Journal of Heart and Lung Transplantation最新文献

{"title":"Transplanting beyond anatomy: When congenital heart disease challenges persist despite a new heart","authors":"Nicola Pradegan MD, Gino Gerosa MD","doi":"10.1016/j.healun.2025.07.025","DOIUrl":"10.1016/j.healun.2025.07.025","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 11","pages":"Page 1830"},"PeriodicalIF":6.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold chain study of donor lungs reminds us to consider the re-warming occurring during the implant procedure","authors":"J.S. Parmar BM, PhD, FRCP, FFICM , P. Catarino MD, FRCS","doi":"10.1016/j.healun.2025.07.021","DOIUrl":"10.1016/j.healun.2025.07.021","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 11","pages":"Pages 1747-1748"},"PeriodicalIF":6.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why Ukraine is important to ISHLT – The Kiev Heart Institute brings hope to the world","authors":"G. Dellgren MD, PhD","doi":"10.1016/j.healun.2025.07.022","DOIUrl":"10.1016/j.healun.2025.07.022","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 11","pages":"Pages 1735-1736"},"PeriodicalIF":6.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S1053-2498(25)02097-2","DOIUrl":"10.1016/S1053-2498(25)02097-2","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 8","pages":"Page A2"},"PeriodicalIF":6.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Video kinematics of an unloaded, ex-vivo beating heart can predict future loaded heart function","authors":"Brian C. Ayers ,&nbsp;George Olverson ,&nbsp;Chijioke Chukwudi ,&nbsp;Manuela Lopera Higuita ,&nbsp;Emmanuella Ajenu ,&nbsp;Maya Bolger-Chen ,&nbsp;Joseph Catricala ,&nbsp;Allison Pitti ,&nbsp;Yaghoubian Koushiar Moshe ,&nbsp;Jagdip Kang ,&nbsp;Aaron D. Aguirre ,&nbsp;Thoralf M. Sundt ,&nbsp;Eriberto Michel ,&nbsp;Asishana Osho ,&nbsp;Shannon N. Tessier ,&nbsp;S. Alireza Rabi ,&nbsp;David D’Alessandro","doi":"10.1016/j.healun.2025.07.023","DOIUrl":"10.1016/j.healun.2025.07.023","url":null,"abstract":"<div><div>There is not a reliable biomarker for identifying which hearts are at highest risk for primary graft dysfunction. We hypothesize that ex-vivo video kinematics (EVVK) of unloaded beating hearts can help predict post-implant heart performance. Porcine hearts procured following a DCD protocol were re-animated in unloaded ex situ heart perfusion (ESHP) before transitioning to a loaded configuration. Five second videos were recorded using a consumer cell phone. Machine learning EVVK software was developed to autonomously quantify heart function. Of 22 porcine hearts, 6 (27%) did not tolerate loading. EVVK demonstrated prognostic capability to differentiate the future loaded performance in terms of both compliance (p=0.004) and contractility (p=0.003). We also demonstrate proof-of-concept in using EVVK on human hearts (n=4) to provide a quantitative functional assessment of the allograft during transportation from the donor to recipient center. Overall, non-invasive EVVK may be able to aid clinicians in quantitative heart evaluation.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 11","pages":"Pages 1823-1826"},"PeriodicalIF":6.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Urschel et al","authors":"Daniel J. Hurst PhD, ThM, MDiv, MSc ,&nbsp;Anthony Merlocco MD, MSt, FSCMR","doi":"10.1016/j.healun.2025.03.028","DOIUrl":"10.1016/j.healun.2025.03.028","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 8","pages":"Page 1354"},"PeriodicalIF":6.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Authors’ Perspective on 'Summary of the International Society for Heart and Lung Transplantation Consensus Conference on Emerging Understanding of Antibodies and Antibody-mediated Rejection in Heart Transplantation'","authors":"Jon Kobashigawa MD ,&nbsp;Andreas Zuckermann MD ,&nbsp;Adriana Zeevi PhD ,&nbsp;Markus J. Barten MD, PhD ,&nbsp;Patricia P. Chang MD, MHS ,&nbsp;Monica Colvin MD, MS ,&nbsp;Guillaume Coutance MD, PhD ,&nbsp;Anne Dipchand MD ,&nbsp;Stephan Ensminger MD, DPhil ,&nbsp;Marta Farrero MD ,&nbsp;Marlena Habal MD ,&nbsp;Anne Halpin PhD ,&nbsp;Annette M. Jackson PhD ,&nbsp;Yosef Manla MD ,&nbsp;Kavitha Muthiah MBBS, PhD ,&nbsp;Luciano Potena MD, PhD ,&nbsp;Elaine F. Reed PhD ,&nbsp;Kelly Schlendorf MD, MHS ,&nbsp;Palak Shah MD, MS ,&nbsp;Anat Tambur DMD, PhD ,&nbsp;Jignesh Patel MD, PhD","doi":"10.1016/j.healun.2025.05.010","DOIUrl":"10.1016/j.healun.2025.05.010","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 8","pages":"Pages 1195-1198"},"PeriodicalIF":6.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments and opinions regarding “Volume calibration with cardiac MRI versus hypertonic saline for right ventricular pressure-volume loops with exercise: Impact on ventricular function and ventricular-vascular coupling” by Raza et al.","authors":"Nils Kremer ,&nbsp;Zvonimir Rako ,&nbsp;Khodr Tello","doi":"10.1016/j.healun.2025.03.024","DOIUrl":"10.1016/j.healun.2025.03.024","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 8","pages":"Pages 1350-1351"},"PeriodicalIF":6.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to comments and opinions by Kremer et al regarding our original manuscript “Volume calibration with cardiac MRI vs hypertonic saline for right ventricular pressure-volume loops with exercise: Impact on ventricular function and ventricular-vascular coupling”","authors":"Farhan Raza MD ,&nbsp;Chris G. Lechuga PhD ,&nbsp;Naomi C. Chesler PhD","doi":"10.1016/j.healun.2025.04.007","DOIUrl":"10.1016/j.healun.2025.04.007","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 8","pages":"Pages 1352-1353"},"PeriodicalIF":6.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of cardiogenic shock patients supported with VA-ECMO: Insights from the Cardiogenic Shock Working Group.","authors":"Jaime Hernandez-Montfort, Kevin J John, Daniel Goldstein, Roberto Lorusso, Shashank S Sinha, Rachel Goodman, Peter Natov, Song Li, Borui Li, Manreet Kanwar, Arthur Reshad Garan, Jacob Abraham, Qiuyue Kong, Paavni Sangal, Karol Walec, Claudius Mahr, Aniket Rali, Daniel Burkhoff, Navin K Kapur","doi":"10.1016/j.healun.2025.07.016","DOIUrl":"10.1016/j.healun.2025.07.016","url":null,"abstract":"<p><strong>Background: </strong>Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) use for cardiogenic shock (CS) is increasing worldwide despite conflicting results from randomized trials, which focused on myocardial infarction-related CS (MI-CS).</p><p><strong>Methods: </strong>We performed a retrospective analysis of the Cardiogenic Shock Working Group multicenter registry to assess outcomes in CS in those supported with VA-ECMO. Continuous variables were presented as mean±SD or median+IQR for normal/non-normal distributions. Group comparisons used the Student's t-test or Mann-Whitney U test for normal/non-normal data and chi-square test for proportions.</p><p><strong>Results: </strong>Between 2019 and 2023, 1,728 out of 11,244 CS patients (15.3%) received VA-ECMO. Median age was 58 years, and 69.9% were male. Etiologies of shock were heart failure (HF-CS: 45%), myocardial infarction (MI-CS; 34%), and other-CS (22%). Mortality was 51% and higher for MI-CS (60% vs 42%, MI vs HF-CS, p < 0.01). Heart replacement therapy was more common among HF-CS patients (24% vs 7%, HF vs MI-CS, p < 0.01); 71% and 43% of HF- and MI-CS underwent cardiac transplantation. VA-ECMO was placed in a non-OR site in 74% of patients, predominantly with peripheral cannulation (71%). Distal perfusion catheters were used in 34% of VA-ECMO cases. In 71% of patients >1 MCS device was used during hospitalization. Complications included acute limb ischemia (14% overall, 10% vs 17%, HF vs MI-CS, p < 0.01), bleeding (53% overall, 47% vs 56%, HF vs MI-CS, p < 0.01), and stroke (13% overall, 10% vs 16%, HF vs MI-CS, p < 0.01).</p><p><strong>Conclusions: </strong>Using a large contemporary real-world CS registry, we report high mortality and complication rates with VA-ECMO. These findings may inform future shock trial designs.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}