Journal of Gastrointestinal Cancer最新文献

{"title":"Clinical Outcome and Safety of Triweekly Modified FOLFIRINOX Therapy in Patients with Advanced Pancreatic Cancer.","authors":"Kana Hosokawa, Kenji Ikezawa, Yugo Kai, Ryoji Takada, Takumi Kinomoto, Takanori Masumoto, Masaki Kawabata, Hiroki Kishimoto, Kazuhiro Kozumi, Makiko Urabe, Kaori Mukai, Tasuku Nakabori, Kazuyoshi Ohkawa","doi":"10.1007/s12029-025-01309-6","DOIUrl":"10.1007/s12029-025-01309-6","url":null,"abstract":"<p><strong>Purpose: </strong>Modified FOLFIRINOX (mFFX) therapy is widely used as first- or second-line treatment for advanced pancreatic cancer. However, adverse effects (AEs), such as cytopenia, often prevent the intended biweekly administration of mFFX therapy. Extending the dosing interval may decrease AEs and allow safer and longer mFFX therapy continuation. Therefore, this study evaluated the efficacy and safety of triweekly mFFX therapy at our institution.</p><p><strong>Methods: </strong>We retrospectively reviewed 17 patients with unresectable pancreatic ductal adenocarcinoma who received mFFX therapy for more than 3 months and switched to a triweekly administration schedule within 2 months of initiating therapy at our institution between April 2017 and December 2023.</p><p><strong>Results: </strong>Patient median age was 58 years (range: 36-75, 52.9% male). Eleven patients received mFFX therapy as the first-line treatment, while the other four patients received it as the second-line treatment. The median number of mFFX cycles was nine (range: 5-56). The median overall survival (OS) and progression-free survival (PFS) for all patients were 14.2 (95% confidence interval [CI], 10.5-26.3) and 6.7 (95% CI, 3.9-9.5) months, respectively. Regarding AEs, because patients with severe hematologic toxicity in the early phase were switched to triweekly treatment, the proportions of grade ≥ 3 leukopenia and neutropenia were high. In contrast, for grade ≥ 3 non-hematologic toxicity, diarrhea and anorexia were observed in only 1 of 17 patients.</p><p><strong>Conclusion: </strong>Triweekly mFFX therapy for unresectable pancreatic cancer may be a feasible treatment option, with relatively low toxicity and valid efficacy.</p>","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"56 1","pages":"187"},"PeriodicalIF":1.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Economic Evaluation of Gastric Cancer Screening Strategies: A Systematic Review.","authors":"Eoghan Burke","doi":"10.1007/s12029-025-01316-7","DOIUrl":"https://doi.org/10.1007/s12029-025-01316-7","url":null,"abstract":"","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"56 1","pages":"186"},"PeriodicalIF":1.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medullary Carcinoma of the Colon: Not as Favourable as Previously Thought?","authors":"Daniel Netto, Mugtaba Dafalla, Karim Muhammad, Haithum Tumeh, Chloe Sowerby, Konstantinos Kamposioras","doi":"10.1007/s12029-025-01304-x","DOIUrl":"10.1007/s12029-025-01304-x","url":null,"abstract":"<p><strong>Introduction: </strong>Medullary carcinoma of the colon (MCC) is a rare, evolving subtype of colorectal cancer that is histologically and clinically distinct from poorly differentiated and undifferentiated adenocarcinoma. Comprehensive meta-analyses show that MCCs predominantly have a mismatch repair-deficient (MMRd) phenotype, which typically predicts a more favourable prognosis.</p><p><strong>Case presentation: </strong>We present a unique case involving a male patient with an aggressive presentation of colon cancer. Histopathology supported a diagnosis of MCC, initially staged as T3N0M0. Shortly after resection, the patient presented with rapidly progressing metastatic disease involving brain and subcutaneous metastases and subsequent mortality.</p><p><strong>Conclusion: </strong>MCC is an understudied subpopulation of colon cancers. Historically, the presence of MMRd in early-stage colon cancer predicts a favourable prognosis and also a lack of benefit from adjuvant chemotherapy. Whether this also extrapolates to MCCs remains unclear, and as such, the case presented highlights the uncertainty in the current evidence base. Further research is warranted to help inform robust clinical management.</p>","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"56 1","pages":"185"},"PeriodicalIF":1.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12426073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gallbladder Squamous Cell Carcinoma with Diffuse β-hCG Expression: A Case Report and Review of the Literature.","authors":"Shengliang He, Dustin E Bosch, Alan Hemming","doi":"10.1007/s12029-025-01308-7","DOIUrl":"10.1007/s12029-025-01308-7","url":null,"abstract":"<p><strong>Purpose: </strong>Gallbladder squamous cell carcinoma (SCC) is a rare subtype of gallbladder malignancy, comprising only 1-4% of cases. Ectopic expression of β-human chorionic gonadotropin (β-hCG) has been described in various epithelial cancers and is associated with aggressive behavior. We report the first known case of gallbladder SCC with diffuse β-hCG expression and markedly elevated serum β-hCG levels, aiming to explore its clinicopathological implications and potential as a prognostic biomarker.</p><p><strong>Methods: </strong>We present the clinical, radiologic, surgical, and pathological findings of a patient with a large gallbladder mass. A literature review was conducted to contextualize our findings.</p><p><strong>Results: </strong>The patient underwent open cholecystectomy with hepatic segment IVb/V resection. Final pathology revealed poorly differentiated SCC with acantholytic features and diffuse β-hCG immunoreactivity. Two metastatic lymph nodes were identified in the low hepatoduodenal nodal basin. Postoperative serum β-hCG was significantly elevated. Despite surgical resection, the patient experienced rapid disease recurrence and progression.</p><p><strong>Conclusion: </strong>This case represents the first documented instance of β-hCG-expressing gallbladder SCC. Diffuse β-hCG expression may reflect a dedifferentiated and aggressive tumor phenotype associated with early metastasis and poor prognosis. Further studies are warranted to investigate the prognostic and biological significance of β-hCG in gallbladder SCC and its potential role as a biomarker.</p>","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"56 1","pages":"184"},"PeriodicalIF":1.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of CRP-Albumin-Lymphocyte (CALLY) Index in Colorectal Cancer Survival: A Multicenter Retrospective Cohort Study.","authors":"Mansour Bahardoust, Mohammadsadra Shamohammadi, Negin Danesh, Armaghan Abbasi Garavand, Mohammad Kasra Rezaei, Homan Alipour, Meisam Haghmoradi, Babak Goodarzy, Seyed Hamzeh Mousavie, Adnan Tizmaghz","doi":"10.1007/s12029-025-01307-8","DOIUrl":"10.1007/s12029-025-01307-8","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) has become one of the major health burdens in the world with high mortality rates, especially at the advanced stages. The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel multidimensional biomarker combining systemic inflammation, nutritional status, and immune function. This study evaluated the association between the CALLY index and overall survival (OS) as well as recurrence-free survival (RFS) in colorectal cancer (CRC) patients.</p><p><strong>Methods: </strong>In this retrospective, multicenter cohort study, the medical characteristics of 1447 CRC patients who were treated at one of the medical centers affiliated with two universities of medical sciences between 2012 and 2022 were examined. Patients were divided into two groups based on the CALLY index: ≥ 2 (945 patients) and < 2 (502 patients). Demographic characteristics, tumor characteristics, and pathological findings of the patients were extracted by referring to the patient records.</p><p><strong>Results: </strong>The 5-year OS rate for patients with a CALLY index ≥ 2 was 80.3%, compared to 64.9% for those with a CALLY index < 2 (log-rank test = 68.2, P = 0.001). The multivariate analysis showed that the CALLY index was significantly associated with OS rate of patients, and OS rate was significantly higher in patients with a CALLY index ≥ 2 than in patients with a CALLY index < 2 (HR 0.84, 95% CI 0.73-0.95, P = 0.001). Also, based on these results, the patients' age, mean BMI, tumor size, T stage, TNM stage, presence of metastasis, tumor location, number of involved lymph nodes, colon diseases, adjuvant chemotherapy, platelet level, and pathological tumor differentiation were all significantly associated with survival in CRC patients (P < 0.05).</p><p><strong>Conclusion: </strong>Our study demonstrated that a higher CALLY index is significantly correlated with improved survival outcomes and a reduced risk of recurrence in CRC patients. CALLY index can be helpful as a criterion for predicting the prognosis of patients with CRC.</p>","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"56 1","pages":"183"},"PeriodicalIF":1.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve for Survival in Patients with Esophageal Cancer Following Esophagectomy.","authors":"Xiaoqin Chen, Xiongmu Tan, Yushang Yang, Linyan Huang, Simeng Wang, Yinqiu Wang, Xueting Pang, Shenmei Liu, Yong Yuan, Liqing Peng","doi":"10.1007/s12029-025-01296-8","DOIUrl":"https://doi.org/10.1007/s12029-025-01296-8","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the predictive value of CT-FFR on survival in patients with esophageal carcinoma (EC) after esophagectomy.</p><p><strong>Methods: </strong>Five hundred and eighty patients with EC who had coronary computed tomography angiography (CCTA) and esophagectomy from January 2012 to September 2023 were included in this study. The lesion-specific fractional flow reserve (FFR) was derived from CCTA. The 580 post-esophagectomy EC patients were divided into two groups: CT-FFR > 0.80 (n = 406) and CT-FFR ≤ 0.80 (n = 174). Propensity score matching (PSM) analysis was used to control for confounding factors. Overall survival (OS) was estimated using Kaplan-Meier curves and Cox proportional hazards models based on univariate and multivariate screening of variables.</p><p><strong>Results: </strong>The CT-FFR ≤ 0.80 group had a higher proportion of males, more patients with coronary artery calcium score (CACS) ≥ 100, lower tumor stages, a higher proportion of patients receiving neoadjuvant therapy, and a higher proportion of patients undergoing full laparoscopy surgery (all p < 0.05). After PSM, the two matched groups of patients had similar characteristics. In our Cox regression model, CT-FFR ≤ 0.80 was an independent factor associated with OS (HR: 1.37; 95% CI: 1.038-1.818; p = 0.026) compared to CT-FFR > 0.80. The results after PSM still showed that CT-FFR ≤ 0.80 was an independent factor associated with OS (HR: 1.43; 95% CI: 1.022-2.009; p = 0.037) compared to CT-FFR > 0.80.</p><p><strong>Conclusion: </strong>CT-FFR is found to be a valuable imaging marker in predicting outcomes of EC patients following esophagectomy. Specifically, a CT-FFR ≤ 0.80 is associated with poorer survival outcomes in EC patients. This underscores the incremental prognostic value of CT-FFR in predicting survival outcomes among post-esophagectomy patients.</p>","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"56 1","pages":"182"},"PeriodicalIF":1.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Gastric Endoscopic Submucosal Dissection in a Non-academic Western Center.","authors":"Sebastian Stefanovic, Rajko Knezevic, Maja Denkovski, Zoran Stanisic, Natasa Brglez Jurecic, Ljiljana Ljepovic, Marjan Gorenc, Andreja Hvalic, Davorin Dajcman, Dejan Urlep, Milan Stefanovic","doi":"10.1007/s12029-025-01300-1","DOIUrl":"https://doi.org/10.1007/s12029-025-01300-1","url":null,"abstract":"<p><strong>Purpose: </strong>Endoscopic submucosal dissection (ESD) is a minimally invasive technique used to treat gastrointestinal neoplasms. Lower incidence of gastric lesions results in fewer studies of gastric ESD in the West. We aimed to show the safety and efficacy of gastric ESD in a non-academic center as compared to the available studies, while adhering to established international guidelines.</p><p><strong>Methods: </strong>We retrospectively analyzed gastric ESDs in our center between June 2015 and December 2024. Included were precancerous lesions, early gastric cancers (EGCs), neuroendocrine neoplasias, and subepithelial lesions. Patient demographics, lesion characteristics, procedural details, adverse events, and treatment outcomes were analyzed. Primary study outcomes included rates of complete R0 resection (horizontal and vertical margins free of GI neoplasia on histopathology), curative resection in EGCs (R0 with no lymphovascular invasion, as defined by JGES criteria), and adverse events. Secondary outcomes were recurrence and diagnostic discrepancies.</p><p><strong>Results: </strong>One hundred gastric ESDs were performed in 91 patients. Conversion to hybrid ESD/EMR was done in six cases. In one early case, ESD was aborted after intraprocedural perforation. R0 resection rates for all lesions were 91%, 100% for low-grade dysplasias, 100% for high-grade dysplasias, 80.9% for EGCs, and 100% for other indications. Curative resection was achieved in 78.7% of EGCs. Adverse events occurred in 11 (11%) cases. During the mean follow-up period of 21.8 ± 24.0 months, recurrence occurred in four of 73 patients with follow-up data (5.5%).</p><p><strong>Conclusions: </strong>Our results demonstrate ESD as a safe and effective option for gastric lesions in non-academic Western centers.</p>","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"56 1","pages":"181"},"PeriodicalIF":1.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-Based Analysis of the Interplay between Rurality and Race in Gastric Adenocarcinoma Survival.","authors":"Nicole M Hwang, Matthew E B Dixon","doi":"10.1007/s12029-025-01301-0","DOIUrl":"https://doi.org/10.1007/s12029-025-01301-0","url":null,"abstract":"<p><strong>Purpose: </strong>Despite growing efforts to understand how rurality impacts cancer outcomes, significant gaps remain in understanding its prognostic influence and its interaction with race in patients with gastric adenocarcinoma (GA).</p><p><strong>Methods: </strong>Using the Surveillance, Epidemiology, and End Results (SEER) database, we evaluated the impact of rurality on cancer-specific survival (CSS) in 45,589 GA patients using Kaplan-Meier methods. A multivariable Weibull regression survival model was used to control for potential confounders. We assessed the interplay between race and rurality by evaluating how the association of rurality on CSS differed across race-stratified groups and through joint-effects analysis.</p><p><strong>Results: </strong>Most patients lived in urban areas (89.5% vs 10.5%). There were no significant differences in age and receipt of chemotherapy between rural and urban populations. Rural patients tended to be male, non-Hispanic White, and more likely to have received radiation but less likely to have undergone surgery. Patients residing in rural areas had significantly worse CSS [hazard ratio (HR) = 1.16; 95% CI: 1.12-1.20; p < 0.001] even after adjusting for potential confounders [adjusted HR = 1.15; 95% CI: 1.11-1.19; p < 0.001]. After stratifying by race, the impact of rurality was not observed in non-Hispanic Black patients (p = 0.223) and was most pronounced in non-Hispanic Asian and Pacific Islanders (p = 0.019).</p><p><strong>Conclusions: </strong>Rurality was associated with worse prognosis in GA patients across most racial groups. These findings highlight the need for further research to understand the mechanisms underlying urban-rural disparities in GA outcomes to identify targeted interventions.</p>","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"56 1","pages":"180"},"PeriodicalIF":1.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Intrahepatic Biliary Neuroendocrine Neoplasms: A Case Report and Literature Review.","authors":"Zhengfu Chen, Lifu Hu, Zixian Guo, Jingxiang Chu, Tao He, Changyong E, Tao Jiang","doi":"10.1007/s12029-025-01302-z","DOIUrl":"https://doi.org/10.1007/s12029-025-01302-z","url":null,"abstract":"<p><strong>Introduction: </strong>Intrahepatic biliary neuroendocrine neoplasms (NENs) are rare neoplasms originating from neuroendocrine cells in the intrahepatic bile ducts. Patients often present without hormone-related symptoms but are admitted due to jaundice or abdominal pain.</p><p><strong>Presentation of case: </strong>This case report describes a 57-year-old female patient who experienced intermittent upper abdominal pain for one month prior to admission. A computed tomography (CT) scan at a local hospital revealed an intrahepatic space-occupying lesion. Magnetic Resonance Cholangiopancreatography (MRCP) at our hospital identified a mass at the root of the left hepatic duct, accompanied by secondary dilation of the left intrahepatic bile ducts. Liver function tests and tumor markers were within normal ranges, and no jaundice or metastatic signs were observed. The patient underwent robot-assisted left hemihepatectomy and cholecystectomy, with a smooth postoperative recovery. Pathological examination confirmed a neuroendocrine tumor (NET G2), measuring 2.2×2×1.6 cm. Postoperative positron emission tomography / computedtomography (PET/CT) scans detected no tumors elsewhere, confirming the intrahepatic bile duct as the primary site.</p><p><strong>Conclusion: </strong>Biliary NENs are exceedingly rare and challenging to diagnose preoperatively. Surgical resection remains the most effective treatment for achieving cure or prolonging survival.</p>","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"56 1","pages":"179"},"PeriodicalIF":1.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Epidemiology of PD-L1 Expression in Epstein-Barr Virus-Associated Gastric Cancer: A Systematic Review and Meta-Analysis.","authors":"Francisco Cezar Aquino de Moraes, Gustavo Tadeu Freitas Uchôa Matheus, Luis Eduardo Rodrigues Sobreira, Shi Juin Lam, Mariana Rachas Reis, Rommel Mario Rodríguez Burbano","doi":"10.1007/s12029-025-01305-w","DOIUrl":"https://doi.org/10.1007/s12029-025-01305-w","url":null,"abstract":"<p><strong>Background: </strong>Epstein-Barr virus-associated gastric cancer (EBVaGC) accounts for ~ 10% of gastric cancers (GC). Programmed death-ligand 1 (PD-L1) expression plays a key role in immune evasion and response to immunotherapy, but its correlation with EBVaGC remains unclear.</p><p><strong>Methods: </strong>We searched PubMed, Embase, and Cochrane databases for studies evaluating PD-L1 expression in EBVaGC. The primary outcome was the association between EBV and PD-L1 expression. Statistical analyses were performed using RStudio.</p><p><strong>Results: </strong>A total of 53 studies with 17,806 patients were included. PD-L1 expression in EBVaGC was 10.34% (95% CI: 6.30-14.38; I² = 94.8%; p < 0.01). Prevalence varied by income level: high-income (8.28%), upper-middle-income (15.18%), and lower-middle-income countries (1.03%). By continent, PD-L1 expression rates were highest in Asia (12.44%) and lowest in Africa (1.03%). Among countries, China (21.51%) and the Czech Republic (22.50%) had the highest prevalence, while the Netherlands (0.83%) and Morocco (1.03%) had the lowest.</p><p><strong>Conclusion: </strong>Our findings reinforce the relevance of molecular classification, particularly the assessment of Epstein-Barr virus status, as a promising tool for improving patient stratification and guiding therapeutic decisions in gastric cancer. These results may contribute to advancing future research aimed at validating and expanding the use of these biomarkers globally.</p>","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"56 1","pages":"178"},"PeriodicalIF":1.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}