catheterization (RHC) for PH diagnosis and treatment assessment. Occult HFpEF was defined as PAWPexercise ≥ 25 mmHg. Receiver operating characteristic curves were constructed, and the area under the curve (AUC) was calculated to evaluate the diagnostic utility of PAWPPLR for identifying occult HFpEF.Results: Among the 619 patients (median age: 61 years, 78% female; median PAWP at rest: 8 mmHg), 80 (13%) demonstrated occult HFpEF. The prevalence was 7%, 21%, and 16% in patients aged < 60 years, 60-69 years, and ≥ 70 years, respectively. PAWPPLR was significantly elevated in the occult HFpEF group compared to the non-HFpEF group across all age categories. The AUC values for detecting occult HFpEF using PAWPPLR were 0.75 for patients < 60 years, 0.78 for those aged 60-69 years, and 0.79 for those ≥ 70 years, with respective cut-off values of 14, 13, and 13 mmHg.Conclusions: Occult HFpEF is prevalent among patients with PH. PAWPPLR serves as a valuable, non-invasive tool, necessitating age-specific thresholds to enhance diagnostic accuracy.","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

They're doing cartwheels-I'm just trying to drink my coffee: Direct procurement DCD lung retrieval remains viable with abdominal normothermic regional perfusion. 他们在做侧手翻——我只是想喝我的咖啡：直接获取DCD肺回收在腹部常温区域灌注下仍然可行。

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-05-27 DOI: 10.1016/j.healun.2025.04.017

Michael T Cain, Sandra Lindstedt

引用次数: 0

Impact of obesity on long term post heart transplantation outcomes. 肥胖对心脏移植术后长期预后的影响。

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-05-27 DOI: 10.1016/j.healun.2025.04.021

Darae Kim, In-Cheol Kim, Jong-Chan Youn, Woo-Sung Chang, Jin-Jin Kim, Mi-Hyang Jung, Jin-Oh Choi, Daniel Seong Kyu Kim, Mason Lee, Evan P Kransdorf, David H Chang, Michelle M Kittleson, Jignesh K Patel, Fardad Esmailian, Jon A Kobashigawa

{"title":"Impact of obesity on long term post heart transplantation outcomes.","authors":"Darae Kim, In-Cheol Kim, Jong-Chan Youn, Woo-Sung Chang, Jin-Jin Kim, Mi-Hyang Jung, Jin-Oh Choi, Daniel Seong Kyu Kim, Mason Lee, Evan P Kransdorf, David H Chang, Michelle M Kittleson, Jignesh K Patel, Fardad Esmailian, Jon A Kobashigawa","doi":"10.1016/j.healun.2025.04.021","DOIUrl":"10.1016/j.healun.2025.04.021","url":null,"abstract":"Background: Obesity is an ongoing pandemic, and the rising trend of body mass index (BMI) in heart transplant (HTx) recipients is well known. However, the long term post-HTx outcomes of obese patients are not clearly documented.Aims: We aimed to investigate long term post-transplant outcomes in obese patients.Methods: Among 1787 consecutively enrolled adult HTx recipients between September 1990 and June 2022, patients were categorized into BMI groups: underweight (<18 kg/m²), normal weight (18.0-24.9 kg/m²), overweight (25-29.9 kg/m²), and obese (≥ 30 kg/m²). The primary outcome was post-HTx mortality, with secondary outcomes including primary graft dysfunction, treated rejection, coronary allograft vasculopathy, retransplant, and nonfatal major adverse cardiac event.Results: Over time, there was a significant increase in obese recipients (BMI ≥ 30 kg/m²) and they were more likely to have comorbidities such as diabetes and hypertension, experience significantly longer wait times, and more frequently received undersized donors compared to those with normal weight. During the median follow up duration of 6 years after HTx, obese recipients showed significantly higher incidence of treated rejection (P =0.027) and lower post-HTx survival compared to those with normal weight (P=0.009). In multivariable analysis, obese patients had a significantly higher risk of post-transplant mortality, primary graft dysfunction, and any treated rejection even after adjusting relevant clinical variables.Conclusions: Obese HTx recipients demonstrated a significantly higher risk of death, primary graft dysfunction, and any treated rejection. Our findings highlight the need for proactive, multidisciplinary management of obesity prior to HTx.","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Fc gamma-binding protein rs1464897604 polymorphism with bronchiolitis obliterans syndrome in lung transplant recipients. Fc γ结合蛋白rs1464897604多态性与肺移植受者闭塞性细支气管炎综合征的关系

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-05-27 DOI: 10.1016/j.healun.2025.05.001

Junho Kang, Yun Hak Kim, Eunjeong Choi, Hee Yun Seol, Seong Hoon Yoon, Eunjeong Son, Seung Eun Lee, Woo Hyun Cho, Hyun-Ji Lee, Seung Hwan Oh, Hye Ju Yeo

{"title":"Association of Fc gamma-binding protein rs1464897604 polymorphism with bronchiolitis obliterans syndrome in lung transplant recipients.","authors":"Junho Kang, Yun Hak Kim, Eunjeong Choi, Hee Yun Seol, Seong Hoon Yoon, Eunjeong Son, Seung Eun Lee, Woo Hyun Cho, Hyun-Ji Lee, Seung Hwan Oh, Hye Ju Yeo","doi":"10.1016/j.healun.2025.05.001","DOIUrl":"10.1016/j.healun.2025.05.001","url":null,"abstract":"Background: Bronchiolitis obliterans syndrome (BOS) is a major challenge after lung transplantation (LT) and hematopoietic stem cell transplantation (HSCT), sharing pathological similarities but lacking identified common genetic mutations.Methods: We conducted a comparative analysis of whole-genome sequencing data from lung tissue samples of patients with BOS after LT and HSCT to identify shared and distinct genetic alterations. Common variants were validated using Sanger sequencing of peripheral blood samples. We then evaluated the association between validated variants and clinical outcomes in an independent LT cohort.Results: Single nucleotide polymorphisms (SNPs) were the most prevalent variants in both cohorts, with a mean of 731 SNPs in post-LT BOS patients and 990 SNPs in post-HSCT BOS patients. Five candidate SNPs-FCGBP rs1464897604, KMT2C rs146238849, LINC01410 rs28440808, PABPC3 rs781717999, and POM121 rs1307236009-were selected based on their higher detection frequencies in BOS tissues compared to the general population. Sanger sequencing of blood samples confirmed that FCGBP rs1464897604 and POM121 rs1307236009 were germline variants. Among these, FCGBP rs1464897604 was prioritized for further analysis due to its relatively low minor allele frequency (MAF) in the Korean population (0.0038) and markedly higher frequency in the BOS cohort (MAF 0.4444). FCGBP rs1464897604 was significantly associated with adverse transplant outcomes, including higher rates of acute rejection, increased incidence of de novo donor-specific antibody formation within two years, and greater BOS occurrence in independent LT cohorts.Conclusion: The common genetic variant FCGBP, identified in patients with post-HSCT and post-LT BOS, was associated with poor clinical outcomes following LT.","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ensuring access to novel donor heart preservation modalities. 确保获得新的供体心脏保存方式。

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-05-27 DOI: 10.1016/j.healun.2025.04.018

Joseph B Lerman, Katherine D Marapese, Amber R Johnson, Ian R Jamieson, Jeffrey E Keenan, Jacob N Schroder, Adam D DeVore, Chetan B Patel

引用次数: 0

An open letter to the ISHLT and its global lung transplantation community. 致ISHLT及其全球肺移植社区的公开信。

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-05-26 DOI: 10.1016/j.healun.2025.05.006

Paul A Corris, Maria M Crespo, Robin Vos, Sangeeta Bhorade, Scott Palmer, Daniel Chambers

引用次数: 0

Re: Optimizing the handling of missing data in the UNOS database. Re：优化UNOS数据库丢失数据的处理。

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-05-26 DOI: 10.1016/j.healun.2025.04.026

William L Baker, Timothy Moore, Eric Baron, Michelle Kittleson, William F Parker, Abhishek Jaiswal

引用次数: 0

Maribavir: Double edged sword 马里巴韦：双刃剑

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-05-19 DOI: 10.1016/j.healun.2025.01.011

Yoichiro Natori MD, MPH , Mohammed Raja MD , Shweta Anjan MD , Jose F. Camargo MD

引用次数: 0

Information for Readers 读者资讯

IF 6.4 1区医学

Journal of Heart and Lung Transplantation Pub Date : 2025-05-19 DOI: 10.1016/S1053-2498(25)01946-1

引用次数: 0