Journal of Indian Society of Periodontology最新文献

{"title":"Assessment of implant stability with resonance frequency analysis and changes in the thickness of keratinized tissue and crestal bone level using cone-beam computed tomography in two-stage implants: A three-dimensional clinicoradiographic study.","authors":"Neha Singh, Nichenametla Rajesh, Amirisetty Ramesh","doi":"10.4103/jisp.jisp_122_23","DOIUrl":"10.4103/jisp.jisp_122_23","url":null,"abstract":"<p><strong>Background: </strong>The present study aims to evaluate a three-dimensional (3D) changes in the crestal bone levels (buccally, lingually/palatally, mesially, and distally) and in the thickness of keratinized tissue around single or multiple implants using cone-beam computed tomography (CBCT) after 1 year.</p><p><strong>Materials and methods: </strong>Twenty-eight implants were placed in the posterior load-bearing areas in 10 patients. The crestal bone levels and the thickness of keratinized tissue surrounding the edentulous area were assessed preoperatively, immediately after implant placement, and 1 year after implant placement using CBCT (3D imaging technique with DICOM software (Carestream Health, Rochester, NY)). Implant stability quotient (ISQ) was measured immediately after implant placement using resonance frequency analysis (RFA) (Penguin RFA Monitor Osseointegration, Integration Diagnostics Sweden AB, Furstenbergsgatan 4 416 64 Göteborg, Sweden).</p><p><strong>Results: </strong>The average crestal bone loss around the implants after 1 year was 0.78 ± 0.26 mm on the buccal side, 0.63 ± 0.27 mm on the lingual side, 0.57 ± 0.18 mm on the mesial side, and 0.53 ± 0.28 mm on the distal side. The average amount of bone loss including all sites was 0.63 ± 0.17 mm and the mean change in keratinized tissue thickness after 1 year was 0.3 ± 0.19 mm. The RFA ranged from 75 to 82 Nm for all the implants immediately after placement.</p><p><strong>Conclusion: </strong>CBCT can be used as a reliable source, as it is compararively more superior and precise than intraoral periapical radiographs in measuring the changes in the bone and thickness of the keratinized tissue before and after implant placement. A thick biotype of the keratinized tissue is as important as the bone topography for the success of the implant. ISQ measurements immediately after implant placement can also act as a major factor in depicting the success of the implant in the future.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 3","pages":"368-375"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of noncanonical pyroptosis biomarkers gasdermin D and caspase 4 in gingiva of periodontitis and diabetes patients: An observational cross-sectional study.","authors":"Lalitha Tanjore Arunachalam, Snophia Suresh, Vamsi Lavu, Shankarram Vedamanickam, John Ebinezer, Bhavishya Balachandran","doi":"10.4103/jisp.jisp_92_24","DOIUrl":"10.4103/jisp.jisp_92_24","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis and diabetes are chronic diseases where inflammation plays a central role, with each condition exacerbating the other. Pyroptosis, an inflammatory form of programmed cell death, is implicated in periodontitis and diabetes. The activation of gasdermin D (GSDMD), a key mediator of pyroptosis, promotes cytokine release and perpetuates tissue destruction in both. However, the role of the noncanonical pyroptosis pathway mediated by caspase 4 (CASP4) remains less understood. The study aimed to determine the gene expression of noncanonical pyroptosis biomarkers CASP4 and GSDMD in periodontitis and diabetes individuals and correlate with the periodontal and diabetic parameters.</p><p><strong>Materials and methods: </strong>Sixty individuals were recruited and divided into four groups: Group 1 (healthy), Group 2 (periodontitis), Group 3 (diabetes), and Group 4 (periodontitis with diabetes). Gingival tissue samples were collected from all groups, and the relative mRNA expression levels of CASP4 and GSDMD were determined using reverse transcription polymerase chain reaction. The correlation between CASP4 and GSDMD expression and periodontal parameters - plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment loss (CAL), as well as diabetic parameters - fasting blood sugar and glycated hemoglobin (HbA1C) was analyzed.</p><p><strong>Results: </strong>The relative mRNA expression of CASP4 and GSDMD was highest in Group 4 and lowest in Group 1. Statistical significance was observed between the groups (<i>P</i> ≤ 0.05) for CASP4 and GSDMD. A significant positive correlation was found between CASP4 and GSDMD expression and periodontal parameters (PI, GI, PPD, and CAL), as well as the diabetic parameter HbA1C (<i>P</i> ≤ 0.01).</p><p><strong>Conclusions: </strong>High expression of CASP4 and GSDMD was present in the gingiva of periodontitis and diabetes individuals and correlated with the diabetic and periodontal clinical parameters. This suggests that noncanonical pyroptosis contributes to periodontitis and diabetes pathogenesis through the CASP4/GSDMD axis. The inhibition of GSDMD offers a promising therapeutic approach in managing periodontitis and diabetes.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 3","pages":"297-303"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implant maintenance - Are the concepts crystal clear??","authors":"Baljeet Singh","doi":"10.4103/jisp.jisp_399_24","DOIUrl":"10.4103/jisp.jisp_399_24","url":null,"abstract":"","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 3","pages":"279-280"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of mucogingival defect following excision of multiple gingival squamous cell papillomas using VISTA - A case report with 24 months follow-up.","authors":"Sharath K Shetty, Anita Kulloli, Dharmarajan Gopalakrishnan, Supriya Kheur, Homayoun H Zadeh","doi":"10.4103/jisp.jisp_133_23","DOIUrl":"10.4103/jisp.jisp_133_23","url":null,"abstract":"<p><p>Oral squamous cell papilloma is a benign proliferation of the stratified squamous epithelium, associated with the human papillomavirus (HPV). The clinical manifestation includes papillary or verrucous exophytic mass. Complete excision of the lesion, including normal margins, followed by histopathological examination is the treatment of choice. However, mucogingival defect may be observed after excision of the lesion, requiring management by perioplastic surgery. In this report, a 27-year-old male with an unremarkable medical history reported multiple sessile growths on his gingiva. The masses were located in the left maxillary canine and mandibular premolar regions, exhibiting finger-like projections with white and pink surface color. The lesions were removed by excisional biopsy and submitted for histopathologic examination. After excision, type II noncervical carious lesions (NCCLs) became exposed that were previously covered by papilloma outgrowths. Miller's class I/RT1 recession defects that were present were managed by vestibular incision subperiosteal tunnel access (VISTA) in concert with amnion-chorion membrane (ACM) with 24 months' follow-up. In this case report, mucogingival defects that resulted after the excision of multiple gingival squamous cell papillomas were managed by VISTA in concert with ACM. A favorable outcome was achieved that was stable during the 24-month follow-up.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 3","pages":"380-383"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of the antibiofilm property of aqueous extract of the <i>Amorphophallus paeoniifolius</i> on some early and late colonizers in an artificially synthesized dental biofilm - An <i>in vitro</i> study.","authors":"B R Sowmya, Aarati Nayak, Vijaylakshmi S Kottrashetti, Preeti Ingalagi, Gandla Harish","doi":"10.4103/jisp.jisp_428_23","DOIUrl":"10.4103/jisp.jisp_428_23","url":null,"abstract":"<p><strong>Background: </strong>Mechanical therapy along with adjunctive therapy, using agents like chlorhexidine digluconate mouthwash helps to disrupt the plaque biofilm. Recently, herbs with medicinal value have been tested for their antimicrobial properties. The present study was designed to assess the anti-biofilm activity of <i>Amorphophallus paeoniifolius</i> against some periodontal pathogens in an artificially synthesized dental biofilm.</p><p><strong>Materials and methods: </strong>The aqueous extract of <i>A. paeoniifolius</i> was constituted and its minimum inhibitory concentration (MIC) against standard strains of some periodontal pathogens was determined. A total of 21 biofilm samples were synthesized on extracted teeth and microtiter plates, and these were divided into two groups of 10 samples each. One group was treated with the predetermined MIC values of <i>A. paeoniifolius</i>, while the other group was treated with chlorhexidine. The anti-biofilm activity of both compounds was assessed by calculating colony-forming units (CFUs) for the extracted teeth and optical density (OD) values for the microtiter plates.</p><p><strong>Results: </strong>The mean CFU at baseline was 55,000/μl while posttreatment with chlorhexidine digluconate and aqueous extract of <i>A. paeoniifolius</i> was 23,280 ± 5274.00 and 28,560 ± 4509.545/μl, respectively. The mean OD value (at 595 nm) posttreatment with chlorhexidine digluconate was 0.9876 ± 0.49179 and <i>A. paeoniifolius</i> was 1.4990 ± 0.37851. Results indicate that the aqueous extract of <i>A. paeoniifolius</i> showed an inhibitory effect on biofilm obtained on microtiter plates and the one constituted on extracted teeth.</p><p><strong>Conclusion: </strong>Anti-biofilm activity of aqueous extract of <i>A. paeoniifolius</i> was appreciable and also comparable to that of chlorhexidine digluconate, both on extracted teeth and microtiter plates.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 3","pages":"325-331"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of low-level laser therapy on proliferation and cytotoxicity of mouse fibroblasts and human fibroblasts: An <i>in vitro</i> study.","authors":"Mallanagouda B Patil, Deeksha D Pai, Shobha Prakash","doi":"10.4103/jisp.jisp_376_23","DOIUrl":"10.4103/jisp.jisp_376_23","url":null,"abstract":"<p><strong>Background: </strong>Diode laser is known for its biostimulatory effects on various cell populations such as osteoblasts and fibroblasts. The usage of low-level laser therapy for photobiomodulation depends on its type, emission wavelength, and energy selected. Previously performed <i>in vitro</i> studies have determined its effect on cell proliferation and cytotoxicity; however, the results were inconsistent.</p><p><strong>Objectives: </strong>The objectives of this study were to evaluate and compare diode laser effect on mouse embryonic fibroblasts (MEFs) and human gingival fibroblasts (HGFs) for proliferation and cytotoxicity.</p><p><strong>Materials and methods: </strong>32 samples, 16 wells of MEF cells (Group I) and HGF cells (Group II) each with 8 subgroups containing control (no laser irradiation) and experimental (laser irradiated) groups were cultured after being seeded at 4000 cells/ well with 4cm inter-well distance. Experimental group cell cultures were irradiated with a single dose of 810 nm diode laser (energy 1J/cm², 12.5 mW, 80 s/well) using continuous wave mode after 1 day of incubation. Spectrophotometric analysis was done after 24 h of laser irradiation for cell proliferation and cell cytotoxicity on the 2^nd, 3^rd, and 7^th days on all groups.</p><p><strong>Results: </strong>Human and mouse fibroblast groups showed positive results when irradiated with an 810 nm laser. A hundred percent proliferation was seen for MEF in 7 days and HGF in 2 days. Two percent cytotoxicity was seen on the 2^nd and 3^rd day in MEF. Increased cell proliferation and minimal cytotoxic effects were seen with diode laser usage.</p><p><strong>Conclusion: </strong>Low-level laser irradiation indicates an increase in cell proliferation with less cytotoxicity on mouse and human fibroblasts.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 3","pages":"338-348"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gingival tissue evaluation using soft tissue-cone-beam computed tomography and root coverage esthetic score in the treatment of isolated gingival recession: A clinical study.","authors":"Navina Ravindran, Uma Sudhakar, Nimisha Mithradas, Snophia Suresh, Kotaru Jhansi Lakshmi, J Steffy","doi":"10.4103/jisp.jisp_491_23","DOIUrl":"10.4103/jisp.jisp_491_23","url":null,"abstract":"<p><strong>Objectives: </strong>Comparative assessment of the effectiveness of coronally advanced flap (CAF) with subepithelial connective tissue graft (SCTG) and the envelope technique with SCTG in Miller's Class I recession utilizing soft tissue-cone-beam computed tomography (ST-CBCT) and root coverage esthetic score (RES).</p><p><strong>Materials and methods: </strong>Twenty patients were randomly assigned to Group I (CAF + SCTG) and Group II (envelope technique + SCTG) using the coin toss method, with 10 patients in each group. Recession height (RH) and width (RW), probing pocket depth (PD), clinical attachment level (CAL), and keratinized tissue height (HKT) were assessed at baseline and 6 months. The thickness of keratinized tissue (TKT) using transgingival probing (TGP) and ST-CBCT and the RES were recorded at the 6^th month.</p><p><strong>Results: </strong>On intragroup comparison, statistically significant difference was seen in the clinical parameters RH, RW, PD, CAL, and HKT, whereas on intergroup comparison, no significant difference was seen at baseline and 6 months. TKT was statistically significant at 6 months between the groups using TGP (<i>P</i> = 0.01) and ST-CBCT (<i>P</i> = 0.01). No statistical difference was seen between the methods in Group 1 (<i>P</i> = 0.61) and Group 2 (<i>P</i> = 0.62). No statistical significance was seen in the RES score (<i>P</i> = 0.10).</p><p><strong>Conclusion: </strong>The study indicates the effectiveness of both the techniques, with the envelope technique demonstrating superior esthetics. Moreover, the research highlights the significance of ST-CBCT as an emerging alternative tool for assessing gingival dimensions.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 3","pages":"312-318"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferences and choice in clinical decision-making with the help of time trade-off and standard gamble techniques among periodontally compromised patients - A cross-sectional study.","authors":"Budhaditya Paul, Ankita Srivastava","doi":"10.4103/jisp.jisp_471_23","DOIUrl":"10.4103/jisp.jisp_471_23","url":null,"abstract":"<p><strong>Background: </strong>To assess the validity of time trade-off (TTO) and standard gamble (SG) techniques of utility valuation among patients with periodontal problems by assessing their relation to two logical constructs; Gingival Index (GI) and Oral Health Impact Profile (OHIP) Questionnaire.</p><p><strong>Materials and methods: </strong>Two hundred and one patients aged 18 years old and above, who visited a tertiary care hospital for treatment/consultation were included. A questionnaire was administered to record the TTO, SG, and OHIP. GI, measuring the severity of the disease, was recorded. Bivariate and backward multiple regression analyses were done to find an association between the oral health utility values, OHIP, and the variables of interest (demographic and clinical characteristics including GI).</p><p><strong>Results: </strong>There was a statistically significant decrease in the TTO and SG utilities (<i>P</i> < 0.05) as the severity of the disease progressed from mild to severe. GI, as well as OHIP scores, were significant predictors in the case of both the TTO as well as SG (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>TTO and SG utilities were found to be valid and correlated well with clinical findings. Health utilities serve as useful and reliable markers of health-related quality of life among individuals as well as communities.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 3","pages":"319-324"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards the next big one: Implant research grants.","authors":"Ashish Jain","doi":"10.4103/jisp.jisp_386_24","DOIUrl":"https://doi.org/10.4103/jisp.jisp_386_24","url":null,"abstract":"","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 3","pages":"283"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11684569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of accuracy of implants placed with thermoplastic and three-dimensional-printed surgical guides: A randomized controlled trial.","authors":"Firasat Husain, Vishakha Grover, Nandini Bhaskar, Ashish Jain","doi":"10.4103/jisp.jisp_256_23","DOIUrl":"https://doi.org/10.4103/jisp.jisp_256_23","url":null,"abstract":"<p><strong>Background: </strong>The current study was planned to evaluate the accuracy of dental implant placement with two different types of surgical guides: Thermoplastic and three-dimensional (3D) printed.</p><p><strong>Materials and methods: </strong>A total of 32 implants were placed in 20 healthy, partially dentate individuals with an isolated single missing tooth. The implant sites were randomly allocated into two treatment groups: Group A (thermoplastic implant surgical guide, <i>n</i> = 16 implants) and Group B (3D printed implant surgical guide, <i>n</i> = 16 implants). All the cases in both groups were digitally planned according to a defined protocol, and a comparison of the planned and actual implant positions was performed using the medical image analysis software. The differences in the outcome variables, i.e., angular deviation (AD), 3D error at the entry, 3D error at the apex (3D EA), vertical deviation (VD), and composite deviation, were statistically analyzed.</p><p><strong>Results: </strong>All the outcome variables showed improvements, but statistically significant improvement was shown by AD (<i>P</i> = 0.005), 3D EA (<i>P</i> = 0.01), and VD (<i>P</i> = 0.007). The mean and standard deviation (SD) for AD, (3D EA), and VD were 5.58° ±1.93°, 0.96 ± 0.32 mm, and 0.58 ± 0.36 mm, respectively, for group A. The mean and SD for AD, (3D EA), and VD were 3.94° ± 0.64°, 0.64 ± 0.35 mm, and 0.29 ± 0.13 mm, respectively, for group B (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Within the limits of the study, dental implants placed using 3D-printed surgical guides were positioned clinically with greater accuracy, and fewer deviations were observed from their presurgical planned positions as compared to the thermoplastic surgical guides.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 2","pages":"244-251"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}