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RAPID DISSOLVE ORAL DOSAGE FORMS- A DETAIL REVIEW 快速溶解口服剂型-详细回顾
Journal of Global Pharma Technology Pub Date : 2012-10-12 DOI: 10.1234/JGPT.V4I10.509
S. S. Mahtre
{"title":"RAPID DISSOLVE ORAL DOSAGE FORMS- A DETAIL REVIEW","authors":"S. S. Mahtre","doi":"10.1234/JGPT.V4I10.509","DOIUrl":"https://doi.org/10.1234/JGPT.V4I10.509","url":null,"abstract":"In the current scenario of novel drug delivery system, much emphasis has been given to effective dosage form in term of producing steady level concentration in plasma for controlled release drug delivery system and rapid release drug for quick effects. In case of allergy, chemotherapeutics side effect treatment, pain medicines and pediatric as well as geriatrics drug delivery prefers rapid response of drug. Numbers of drug from above categories have been formulated in rapid release tablet or film. With the use of natural polymers and superdisintegrants it is feasible to prepare these dosage forms to dissolve within 1min with minimum quantity of water. The aim of present review is to give complete detailed including all formulation aspects and evaluation parameters of rapid dissolve tablets and films. This review is first of its kind, as per our knowledge, which compiles complete information in one article. Rapid dissolve formulation have very high acceptance rate due to patient friendly formulation. Several technologies have been developed and patented. This review also covers patented technology.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"62 1","pages":"01-14"},"PeriodicalIF":0.0,"publicationDate":"2012-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76193021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
A REVIEW ARTICLE ON: SUPERDISINTEGRANTS 超级崩解剂综述
Journal of Global Pharma Technology Pub Date : 2012-10-12 DOI: 10.1234/JGPT.V4I10.511
P. Shrivastava
{"title":"A REVIEW ARTICLE ON: SUPERDISINTEGRANTS","authors":"P. Shrivastava","doi":"10.1234/JGPT.V4I10.511","DOIUrl":"https://doi.org/10.1234/JGPT.V4I10.511","url":null,"abstract":"Disintegration has play a major role in improving the drug activity and hence increases the patient compatibility. The therapeutic activity of the formulations is obtained by disteintegration followed by dissolution. The inclusion of right disintegrants is a prerequisite to get optimal bioavailability in tablets and capsules. Disintegrants are the substances that causes the rapid disintegration of the capsules or tablets into smaller particles that dissolves more rapidly than in the absence of the disintegrants. On the other hand superdisintegrants ,as it name suggests superior to disintegrants are the substances which facilitates or increases the disintegration time even at low level ,typically 1-10% by weight relative to the total weight of the dosage unit. This article comprises of study of superdisintegrants which are being used in the formulation to provide safe and effective drug delivery with improved patient compliance.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"8 1","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"2012-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89040900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
REVIEW ON TRADITIONAL USES, PHYTOCONSTITUENT & PHARMACOLOGICAL ACTIVITY OF EMBELIA RIBES 牛蒡子的传统用途、植物成分及药理活性综述
Journal of Global Pharma Technology Pub Date : 2012-09-12 DOI: 10.1234/JGPT.V4I6.508
S. Wadhwa
{"title":"REVIEW ON TRADITIONAL USES, PHYTOCONSTITUENT & PHARMACOLOGICAL ACTIVITY OF EMBELIA RIBES","authors":"S. Wadhwa","doi":"10.1234/JGPT.V4I6.508","DOIUrl":"https://doi.org/10.1234/JGPT.V4I6.508","url":null,"abstract":"Herbal drugs are in great demand in the developed world for primary health care because of their efficacy, safety and lesser side effects. ? The World Health Organization (WHO) recently defined traditional medicine (including herbal drugs) as comprising therapeutic that have been in existence, often for hundreds of years, before the development of modern medicine and are still in use today. The traditional preparations comprise medicines which primarily use medicinal plant preparations for therapy. Embelia ribes is most widely used in traditional herbal medicine in India. The fruits of Embelia ribes reported to contain mainly benzoquinone derivatives such as Embelin and Vilangin. The dried fruit has been used in India since ancient times as an anthelmintic. Embelia ribes has been shown to possess astringent carminative, stimulant, antioxidant, anti-spermetogenic, anti-bacterial and anticancer activity. The plant Embelia ribes contains embelin, quercitol, and fatty ingredients, christembine, resinoid, tannins and minute quantities of a volatile oil.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"24 1","pages":"18-27"},"PeriodicalIF":0.0,"publicationDate":"2012-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87209854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
FORMULATION, CHARACTERIZATION AND EVALUATION OF MICROSPHERES OF ACECLOFENAC 乙酰氯芬酸微球的制备、表征及评价
Journal of Global Pharma Technology Pub Date : 2012-08-23 DOI: 10.1234/JGPT.V4I7.488
Sp Gupta
{"title":"FORMULATION, CHARACTERIZATION AND EVALUATION OF MICROSPHERES OF ACECLOFENAC","authors":"Sp Gupta","doi":"10.1234/JGPT.V4I7.488","DOIUrl":"https://doi.org/10.1234/JGPT.V4I7.488","url":null,"abstract":"Aceclofenac is a novel non-steroidal anti-inflammatory drug (NSAID) having anti-inflammatory and analgesic \u0000properties, and is widely used in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. The aim of this \u0000present research work was to microencapsulate the anti-inflammatory drug (aceclofenac) to provide controlled and continuous \u0000release and minimizing or eliminating local side effect by avoiding the drug release in the upper gastrointestinal track. Aceclofenac \u0000was microencapsulated with Eudragit (RS 100), using an emulsion-solvent diffusion technique. Aceclofenac microspheres were \u0000subjected to micromeritic properties including true density, tapped density, angle of repose, and particle size determination. \u0000Microspheres were subjected to drug loading, in vitro drug release as well as for scanning electron microscopy.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"62 1","pages":"10-16"},"PeriodicalIF":0.0,"publicationDate":"2012-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85637566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PHYSICOCHEMICAL AND PHYTOCHEMICAL EVALUATION OF PISTACIA INTEGERRIMA STEW EX BRAND 原厂黄连木炖菜的理化及植物化学评价
Journal of Global Pharma Technology Pub Date : 2012-08-23 DOI: 10.1234/JGPT.V4I7.489
A. Jindal
{"title":"PHYSICOCHEMICAL AND PHYTOCHEMICAL EVALUATION OF PISTACIA INTEGERRIMA STEW EX BRAND","authors":"A. Jindal","doi":"10.1234/JGPT.V4I7.489","DOIUrl":"https://doi.org/10.1234/JGPT.V4I7.489","url":null,"abstract":"Physicochemical evaluation is the parameters to evaluate the presence of inorganic ion fraction in the drug whereas the phytochemical screening enables to find out the presence of total phytoconstituents in the drug material. Both Physicochemical and Phytochemical evaluation are use to evaluate the drug by comparing it with the standard parameters. The present study is therefore focused on the evaluation of physicochemical (ash value and extractive values) values of the leave powder and Phytochemical screening of the ethanolic extract of Pistacia integerrima stew ex brand. The Phytochemical screening showed the presence of tannins, alkaloids, saponins, carbohydrates and glycosides phenolic compounds, gum and mucilage whereas protein and amino acids were found to be absent.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"74 1","pages":"24-27"},"PeriodicalIF":0.0,"publicationDate":"2012-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88524552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
NASAL DYSFUNCTIONS AND INTRANASAL DRUG DELIVERY SYSTEM: A REVIEW ON FORMULATION CONSIDERATIONS AND EVALUATION PARAMETERS FOR NASAL SPRAY 鼻功能障碍与鼻内给药系统:鼻喷雾剂的配方考虑及评价参数综述
Journal of Global Pharma Technology Pub Date : 2012-08-11 DOI: 10.1234/JGPT.V4I9.504
Kapilesh Dave
{"title":"NASAL DYSFUNCTIONS AND INTRANASAL DRUG DELIVERY SYSTEM: A REVIEW ON FORMULATION CONSIDERATIONS AND EVALUATION PARAMETERS FOR NASAL SPRAY","authors":"Kapilesh Dave","doi":"10.1234/JGPT.V4I9.504","DOIUrl":"https://doi.org/10.1234/JGPT.V4I9.504","url":null,"abstract":"This paper aimed to give a brief review on nasal dysfunctions and their treatment by using nasal spray formulation with special emphasis of formulation consideration and evaluation parameter. These reviewed approaches will defiantly help researchers to design and develop a new intranasal drug delivery system for the treatment of allergic rhinitis and other related nasal dysfunctions.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"27 1","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2012-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88762764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study on In Vitro dissolution of Cephradine in presence of Mango Juice 芒果汁中头孢拉定体外溶出度的研究
Journal of Global Pharma Technology Pub Date : 2012-08-11 DOI: 10.1234/JGPT.V4I9.485
Jony Mallik
{"title":"A study on In Vitro dissolution of Cephradine in presence of Mango Juice","authors":"Jony Mallik","doi":"10.1234/JGPT.V4I9.485","DOIUrl":"https://doi.org/10.1234/JGPT.V4I9.485","url":null,"abstract":"","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"115 1","pages":"24-29"},"PeriodicalIF":0.0,"publicationDate":"2012-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81614511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
ROLE OF CALCIUM AND ASCORBIC ACID ON INSULIN REGULATORY MECHANISM: A THERAPEUTIC APPROACH FOR TYPE II DIABETES USING MIN 6 CELLS AS MODEL 钙和抗坏血酸在胰岛素调节机制中的作用:以min 6细胞为模型的ii型糖尿病治疗方法
Journal of Global Pharma Technology Pub Date : 2012-07-24 DOI: 10.1234/JGPT.V4I6.425
Priyanka Sharma, S. Mishra, A. Tiwari
{"title":"ROLE OF CALCIUM AND ASCORBIC ACID ON INSULIN REGULATORY MECHANISM: A THERAPEUTIC APPROACH FOR TYPE II DIABETES USING MIN 6 CELLS AS MODEL","authors":"Priyanka Sharma, S. Mishra, A. Tiwari","doi":"10.1234/JGPT.V4I6.425","DOIUrl":"https://doi.org/10.1234/JGPT.V4I6.425","url":null,"abstract":"Insulin secretion from pancreatic ?-cell maintains the blood glucose homeostasis. A defective insulin secretion disturbs the blood glucose level, which ultimately results into the Type-II diabetes mellitus. The rise in cytosolic Ca2+ concentration due to extracellular Ca2+ influx through voltage-gated Ca2+ channels acts as a key regulator for insulin secretion. Ca2+ influx is a triggering signal for insulin release which takes place in a biphasic manner. Ascorbic acid shares structural similarity with glucose and have evidences that supplementation of ascorbic acid relieved various complications of diabetes. This review focuses on the role of extracellular calcium and ascorbic acid in the management of Type 2 diabetes in MIN6 cell line which has unique ability to induce glucose-stimulated insulin secretion similar to the isolated pancreatic islet. Individual studies has been made for both the regulators hence we reviewed simultaneous literature together in order to have new approach which can be of therapeutic use in Type 2 diabetes.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"37 1","pages":"01-07"},"PeriodicalIF":0.0,"publicationDate":"2012-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83306213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FORMULATION AND CHARACTERIZATION OF GASTRORETENTIVE MUCOADHESIVE QUETIAPINE FUMARATE TABLETS 富马酸奎硫平胃保留黏附片的研制与表征
Journal of Global Pharma Technology Pub Date : 2012-07-24 DOI: 10.1234/JGPT.V4I6.430
A. Setia
{"title":"FORMULATION AND CHARACTERIZATION OF GASTRORETENTIVE MUCOADHESIVE QUETIAPINE FUMARATE TABLETS","authors":"A. Setia","doi":"10.1234/JGPT.V4I6.430","DOIUrl":"https://doi.org/10.1234/JGPT.V4I6.430","url":null,"abstract":"Background and the purpose of the study: Development of gastroretentive delivery system is one of novel approach in oral route of drug administration. Prolonging the gastric retention time is desirable for achieving greater therapeutic benefit of drug substance. The research was aimed to develop gastroretentive mucoadhesive tablets of quetiapine for prolonged residence time. \u0000Methods: The wet granulation method was used for the preparation of various formulations (F1-F12) using different mucoadhesive polymers viz. hydroxyl propyl methyl cellulose K4M, hydroxyl propyl cellulose, chitosan, carbopol 934P and sodium carboxy methyl cellulose in different combinations. The formulations were subjected to various evaluation parameters such as swelling index, mucoadhesive strength, in vitro drug release profile and physical properties. Results: The study showed that the formulation containing chitosan and carbopol 934P in combination (F7) exhibited good swelling index, high mucoadhesive strength of 192.66 g and maximum in vitro residence time (10.14 hrs) and in vitro cumulative drug release after 24 hrs (96.26%). The optimized formulation (F7) was further subjected to in vivo retention time determination in rabbit by X-ray technique and accelerated stability studies. \u0000Conclusion: The formulation (F7) had shown promising potential to achieve desired goal as depicted from the release studies, swelling studies & mucoadhesion studies.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"411 1","pages":"12-17"},"PeriodicalIF":0.0,"publicationDate":"2012-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78086147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFICACY OF MYRRH TOTAL OIL EMULSION AGAINST HYMENOLEPIS NANA IN RATS 没药总油乳剂对大鼠膜膜炎的防治作用
Journal of Global Pharma Technology Pub Date : 2012-07-24 DOI: 10.1234/JGPT.V4I6.472
M. Etman, M. Amin, A. Nada, M. Shams-Eldin, O. Salama
{"title":"EFFICACY OF MYRRH TOTAL OIL EMULSION AGAINST HYMENOLEPIS NANA IN RATS","authors":"M. Etman, M. Amin, A. Nada, M. Shams-Eldin, O. Salama","doi":"10.1234/JGPT.V4I6.472","DOIUrl":"https://doi.org/10.1234/JGPT.V4I6.472","url":null,"abstract":"The study aims investigating the efficacy of Myrrh Total Oil (MTO), formulated as emulsion, in treating naturally acquired Hymenolepis nana infection in rats. White albino male rats were used and different treatment regimens were studied using praziquantel as a reference compound. MTO dose of 834 mg/kg for 3 days, cured the infection in 75% of the rats, while lower doses exhibited less success. The number of worms was around 24 when the infected rats received a dose of 333 mg/kg for one day or for 3 successive days. Increasing dosing duration to 4 days, the mean number of worms decreased to 2 worms. Praziquantel produced a 100% cure of all infected rats in the assigned group. MTO emulsion proved to be effective against Hymenolepis nana. Although the results indicate the superiority of praziquantel, nevertheless the data obtained is promising for the interest of using natural products and warrants further investigation.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"74 1","pages":"08-11"},"PeriodicalIF":0.0,"publicationDate":"2012-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90400736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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