心脏移植中不同供体通路的机器灌注:系统回顾和网络荟萃分析。

IF 6 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Dong-Young Kim, Minseok Kang, Jaeyoung Kim, Dongho Choi, Sook-Jin Lee
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引用次数: 0

摘要

背景:供体心脏的短缺严重限制了心脏移植。创新的机器灌注策略已经出现,以解决传统的脑死亡后静态冷藏(SCS-DBD)的缺点,潜在地提高了结果并扩大了供体资格。我们进行了系统回顾和网络荟萃分析,以比较机器灌注技术与常规SCS-DBD心脏移植的有效性。方法:系统检索2024年1月至2025年3月间发表的MEDLINE、Embase和PubMed数据库。通过之前的系统综述和参考文献列表,确定了2014年至2023年的其他相关研究。包括随机临床试验和非随机研究,评估使用脑死亡(DBD)和循环死亡(DCD)供者心脏移植方法的结果。对30天和1年生存率、急性排斥反应和原发性移植物功能障碍进行meta分析。结果:从1,758个筛选记录中,19项研究涉及22,029例患者符合纳入标准。不同保存方法的30天死亡率无显著差异。1年后,直接采购灌注DCD(风险比[RR] 0.63[95%可信区间[CrI] 0.45-0.89],高确定性)和常温局部灌注DCD (RR 0.68 [CrI 0.47-0.96],低确定性)与SCS-DBD相比,显著降低了死亡率。在DBD组中,死亡率没有出现差异。与SCS-DBD相比,低温氧合机灌注DBD显著降低了严重的原发性移植物功能障碍(0.27[0.10-0.63];高确定性),但所有方法的急性排斥率相似。结论:机器灌注策略的结果不逊于传统SCS,证明了其扩大供体池的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Machine perfusion across different donor pathways in heart transplantation: A systematic review and network meta-analysis.

Background: The shortage of donor hearts significantly limits heart transplantation. Innovative machine perfusion strategies have emerged to address the shortcomings of traditional static cold storage after brain death (SCS-DBD), potentially enhancing outcomes and broadening donor eligibility. We performed a systematic review and network meta-analysis to compare the effectiveness of heart transplantation using machine perfusion techniques with conventional SCS-DBD.

Methods: The MEDLINE, Embase, and PubMed databases were systematically searched for articles published between January 2024 and March 2025. Additional relevant studies from 2014-2023 were identified through previous systematic reviews and reference lists. Included were randomized clinical trials and nonrandomized studies evaluating outcomes of heart transplantation methods utilizing hearts from donors after brain death (DBD) and donors after circulatory death (DCD). Meta-analysis was performed examining 30-day and 1-year survival, acute rejection, and primary graft dysfunction.

Results: From 1,758 screened records, 19 studies involving 22,029 patients met the inclusion criteria. No significant differences in 30-day mortality were observed between preservation methods. At 1 year, direct procurement with perfusion of DCD (risk ratio [RR] 0.63 [95% credible interval [CrI] 0.45-0.89]; high certainty) and normothermic regional perfusion of DCD (RR 0.68 [CrI 0.47-0.96]; low certainty) significantly reduced mortality compared with SCS-DBD. Among DBD groups, no mortality differences emerged. Hypothermic oxygenated machine perfusion of DBD significantly reduced severe primary graft dysfunction compared with SCS-DBD (0.27 [0.10-0.63]; high certainty), but acute rejection rates were similar across all methods.

Conclusions: Outcomes of machine perfusion strategies appear noninferior to those of the conventional SCS, proving its potential to broaden the donor pool.

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来源期刊
CiteScore
10.10
自引率
6.70%
发文量
1667
审稿时长
69 days
期刊介绍: The Journal of Heart and Lung Transplantation, the official publication of the International Society for Heart and Lung Transplantation, brings readers essential scholarly and timely information in the field of cardio-pulmonary transplantation, mechanical and biological support of the failing heart, advanced lung disease (including pulmonary vascular disease) and cell replacement therapy. Importantly, the journal also serves as a medium of communication of pre-clinical sciences in all these rapidly expanding areas.
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