Journal of Heart and Lung Transplantation最新文献

{"title":"Re-Do Sternotomy in Donation After Circulatory Determination of Death (DCD) and Donation After Brain Death (DBD) Lung Donors - A Case Series","authors":"L.E. Spinetta , B. Jafari , A. Lawrence , V. Kaza , M. Peltz , C. Heid , S. Keshavamurthy , J. Murala","doi":"10.1016/j.healun.2025.02.084","DOIUrl":"10.1016/j.healun.2025.02.084","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 4","pages":"Page S38"},"PeriodicalIF":6.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding Sex and Race Differences in Antibody-Mediated Rejection (ABMR): Insights from Molecular Microscope (MMDx)","authors":"A. Fernandez Valledor , C. Moeller , D. Oren , J. Baranowska , S. Rahman , A. Rahman , B. Elad , C. Hennecken , E.M. DeFilippis , D. Lotan , A. Yunis , J. Raikhelkar , J. Fried , D. Majure , K. Clerkin , F. Latif , G. Sayer , N. Uriel","doi":"10.1016/j.healun.2025.02.064","DOIUrl":"10.1016/j.healun.2025.02.064","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 4","pages":"Page S29"},"PeriodicalIF":6.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal-Organic Framework-Modified Hydrogel Attenuates Ischemia-Reperfusion Injury in Donor Hearts After Transplantation","authors":"J. Ji , S. Liu , Z. Zhang , X. Liu , X. Pan , C. Niu , S. Zheng , P. Zhou , H. Hou , J. Lu","doi":"10.1016/j.healun.2025.02.076","DOIUrl":"10.1016/j.healun.2025.02.076","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 4","pages":"Page S34"},"PeriodicalIF":6.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Resource Allocation in Lung Transplantation: Assessment of Back-Table Evaluation Tools for Marginal Donor Lungs","authors":"A. Tantawi , K. Ayyat , T. Okamoto , S. Unai , H. Elgharably , J. Yun , M. Budev , K. McCurry","doi":"10.1016/j.healun.2025.02.072","DOIUrl":"10.1016/j.healun.2025.02.072","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 4","pages":"Pages S32-S33"},"PeriodicalIF":6.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Silver Lining in the VAD Sky: A Prospective Randomized Controlled Study of a Silver Patch","authors":"S. Baudart , J. Lee , L. Klein","doi":"10.1016/j.healun.2025.02.036","DOIUrl":"10.1016/j.healun.2025.02.036","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 4","pages":"Page S16"},"PeriodicalIF":6.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amniotic Fluid-Derived Stem Cells and Mesenchymal Stromal Cells Restored Aspiration Damaged Donor Lungs and Reduced Primary Graft Dysfunction in a Porcine Lung Transplantation Model","authors":"S. Lindstedt , M. Mittendorfer , A. Niroomand , N.B. Bechet , G. Hirdman , H. Ghaidan , D. Edström , E. Bodén , M. Oller , K. Schallmoser , G. Kjellberg , M. Stenlo , S. Scheding , L. Pierre , S. Hyllén , F. Olm","doi":"10.1016/j.healun.2025.02.032","DOIUrl":"10.1016/j.healun.2025.02.032","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 4","pages":"Page S14"},"PeriodicalIF":6.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Case of Olipudase Alfa Enzyme Replacement Therapy to Treat Niemann-Pick Disease Type-B Following Lung Transplant","authors":"J. Ng , G.F. Watts , M. Musk , J. Wrobel , M. Lavender , S. Lawrence , C.J. Welman , C. Wood , J. Polce , M. Yaw","doi":"10.1016/j.healun.2025.02.082","DOIUrl":"10.1016/j.healun.2025.02.082","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 4","pages":"Page S37"},"PeriodicalIF":6.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TELEHEALTH INTERVENTIONS TO IMPROVE OUTCOMES IN LUNG TRANSPLANT RECIPIENTS: Primary Results of the INSPIRE III Randomized Clinical Trial.","authors":"James A Blumenthal, Stephanie Mabe, David Arthur, Courtney Frankel, Daphne C McKee, Samantha Morrison, Andrew Sherwood, Laurie D Snyder, Scott M Palmer","doi":"10.1016/j.healun.2025.03.017","DOIUrl":"https://doi.org/10.1016/j.healun.2025.03.017","url":null,"abstract":"<p><strong>Background: </strong>There is growing evidence that many patients undergoing lung transplantation report significant distress and low physical activity (PA), which might not improve despite lung transplantation and may be associated with worse clinical outcomes. Few studies have attempted to improve psychological outcomes and functional capacity and PA after transplant.</p><p><strong>Methods: </strong>INSPIRE-III is a single-site, randomized clinical trial in which 180 post-lung transplant patients, recruited between November 2019 and October 2023, completed a psychometric test battery to assess distress and functional capacity measured by the Six-Minute Walk Test and PA assessed by 7 consecutive days of continuous activity monitoring. Participants were then were randomly assigned to either a 12-week Coping Skills Training and Exercise intervention (CSTEX) or a Standard of Care and Education (SoC-ED) program delivered via telephone. Participants were then retested after completion of the telehealth interventions.</p><p><strong>Results: </strong>After 12 weeks, both intervention groups achieved small but similar improvements in distress and functional capacity. Although there were no between group differences overall, patients who were considered clinically depressed at baseline and received CSTEX achieved greater improvements in depression compared to depressed patients who received SoC-ED.</p><p><strong>Conclusions: </strong>Although patients in both CSTEX and SoC-ED showed only modest benefit from their respective interventions, a subgroup of patients in CSTEX who were depressed at study entry had greater reductions in depressive symptoms compared to SoC-ED. Depressive symptoms should be carefully monitored post-transplant and referred for treatment if symptoms persist.</p><p><strong>Trial registry: </strong>NCT04093869.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The United Kingdom's experience of controlled donation after circulatory death direct procurement of lungs with concomitant abdominal normothermic regional perfusion with an analysis of short-term outcomes.","authors":"Luke John Lloyd Williams, Rachel Hogg, Miguel Angel Reyes Roque, Sarah Beale, Mubassher Husain, Anand Jothidasan, Pradeep Kaul, Steven Tsui, Hassiba Smail, Ahmed Al Adhami, Jasvir Parmar, Stephen Pettit, Sri Aurovind Periasamy, Prashant Mohite, Philip Curry, Simon Messer, Karim Morcos, Rajamiyer Venkateswaran, Vipin Mehta, Vamsidhar Dronavalli, B C Ramesh, Aaron Ranasinghe, David Quinn, Binu Raj, Ruth Sutcliffe, Dharmic Suresh, Chris Johnston, Gavin Pettigrew, Andrew Butler, Anne Olland, Gillian Hardman, Christopher Watson, Derek Manas, Ian Currie, Marius Berman","doi":"10.1016/j.healun.2025.03.019","DOIUrl":"https://doi.org/10.1016/j.healun.2025.03.019","url":null,"abstract":"<p><strong>Background: </strong>Abdominal Normothermic Regional Perfusion (A-NRP) improves outcomes for transplanted abdominal organs from Donation after Circulatory Death (DCD) donors. Concerns have been raised about the effect of A-NRP on lungs procured during multi-organ donation. We present the UK experience of performing direct procurement (DRP) of lungs from DCD donors with A-NRP.</p><p><strong>Methods: </strong>Retrospective analysis of all 487 UK DCD lung donors between 1 April 2011 and 31 December 2023. Organ transplantation rate and30-day, 90-day and 1-year survival rates were compared between DRP of DCD lungs, DRP of DCD lungs with A-NRP and DBD lungs. PGD rates were compared between DCD lungs with and without A-NRP.</p><p><strong>Results: </strong>Three hundred ninety-seven DCD donors resulted in a lung transplant (22 retrieved by DRP with A-NRP). There was no difference in lung transplantation rates between DRP and DRP with A-NRP. Of the 390 first adult-only lung transplants performed from DCD donors, there was no significant difference in 30-day, 90-day and 1-year survival between DRP of DCD lungs and DRP with A-NRP. There was a significant difference in survival between standard DCD donors and DBD donors at 30-days and 90-days, but not 1 year. There was no significant difference in grade 3 PGD rates at 72 hours post-implantation for DCD lungs with or without A-NRP.</p><p><strong>Conclusion: </strong>In the UK experience, use of A-NRP is not detrimental to procurement of DCD lungs. We advocate the use of this technique until further studies can explore the safety and efficacy of thoraco-abdominal NRP for lungs in multi-organ retrieval.</p>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung Preservation at Controlled 4-8°C for Extended Criteria Donors Improves Outcome After Transplantation","authors":"L. Ceulemans ,&nbsp;S. Forest ,&nbsp;J. Van Slambrouck ,&nbsp;B. Ferrell ,&nbsp;N. Langer ,&nbsp;E. Bush ,&nbsp;N. Shigemura ,&nbsp;J. Kukreja ,&nbsp;P. Carrott ,&nbsp;G. Schwartz ,&nbsp;H. Huang ,&nbsp;M. Hartwig","doi":"10.1016/j.healun.2025.02.018","DOIUrl":"10.1016/j.healun.2025.02.018","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 4","pages":"Pages S7-S8"},"PeriodicalIF":6.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}