Journal of forensic sciences最新文献

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Use of statement validity analysis in minors alleging sexual assault: A systematic review 在未成年人性侵犯指控中使用陈述有效性分析:系统回顾。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2024-08-23 DOI: 10.1111/1556-4029.15604
Emilie Wouters MSc, Lauriane Constanty MSc, Sébastien Urben PhD, Joëlle Rosselet Amoussou Master IS, Jacques Gasser PhD
{"title":"Use of statement validity analysis in minors alleging sexual assault: A systematic review","authors":"Emilie Wouters MSc,&nbsp;Lauriane Constanty MSc,&nbsp;Sébastien Urben PhD,&nbsp;Joëlle Rosselet Amoussou Master IS,&nbsp;Jacques Gasser PhD","doi":"10.1111/1556-4029.15604","DOIUrl":"10.1111/1556-4029.15604","url":null,"abstract":"<p>This systematic review aims to report on the use of Statement Validity Analysis (SVA) with minors involved in criminal justice proceedings. We conducted a literature search of six bibliographic databases up to March 2024. Additional searches were performed using citation tracing strategies. Nineteen studies published between 1991 and 2023 were retained. Most were published between 1991 and 2000, mainly in the USA. A scientific gap was observed for 10 years before studies resumed between 2011 and 2022. These 19 studies involved 2931 children; most were girls (<i>n</i> = 2080; 71%). The mean age was 9.4 years (SD = 2.40; min = 2; max = 17.5). Most studies did not mention the nature of the relationship between the child and the alleged perpetrator of sexual violence, three studies involved intra-family violence and six studies involved victims of intra- and extra-family violence. Nearly 75% of the interviewers were trained with SVA methods. Most were mental health professionals (52.6%) or police officers (15.8%). No study used the SVA as a whole, 10 studies used 19 criteria of the Criteria-Based Content Analysis (CBCA), and no study used the Validity Check List (VCL). Most studies performed SVA on interview transcripts (<i>n</i> = 8), and two studies performed their analysis on both verbatims and video. The conclusion of our literature review highlights the methodological weaknesses of these studies and encourages more research about the use of SVA in the judicial field to reduce the risk of misleading the judiciary.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"69 6","pages":"1948-1958"},"PeriodicalIF":1.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1556-4029.15604","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined interpretation of objective firearm evidence comparison algorithms using Bayesian networks 利用贝叶斯网络综合解释客观火器证据比较算法。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2024-08-22 DOI: 10.1111/1556-4029.15606
Jamie S. Spaulding PhD, Lauren S. LaCasse BA
{"title":"Combined interpretation of objective firearm evidence comparison algorithms using Bayesian networks","authors":"Jamie S. Spaulding PhD,&nbsp;Lauren S. LaCasse BA","doi":"10.1111/1556-4029.15606","DOIUrl":"10.1111/1556-4029.15606","url":null,"abstract":"<p>Traditionally, firearm and toolmark examiners manually evaluate the similarity of features on two bullets using comparison microscopy. Advances in microscopy have made it possible to collect 3D topographic data, and several automated comparison algorithms have been introduced for the comparison of bullet striae using these data. In this study, open-source approaches for cross-correlation, congruent matching profile segments, consecutive matching striations, and a random forest model were evaluated. A statistical characterization of these automated approaches was performed using four datasets of consecutively manufactured firearms to provide a challenging comparison scenario. Each automated approach was applied to all samples in a pairwise fashion, and classification performance was compared. Based on these findings, a Bayesian network was empirically learned and constructed to leverage the strengths of each individual approach, model the relationship between the automated results, and combine them into a posterior probability for the given comparison. The network was evaluated similarly to the automated approaches, and the results were compared. The developed Bayesian network classified 99.6% of the samples correctly, and the resultant probability distributions were significantly separated more so than the automated approaches when used in isolation.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"69 6","pages":"2028-2040"},"PeriodicalIF":1.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of the Agilent 2100 Bioanalyzer instrument as quality control for next-generation sequencing 将安捷伦 2100 生物分析仪应用于下一代测序的质量控制。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2024-08-21 DOI: 10.1111/1556-4029.15601
Alina Senst PhD, Hannah Bonsiepe MSc, Sarah Kron, Iris Schulz PhD
{"title":"Application of the Agilent 2100 Bioanalyzer instrument as quality control for next-generation sequencing","authors":"Alina Senst PhD,&nbsp;Hannah Bonsiepe MSc,&nbsp;Sarah Kron,&nbsp;Iris Schulz PhD","doi":"10.1111/1556-4029.15601","DOIUrl":"10.1111/1556-4029.15601","url":null,"abstract":"<p>Next-generation sequencing (NGS) technologies have expanded the spectrum of forensic DNA analysis by facilitating efficient and precise genotyping of a large number of genetic markers. Yet, challenges persist regarding complex sample processing and assurance of equal molar concentrations across pooled samples. Since optimal cluster density is crucial for sequencing performance, the determination of both quantity and quality is indispensable for library preparation. In this study, we investigated the application of the Agilent 2100 Bioanalyzer for library quality control, as studies for forensic approaches, particularly for highly degraded postmortem samples, are rare. Our analysis encompassed assessing total DNA concentrations, fluorescence unit (FU) values, and adapter dimer concentrations in purified DNA libraries derived from buccal swabs and tissue samples of decomposed corpses. The sensitivity study tested a serial dilution derived from buccal swabs and revealed a decrease in FU values and an increase in adapter dimers with declining DNA input concentrations. Deviations in total DNA concentrations and average peak heights between the Agilent 2100 Bioanalyzer runs indicated a lack of repeatability in data and presented challenges in accurate quantification, which was also observed in previous studies. Yet, the analysis of degraded samples from decomposed human remains has shown the ability to detect adapter dimer concentrations, which can be crucial for the quality of subsequent NGS library preparation and sequencing success. Therefore, the Agilent 2100 Bioanalyzer proves to be a valuable tool for NGS quality control.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"69 6","pages":"2192-2196"},"PeriodicalIF":1.5,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1556-4029.15601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary on: Downing NR, Scafide KN, Ali Z, Hayat MJ. Visibility of inflicted bruises by alternate light: Results of a randomized controlled trial. J Forensic Sci. 2024;69(3):880–7. https://doi.org/10.1111/1556-4029.15481 评论: Downing NR, Scafide KN, Ali Z, Hayat MJ:Downing NR、Scafide KN、Ali Z、Hayat MJ。交替光照下瘀伤的可见度:随机对照试验的结果。J Forensic Sci. 2024;69(3):880-7. https://doi.org/10.1111/1556-4029.15481.
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2024-08-16 DOI: 10.1111/1556-4029.15599
William Hauda II MD, Sue Rotolo PhD, RN, Ralph Riviello MD, W. Anthony Gerard MD
{"title":"Commentary on: Downing NR, Scafide KN, Ali Z, Hayat MJ. Visibility of inflicted bruises by alternate light: Results of a randomized controlled trial. J Forensic Sci. 2024;69(3):880–7. https://doi.org/10.1111/1556-4029.15481","authors":"William Hauda II MD,&nbsp;Sue Rotolo PhD, RN,&nbsp;Ralph Riviello MD,&nbsp;W. Anthony Gerard MD","doi":"10.1111/1556-4029.15599","DOIUrl":"10.1111/1556-4029.15599","url":null,"abstract":"&lt;p&gt;We read with interest the article by Downing NR, et al. regarding the use of alternate light to view bruises [&lt;span&gt;1&lt;/span&gt;]. We agree with the authors that the identification of injuries in patients who have experienced physical violence is important. As colleagues who are forensic medicine experts, we recognize the importance of visualizing bruises in cases of interpersonal violence, especially in individuals with darkly pigmented skin, so we applaud your research on this issue. Practitioners need to be as accurate as possible in their evaluation. The use of tools to assist in the identification of injuries can be very helpful. We also recognize that forensic sciences and the associated analysis or evaluation must remain accurate and valid and not utilize “presumptive tests without confirmation” or tests lacking “reliability, reproducibility, repeatability, and replicability” [&lt;span&gt;2, 3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;When reading this article, we were struck by the remarkable similarity in methods with previous publications by these authors on this topic [&lt;span&gt;4, 5&lt;/span&gt;]. All three studies have the same number of 157 participants. This study and the study published in 2020 describe the same methodology of “quota sampling” to “recruit equal numbers of healthy participants.” The study published in 2022, however, stated that “a convenience sample of 157 subjects” was obtained. If these studies are of the same participants, then the statement in the 2022 publication about how the participants were recruited appears to be incorrect and potentially misleading. We are concerned that multiple studies analyzing the same data set create an improper opportunity for bias and post hoc analysis error.&lt;/p&gt;&lt;p&gt;The authors found in a previous analysis of the participants that both the 415 nm ALS with a yellow filter and the 450 nm ALS with a yellow filter to be “optimal for detecting evidence of bruising on individuals with known trauma” [&lt;span&gt;5&lt;/span&gt;]. This was also apparent from table 5 of their 2020 study with the same data [&lt;span&gt;4&lt;/span&gt;]. With this current publication, the authors state “only 415nm viewed through a yellow filter resulted in a clinically meaningful improvement (0.46 points) in visibility rating when compared to white light.” [&lt;span&gt;1&lt;/span&gt;] In figure 1, of this study, we find it difficult to visually discern any difference between the various light frequencies used in very light skin or very dark skin. Additionally, we noted that all modalities of light had reduced visualization of bruises; no modality was clearly better in most or all skin color categories.&lt;/p&gt;&lt;p&gt;Reviewing table 2 in this recent paper shows that the 450 nm ALS with the yellow filter did not have as high a visibility rating improvement, but it was the only other assessment with a visibility rating improvement above 0.2. How should the reader discern what a clinically meaningful improvement in the visibility score would be?&lt;/p&gt;&lt;p&gt;Based upon the methods described by the authors, t","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"69 6","pages":"2339-2341"},"PeriodicalIF":1.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1556-4029.15599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authors' response 作者回复。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2024-08-16 DOI: 10.1111/1556-4029.15600
Nancy R. Downing PhD, RN, Katherine N. Scafide PhD, RN, Zahra Ali MPH, Matthew J. Hayat PhD
{"title":"Authors' response","authors":"Nancy R. Downing PhD, RN,&nbsp;Katherine N. Scafide PhD, RN,&nbsp;Zahra Ali MPH,&nbsp;Matthew J. Hayat PhD","doi":"10.1111/1556-4029.15600","DOIUrl":"10.1111/1556-4029.15600","url":null,"abstract":"","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"69 6","pages":"2342-2343"},"PeriodicalIF":1.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: The false promise of firearms examination validation studies: Lay controls, simplistic comparisons, and the failure to soundly measure misidentification rates 更正:枪支检查验证研究的虚假承诺:外行控制、简单化比较以及未能正确衡量错误识别率。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2024-08-16 DOI: 10.1111/1556-4029.15602
{"title":"Correction to: The false promise of firearms examination validation studies: Lay controls, simplistic comparisons, and the failure to soundly measure misidentification rates","authors":"","doi":"10.1111/1556-4029.15602","DOIUrl":"10.1111/1556-4029.15602","url":null,"abstract":"<p>Gutierrez RE, Prokesch EJ. The false promise of firearms examination validation studies: Lay controls, simplistic comparisons, and the failure to soundly measure misidentification rates. <i>J Forensic Sci</i>. 2024;69(4):1334–49. https://doi.org/10.1111/1556-4029.15531</p><p>The list of affiliations listed for RE Gutierrez has been modified; in that, the Academy Standards Board, Firearms and Toolmarks Consensus Body, has been removed. This comunication also corrects two inadvertent typographical errors from the publication. First, Reference 53 included a misspelling of Dr. Ryan Lilien’s name (“Lillien” as opposed to the correct “Lilien”). Second, Table 2 provided an incorrect value for the inconclusive rate on different source comparisons for the “Duez examiners” group (15% as opposed to the correct 13%). That typographical error did not, however, carry over into other figures and calculations (e.g. confidence intervals) provided throughout the remainder of the piece.</p><p>We apologize for these errors.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"69 5","pages":"1937"},"PeriodicalIF":1.5,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1556-4029.15602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction to the JFS Special Section on Disaster Victim Identification (DVI) JFS 灾民身份识别(DVI)特别小组简介。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2024-08-14 DOI: 10.1111/1556-4029.15603
Michael A. Peat PhD, Suni M. Edson PhD, Mechthild Prinz PhD
{"title":"Introduction to the JFS Special Section on Disaster Victim Identification (DVI)","authors":"Michael A. Peat PhD,&nbsp;Suni M. Edson PhD,&nbsp;Mechthild Prinz PhD","doi":"10.1111/1556-4029.15603","DOIUrl":"10.1111/1556-4029.15603","url":null,"abstract":"","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"69 5","pages":"1529-1530"},"PeriodicalIF":1.5,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXPRESSION OF CONCERN: Forensic Investigation of a Shawl Linked to the “Jack the Ripper” Murders 表达关切:对与 "开膛手杰克 "谋杀案有关的披肩的法医调查。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2024-08-12 DOI: 10.1111/1556-4029.15595
{"title":"EXPRESSION OF CONCERN: Forensic Investigation of a Shawl Linked to the “Jack the Ripper” Murders","authors":"","doi":"10.1111/1556-4029.15595","DOIUrl":"10.1111/1556-4029.15595","url":null,"abstract":"<p>EXPRESSION OF CONCERN: J. Louhelainen, and D. Miller, “Forensic Investigation of a Shawl Linked to the “Jack the Ripper” Murders.” Journal of Forensic Sciences 65 no. 1 (2020): 295–303, https://doi.org/10.1111/1556-4029.14038.</p><p>This Expression of Concern is for the above article, published online on 12 March 2019 in Wiley Online Library (wileyonlinelibrary.com), and has been published by agreement between the journal Editor-in-Chief, Michael Peat; and the Publisher, Wiley Periodicals LLC, on behalf of the American Academy of Forensic Sciences. Following an investigation by the publisher, the Expression of Concern has been agreed due to concerns raised by third parties after publication regarding the conclusions drawn from the mtDNA analysis performed by the authors. Related concerns were also summarized in two Letters to the Editor [<span>1, 2</span>] published by the journal, to which the authors responded with their own Letters to the Editor [<span>3, 4</span>]. During the investigation, the publisher and Editor-in-Chief made every effort to obtain from the authors the original raw data from the mtDNA analysis. However, the authors stated that the data were no longer available, due to instrument data failure and other complications. Through further investigation it was concluded that, because it was not possible to examine the original data, no determination could be made regarding the third-party complaints. The journal is issuing this Expression of Concern because the concerns regarding the data and the results presented cannot be resolved. The authors have been informed about this Expression of Concern and agree to its publication.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"69 5","pages":"1938"},"PeriodicalIF":1.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1556-4029.15595","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The quantitative and qualitative analysis of dye in fentanyl tablets via ultraviolet-visible spectroscopy—A forensic approach 通过紫外可见光谱定量和定性分析芬太尼片剂中的染料--一种法医学方法。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2024-08-12 DOI: 10.1111/1556-4029.15598
Charley K. Mitchell BS, Jonathan C. Dumke PhD, Charlotte A. Corbett PhD, Laura M. Jones BS, Kristin E. Ceniccola-Campos PhD
{"title":"The quantitative and qualitative analysis of dye in fentanyl tablets via ultraviolet-visible spectroscopy—A forensic approach","authors":"Charley K. Mitchell BS,&nbsp;Jonathan C. Dumke PhD,&nbsp;Charlotte A. Corbett PhD,&nbsp;Laura M. Jones BS,&nbsp;Kristin E. Ceniccola-Campos PhD","doi":"10.1111/1556-4029.15598","DOIUrl":"10.1111/1556-4029.15598","url":null,"abstract":"<p>In the United States, illicit fentanyl is often trafficked as blue tablets mimicking the legitimate M-30 oxycodone tablet produced by Mallinckrodt. The analysis of dyes extracted from seized fentanyl tablets could provide a useful tool for law enforcement to establish linkages between cases and could prove useful for attributing a seizure to a given trafficking organization. Fentanyl tablet seizures associated with a particular drug trafficking organization (DTO), either through investigative or intelligence information, were used as the sample set for this study. The blue dye from the tablets was isolated by solid phase extraction and then qualitatively and quantitatively analyzed via ultraviolet-visible spectroscopy. This research revealed that the illicit tableting facilities use a different dye than several known pharmaceutical companies. The concentration of dye in individual tablets within a seizure proved to be very minimal, and the small sample size made it difficult to draw linkages from case to case. Analysis of the dyes could not effectively differentiate between the drug trafficking organizations in the tested population due to each DTO using the same dye; however, it is important to note that the dye found was consistent between illicit tablets.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"69 6","pages":"2222-2229"},"PeriodicalIF":1.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of fentanyl in the pediatric postmortem population from 2019 to 2023 2019年至2023年芬太尼在儿科尸检人群中的流行率。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2024-08-11 DOI: 10.1111/1556-4029.15596
Brianna L. Peterson PhD, Kari M. Midthun PhD
{"title":"Prevalence of fentanyl in the pediatric postmortem population from 2019 to 2023","authors":"Brianna L. Peterson PhD,&nbsp;Kari M. Midthun PhD","doi":"10.1111/1556-4029.15596","DOIUrl":"10.1111/1556-4029.15596","url":null,"abstract":"<p>For the past decade, illicitly manufactured fentanyl has been a primary contributor in drug overdose deaths regardless of age. The pediatric population is particularly vulnerable to fentanyl exposure, yet there are limited case reports involving this population. Postmortem cases from 2019 to 2023 were retrospectively analyzed to determine the prevalence of fentanyl in decedents between 0 and 12 years of age. Over this time frame, the fentanyl positivity rate increased from 2.6 to 6.2% (<i>n</i> = 632). The most commonly reported age group was 0–4 years, with a peak around 1 year of age for toddlers. Fentanyl concentrations in blood (<i>n</i> = 573) ranged from 0.19 to 360 ng/mL (mean 18 ng/mL, median 6.9 ng/mL). Polydrug use was present in 428 cases; midazolam (<i>n</i> = 96) and methamphetamine (<i>n</i> = 66) were the most common drugs found concurrently in blood with fentanyl, followed by markers of illicitly manufactured fentanyl, such as xylazine (<i>n</i> = 23), para-fluorofentanyl (<i>n</i> = 18), and acetyl fentanyl (<i>n</i> = 17). This report contrasts the differences in postmortem pediatric fentanyl toxicology results for three groups of case histories: likely medical intervention (<i>n</i> = 113), pregnancy/birth related (<i>n</i> = 136), and inadvertent/intentional exposure (<i>n</i> = 196). Overall, this study provides a retrospective review of postmortem pediatric fentanyl concentrations in a variety of biological matrices and highlights the need for comprehensive toxicology testing in postmortem pediatric casework.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"69 6","pages":"2308-2316"},"PeriodicalIF":1.5,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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