Journal of Indian Society of Periodontology最新文献

{"title":"Effect of exposure to the carcinogen 50 ppm 4-nitroquinoline 1-oxide on alveolar bone loss.","authors":"Marcelo Ekman Ribas, Tobias Rauber Spuldaro, Harry Juan Rivera Oballe, Juliano Cavagni, Eduardo José Gaio, Marcelo Lazzaron Lamers, Francisco Wilker Mustafa Gomes Muniz, Cassiano Kuchenbecker Rösing","doi":"10.4103/jisp.jisp_565_23","DOIUrl":"10.4103/jisp.jisp_565_23","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to analyze the effect of exposure to the carcinogen 4-nitroquinoline 1-oxide (4NQO), with or without experimental periodontitis (EP), on alveolar bone loss (ABL) in rats.</p><p><strong>Materials and methods: </strong>Male Wistar rats (<i>n</i> = 84) were divided into Group 1: no EP and no exposure to 4NQO; Group 2: exposure to 4NQO (50 ppm) only; Group 3: EP only; and Group 4: after 20 weeks of exposure to 4NQO (50 ppm), EP was induced by placing a silk ligature on the upper right maxillary second molar for 15 days. Macroscopic analysis of the tongue and morphometric analysis of ABL were performed. Kruskal-Wallis and Mann-Whitney U tests were used, and a significance level of <i>P</i> < 0.05 was adopted.</p><p><strong>Results: </strong>All animals exposed to 4NQO presented macroscopic lesions on the tongue. When considering the side with EP, no statistically significant difference was demonstrated between Groups 3 (median: 0.76; intervals interquartile [IQ]: 0.42-0.45) and 4 (median: 0.78; IQ: 0.70-0.80). In the side without EP, Group 4 (median: 0.51 mm; IQ: 0.45-0.70) presented significantly higher ABL compared to Group 1 (median: 0.41 mm; IQ: 0.38-0.43). Group 3 (median: 0.44; IQ: 0.41-0.47) showed no significant difference when compared to Groups 1 (median: 0.41; IQ: 0.38-0.43) and 2 (median: 0.46; IQ: 0.41-0.54).</p><p><strong>Conclusions: </strong>It was concluded that higher ABL occurred in the presence of a carcinogen. However, the combination of both 4NQO and EP did not promote higher ABL.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"516-521"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of vascular endothelial growth factor levels in periodontal tissues of patients suffering from periodontitis and/or diabetes mellitus: An immunohistochemical study.","authors":"Harshavardhana Babu, Saroj Kumar Rath, Nitin Gupta","doi":"10.4103/jisp.jisp_7_24","DOIUrl":"10.4103/jisp.jisp_7_24","url":null,"abstract":"<p><strong>Background and objectives: </strong>Pathogenesis of periodontal diseases over the years has been a subject of discussion in the field of periodontology. Search is on for novel biomarkers that designate the presence or absence of the disease. Vascular endothelial growth factor (VEGF) is one such marker investigated recently which has been seen to increase both in periodontitis and diabetes. Hence, this study was under taken to evaluate and compare the VEGF levels in periodontal tissues of patients having either periodontitis or diabetes mellitus (DM) with those having both.</p><p><strong>Materials and methods: </strong>The study group was divided into the four groups of 25 patients in each group. Group A were patients having healthy periodontium and without any systemic diseases. Group B were patients having periodontitis without any systemic diseases. Group C were patients having both periodontitis and DM. Group D were patients having only DM without any periodontitis. The VEGF levels were graded into three grades of 0, 1 and 2. They were evaluated through immunohistochemistry in tissue samples obtained from all the groups.</p><p><strong>Results: </strong>Healthy patients generally had Grade 0 level whereas patients having only periodontitis or only DM had primarily Grade 1. Most of the patients having both periodontitis and diabetes had Grade 2 level of VEGF.</p><p><strong>Conclusion: </strong>The outcome of this cross-sectional study to assess the relationship between periodontitis, diabetes and VEGF levels is declarative toward a positive correlation between periodontitis, diabetes and increase in the VEGF levels.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"511-515"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of mucogingival surgery to periodontal plastic surgery.","authors":"Dharmarajan Gopalakrishnan","doi":"10.4103/jisp.jisp_415_24","DOIUrl":"10.4103/jisp.jisp_415_24","url":null,"abstract":"","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"507-508"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implants and us - The path ahead.","authors":"Ashish Jain","doi":"10.4103/jisp.jisp_2_25","DOIUrl":"https://doi.org/10.4103/jisp.jisp_2_25","url":null,"abstract":"","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"509-510"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial efficacy of extracts obtained from aerial part, leaves, and flowers of <i>Sphaeranthus indicus</i> on different periodontal pathogens: An <i>in vitro</i> study.","authors":"Mahendra Rawaji Gawade, Amit Arvind Agrawal, Meenakshi Sreeram, Mahalaxmi Mohan","doi":"10.4103/jisp.jisp_397_23","DOIUrl":"10.4103/jisp.jisp_397_23","url":null,"abstract":"<p><strong>Introduction: </strong><i>Sphaeranthus indicus</i> is a medicinal plant widely used in the Indian traditional system of medicine for curing various ailments. However, there has been no report of any study testing its antimicrobial action against dental or periodontal pathogens. Hence, the aim of this study was to evaluate the <i>in vitro</i> antimicrobial activity of extract of whole plant, leaves, and flowers of <i>S</i>. <i>indicus</i> against four periodontal pathogens, namely, <i>Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans.</i></p><p><strong>Materials and methods: </strong>Extracts of the aerial part (whole plant), leaves, and flowers of <i>Sphaeranthus indicus</i> were prepared using cold maceration and ethanol extraction. The extracts were tested for their antimicrobial activity against periodontal pathogens by using <i>in vitro</i> serial dilution method at concentration of 12.5, 25, 50, and 100 μg/ml. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of all three groups were determined against all four periodontal pathogenic using thioglycollate broth and chlorhexidine as a positive control.</p><p><strong>Results: </strong><i>P</i>. <i>gingivalis</i> and <i>Fusobacterium nucleatum</i> were most susceptible to leaves extract (12.5 μg/ml and 25 μg/ml) followed by whole aerial plant extract (25 μg/ml and 50 μg/ml), but were least susceptible to flower extract (100 μg/ml). Another pathogen, <i>T</i>. <i>forsythia</i> was most susceptible to whole plant and flower extracts (25 μg/ml), followed by leaves extract (100 μg/ml). Finally, <i>A</i>. <i>actinomycetemcomitans</i> was most susceptible to flower extract (25 μg/ml), followed by equal susceptibility at 50 μg/ml concentration of either whole plant or leaves extracts.</p><p><strong>Conclusion: </strong>The <i>S</i>. <i>indicus</i> ethanol extracts of aerial parts, leaves, and flowers showed good antimicrobial activity against periodontal pathogens.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"544-550"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of implant stability and esthetics by partial extraction therapy and immediate implant placement in maxillary anterior region: A clinical study.","authors":"Venkateshwarapuram Rengaswami Balaji, Krishnaveni Boobalan, Manikandan Dhanasekaran","doi":"10.4103/jisp.jisp_112_23","DOIUrl":"10.4103/jisp.jisp_112_23","url":null,"abstract":"<p><strong>Background: </strong>Partial extraction technique is a method of immediate implant placement, wherein the segment of root is retained in the socket to establish a continuous blood supply and prevent resorption of buccal bundle bone. This study was designed to compare and evaluate implant stability and esthetics by partial extraction therapy (PET) and immediate implant placement in the maxillary anterior region.</p><p><strong>Materials and methods: </strong>A total of 10 sites were included in the study and divided into two groups; the test group (PET) and the control group (immediate implant). The primary parameters assessed were implant stability, evaluated immediately, 3^rd month and at 6^th month; pink esthetic (PE) score, evaluated immediately, 3^rd month and at 6^th month; and cone-beam computed tomography for evaluating ridge width postoperatively and at the end of 6 months. The secondary parameters such as the Visual Analog Scale were assessed at the end of 24 h of surgical procedure; the sulcular bleeding index was evaluated at the 3^rd month and 6^th month; peri-implant probing depth was evaluated at the end of the 3^rd month and 6^th month.</p><p><strong>Results: </strong>At the end of the 6^th month, the test group (PET) showed improvement in implant stability, PEs, and ridge width than the control group (immediate implant placement). However, the difference was not statistically significant.</p><p><strong>Conclusion: </strong>Implant placement by PET, serves as a dependable technique for preserving and maintaining alveolar bone and PEs as the retained root fragment within the socket prevents buccal bundle bone from resorption.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 4","pages":"436-442"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of vestibular incision subperiosteal tunnel access technique in the treatment of multiple adjacent gingival recession defects: A systematic review.","authors":"Prabhnoor Tuli, Abhay Pandurang Kolte, Rajashri Abhay Kolte, Vrushali Nilesh Lathiya","doi":"10.4103/jisp.jisp_66_24","DOIUrl":"10.4103/jisp.jisp_66_24","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effectiveness of Vestibular Incision Subperiosteal Tunnel Access (VISTA) technique over other root coverage (RC) procedures for treating Millers Class I and II multiple adjacent gingival recession defects (MAGRD).</p><p><strong>Methods: </strong>Patient, Intervention, Comparison, and Outcome question was established, and a literature review was carried out across PubMed, Cochrane Libraries, EMBASE, and hand-searched journals till April 2023 to identify the clinical research on the effectiveness of the VISTA Technique for RC procedures. Only randomized controlled trials (RCTs) with a minimum of 6 months' follow-up were considered. The outcomes assessed were complete RC (CRC), width of keratinized gingiva, and gingival thickness.</p><p><strong>Results: </strong>A total of 30 articles were retrieved and ultimately 7 RCTs that met the inclusion criteria were incorporated into the systematic review. VISTA with biomaterials showed significant improvements in all the treatment outcomes over other RC procedures. Specifically, VISTA + subepithelial connective tissue graft (CTG)/CTG achieved an average CRC of 93.95%, along with significant increase in other parameters. In addition, biomaterials such as platelet concentrates, collagen membrane, Bioguide enhanced GEM21S, and Acellular dermal matrix proved viable alternatives producing similar outcomes.</p><p><strong>Conclusion: </strong>VISTA technique is an effective procedure for treating MAGRD in terms of achieving CRC over other RC procedures. In addition, the use of biomaterials further enhances the treatment outcomes.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 4","pages":"407-416"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of surface texture on osteogenic differentiation of dental pulp stem cells: An <i>in vitro</i> study.","authors":"Komal Rajpurohit, Vidya Dodwad, Avinash Kharat, Spoorthi Belludi, Pooja Pharne, Sarah Marium","doi":"10.4103/jisp.jisp_307_23","DOIUrl":"10.4103/jisp.jisp_307_23","url":null,"abstract":"<p><strong>Background: </strong>In comparison with perfectly machined surface implants, surface topographic modifications like roughness accelerate the osteogenesis of dental pulpal stem cells (DPSC). This greatly enhances bone-implant contact and osteogenic potential of the stem cells. Hence, the aim of the current study was to evaluate and compare the differentiation and proliferation potential of stem cells obtained from dental pulp on sand-blasted and acid etched implant discs surfaces.</p><p><strong>Materials and methods: </strong>Stem cells from dental pulp were extracted from the premolar region of oral cavity. Titanium discs that measured one centimeter in diameter and three millimetres in thickness were used as investigation surfaces. Titanium surface disc were acid etched and sandblasted. Investigation had three group: acid etched (Group A), sandblasted (Group B), and standard control group, i.e., cells treated with osteogenic induction media only (Group C). In Group C, mesenchymal stem cells (MSCs) were treated with osteogenic induction medium without any titanium disc and these cells were used as standard controls. To identify which modified implant surface had greater potential for proliferation, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed using the explant culture. MTT assay assessed the viability of the cells as a function of its redox potential. This was followed by recognition of the stem cells for CD90, CD73, and CD 105 markers using flow cytometry with RUNX2 antibody on days 7 and 21 of incubation. The isolated cells were stained using 1% alizarin red stain to identify the number of stem cells per square centimeter area under the light microscope.</p><p><strong>Results: </strong>The osteogenic differentiation of both the materials was compared with standard control (MSCs treated with osteogenic differentiation media only). The osteoblastic cells on the acid-etched and sand-blasted implant surface disc had an almost identical capacity for proliferation till the MTT assay but according to the results of the alizarin red staining there was a slightly higher proliferation potential on acid etched surfaces compared to the sand blasted surfaces. Therefore, acid etched surfaces showed higher potential of osteogenic differentiation of DPSCs compared with sand-blasted surfaces.</p><p><strong>Conclusion: </strong>In comparison with perfectly machined surface implants, topographic surface modifications such as roughness can accelerate the osteogenesis of DPSC <i>in</i> <i>vitro</i>.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 4","pages":"478-483"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation, identification, and quantification of <i>Prevotella intermedia</i> and <i>Prevotella nigrescens</i> in subgingival plaque samples of periodontally healthy and chronic periodontitis patients through chromogenic <i>in situ</i> hybridization.","authors":"Vijayalakshmi Sharadindu Kotrashetti, Kishore Gajanan Bhat, Vijay Mahadev Kumbar, Sachita Shrikant Naik","doi":"10.4103/jisp.jisp_99_23","DOIUrl":"10.4103/jisp.jisp_99_23","url":null,"abstract":"<p><strong>Background: </strong>The genus <i>Prevotella</i> comprising over 50 identified species is a normal commensal of the oral cavity. The commonly studied species are <i>Prevotella intermedia</i> (PI) and <i>Prevotella nigrescens</i> (PN). The molecular technique, used for isolating and identifying these species, requires specialized equipment, making them not feasible in a standard laboratory. Chromogenic <i>in situ</i> hybridization (CISH) can be performed in routine laboratory and is economical and less time-consuming. Hence, the aim of this study was to isolate, identify, and quantify PI and PN from subgingival plaque samples of chronic periodontitis (CP) and periodontally healthy individuals through CISH.</p><p><strong>Materials and methods: </strong>A total of 100 individuals in the age group of 20-70 years (50 CP and 50 healthy individuals) were considered. Detailed demographic data were obtained from both the groups. Subgingival plaque was collected from the individuals and transferred to reduced transport media and sent to the laboratory for CISH staining. The samples were fixed in 4% paraformaldehyde and then smeared on gelatin-coated slides. The slides were stained using a specific oligonucleotide probe for PI and PN and then subjected to streptavidin-biotinylated horseradish peroxidase complex. The slides were analyzed for bacilli under a light microscope at ×100 magnification for identification and quantification.</p><p><strong>Results: </strong>The number of positive cases for PI was higher in CP (54%) compared to healthy (46%), whereas in PN, the number of positive cases was higher in healthy (66%) compared to CP (54%). When grades of periodontitis were considered, a number of positive cases were higher in percentage with an increase in grade of periodontitis. Quantification of the bacilli showed a mean score of 23 and 33 for PI and PN, respectively, in the healthy group, and a score of 27 for both PI and PN in the CP group.</p><p><strong>Conclusion: </strong>PI appears to have a role in CP when compared to PN based on the quantification of the bacilli in healthy subjects, which showed a decreased PI score and increased PN score. CISH appears to be one of the promising diagnostic tools for the identification of oral bacteria, as it is simple, less time-consuming, accurate, and specific for the identification of microbes.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 4","pages":"443-448"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation of platelet rich fibrin as barrier membrane in treatment of grade II furcation defects.","authors":"B Harshavardhana, Nitin Gupta, Spandana Reddy Vantary, Ankit Krishna","doi":"10.4103/jisp.jisp_6_24","DOIUrl":"10.4103/jisp.jisp_6_24","url":null,"abstract":"<p><strong>Background and objectives: </strong>Various guided tissue regenerative procedures have been used in treatment of furcation defects. A combination of various graft materials and barrier membranes have been used over a period of time. The present study was designed to test whether autologous platelet-rich fibrin (PRF) can be effectively used as a barrier membrane along with porous hydroxyapatite (HA) bone graft in the treatment of Grade II furcation defects.</p><p><strong>Materials and methods: </strong>The present study was a split-mouth design, in which a total of thirty patients with bilateral grade II furcation defects in the mandibular molars were selected. On the control side, the furcation defect was treated using only HA bone graft and in the test side, the furcation defect was treated using a combination of HA bone graft and PRF as barrier membrane. The clinical and radiological parameters were recorded presurgically, postsurgical at 3 and 6 months, respectively, and the results were statistically analyzed and compared.</p><p><strong>Results: </strong>The furcation defects treated in the test side showed better healing and bone fill when compared to control side. The clinical parameters of the test and control sides when compared were found to be statistically significant.</p><p><strong>Conclusion: </strong>PRF can be effectively used as barrier membrane along with a graft material thus enhancing the regenerative potential of the graft material while regenerating the lost periodontal tissue in Grade II furcation defects.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 4","pages":"431-435"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}