Journal of Gastrointestinal Cancer最新文献

{"title":"Model-Based Prognostication and Symptom Distress in Patients with Advanced Hepatopancreaticobiliary Cancers Receiving Best Supportive Care: A Prospective Cohort Study.","authors":"Sumith Surendran, Jayita Deodhar, Jyothsna Kuriakose, Shamali Poojary, K V Ganpathy, Raghu Thota","doi":"10.1007/s12029-026-01471-5","DOIUrl":"https://doi.org/10.1007/s12029-026-01471-5","url":null,"abstract":"","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"57 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Impact of Adjuvant Chemotherapy on Stage IB Gastric Cancer Patients After Radical Surgery.","authors":"Yi-Fu Chen, Hao-Wei Kou, Tsung-Hsing Chen, Puo-Hsien Le, Chia-Jung Kuo, Shang-Yu Wang, Wen-Chi Chou, Ta-Sen Yeh, Jun-Te Hsu","doi":"10.1007/s12029-026-01472-4","DOIUrl":"https://doi.org/10.1007/s12029-026-01472-4","url":null,"abstract":"<p><strong>Purpose: </strong>Radical surgery is the primary treatment for localized gastric cancer (GC), but the benefit of adjuvant chemotherapy in stage IB GC remains unclear. This study evaluates its impact on recurrence and survival post-gastrectomy.</p><p><strong>Methods: </strong>We retrospectively analyzed 357 patients with pathological T1N1M0 or T2N0M0 GC who underwent radical gastrectomy (1994-2020). Clinicopathological data were collected, and propensity score matching (PSM) was used to minimize selection bias.</p><p><strong>Results: </strong>The chemotherapy group was younger (p = 0.007), had lower Charlson comorbidity index scores (p = 0.006), more partial gastrectomies (p = 0.048), and higher lymphovascular invasion rates (p = 0.023). No significant differences were observed in disease-free (p = 0.346) or cancer-specific survival (p = 0.358) between groups, even after PSM.</p><p><strong>Conclusions: </strong>Adjuvant chemotherapy did not improve survival. Large-scale randomized trials are needed to clarify its role in stage IB GC.</p>","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"57 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Beam Radiation Therapy for Intrahepatic Cholangiocarcinoma.","authors":"Alexandra E Hotca, Mary Feng","doi":"10.1007/s12029-026-01463-5","DOIUrl":"10.1007/s12029-026-01463-5","url":null,"abstract":"","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"57 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Probiotics on the Clinical Outcome and Inflammatory Response in Gastric Cancer Surgery: A Double Blinded Randomized Control Trial.","authors":"Debolina Pal, Amaranathan Anandhi, Andi Rajendhran Keerthi, Nivedita Nanda, Vikram Kate","doi":"10.1007/s12029-026-01449-3","DOIUrl":"https://doi.org/10.1007/s12029-026-01449-3","url":null,"abstract":"<p><strong>Background and aim: </strong>Gut dysbiosis contributes to postoperative complications and worsens the inflammatory and immune dysfunction in gastric cancer (GC) patients. Probiotics may mitigate these effects by modulating gut microbiota. This study aimed to evaluate the effect of probiotics on the length of hospital stay, other post-operative clinical outcomes, nutritional status, inflammatory and immune markers in patients undergoing gastrectomy for gastric cancer.</p><p><strong>Methods: </strong>This was a single-centred, prospective, double blinded, placebo-controlled trial. Participants were patients who underwent open gastrectomy for gastric cancer. Participants were randomized to receive probiotics or placebo for 10 days starting on postoperative day (POD) 1. Blood samples were collected preoperatively and POD 10 to assess haemoglobin, total counts, albumin, IL6, TNFα, and IgA. Clinical outcomes including time to first flatus, first passage of stools, oral diet resumption and length of hospital stay (LOHS). Postoperative complications were monitored for 30 days and classified using the Clavien-Dindo system.</p><p><strong>Results: </strong>Of 42 participants (22 probiotic, 20 placebo), baseline characteristics were comparable. The probiotic group had a significantly shorter median LOHS (9 vs. 12 days, p<0.05), earlier time to first passage of flatus (2.6 vs. 4.3 days, p<0.05), earlier time to first passage of stools (3.6 vs. 5.7 days, p<0.05), and oral diet resumption (3.6 vs. 5.7 days, p<0.05). No significant differences were observed in inflammatory markers (TLC, IL-6, TNF-α), immune markers (IgA), nutritional status (albumin, haemoglobin), or postoperative complications (p>0.05).</p><p><strong>Conclusion: </strong>Postoperative probiotic supplementation reduced LOHS and improved gastrointestinal recovery in GC patients undergoing gastrectomy, but did not significantly affect inflammatory, immune, or nutritional markers.</p>","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"57 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Bowel Function After Low Anterior Resection with Delayed or Immediate Colo-anal Anastomosis for Rectal Cancer: the ACAQOL Study.","authors":"François Delattre, Fatah Tidadini, Joey Fournier, Emmanuel Devant, Pierre-Yves Sage, Alison Foote, Jean-Luc Faucheron, Bertrand Trilling","doi":"10.1007/s12029-026-01464-4","DOIUrl":"https://doi.org/10.1007/s12029-026-01464-4","url":null,"abstract":"","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"57 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival and Tumour Microenvironment in Spatially Distinct Regions in Patients Resected for Hepatocellular Carcinoma: A Multicentre Study.","authors":"Sophie Bull Nordkild, Jeanett Klubien, Delal Akdag, Colm O'Rourke, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Torben Steiniche, Gerda Elisabeth Villadsen, Anders Riegels Knudsen, Gro Linno Willemoe, Jesper Bøje Andersen, Susanne Dam Nielsen, Hans-Christian Lykkegaard Pommergaard","doi":"10.1007/s12029-026-01467-1","DOIUrl":"10.1007/s12029-026-01467-1","url":null,"abstract":"","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"57 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13083490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Based Left-Digit Bias in the Treatment of Pancreatic Adenocarcinoma.","authors":"Qianyun Luo, Bethel Ozed-Williams, David G Brauer, Bryan Trottier, Todd M Tuttle, Jane Y C Hui, Eric H Jensen, Jacob S Ankeny, Christopher J LaRocca, Schelomo Marmor","doi":"10.1007/s12029-026-01459-1","DOIUrl":"10.1007/s12029-026-01459-1","url":null,"abstract":"","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"57 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Global Landscape of Colorectal cancer Incidence and Mortality in 2022 and Projections to 2045: New Estimates From GLOBOCAN 2022.","authors":"Jiannan Tu, Lingling Zheng, Lilin Yan, Liangwen Shi, Zhixing Kuang","doi":"10.1007/s12029-026-01465-3","DOIUrl":"https://doi.org/10.1007/s12029-026-01465-3","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC), ranking as the third most common cancer globally, poses a serious public health threat. Updated assessment of its geographic and temporal burden is crucial to understand evolving risk factors and CRC control strategy efficacy.</p><p><strong>Methods: </strong>Data on CRC incidence and mortality in 2022 were extracted from the GLOBOCAN database. Age-standardized Incidence/Mortality rates (ASIRs/ASMRs) were calculated by sex, country, and region. Burden estimates by age group and CRC subsites were derived, and future projections for 2045 were modeled using global population forecasts.</p><p><strong>Results: </strong>In 2022, an estimated 1,926,425 new CRC cases and 904,019 deaths occurred globally. CRC cases comprise 59.3% colon cancer, 37.9% rectal cancer, and 2.8% anal cancer. Age-specific analysis revealed that although the highest ASIR and ASMR were both observed in individuals aged ≥ 85 years (232.6 and 192.3 per 100,000, respectively), the highest number of CRC cases occurred in the 60-69 age group. East Asia accounted for 36.33% of global cases, with China alone contributing 26.84%. The highest ASIRs were observed in Australia/New Zealand (35.3 per 100,000), Europe (30.5), and North America (27.2), while the lowest ASIR was in Africa and South Asia. ASMRs mirrored the geographic patterns of ASIR, with Eastern Europe having the highest ASMRs (19.6 per 100,000 males) and South Asia the lowest (2.5 per 100,000 females). Moreover, rising CRC rates in transitioning economies and younger populations were noted. By 2045, the global CRC burden is projected to reach 3.28 million new cases and 1.66 million deaths, predominantly in very high and high Human Development Index (HDI) countries.</p><p><strong>Conclusion: </strong>With the population aging and changing lifestyles, the burden of CRC is expected to increase, underscores the urgent need for targeted interventions, enhanced global surveillance, early screening programs, and precision prevention strategies to mitigate future incidence and mortality.</p>","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"57 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant Treatment Strategies in Unresectable Gallbladder Cancer (GBC) in a Regional Cancer Centre in India: a Prospective Cohort Study.","authors":"Sushma Agrawal, Rahul Rahul, Ashish Singh, Rajan Saxena","doi":"10.1007/s12029-026-01466-2","DOIUrl":"https://doi.org/10.1007/s12029-026-01466-2","url":null,"abstract":"","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"57 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147674144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Study of anti-PD-1 Combined with Regorafenib and Raltitrexed as Third-Line Therapy in Colorectal Cancer.","authors":"Yi Yu, Laixiang Li, Wei Gan, Jinxiu Zheng, Jinbo Li, Honglian Zhang, Meiqi Zhong, Hui Zhan, Jiehao Lai, Junhe Li, Jun Chen","doi":"10.1007/s12029-026-01460-8","DOIUrl":"https://doi.org/10.1007/s12029-026-01460-8","url":null,"abstract":"","PeriodicalId":15895,"journal":{"name":"Journal of Gastrointestinal Cancer","volume":"57 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147645509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}