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Journal of Heart and Lung Transplantation最新文献

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A plea to implement lung donor management protocols in cDCD. 呼吁在慢性阻塞性肺疾病中实施肺供体管理方案。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2024-12-28 DOI: 10.1016/j.healun.2024.12.015
Jose Luis Campo-Cañaveral de la Cruz, Eduardo Miñambres
{"title":"A plea to implement lung donor management protocols in cDCD.","authors":"Jose Luis Campo-Cañaveral de la Cruz, Eduardo Miñambres","doi":"10.1016/j.healun.2024.12.015","DOIUrl":"10.1016/j.healun.2024.12.015","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating Donor Lungs: The Importance of a Fresh Perspective for Every Case. 评估供体肺：每个病例的新视角的重要性。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2024-12-28 DOI: 10.1016/j.healun.2024.12.012
Sahar A Saddoughi
{"title":"Evaluating Donor Lungs: The Importance of a Fresh Perspective for Every Case.","authors":"Sahar A Saddoughi","doi":"10.1016/j.healun.2024.12.012","DOIUrl":"https://doi.org/10.1016/j.healun.2024.12.012","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cracking the code of BOS and RAS. 破解BOS和RAS的密码。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2024-12-28 DOI: 10.1016/j.healun.2024.12.009
Emmanuel Zorn, Philippe Lemaitre
{"title":"Cracking the code of BOS and RAS.","authors":"Emmanuel Zorn, Philippe Lemaitre","doi":"10.1016/j.healun.2024.12.009","DOIUrl":"10.1016/j.healun.2024.12.009","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sotatercept in PAH: A promising pathway while awaiting long-term outcomes. 索泰特受体治疗 PAH：在等待长期结果的同时，一条充满希望的途径。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2024-12-28 DOI: 10.1016/j.healun.2024.12.008
Mads Jønsson Andersen, Mark Toshner
{"title":"Sotatercept in PAH: A promising pathway while awaiting long-term outcomes.","authors":"Mads Jønsson Andersen, Mark Toshner","doi":"10.1016/j.healun.2024.12.008","DOIUrl":"10.1016/j.healun.2024.12.008","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards a nuanced understanding of donor risk 对捐赠者风险的细致理解。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2024-12-28 DOI: 10.1016/j.healun.2024.12.023
Brian Wayda MD, MPH
{"title":"Towards a nuanced understanding of donor risk","authors":"Brian Wayda MD, MPH","doi":"10.1016/j.healun.2024.12.023","DOIUrl":"10.1016/j.healun.2024.12.023","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 3","pages":"Pages 376-377"},"PeriodicalIF":6.4,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increases in donor/recipient predicted heart mass ratios do not result in large donor right ventricles. 供体/受体预测心脏质量比的增加不会导致供体右心室变大。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2024-12-20 DOI: 10.1016/j.healun.2024.12.016
Samantha Weller, Sarah Li, Luke Masha
{"title":"Increases in donor/recipient predicted heart mass ratios do not result in large donor right ventricles.","authors":"Samantha Weller, Sarah Li, Luke Masha","doi":"10.1016/j.healun.2024.12.016","DOIUrl":"10.1016/j.healun.2024.12.016","url":null,"abstract":"<p><p>Pulmonary hypertension puts strain on the right ventricle (RV), leading to the widespread practice of oversizing donor hearts to mitigate complications. However, contemporary evidence for this practice is neutral. We studied the relationship between donor-recipient predicted heart mass (D/R PHM) ratios and increases in donor left ventricle (LV) and RV mass. We also studied the relationship between predicted D/R PHM ratios and predicted D/R LV mass difference and RV mass difference. We find that increases in D/R PHM ratios result in minimal change in donor RV mass as well as minimal change in predicted D/R RV mass difference. However, increases in D/R PHM ratios were associated with marked increases in predicted D/R LV mass difference. We conclude that the utilization of donors with high predicted D/R PHM ratios generally does not result in the delivery of larger RVs to transplant recipients, but predominantly the delivery of larger LVs.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The waiting is the hardest part 等待是最艰难的部分。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2024-12-18 DOI: 10.1016/j.healun.2024.12.004
Kevin J. Clerkin MD, MSc, Nir Uriel MD, MSc
{"title":"The waiting is the hardest part","authors":"Kevin J. Clerkin MD, MSc,&nbsp;Nir Uriel MD, MSc","doi":"10.1016/j.healun.2024.12.004","DOIUrl":"10.1016/j.healun.2024.12.004","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 3","pages":"Pages 386-388"},"PeriodicalIF":6.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel therapeutic agents for cardiometabolic risk mitigation in heart transplant recipients. 降低心脏移植受者心脏代谢风险的新型治疗药物
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2024-12-17 DOI: 10.1016/j.healun.2024.12.006
Ananya Gorrai, Maryjane Farr, Patrick O'hara, Hadi Beaini, Nicholas Hendren, Christopher Wrobel, Elizabeth Ashley Hardin, Darren McGuire, Amit Khera, Thomas J Wang, Mark Drazner, Sonia Garg, Matthias Peltz, Lauren K Truby
{"title":"Novel therapeutic agents for cardiometabolic risk mitigation in heart transplant recipients.","authors":"Ananya Gorrai, Maryjane Farr, Patrick O'hara, Hadi Beaini, Nicholas Hendren, Christopher Wrobel, Elizabeth Ashley Hardin, Darren McGuire, Amit Khera, Thomas J Wang, Mark Drazner, Sonia Garg, Matthias Peltz, Lauren K Truby","doi":"10.1016/j.healun.2024.12.006","DOIUrl":"10.1016/j.healun.2024.12.006","url":null,"abstract":"<p><p>Heart transplant (HT) recipients experience high rates of cardiometabolic disease. Novel therapies targeting hyperlipidemia, diabetes, and obesity, including proprotein convertase subtilisin/kexin inhibitors, sodium-glucose cotransporter-2 inhibitors, and glucagon-like peptide-1 agonists, are increasingly used for cardiometabolic risk mitigation in the general population. However, limited data exist to support the use of these agents in patients who have undergone heart transplantation. Herein, we describe the mechanisms of action and emerging evidence supporting the use of novel pharmacologic agents in the post-HT setting for cardiometabolic risk mitigation and review evidence supporting their ability to modulate immune pathways associated with atherogenesis, epicardial adipose tissue, and coronary allograft vasculopathy.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Goodnight Moon: The (not so) mystical effect of folklore and superstitions on cardiac transplantation. 晚安月亮民间传说和迷信对心脏移植的（不那么）神秘影响。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2024-12-13 DOI: 10.1016/j.healun.2024.12.007
Michaela Asher, Amit Iyengar, David Rekhtman, Joyce Jiang, Cindy Song, Noah Weingarten, Max Shin, Lindsay Nitsche, Constantine D Mavroudis
{"title":"Goodnight Moon: The (not so) mystical effect of folklore and superstitions on cardiac transplantation.","authors":"Michaela Asher, Amit Iyengar, David Rekhtman, Joyce Jiang, Cindy Song, Noah Weingarten, Max Shin, Lindsay Nitsche, Constantine D Mavroudis","doi":"10.1016/j.healun.2024.12.007","DOIUrl":"https://doi.org/10.1016/j.healun.2024.12.007","url":null,"abstract":"<p><strong>Background: </strong>The effect of Friday the 13th and Full Moons on cardiac transplantation is unknown. We investigated the impact of these superstitious events on recipient and donor qualities, complications, survival, and volume.</p><p><strong>Methods: </strong>All adult transplants from 2013-2023 in the United Network for Organ Sharing database were retrospectively reviewed. Friday the 13th recipients were compared to Adjacent Friday recipients and all other recipients. Full Moon recipients were compared to New Moon recipients and all other transplants. Recipient and donor characteristics were statistically compared, and outcomes including transplant volume, frequency, complications, and survival were assessed between groups before, and after, the 2018 allocation change.</p><p><strong>Results: </strong>One thousand and twenty transplants occurred on a Full Moon, and 134 occurred on a Friday the 13th. No differences between donors, recipients, or outcomes and volume across eras were found in the Lunar analysis (all p > 0.05). Compared to Adjacent Friday recipients, but not to the control group, Friday the 13th recipients had higher rates of severe functional impairment (44% vs 41%), longer admissions before transplant (4 vs 1 day), and a higher prevalence of intensive care unit placement (40% vs 35%) (all p < 0.05). However, no differences were found in donor characteristics, outcomes, survival, or volume in either era (all p > 0.05).</p><p><strong>Conclusions: </strong>There is likely no substantial adverse or unlucky influence of the Full Moon or Friday the 13th on cardiac transplantation. However, perceived stress has demonstrated effects on medical outcomes and health system functioning. Therefore, further research should investigate the persistence of these beliefs in health care settings.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary graft dysfunction, dysbiosis, and innate immune activation after lung transplantation 肺移植后原发性移植物功能障碍、生态失调和先天免疫激活。
IF 6.4 1区 医学
Journal of Heart and Lung Transplantation Pub Date : 2024-12-11 DOI: 10.1016/j.healun.2024.11.043
Adam G. Stewart , Daniel C. Chambers
{"title":"Primary graft dysfunction, dysbiosis, and innate immune activation after lung transplantation","authors":"Adam G. Stewart ,&nbsp;Daniel C. Chambers","doi":"10.1016/j.healun.2024.11.043","DOIUrl":"10.1016/j.healun.2024.11.043","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 3","pages":"Pages 435-436"},"PeriodicalIF":6.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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