{"title":"The menace of overusage of antibiotics and antibiotic resistance - Are we heading towards the disaster??","authors":"Baljeet Singh","doi":"10.4103/jisp.jisp_19_25","DOIUrl":"10.4103/jisp.jisp_19_25","url":null,"abstract":"","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"505-506"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Indian Society of Periodontology Scientific Events.","authors":"","doi":"10.4103/jisp.jisp_32_25","DOIUrl":"https://doi.org/10.4103/jisp.jisp_32_25","url":null,"abstract":"","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"596-598"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of the donor site healing following free gingival graft procedure with and without topically applied ozonated oil as wound dressing.","authors":"Kalaiselvan Dharani, P T Priyangha","doi":"10.4103/jisp.jisp_144_24","DOIUrl":"10.4103/jisp.jisp_144_24","url":null,"abstract":"<p><strong>Aim: </strong>The present study aimed to compare and assess the wound healing efficacy of topically applied ozonated oil in palatal wounds following a free gingival graft (FGG) procedure.</p><p><strong>Materials and methods: </strong>A total of 10 patients were selected and randomly assigned to control or test groups. FGG surgery was carried out on all the patients. In the test group, the patients received ozonated oil of 14 μg/mL concentration at the donor site. In the control group, the patients were not treated with ozonated oil and received only stent at the donor site. The primary outcomes calculated were postoperative pain (Visual Analog Scale) and wound healing index (Landry <i>et al</i>.), and the secondary outcome calculated was wound size for up to 28 days.</p><p><strong>Results: </strong>A total of 10 individuals completed the study. A statistically significant reduction was observed in both primary and secondary outcomes. Statistically significant differences were noted in intergroup comparison at 5<sup>th</sup>, 7<sup>th</sup>, 14<sup>th</sup>, 21<sup>st</sup>, and 28<sup>th</sup> day with a mean difference of -3.200 (<i>P</i> = 0.001), -2.200 (<i>P</i> = 0.018), -1.600 (<i>P</i> = 0.027), -1.800 (<i>P</i> = 0.037), and 2.600 (<i>P</i> = 0.001), respectively. In intragroup comparison, there were no statistically significant differences in the index scores in the groups on the 5<sup>th</sup> and 7<sup>th</sup> day, and a significant improvement in healing was observed in both the groups by time from the 14<sup>th</sup> to 28<sup>th</sup> day. In intergroup comparison, statistically significant differences were noted on the 5<sup>th</sup>, 7<sup>th</sup>, 21<sup>st</sup>, and 28<sup>th</sup> days with a mean difference of 1.400 (<i>P</i> = 0.005), 1.400 (<i>P</i> = 0.005), 1.000 (<i>P</i> = 0.020), and 1.400 (<i>P</i> = 0.002), respectively. Statistically significant reduction in coronal-apical dimension of wound size was noted at the 5<sup>th</sup>, 7<sup>th</sup>, 14<sup>th</sup>, 21<sup>st</sup>, and 28<sup>th</sup> day from baseline with a mean difference of -1.400 (<i>P</i> = 0.002), -1.200 (<i>P</i> = 0.040), -1.600 (<i>P</i> = 0.001), -2.200 (<i>P</i> ≤ 0.001), and -1.800 (<i>P</i> = 0.007), respectively. There was no statistically significant reduction in the mesiodistal dimension of wound size on the 5<sup>th</sup> and 7<sup>th</sup> day with a mean difference of - 0.600 (<i>P</i> = 0.174) and - 0.600 (<i>P</i> = 0.208). Significant differences were noted on the 14<sup>th</sup>, 21<sup>st</sup>, and 28<sup>th</sup> days from day 0 with a mean of - 1.600 (<i>P</i> = 0.019), -2.600 (<i>P</i> = 0.001), and -2.200 (<i>P</i> = 0.003).</p><p><strong>Conclusion: </strong>These results suggest that topical ozonated oil application on palatal wounds following FGG harvesting enhances tissue healing in terms of epithelialization and wound size reduction and also reduces postoperative discomfort.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"575-580"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nimisha Mithradas, Uma Sudhakar, Vijayalakshmi Rajaram, Shankar Ram, Navina Ravindran
{"title":"Galectin-3 as a biomarker for periodontal disease severity in postcoronavirus disease 2019 patients: A clinical and biochemical investigation.","authors":"Nimisha Mithradas, Uma Sudhakar, Vijayalakshmi Rajaram, Shankar Ram, Navina Ravindran","doi":"10.4103/jisp.jisp_38_24","DOIUrl":"10.4103/jisp.jisp_38_24","url":null,"abstract":"<p><strong>Background: </strong>The relationship between coronavirus disease 2019 (COVID-19) and periodontitis has been interesting. Understanding this connection is crucial for comprehensive patient care and highlights the importance of monitoring and addressing oral health issues in an individual's post-COVID-19 recovery. This study compared and evaluated the serum Galectin-3 (Gal-3) levels and clinical parameters in healthy individuals with chronic periodontitis with no history of COVID-19 and post-COVID-19 patients with periodontitis.</p><p><strong>Materials and methods: </strong>Group I consists of 25 post-COVID-19 patients with Stage II Grade B periodontitis, 25 patients with Stage II Grade B periodontitis without any history of COVID-19 (Group II), and 25 healthy controls (Group III) were recruited for the study. Gal-3 levels in serum were assessed using an enzyme-linked immunosorbent assay (ELISA) kit. Clinical periodontal variables were measured and recorded, including clinical attachment level (CAL), plaque index (PI), and probing pocket depth (PPD). Data analyses were done using the one-way analysis of variance (ANOVA) test and Tukey's honest significant difference <i>post hoc</i> tests.</p><p><strong>Results: </strong>Group I patients had a higher serum Gal-3 concentrations of 14.757 ng/ml compared to 11.127 ng/ml and 8.673 ng/ml in Group II and Group III, respectively, and the mean difference in Gal-3 levels was statistically significant with <i>P</i> = 0.000. The mean PPD, CAL, and PI were significantly high in Groups I and II compared to Groups II and III with <i>P</i> = 0.000.</p><p><strong>Conclusion: </strong>The current study's findings demonstrated that periodontitis patients and individuals with post-COVID-19 and periodontitis had increased Gal-3 levels in the serum compared to healthy participants. This study highlights the relevance of treating periodontitis during the post-COVID-19/long-COVID era and the need to maintain oral hygiene by identifying possible biomarkers and understanding specific underlying processes.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"551-556"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcelo Ekman Ribas, Tobias Rauber Spuldaro, Harry Juan Rivera Oballe, Juliano Cavagni, Eduardo José Gaio, Marcelo Lazzaron Lamers, Francisco Wilker Mustafa Gomes Muniz, Cassiano Kuchenbecker Rösing
{"title":"Effect of exposure to the carcinogen 50 ppm 4-nitroquinoline 1-oxide on alveolar bone loss.","authors":"Marcelo Ekman Ribas, Tobias Rauber Spuldaro, Harry Juan Rivera Oballe, Juliano Cavagni, Eduardo José Gaio, Marcelo Lazzaron Lamers, Francisco Wilker Mustafa Gomes Muniz, Cassiano Kuchenbecker Rösing","doi":"10.4103/jisp.jisp_565_23","DOIUrl":"10.4103/jisp.jisp_565_23","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to analyze the effect of exposure to the carcinogen 4-nitroquinoline 1-oxide (4NQO), with or without experimental periodontitis (EP), on alveolar bone loss (ABL) in rats.</p><p><strong>Materials and methods: </strong>Male Wistar rats (<i>n</i> = 84) were divided into Group 1: no EP and no exposure to 4NQO; Group 2: exposure to 4NQO (50 ppm) only; Group 3: EP only; and Group 4: after 20 weeks of exposure to 4NQO (50 ppm), EP was induced by placing a silk ligature on the upper right maxillary second molar for 15 days. Macroscopic analysis of the tongue and morphometric analysis of ABL were performed. Kruskal-Wallis and Mann-Whitney U tests were used, and a significance level of <i>P</i> < 0.05 was adopted.</p><p><strong>Results: </strong>All animals exposed to 4NQO presented macroscopic lesions on the tongue. When considering the side with EP, no statistically significant difference was demonstrated between Groups 3 (median: 0.76; intervals interquartile [IQ]: 0.42-0.45) and 4 (median: 0.78; IQ: 0.70-0.80). In the side without EP, Group 4 (median: 0.51 mm; IQ: 0.45-0.70) presented significantly higher ABL compared to Group 1 (median: 0.41 mm; IQ: 0.38-0.43). Group 3 (median: 0.44; IQ: 0.41-0.47) showed no significant difference when compared to Groups 1 (median: 0.41; IQ: 0.38-0.43) and 2 (median: 0.46; IQ: 0.41-0.54).</p><p><strong>Conclusions: </strong>It was concluded that higher ABL occurred in the presence of a carcinogen. However, the combination of both 4NQO and EP did not promote higher ABL.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"516-521"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of vascular endothelial growth factor levels in periodontal tissues of patients suffering from periodontitis and/or diabetes mellitus: An immunohistochemical study.","authors":"Harshavardhana Babu, Saroj Kumar Rath, Nitin Gupta","doi":"10.4103/jisp.jisp_7_24","DOIUrl":"10.4103/jisp.jisp_7_24","url":null,"abstract":"<p><strong>Background and objectives: </strong>Pathogenesis of periodontal diseases over the years has been a subject of discussion in the field of periodontology. Search is on for novel biomarkers that designate the presence or absence of the disease. Vascular endothelial growth factor (VEGF) is one such marker investigated recently which has been seen to increase both in periodontitis and diabetes. Hence, this study was under taken to evaluate and compare the VEGF levels in periodontal tissues of patients having either periodontitis or diabetes mellitus (DM) with those having both.</p><p><strong>Materials and methods: </strong>The study group was divided into the four groups of 25 patients in each group. Group A were patients having healthy periodontium and without any systemic diseases. Group B were patients having periodontitis without any systemic diseases. Group C were patients having both periodontitis and DM. Group D were patients having only DM without any periodontitis. The VEGF levels were graded into three grades of 0, 1 and 2. They were evaluated through immunohistochemistry in tissue samples obtained from all the groups.</p><p><strong>Results: </strong>Healthy patients generally had Grade 0 level whereas patients having only periodontitis or only DM had primarily Grade 1. Most of the patients having both periodontitis and diabetes had Grade 2 level of VEGF.</p><p><strong>Conclusion: </strong>The outcome of this cross-sectional study to assess the relationship between periodontitis, diabetes and VEGF levels is declarative toward a positive correlation between periodontitis, diabetes and increase in the VEGF levels.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"511-515"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evolution of mucogingival surgery to periodontal plastic surgery.","authors":"Dharmarajan Gopalakrishnan","doi":"10.4103/jisp.jisp_415_24","DOIUrl":"10.4103/jisp.jisp_415_24","url":null,"abstract":"","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"507-508"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Implants and us - The path ahead.","authors":"Ashish Jain","doi":"10.4103/jisp.jisp_2_25","DOIUrl":"https://doi.org/10.4103/jisp.jisp_2_25","url":null,"abstract":"","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"509-510"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahendra Rawaji Gawade, Amit Arvind Agrawal, Meenakshi Sreeram, Mahalaxmi Mohan
{"title":"Antimicrobial efficacy of extracts obtained from aerial part, leaves, and flowers of <i>Sphaeranthus indicus</i> on different periodontal pathogens: An <i>in vitro</i> study.","authors":"Mahendra Rawaji Gawade, Amit Arvind Agrawal, Meenakshi Sreeram, Mahalaxmi Mohan","doi":"10.4103/jisp.jisp_397_23","DOIUrl":"10.4103/jisp.jisp_397_23","url":null,"abstract":"<p><strong>Introduction: </strong><i>Sphaeranthus indicus</i> is a medicinal plant widely used in the Indian traditional system of medicine for curing various ailments. However, there has been no report of any study testing its antimicrobial action against dental or periodontal pathogens. Hence, the aim of this study was to evaluate the <i>in vitro</i> antimicrobial activity of extract of whole plant, leaves, and flowers of <i>S</i>. <i>indicus</i> against four periodontal pathogens, namely, <i>Porphyromonas gingivalis, Tannerella forsythia, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans.</i></p><p><strong>Materials and methods: </strong>Extracts of the aerial part (whole plant), leaves, and flowers of <i>Sphaeranthus indicus</i> were prepared using cold maceration and ethanol extraction. The extracts were tested for their antimicrobial activity against periodontal pathogens by using <i>in vitro</i> serial dilution method at concentration of 12.5, 25, 50, and 100 μg/ml. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of all three groups were determined against all four periodontal pathogenic using thioglycollate broth and chlorhexidine as a positive control.</p><p><strong>Results: </strong><i>P</i>. <i>gingivalis</i> and <i>Fusobacterium nucleatum</i> were most susceptible to leaves extract (12.5 μg/ml and 25 μg/ml) followed by whole aerial plant extract (25 μg/ml and 50 μg/ml), but were least susceptible to flower extract (100 μg/ml). Another pathogen, <i>T</i>. <i>forsythia</i> was most susceptible to whole plant and flower extracts (25 μg/ml), followed by leaves extract (100 μg/ml). Finally, <i>A</i>. <i>actinomycetemcomitans</i> was most susceptible to flower extract (25 μg/ml), followed by equal susceptibility at 50 μg/ml concentration of either whole plant or leaves extracts.</p><p><strong>Conclusion: </strong>The <i>S</i>. <i>indicus</i> ethanol extracts of aerial parts, leaves, and flowers showed good antimicrobial activity against periodontal pathogens.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 5","pages":"544-550"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative evaluation of implant stability and esthetics by partial extraction therapy and immediate implant placement in maxillary anterior region: A clinical study.","authors":"Venkateshwarapuram Rengaswami Balaji, Krishnaveni Boobalan, Manikandan Dhanasekaran","doi":"10.4103/jisp.jisp_112_23","DOIUrl":"10.4103/jisp.jisp_112_23","url":null,"abstract":"<p><strong>Background: </strong>Partial extraction technique is a method of immediate implant placement, wherein the segment of root is retained in the socket to establish a continuous blood supply and prevent resorption of buccal bundle bone. This study was designed to compare and evaluate implant stability and esthetics by partial extraction therapy (PET) and immediate implant placement in the maxillary anterior region.</p><p><strong>Materials and methods: </strong>A total of 10 sites were included in the study and divided into two groups; the test group (PET) and the control group (immediate implant). The primary parameters assessed were implant stability, evaluated immediately, 3<sup>rd</sup> month and at 6<sup>th</sup> month; pink esthetic (PE) score, evaluated immediately, 3<sup>rd</sup> month and at 6<sup>th</sup> month; and cone-beam computed tomography for evaluating ridge width postoperatively and at the end of 6 months. The secondary parameters such as the Visual Analog Scale were assessed at the end of 24 h of surgical procedure; the sulcular bleeding index was evaluated at the 3<sup>rd</sup> month and 6<sup>th</sup> month; peri-implant probing depth was evaluated at the end of the 3<sup>rd</sup> month and 6<sup>th</sup> month.</p><p><strong>Results: </strong>At the end of the 6<sup>th</sup> month, the test group (PET) showed improvement in implant stability, PEs, and ridge width than the control group (immediate implant placement). However, the difference was not statistically significant.</p><p><strong>Conclusion: </strong>Implant placement by PET, serves as a dependable technique for preserving and maintaining alveolar bone and PEs as the retained root fragment within the socket prevents buccal bundle bone from resorption.</p>","PeriodicalId":15890,"journal":{"name":"Journal of Indian Society of Periodontology","volume":"28 4","pages":"436-442"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}