Journal of Global Pharma Technology最新文献_第2页

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF ONDANSETRON HYDROCHLORIDE IN BULK AND FORMULATION 分光光度法测定盐酸昂丹司琼原料药和制剂含量的建立与验证

Journal of Global Pharma Technology Pub Date : 2013-12-02 DOI: 10.1234/JGPT.V5I01.517

D. Gangwal

{"title":"DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF ONDANSETRON HYDROCHLORIDE IN BULK AND FORMULATION","authors":"D. Gangwal","doi":"10.1234/JGPT.V5I01.517","DOIUrl":"https://doi.org/10.1234/JGPT.V5I01.517","url":null,"abstract":"Ondansetron is used as selective 5-HT3 receptor antagonist. In present study, a simple, rapid, accurate, and economical UV-spectrophotometric method has been developed for the estimation of ondansetron hydrochloride from bulk and pharmaceutical formulation. The developed method was statistically validated in accordance with ICH requirement on the basis of various parameters like linearity, accuracy, precision, sensitivity, repeatability and ruggedness. The drug follows linearity in the concentration range 4-20 ?g/ml with a correlation coefficient value of 0.999 at ?max of 284 nm. The accuracy of the method was checked by recovery experiment performed at three different levels, i.e., 80%, 100%, and 120%. The % recovery was found to be in the range of 101.08- 101.54%. The precision of the method was studied as an intraday; interday variations, and repeatability. The % RSD value < 2 indicates that the method is precise, reproducible and accurate. Ruggedness of the proposed method was also studied with the help of two analysts. The proposed method was then successfully applied to pharmaceutical formulation. Amount of drug estimated was found to be 98-102%, which was in good agreement with the label claim. Excipients used in tablet formulation did not interfere in the estimation of ondansetron by developed method. The proposed method can be successfully employed in the routine analysis of drug in pharmaceutical dosage forms.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"16 1","pages":"06-10"},"PeriodicalIF":0.0,"publicationDate":"2013-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81007998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

ANTIMICROBIAL EVALUTION OF PHENOLIC FRACTION OF BIXA ORELLANA L. BIXACEAE biaxa orellana l. bixaceae植物酚类成分的抗菌评价

Journal of Global Pharma Technology Pub Date : 2013-12-02 DOI: 10.1234/JGPT.V5I01.519

P. Mital

引用次数: 0

NECROTISING ENTEROCOLITIS IN INFANTS- A REVIEW 婴儿坏死性小肠结肠炎综述

Journal of Global Pharma Technology Pub Date : 2013-11-05 DOI: 10.1234/JGPT.V5I4.539

V. Sona

引用次数: 0

STRATEGIES FOR ENHANCING ORAL BIOAVAILABILITY OF POORLY SOLUBLE DRUGS 提高难溶性药物口服生物利用度的策略

Journal of Global Pharma Technology Pub Date : 2013-11-05 DOI: 10.1234/JGPT.V5I3.536

A. Sushmitha

{"title":"STRATEGIES FOR ENHANCING ORAL BIOAVAILABILITY OF POORLY SOLUBLE DRUGS","authors":"A. Sushmitha","doi":"10.1234/JGPT.V5I3.536","DOIUrl":"https://doi.org/10.1234/JGPT.V5I3.536","url":null,"abstract":"Bioavailability is defined as the rate and extent of absorption of unchanged drug from its dosage form in to the systemic circulation. A drug with poor bioavailability is one with poor aqueous solubility, slow dissolution rate in biological fluids, poor stability of drug dissolved at physiological pH, poor permeation through biomembrane, extensive presystemic metabolism. Oral ingestion is most convenient and commonly employed route of drug delivery due to its ease of administration, high patient compliance, cost effectiveness, least sterility constraints, and flexibility in the design of dosage form. As a result, many of the generic drug companies are inclined more to produce bioequivalent oral drug products. The main technologies to achieve the enhanced oral bioavailability of drugs with poor aqueous solubility include the use of solid dispersions, micronization, nanonization, solid lipid nanoparticles and colloidal drug delivery systems etc. Colloidal drug delivery systems include microemulsions, self emulisifying drug delivery systems, liposomes, self micro emulsifying drug delivery systems (SMEDDS). One of the challenges in formulating micro emulsions, self emulsifying drug delivery systems is the limited bioavailability of formulation components with GRAS (generally regarded as safe) status. Bioavailability of the drug is the most important factor that controls the formulation of drug as well as the therapeutic efficacy of the drug, hence the most critical factor in the formulation development.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"47 1","pages":"01-10"},"PeriodicalIF":0.0,"publicationDate":"2013-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90947847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ESTIMATION OF CEFEPIME HYDROCHLORIDE IN INJECTABLE DOSAGE FORM BY DIFFERENCE SPECTROPHOTOMETRY 差示分光光度法测定注射剂型盐酸头孢吡肟的含量

Journal of Global Pharma Technology Pub Date : 2013-05-07 DOI: 10.1234/JGPT.V5I6.545

C. A. Patel

{"title":"ESTIMATION OF CEFEPIME HYDROCHLORIDE IN INJECTABLE DOSAGE FORM BY DIFFERENCE SPECTROPHOTOMETRY","authors":"C. A. Patel","doi":"10.1234/JGPT.V5I6.545","DOIUrl":"https://doi.org/10.1234/JGPT.V5I6.545","url":null,"abstract":"Cefepime is used as beta- lactam antibiotic. In present study, a simple, rapid, accurate, and economical differencespectrophotometric \u0000method has been developed for the estimation of cefepime hydrochloride from pharmaceutical formulation. \u0000The developed method was statistically validated in accordance with ICH guideline on the basis of various parameters like \u0000linearity, accuracy, precision, sensitivity,and repeatability . The drug follows linearity in the concentration range 30-80 ?g/ml with \u0000a correlation coefficient value of 0.997 at ?max of 268.80 nm. The accuracy of the method was checked by recovery experiment \u0000performed at three different levels. The % recovery was found to be in the range of 99.30 to 100.25 %.The precision of the method \u0000was studied as an intraday; interday variations, and repeatability. The % RSD value < 2 indicates that the method is precise, \u0000reproducible and accurate. The proposed method was then successfully applied to pharmaceutical formulation. Amount of drug \u0000estimated was found between 99.7%, which was in good agreement with the label claim. Excipients used in injection did not \u0000interfere in the estimation of cefepime by developed method. The proposed method can be successfully employed in the routine \u0000analysis of drug in pharmaceutical dosage forms.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"104 1","pages":"11-14"},"PeriodicalIF":0.0,"publicationDate":"2013-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76053819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

SCREENING OF SELECTED TERRESTRIAL PLANTS FOR THEIR EFFECTS ON SEED GERMINATION OF THREE AGRICULTURAL CROPS 陆生植物对三种农作物种子萌发影响的筛选

Journal of Global Pharma Technology Pub Date : 2013-02-07 DOI: 10.1234/JGPT.V5I5.541

P. Dhanya

引用次数: 0

FORMULATION AND CHARACTERIZATION OF CROSS LINK CHITOSAN MICROSPHERE: APPLICATION AS A MUCOADHESIVE DRUG DELIVERY OF NIFEDIPINE 交联壳聚糖微球的制备及表征:作为硝苯地平黏附给药的应用

Journal of Global Pharma Technology Pub Date : 2012-11-12 DOI: 10.1234/JGPT.V4I11.415

N. Pandya, R. R. Jivani, N. P. Jivani

{"title":"FORMULATION AND CHARACTERIZATION OF CROSS LINK CHITOSAN MICROSPHERE: APPLICATION AS A MUCOADHESIVE DRUG DELIVERY OF NIFEDIPINE","authors":"N. Pandya, R. R. Jivani, N. P. Jivani","doi":"10.1234/JGPT.V4I11.415","DOIUrl":"https://doi.org/10.1234/JGPT.V4I11.415","url":null,"abstract":"The purpose of this research was to formulate and systematically evaluate in vitro performance of mucoadhesive microspheres of nifedipine. Cross-linking Nifedipine microspheres containing chitosan were prepared by simple emulsification phase separation technique using glutaraldehyde as a cross-linking agent. A simple lattice design was employed to study the effect of independent variables, volume of cross-linking agent (X1), cross-linking time (X2) and total stirring time (X3) on dependent variables percentage mucoadhesion, drug entrapment efficiency and release of nifedipine. Results of preliminary trials indicate that volume of cross-linking agent, time for cross-linking and total stirring time affected characteristics of microspheres. Microspheres were discrete, spherical, and free flowing. The microspheres exhibited good mucoadhesive property in the in vitro wash-off test and also showed high percentage drug entrapment efficiency. From the statistical evaluation, best batch found showed 60.47 % mucoadhesion after 1 hour, 60 % drug entrapment efficacy and desired drug release profile upto 12 hours by taking 3.2 ml of cross-linking agent, 3 hours of crosslinking time and 3.8 hours of total stirring time. This statistically optimized batch was repeated to validate the results.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"152 1","pages":"01-07"},"PeriodicalIF":0.0,"publicationDate":"2012-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79873456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies on antimicrobial and anthelmintic potential of Wheatgrass 小麦草抗菌和驱虫潜力的研究

Journal of Global Pharma Technology Pub Date : 2012-11-12 DOI: 10.1234/JGPT.V4I11.491

P. Dubey, R. Netam, Neetu Bais, Verma, S. Dubey, A. Kakkar

引用次数: 1

ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF THESPESIA POPULNEA 白杨叶甲醇提取物的抗炎镇痛作用

Journal of Global Pharma Technology Pub Date : 2012-10-21 DOI: 10.1234/JGPT.V4I8.401

Mukesh R Radadiya, Vibhisha Patel, Nikunj Patel, Chetan Ahir, P. Gajera, Alpesh Virani

{"title":"ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF THESPESIA POPULNEA","authors":"Mukesh R Radadiya, Vibhisha Patel, Nikunj Patel, Chetan Ahir, P. Gajera, Alpesh Virani","doi":"10.1234/JGPT.V4I8.401","DOIUrl":"https://doi.org/10.1234/JGPT.V4I8.401","url":null,"abstract":"The methanolic extract of Thespesia populnea leaves (METP) was investigated for anti-inflammatory and analgesic activity. For evaluation of inflammation carrageenan induced paw edema served as acute model and formaldehyde-induced arthritis served as a chronic model in rats. The acetic acid-induced writhing response, reaction time in hot plate test and formalin-induced paw licking time in the early and late phases of mice were used to assess analgesic activity. METP (200 and 400 mg/kg, p.o.) were significantly (p<0.01) inhibiting carrageenan induced paw edema as well as formaldehyde-induced arthritis dose dependently. In addition, METP (200 and 400 mg/kg, p.o.) significantly (p<0.01) attenuated the writhing responses induced by an intraperitoneal injection of acetic acid and late phase of pain response induced by an subplantar injection of formalin in mice. METP (200 and 400 mg/kg, p.o.) significantly (p<0.01) also increased reaction time in hot plate test. The results of the experimental study support the traditional use of Thespesia populnea leaves for inflammatory and pain disorders.","PeriodicalId":15889,"journal":{"name":"Journal of Global Pharma Technology","volume":"86 1","pages":"11-17"},"PeriodicalIF":0.0,"publicationDate":"2012-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72766176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STUDIES ON GC/MS SPECTROSCOPIC ANALYSIS OF SOME DIFFERENT IN VIVO PLANT EXTRACTS OF (KARANJ) PONGAMIA PINNATA (L.): PIERRE 几种不同芍药提取物的gc / ms谱分析研究[j]:皮埃尔

Journal of Global Pharma Technology Pub Date : 2012-10-21 DOI: 10.1234/JGPT.V4I8.502

Savita Sagwan

引用次数: 5