A REVIEW ARTICLE ON: SUPERDISINTEGRANTS

Abstract

Disintegration has play a major role in improving the drug activity and hence increases the patient compatibility. The therapeutic activity of the formulations is obtained by disteintegration followed by dissolution. The inclusion of right disintegrants is a prerequisite to get optimal bioavailability in tablets and capsules. Disintegrants are the substances that causes the rapid disintegration of the capsules or tablets into smaller particles that dissolves more rapidly than in the absence of the disintegrants. On the other hand superdisintegrants ,as it name suggests superior to disintegrants are the substances which facilitates or increases the disintegration time even at low level ,typically 1-10% by weight relative to the total weight of the dosage unit. This article comprises of study of superdisintegrants which are being used in the formulation to provide safe and effective drug delivery with improved patient compliance.