Journal of Heart and Lung Transplantation最新文献

{"title":"Response to Urschel et al","authors":"Daniel J. Hurst PhD, ThM, MDiv, MSc , Anthony Merlocco MD, MSt, FSCMR","doi":"10.1016/j.healun.2025.03.028","DOIUrl":"10.1016/j.healun.2025.03.028","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 8","pages":"Page 1354"},"PeriodicalIF":6.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Authors’ Perspective on 'Summary of the International Society for Heart and Lung Transplantation Consensus Conference on Emerging Understanding of Antibodies and Antibody-mediated Rejection in Heart Transplantation'","authors":"Jon Kobashigawa MD , Andreas Zuckermann MD , Adriana Zeevi PhD , Markus J. Barten MD, PhD , Patricia P. Chang MD, MHS , Monica Colvin MD, MS , Guillaume Coutance MD, PhD , Anne Dipchand MD , Stephan Ensminger MD, DPhil , Marta Farrero MD , Marlena Habal MD , Anne Halpin PhD , Annette M. Jackson PhD , Yosef Manla MD , Kavitha Muthiah MBBS, PhD , Luciano Potena MD, PhD , Elaine F. Reed PhD , Kelly Schlendorf MD, MHS , Palak Shah MD, MS , Anat Tambur DMD, PhD , Jignesh Patel MD, PhD","doi":"10.1016/j.healun.2025.05.010","DOIUrl":"10.1016/j.healun.2025.05.010","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 8","pages":"Pages 1195-1198"},"PeriodicalIF":6.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments and opinions regarding “Volume calibration with cardiac MRI versus hypertonic saline for right ventricular pressure-volume loops with exercise: Impact on ventricular function and ventricular-vascular coupling” by Raza et al.","authors":"Nils Kremer , Zvonimir Rako , Khodr Tello","doi":"10.1016/j.healun.2025.03.024","DOIUrl":"10.1016/j.healun.2025.03.024","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 8","pages":"Pages 1350-1351"},"PeriodicalIF":6.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to comments and opinions by Kremer et al regarding our original manuscript “Volume calibration with cardiac MRI vs hypertonic saline for right ventricular pressure-volume loops with exercise: Impact on ventricular function and ventricular-vascular coupling”","authors":"Farhan Raza MD , Chris G. Lechuga PhD , Naomi C. Chesler PhD","doi":"10.1016/j.healun.2025.04.007","DOIUrl":"10.1016/j.healun.2025.04.007","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 8","pages":"Pages 1352-1353"},"PeriodicalIF":6.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of cardiogenic shock patients supported with VA-ECMO: Insights from the Cardiogenic Shock Working Group.","authors":"Jaime Hernandez-Montfort, Kevin J John, Daniel Goldstein, Roberto Lorusso, Shashank S Sinha, Rachel Goodman, Peter Natov, Song Li, Borui Li, Manreet Kanwar, Arthur Reshad Garan, Jacob Abraham, Qiuyue Kong, Paavni Sangal, Karol Walec, Claudius Mahr, Aniket Rali, Daniel Burkhoff, Navin K Kapur","doi":"10.1016/j.healun.2025.07.016","DOIUrl":"10.1016/j.healun.2025.07.016","url":null,"abstract":"<p><strong>Background: </strong>Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) use for cardiogenic shock (CS) is increasing worldwide despite conflicting results from randomized trials, which focused on myocardial infarction-related CS (MI-CS).</p><p><strong>Methods: </strong>We performed a retrospective analysis of the Cardiogenic Shock Working Group multicenter registry to assess outcomes in CS in those supported with VA-ECMO. Continuous variables were presented as mean±SD or median+IQR for normal/non-normal distributions. Group comparisons used the Student's t-test or Mann-Whitney U test for normal/non-normal data and chi-square test for proportions.</p><p><strong>Results: </strong>Between 2019 and 2023, 1,728 out of 11,244 CS patients (15.3%) received VA-ECMO. Median age was 58 years, and 69.9% were male. Etiologies of shock were heart failure (HF-CS: 45%), myocardial infarction (MI-CS; 34%), and other-CS (22%). Mortality was 51% and higher for MI-CS (60% vs 42%, MI vs HF-CS, p < 0.01). Heart replacement therapy was more common among HF-CS patients (24% vs 7%, HF vs MI-CS, p < 0.01); 71% and 43% of HF- and MI-CS underwent cardiac transplantation. VA-ECMO was placed in a non-OR site in 74% of patients, predominantly with peripheral cannulation (71%). Distal perfusion catheters were used in 34% of VA-ECMO cases. In 71% of patients >1 MCS device was used during hospitalization. Complications included acute limb ischemia (14% overall, 10% vs 17%, HF vs MI-CS, p < 0.01), bleeding (53% overall, 47% vs 56%, HF vs MI-CS, p < 0.01), and stroke (13% overall, 10% vs 16%, HF vs MI-CS, p < 0.01).</p><p><strong>Conclusions: </strong>Using a large contemporary real-world CS registry, we report high mortality and complication rates with VA-ECMO. These findings may inform future shock trial designs.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing driveline infection risk in durable mechanical circulatory support devices with ultra-flexible wires for energy transfer.","authors":"Andreas P Kourouklis, Xi Wu, Julius Kaemmel, Sanne Hertegonne, Srikanth Mairpady Shambat, Mihyun Lee, Christian Grossmann, Raphael Hagen, Daniel Fehr, Fabrizio Spano, Carolina Pietsch, Simone de Brot, Nikola Cesarovic, Qun Ren, Mathias Bonmarin, Miriam Weisskopf, Annelies S Zinkernagel, Evgenij Potapov, Volkmar Falk, Edoardo Mazza","doi":"10.1016/j.healun.2025.07.012","DOIUrl":"10.1016/j.healun.2025.07.012","url":null,"abstract":"<p><strong>Background: </strong>Driveline infections (DLIs) pose a burden to heart failure patients supported by durable mechanical circulatory support devices (dMCSs). A major factor to DLI comes from the low mechanical compliance of drivelines, affecting wound healing. New drivelines that mitigate mechanical stress on skin may reduce the risk of DLI. We investigate macroscopic and microscopic effects of wires with low flexural stiffness on the risk of DLI.</p><p><strong>Methods: </strong>Prototypes equipped with ultra-flexible wires, due to their stranded metallic core and small diameter, were percutaneously implanted in an adult ovine model of DLI and subjected to electric conditions typical of dMCS operation. In the control (no bacterial inoculation, n=2 animals, follow-up period around 2 months) and inoculation (with Staphylococcus epidermidis, n=2 animals, follow-up period 1.5 months) study groups, the commercial dMCS drivelines and the prototypes were implanted at equivalent surgical sites of each animal. In the inoculation group, the surgical sites were infected with Staphylococcus epidermidis 2 weeks post-implantation.</p><p><strong>Results: </strong>Ultra-flexible wires showed flawless electromechanical performance, enabled fast recovery of skin redness in the first 2 weeks (p<0.05), and reduced inflammation (p<0.0001) at the exit site compared to commercial dMCS drivelines. After S. epidermidis inoculation at the exit site, ultra-flexible wires displayed reduced bacterial number (34 times lower) compared to commercial dMCS drivelines, avoiding internal biofilm formation and macroscopic signs of infection.</p><p><strong>Conclusions: </strong>Using small, ultra-flexible wires reduced wound size and mechanical stress at the exit site, strengthening barrier function and lowering the risk of DLI. The use of ultra-flexible wires may improve the quality and duration of life of patients supported with dMCS.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond cold storage: Rise of the machines.","authors":"Shivank Madan, Daniel J Goldstein","doi":"10.1016/j.healun.2025.07.019","DOIUrl":"10.1016/j.healun.2025.07.019","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic and metabolomic profiling nominates druggable targets and biomarkers for pulmonary arterial hypertension-associated myopathy and exercise intolerance in male monocrotaline rats.","authors":"Phablo Abreu, Ryan Moon, Jenna B Mendelson, Todd Markowski, LeeAnn Higgins, Kevin Murray, Candace Guerrero, Jeffrey Blake, Sasha Z Prisco, Kurt W Prins","doi":"10.1016/j.healun.2025.06.034","DOIUrl":"10.1016/j.healun.2025.06.034","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary arterial hypertension (PAH) is a rare but debilitating condition that causes exercise intolerance and ultimately death. Skeletal muscle derangements contribute to depressed exercise capacity in PAH, but the mechanisms underlying muscle dysfunction, including the changes in muscle biology based on fiber type, are understudied.</p><p><strong>Methods: </strong>We evaluated exercise capacity, muscle histopathology, mitochondrial density, mitochondrial proteomics, and metabolomics/lipidomics of quadriceps (predominately fast fibers) and soleus (predominately slow fibers) muscles in the monocrotaline (MCT) rat model of PAH.</p><p><strong>Results: </strong>MCT rats exhibited impaired exercise capacity. Surprisingly, there were divergent atrophic and metabolic remodeling in the quadriceps and soleus muscles of MCT rats. In the quadriceps, there was a mild atrophic response only in type II fibers. In contrast, both type I and II fibers atrophied in the soleus. Both muscles exhibited fibrotic infiltration, but mitochondrial density was reduced in the quadriceps only. Mitochondrial proteomics and tissue metabolomics/lipidomics profiling demonstrated that the 2 muscles exhibited distinct responses, as the quadriceps had impairments in oxidative phosphorylation/fat metabolism and storage of triacylglycerides. However, the soleus showed signs of proteasome deficiencies and alterations in phosphatidylcholine/phosphatidylethanolamine homeostasis. Finally, profiling of metabolites/lipids in the serum identified potential novel biomarkers of exercise intolerance in PAH, including the dimethylarginine pathway, cysteine, and triacylglycerides.</p><p><strong>Conclusions: </strong>Our data suggest differential cachectic and metabolic responses occur in PAH-induced myopathy. We nominate mitochondrial biogenesis and proteasome activation as potential druggable targets for PAH myopathy.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144618581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revitalizing donor organs: The potential of mitochondrial transplantation in heart and lung transplantation","authors":"Aybuke Celik ,&nbsp;Sandra Lindstedt ,&nbsp;David C. McGiffin ,&nbsp;Jacky Y. Suen ,&nbsp;John F. Fraser ,&nbsp;Pedro J. del Nido ,&nbsp;Sitaram M. Emani ,&nbsp;James D. McCully","doi":"10.1016/j.healun.2025.07.002","DOIUrl":"10.1016/j.healun.2025.07.002","url":null,"abstract":"<div><div>Heart and lung transplantation remain the primary treatments for end-stage organ failure; yet organ shortages and ischemia-reperfusion injury (IRI) limit their success. Extended criteria donors (ECDs) have expanded the donor pool; however, prolonged cold ischemia times increase the risk of primary graft dysfunction (PGD). Static cold storage (SCS), the standard organ preservation method, is suboptimal, leading to mitochondrial dysfunction, ATP depletion, and oxidative stress. Recent advancements in organ storage show promise in maintaining graft viability. Mitochondria are key regulators of cellular homeostasis, and their dysfunction exacerbates IRI, contributing to inflammation and graft failure. Mitochondrial transplantation (MTx) has emerged as a novel therapeutic strategy to restore cellular bioenergetics, reduce oxidative stress, and improve graft function. Further research is needed to optimize MTx protocols and integrate them into current preservation techniques to enhance transplant success and long-term graft survival.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 10","pages":"Pages 1648-1658"},"PeriodicalIF":6.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACUTE PULMONARY EMBOLISM IN PATIENTS WITH CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION, TWO CLINICAL CASES","authors":"A.-M. Claveau ,&nbsp;M.J. Eisenberg ,&nbsp;A.O. Abualsaud","doi":"10.1016/j.healun.2024.04.022","DOIUrl":"10.1016/j.healun.2024.04.022","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 7","pages":"Page S22"},"PeriodicalIF":6.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}