Journal of Indian Society of Periodontology最新文献

{"title":"Exploring the efficacy of different agents for treatment of dentin hypersensitivity.","authors":"Harmesh Sharma, Divya Jyoti, Ravneet Kaur, Shanteri Nayak, Anamika Garg, Swarnim Singh","doi":"10.4103/jisp.jisp_184_24","DOIUrl":"10.4103/jisp.jisp_184_24","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study was to determine the efficacy of casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACP), bonding agent, and herbal agent for the reduction of dentin hypersensitivity (DH).</p><p><strong>Materials and methods: </strong>A multi-centered, single-blinded study was carried out, comprising 210 systemically healthy subjects with at least 2 sensitive teeth. Three sessions of therapy were administered to each of the three groups, with a 72-h interval in between administrations. The hypersensitive teeth were subjected to tactile and evaporative stimuli at baseline, after the 1^st, 2^nd, and 3^rd sessions, and then after the 1^st week and 4^th week posttreatment. On the Visual Analog Scale, the individuals' reactions to the stimuli were noted. Furthermore, the Dentin Hypersensitivity Experience Questionnaire was given to the subjects and was asked to fill on the basis of 5-point Likert scale at baseline and after 1 month of the treatment.</p><p><strong>Results: </strong>The collected data showed that all the three agents are effective in the treatment of DH; however, CPP-ACP is the most effective followed by bonding agent followed by herbal agents. Treatment of DH showed a positive impact on the quality of life of all subjects.</p><p><strong>Conclusion: </strong>This study showed that, following a 1-month follow-up, the CPP-ACP, bonding agent, and herbal agent were successful in lowering DH and improving the participants' quality of life.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 6","pages":"665-668"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Together we grow - \"2025, A shared journey of excellence in periodontal research\".","authors":"Baljeet Singh","doi":"10.4103/jisp.jisp_33_26","DOIUrl":"10.4103/jisp.jisp_33_26","url":null,"abstract":"","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 6","pages":"575-576"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From foundations to frontiers: The evolving continuum of periodontology and implant-based care.","authors":"Neeraj Deshpande","doi":"10.4103/jisp.jisp_6_26","DOIUrl":"10.4103/jisp.jisp_6_26","url":null,"abstract":"","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 6","pages":"577"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and characterization of a hydrogel containing active principles of lotus leaves (<i>Nelumbo nucifera</i>): An <i>in vitro</i> study.","authors":"Akshatha Raj, Rohit Prasad, Bhavya Shetty, Dafney Melissa Rodrigues, Debasmita Das, K Deekshitha, S Gaanashree","doi":"10.4103/jisp.jisp_479_24","DOIUrl":"10.4103/jisp.jisp_479_24","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to formulate and evaluate the antibacterial efficacy of a hydrogel incorporating lotus leaf extract as a potential local drug delivery system for periodontal disease treatment.</p><p><strong>Materials and methods: </strong>Lotus leaves were extracted using a hydroalcoholic Soxhlet method, and the resulting extract was incorporated into a hydrogel. The antibacterial activity of the hydrogel was assessed <i>in vitro</i> against <i>Fusobacterium nucleatum</i>, a key pathogen in periodontal disease. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined. The gel's physical characteristics, including pH, consistency, and appearance, were also evaluated.</p><p><strong>Results: </strong>The lotus leaf extract demonstrated significant antibacterial activity with an MIC and MBC of 600 μg/mL (0.6 mg/mL) against <i>F</i>. <i>nucleatum</i>. The hydrogel formulation was green, clear, and semisolid and exhibited a uniform texture with a pH of 7.0, indicating suitability for periodontal application.</p><p><strong>Conclusion: </strong>The lotus leaf extract-based hydrogel showed promising antimicrobial properties and favorable physical characteristics, suggesting its potential as an effective local treatment for periodontitis. These findings highlight the viability of using natural plant extracts in innovative hydrogel formulations to address periodontal disease. Further research is needed to evaluate the lotus leaf extract gel's efficacy, stability, and safety both <i>in vitro</i> and <i>in vivo</i> and its impact on a broader range of periodontal pathogens.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 6","pages":"611-617"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of locally delivered biodegradable cefixime strips as an adjunct to scaling and root planing in chronic periodontitis: A clinical study.","authors":"Shailja S Vediya, Payal Jain, Neema Shetty, Aditi Mathur, Ashish Bali","doi":"10.4103/jisp.jisp_383_24","DOIUrl":"10.4103/jisp.jisp_383_24","url":null,"abstract":"<p><strong>Background and objectives: </strong>Local drug delivery systems provide targeted therapy within periodontal pockets, enhancing the effectiveness of nonsurgical periodontal treatment. The present study aimed to evaluate the clinical efficacy of locally delivered biodegradable cefixime strips as an adjunct to scaling and root planing (SRP) in the management of generalized chronic periodontitis.</p><p><strong>Materials and methods: </strong>A split-mouth, randomized, placebo-controlled clinical trial was conducted in 40 patients diagnosed with generalized chronic periodontitis. In Group I (test group, 40 sites), biodegradable cefixime strips were inserted into sites with probing pocket depths (PPDs) ≥5 mm following SRP at baseline. In Group II (control group, 40 sites), placebo strips were inserted into sites with similar pocket depths post-SRP. Clinical parameters, including plaque index, gingival index (GI), PPD, and clinical attachment level (CAL), were recorded at baseline, 1 month, and 3 months posttreatment.</p><p><strong>Results: </strong>Both groups demonstrated improvement in all clinical parameters over time. However, the test group (SRP + cefixime strip) showed significantly greater reductions in PPD and GI scores and a higher gain in CAL, compared to the control group (SRP + placebo strip) at 1 and 3 months.</p><p><strong>Conclusion: </strong>Local delivery of biodegradable cefixime strips as an adjunct to SRP is an effective and safe therapeutic approach for the management of generalized chronic periodontitis. This technique enhances local drug concentration within periodontal pockets and exhibits bactericidal activity against major periodontal pathogens.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 6","pages":"642-646"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the landscape of antimicrobial peptides in periodontology: A scoping review.","authors":"Nikita D Patil, Sneha R Haran, Ankita V Deshmukh, Arvind Shetty, Gaurav P Shetty","doi":"10.4103/jisp.jisp_251_25","DOIUrl":"10.4103/jisp.jisp_251_25","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial peptides (AMPs) are gaining attention as adjunctive agents in periodontal therapy due to their antimicrobial, anti-inflammatory, and host-modulatory properties. Their potential adjunctive applications include use as local drug delivery agents, topical pastes, gels or mouthrinses, reinforcements of membranes or implant surfaces, and other applications. While numerous <i>in vitro</i> and animal studies have investigated their utility, the evidence remains scattered, with no comprehensive synthesis available.</p><p><strong>Objective: </strong>This scoping review aimed to map the existing available evidence on AMPs in periodontal therapy, focusing on AMP types, delivery systems, and reported biological, microbiological, and clinical outcomes.</p><p><strong>Materials and methods: </strong>A systematic literature search was conducted across Medline-PubMed, Cochrane, and Google Scholar for studies published in the past 20 years. Studies were included if they evaluated AMPs for periodontal therapy <i>in vivo</i> or <i>in vitro</i>. The key data extracted included the type of AMP, study model, outcomes, and conclusions. The review followed PRISMA-ScR guidelines.</p><p><strong>Results: </strong>A total of 21 studies were included, comprising 13 <i>in vitro</i> studies, 5 animal studies, and 3 clinical studies. The commonly investigated AMP was LL-37. Delivery systems ranged from gels, spays, nanoparticles, and conjugates. Included studies reported significant antimicrobial activity against various periodontal pathogens. Preclinical models and clinical models showed enhanced healing and tissue regeneration. However, variability in experimental design, AMP concentrations, and outcome measures limits comparability across various designs.</p><p><strong>Conclusion: </strong>The existing literature proves AMPs to be a promising therapeutic adjunct in periodontal applications. Clinical data, however, are lacking. Bridging the gap between experimental findings and clinical application requires robust translational research, including well-designed human trials, to evaluate safety, efficacy, and long-term outcomes. This scoping review serves as a foundational reference for guiding future studies toward the clinical integration of AMPs in periodontal therapy.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 6","pages":"582-595"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of antibiotic resistance in <i>Porphyromonas gingivalis</i> to commonly prescribed antibiotics in gingival crevicular fluid samples from chronic periodontitis patients with and without prior antibiotic exposure: A pilot <i>ex vivo</i> study.","authors":"Aashna Joe, B Manovijay, Mathew Jacob, D Vanathy, E Prince Ruban","doi":"10.4103/jisp.jisp_485_24","DOIUrl":"10.4103/jisp.jisp_485_24","url":null,"abstract":"<p><strong>Background: </strong>Antibiotic resistance poses a major challenge in the control of bacterial infections, including chronic periodontitis. This study aimed to evaluate the antibiotic resistance of <i>Porphyromonas gingivalis</i> to commonly prescribed antibiotics, amoxicillin, amoxicillin-clavulanic acid, and metronidazole, in gingival crevicular fluid (GCF) samples obtained from patients with chronic periodontitis, with and without prior antibiotic exposure.</p><p><strong>Materials and methods: </strong>This study included 24 patients diagnosed with chronic periodontitis, divided into two groups: Group 1 comprised 12 patients with a history of antibiotic exposure within the preceding 6 months and Group 2 comprised 12 patients without any prior antibiotic exposure. GCF samples were collected using sterile absorbent paper points and cultured under anaerobic conditions for the isolation of <i>P</i>. <i>gingivalis</i>. Antibiotic sensitivity was assessed by measuring the zone of inhibition (ZOI) on nutrient agar plates. The data were analyzed using the Mann-Whitney <i>U</i>-test, and statistical significance was set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>Patients without prior antibiotic exposure demonstrated a slightly higher mean ZOI (17.66 mm) compared to patients with prior antibiotic exposure (16.66 mm), suggesting marginally better antibiotic effectiveness in the former group. However, this difference was not statistically significant (<i>P</i> = 0.663).</p><p><strong>Conclusion: </strong>The findings indicate a reduced antibiotic effectiveness in patients with previous antibiotic exposure. These results underscore the importance of avoiding empirical antibiotic use and support the consideration of narrow-spectrum antibiotics or alternative treatment approaches, such as local drug delivery systems, to mitigate the development of antibiotic resistance.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 6","pages":"669-672"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soft-tissue augmentation techniques for enhancing peri-implant volume: A systematic review.","authors":"Farjad Zafar, Maryam Riaz, Rahul Kumar, Rafay Ahmed","doi":"10.4103/jisp.jisp_94_25","DOIUrl":"10.4103/jisp.jisp_94_25","url":null,"abstract":"<p><strong>Background: </strong>This systematic review aimed to critically evaluate the effectiveness of soft-tissue augmentation (STA) techniques for enhancing peri-implant soft-tissue thickness and volume around dental implants with compromised soft tissue.</p><p><strong>Materials and methods: </strong>A comprehensive electronic and manual search was performed in MEDLINE via PubMed and EMBASE via Ovid, covering studies published in English up to December 2024. Human studies investigating STA techniques for peri-implant soft-tissue volume augmentation were included. The Joanna Briggs Institute critical appraisal tools, selected according to study design, were used to assess the risk of bias in randomized controlled trials (RCTs), prospective clinical studies (PCS), and case series (CS). Due to methodological heterogeneity, data were synthesized qualitatively rather than through meta-analysis.</p><p><strong>Results: </strong>Thirty-one studies (20 RCTs, 5 PCS, and 6 CS) were included. Reported soft-tissue thickness gain ranged from 0.08 to 3.59 mm and volume gain from 0.16 to 186.38 mm³, where gains ≥2 mm were generally considered clinically relevant for peri-implant tissue improvement and mucosal stability. Despite a predominantly high risk of bias, the subepithelial connective tissue graft (SCTG) combined with a split-thickness flap provided the most consistent outcomes. Variations in surgical protocols, follow-up durations, and measurement methods precluded quantitative meta-analysis.</p><p><strong>Conclusion: </strong>Within the limitations of heterogeneity and potential bias, STA techniques, particularly SCTGs, show promising potential for enhancing peri-implant soft-tissue thickness and volume. However, given the moderate-to-high risk of bias and the lack of a pooled analysis, these results should be interpreted with caution. Further well-designed RCTs with standardized methodologies, consistent outcome measures, and long-term follow-up are essential to validate these findings and optimize clinical protocols.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 6","pages":"596-610"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fifty years of periodontal excellence: Reflections from a landmark Golden Jubilee.","authors":"Ashish Jain","doi":"10.4103/jisp.jisp_600_25","DOIUrl":"10.4103/jisp.jisp_600_25","url":null,"abstract":"","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 6","pages":"578-579"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-infective activity of simvastatin against <i>Candida</i> and selected periodontal pathogens - An <i>in vitro</i> study.","authors":"Sayantan Mukherjee, Pratibha Gopalkrishna","doi":"10.4103/jisp.jisp_439_24","DOIUrl":"10.4103/jisp.jisp_439_24","url":null,"abstract":"<p><strong>Background: </strong>Statins, in addition to their hypolipidemic action, also show antibacterial and antifungal activity. The present research examines the antimicrobial activity of simvastatin (SMV) against periodontal microorganisms: <i>Prevotella intermedia</i> (Pi), <i>Tannerella forsythia</i> (Tf), <i>Fusobacterium nucleatum</i> (Fn), and <i>Candida tropicalis</i> (Ct).</p><p><strong>Materials and methods: </strong>SMV was evaluated for minimum inhibitory concentration by microdilution and for antimicrobial susceptibility by agar disc diffusion. The antibiofilm effect of SMV was further compared with chlorhexidine (0.2%) (CHX) at 6 h, 24 h, 48 h, and 72 h.</p><p><strong>Results: </strong>SMV inhibited all three periodontal bacteria at 0.8 μg/ml and inhibited <i>Ct</i> at a minimum concentration of 50 μg/mL. The mean diameter of the zone of inhibition by SMV for <i>Pi, Fn, Tf</i>, and <i>Ct</i> was 13 ± 0.81 mm, 13.33 ± 0.47 mm, 15.33 ± 0.47 mm, and 14 ± 0.81 mm, respectively. SMV showed a peak reduction in colony-forming unit (CFU) counts from baseline (223.42 ± 10.50 CFU/mm) to 6 h (157.25 ± 8.081 CFU/mm), which was subsequently sustained. Compared with SMV, CHX demonstrated a slower but more consistent reduction in CFU counts for up to 72 h.</p><p><strong>Conclusion: </strong>The tested microorganisms were sensitive to SMV. In addition, SMV was as effective as the common antiplaque agent CHX at preventing these organisms and their proliferation in a biofilm environment during the testing periods. The study provides preliminary evidence of the antimicrobial effects of SMV, which warrants further exploration for its dual therapeutic benefits in periodontal applications.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"29 6","pages":"627-633"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}