Journal of Heart and Lung Transplantation最新文献

{"title":"Information for Readers","authors":"","doi":"10.1016/S1053-2498(24)02070-9","DOIUrl":"10.1016/S1053-2498(24)02070-9","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 2","pages":"Page A2"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143321430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical circulatory support early after pediatric heart transplantation—an analysis from the Pediatric Heart Transplant Society","authors":"Jacob Simmonds MD (Res) ,&nbsp;Steven D. Zangwill MD ,&nbsp;Bethany Wisotzkey MD ,&nbsp;Ryan Cantor PhD ,&nbsp;Hong Zhao PhD ,&nbsp;James K. Kirklin MD ,&nbsp;Dipankar Gupta MD","doi":"10.1016/j.healun.2024.09.003","DOIUrl":"10.1016/j.healun.2024.09.003","url":null,"abstract":"<div><h3>Background</h3><div>The use of early mechanical circulatory support (MCS) following pediatric heart transplantation is not well-published. This paper attempts to uncover the incidence, predisposing factors, and outcomes of MCS in a large, international cohort.</div></div><div><h3>Methods</h3><div>The Pediatric Heart Transplant Society Database (an international, prospective, event-driven database) was retrospectively analyzed for all cases of primary heart transplant over an 11-year period (2010-2020), dividing the cohort based on need for MCS within 30 days of transplantation.</div></div><div><h3>Results</h3><div>Of 4,321 primary transplants, 249 (5.8%) required MCS (230 ECMO (Extracoporeal Membranous Oxygenation), 19 ventricular assist device). In a Cox proportional hazard model, congenital heart disease (<em>p</em> = 0.0002), older donor age (<em>p</em> &lt; 0.0001), and longer ischemic time (<em>p</em> = 0.018) were each related to an increased need for MCS; increasing recipient body surface area (<em>p</em> &lt; 0.0001) and increasing donor left ventricular ejection fraction (<em>p</em> = 0.016) were both correlated with less MCS use. One-year survival in those requiring MCS was 54.2%, compared with 94.8% in those who did not need MCS (<em>p</em> &lt; 0.0001). Later survival in patients surviving to 1 year was similar between the groups.</div></div><div><h3>Conclusions</h3><div>MCS is used infrequently following pediatric heart transplant and is related to donor, recipient, and transplant factors. Although mortality is high, those surviving the first year post transplant have excellent outcomes. Judicious use in those patients who would otherwise perish is therefore justified.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 2","pages":"Pages 227-233"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can sinoatrial reinnervation improve survival after heart transplantation?","authors":"Anders H. Christensen MD","doi":"10.1016/j.healun.2024.11.004","DOIUrl":"10.1016/j.healun.2024.11.004","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 2","pages":"Pages 213-214"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of riociguat in patients with pulmonary arterial hypertension and cardiometabolic comorbidities: Data from interventional clinical trials","authors":"Stephan Rosenkranz MD ,&nbsp;Hossein-Ardeschir Ghofrani MD ,&nbsp;Marius M. Hoeper MD ,&nbsp;David Langleben MD ,&nbsp;Sara Hegab MD ,&nbsp;Claudia Rahner Dipl Stat ,&nbsp;Jean-François Richard PharmD ,&nbsp;Vallerie V. McLaughlin MD","doi":"10.1016/j.healun.2024.08.018","DOIUrl":"10.1016/j.healun.2024.08.018","url":null,"abstract":"<div><h3>Background</h3><div>There is limited evidence to support treatment recommendations in patients with pulmonary arterial hypertension (PAH) and comorbidities. To investigate the impact of riociguat treatment in this patient population, we analyzed pooled data from randomized controlled trials of riociguat.</div></div><div><h3>Methods</h3><div>This post hoc analysis included data from the PATENT-1, PATENT-2, PATENT PLUS, and REPLACE studies. Safety, efficacy (6-minute walk distance [6MWD], World Health Organization functional class [WHO-FC], and N-terminal probrain natriuretic peptide [NT-proBNP]), and COMPERA 2.0 risk status were assessed in patients with 0, 1 to 2, or 3 to 4 cardiometabolic comorbidities (obesity, systemic hypertension, diabetes mellitus, coronary artery disease) in the main phase of the studies. Safety was also assessed in the long-term extensions.</div></div><div><h3>Results</h3><div>The analysis included 686 patients (riociguat, <em>n</em> = 440; placebo, <em>n</em> = 132; phosphodiesterase type 5 inhibitors [PDE5i], <em>n</em> = 114), of whom 55%, 39%, and 6% had 0, 1 to 2, and 3 to 4 comorbidities, respectively. In the main phase, rates and severity of adverse events (AEs) were similar in riociguat-treated patients across comorbidity subgroups. After 2 years, discontinuations of riociguat due to AEs were also similar across subgroups. Compared with placebo and PDE5i, riociguat improved 6MWD and NT-proBNP across comorbidity groups and improved WHO-FC and COMPERA 2.0 risk status in patients with 0 or 1 to 2 comorbidities.</div></div><div><h3>Conclusions</h3><div>Riociguat had an acceptable safety profile in PAH patients with cardiometabolic comorbidities. Efficacy and risk assessment results suggest that riociguat can be beneficial for patients with PAH, irrespective of the presence of comorbidities.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 2","pages":"Pages 135-146"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A supply-based scoring approach to account for biological disadvantages in accessing lung transplant","authors":"Johnie Rose MD, PhD ,&nbsp;Paul R. Gunsalus MS ,&nbsp;Carli J. Lehr MD, PhD ,&nbsp;Mark F. Swiler BS ,&nbsp;Jarrod E. Dalton PhD ,&nbsp;Maryam Valapour MD, MPP","doi":"10.1016/j.healun.2024.09.022","DOIUrl":"10.1016/j.healun.2024.09.022","url":null,"abstract":"<div><h3>Background</h3><div>The lung Composite Allocation Score (CAS) accounts separately for biological disadvantages stemming from candidate blood type and height using consensus-derived heuristics, which do not reflect the true supply of compatible organs available to candidates with specific combinations of blood type and height. Here, we develop an alternative CAS biological disadvantages subscore using a novel measure of donor supply.</div></div><div><h3>Methods</h3><div>Using Scientific Registry of Transplant Recipients data from February 19, 2015 to September 1, 2021, we modeled daily distance-adjusted supply of compatible donors, as a function of candidate blood type, height, and diagnosis group, using Poisson rate regression and applied the model to create a 10-point supply-based subscore. Substituting this subscore in place of the 10 total points allocated to blood type and height in CAS created a “Supply-Adjusted CAS\". We simulated population outcomes under Supply-Adjusted CAS, original CAS (March 2023) and “ABO Modified” CAS (September 2023).</div></div><div><h3>Results</h3><div>The supply-based subscore was more responsive to variations in candidate blood type, height, and diagnosis group than corresponding CAS or ABO-Modified CAS subscores. In simulation, waitlist mortality improved from 13.95 per 100 waitlist years under CAS and 14.12 under ABO-Modified CAS to 13.09 under Supply-Adjusted CAS. Transplant rates improved from 121.6 and 126.2 under CAS and ABO-Modified CAS, respectively, to 128.8 under Supply-Adjusted CAS. Height disparities improved substantially, while blood type disparities grew slightly relative to ABO-Modified CAS.</div></div><div><h3>Conclusions</h3><div>Supply-Adjusted CAS may improve lung transplant population outcomes overall while providing a more empirically based method to address equity.</div></div>","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 2","pages":"Pages 193-201"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung re-transplantation for recipients with cystic fibrosis: Procedure choice and other considerations","authors":"Siddhartha G. Kapnadak MD,&nbsp;Tijana Milinic MD,&nbsp;Kathleen J. Ramos MD MS","doi":"10.1016/j.healun.2024.10.004","DOIUrl":"10.1016/j.healun.2024.10.004","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 2","pages":"Pages 191-192"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging gaps in lung allocation: A data-driven approach to overcome biological disparities","authors":"Ankit Bharat MD, FACS","doi":"10.1016/j.healun.2024.10.008","DOIUrl":"10.1016/j.healun.2024.10.008","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 2","pages":"Pages 202-203"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe primary graft dysfunction after heart transplantation—defining the subtypes","authors":"Sanjay Dutta MBBS ,&nbsp;Peter S. Macdonald MBBS MD PHD","doi":"10.1016/j.healun.2024.10.010","DOIUrl":"10.1016/j.healun.2024.10.010","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 2","pages":"Pages 171-172"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peak VO2: An old-school prognostic metric for all heart failure seasons","authors":"Paolo C. Colombo MD,&nbsp;Melana Yuzefpolskaya MD","doi":"10.1016/j.healun.2024.11.015","DOIUrl":"10.1016/j.healun.2024.11.015","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 2","pages":"Pages 246-248"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The balance of risks: Outcomes associated with mechanical circulatory support after pediatric heart transplant","authors":"Hari Tunuguntla MD, MPH ,&nbsp;Aamir Jeewa MB B.Ch., FAAP, FRCPC","doi":"10.1016/j.healun.2024.10.024","DOIUrl":"10.1016/j.healun.2024.10.024","url":null,"abstract":"","PeriodicalId":15900,"journal":{"name":"Journal of Heart and Lung Transplantation","volume":"44 2","pages":"Pages 234-235"},"PeriodicalIF":6.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}