Journal of forensic sciences最新文献

筛选
英文 中文
AI as a decision support tool in forensic image analysis: A pilot study on integrating large language models into crime scene investigation workflows 人工智能作为法医图像分析中的决策支持工具:将大型语言模型集成到犯罪现场调查工作流程中的试点研究。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2025-04-04 DOI: 10.1111/1556-4029.70035
Shai Farber PhD
{"title":"AI as a decision support tool in forensic image analysis: A pilot study on integrating large language models into crime scene investigation workflows","authors":"Shai Farber PhD","doi":"10.1111/1556-4029.70035","DOIUrl":"10.1111/1556-4029.70035","url":null,"abstract":"<p>This study evaluates the effectiveness of artificial intelligence (AI) tools (ChatGPT-4, Claude, and Gemini) in forensic image analysis of crime scenes, marking a significant step toward developing bespoke AI models for forensic applications. The research involved independent analysis of 30 crime scene images by the AI tools, with the resulting reports rigorously assessed by 10 forensic experts. Findings reveal promising potential for AI as a decision support tool in forensic science, serving as a rapid initial screening mechanism to assist human experts in their comprehensive analysis. The results emphasize that current AI tools function optimally as assistive technologies, enhancing rather than replacing expert forensic analysis, particularly in scenarios involving multiple evidence points or high-volume caseloads. The AI tools demonstrated high accuracy in observations but faced challenges in evidence identification, with performance varying across different crime scene types—excelling in homicide scenarios (average score of 7.8) but encountering difficulties in arson scenes (average score of 7.1). This study's findings could significantly impact investigative procedures, forensic training, and the development of AI tools in law enforcement, while emphasizing the importance of establishing robust ethical guidelines for the integration of AI in criminal justice systems.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"70 3","pages":"932-943"},"PeriodicalIF":1.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1556-4029.70035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CMV2U-Net: A U-shaped network with edge-weighted features for detecting and localizing image splicing CMV2U-Net:带有边缘加权特征的 U 型网络,用于检测和定位图像拼接。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2025-04-03 DOI: 10.1111/1556-4029.70033
Arslan Akram PhD, Muhammad Arfan Jaffar PhD, Javed Rashid PhD, Salah Mahmoud Boulaaras PhD, Muhammad Faheem PhD
{"title":"CMV2U-Net: A U-shaped network with edge-weighted features for detecting and localizing image splicing","authors":"Arslan Akram PhD,&nbsp;Muhammad Arfan Jaffar PhD,&nbsp;Javed Rashid PhD,&nbsp;Salah Mahmoud Boulaaras PhD,&nbsp;Muhammad Faheem PhD","doi":"10.1111/1556-4029.70033","DOIUrl":"10.1111/1556-4029.70033","url":null,"abstract":"<p>The practice of cutting and pasting portions of one image into another, known as “image splicing,” is commonplace in the field of image manipulation. Image splicing detection using deep learning has been a hot research topic for the past few years. However, there are two problems with the way deep learning is currently implemented: first, it is not good enough for feature fusion, and second, it uses only simple models for feature extraction and encoding, which makes the models vulnerable to overfitting. To tackle these problems, this research proposes CMV2U-Net, an edge-weighted U-shaped network-based image splicing forgery localization approach. An initial step is the development of a feature extraction module that can process two streams of input images simultaneously, allowing for the simultaneous extraction of semantically connected and semantically agnostic features. One characteristic is that a hierarchical fusion approach has been devised to prevent data loss in shallow features that are either semantically related or semantically irrelevant. This approach implements a channel attention mechanism to monitor manipulation trajectories involving multiple levels. Extensive trials on numerous public datasets prove that CMV2U-Net provides high AUC and <i>F</i><sub>1</sub> in localizing tampered regions, outperforming state-of-the-art techniques. Noise, Gaussian blur, and JPEG compression are post-processing threats that CMV2U-Net has successfully resisted.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"70 3","pages":"1026-1043"},"PeriodicalIF":1.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of mounting a sound suppressor on distribution and total amount of inorganic gunshot residue on targets 安装消声器对靶上无机射击残余物分布和总量的影响。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2025-04-03 DOI: 10.1111/1556-4029.70025
Matteo Donghi PhD, Alessandro Girella PhD, Debora Pellegrino MSc, Federica Maraschi MSc, Antonella Profumo PhD, Chiara Milanese PhD, Daniele Merli PhD
{"title":"Effect of mounting a sound suppressor on distribution and total amount of inorganic gunshot residue on targets","authors":"Matteo Donghi PhD,&nbsp;Alessandro Girella PhD,&nbsp;Debora Pellegrino MSc,&nbsp;Federica Maraschi MSc,&nbsp;Antonella Profumo PhD,&nbsp;Chiara Milanese PhD,&nbsp;Daniele Merli PhD","doi":"10.1111/1556-4029.70025","DOIUrl":"10.1111/1556-4029.70025","url":null,"abstract":"<p>Sound suppressors critically modify barrel overall length and ballistic performances of hosting guns and are therefore expected to influence the patterns of the plumes of gunshot residues (GSR) reaching the targets. Despite the forensic interest, in recent years, a single paper was published on the variations induced by the use of a suppressor in the spatial distribution of visible soot clouds on close targets and in the number of a few selected classes of GSR particles detected by scanning electron microscopy. A different approach, based on x-ray fluorescence (XRF) and inductively coupled plasma-optical emission (ICP-OES) spectroscopies, that points to most of the metallic elements ejected from the barrel, is suggested here. The confirmed effect of a sound suppressor up to a distance of 20 cm is to gather the cone of particles reaching the target. Despite this pattern modification, the global concentrations of the ammunition-related elements of interest (Pb, Ba, Sb, Cu) on targets cannot be considered significant (i.e., with 95% confidence) reduced by the use of a suppressor, due to the high intra-specimen and inter-specimen ICP-OES data dispersions. Differently, the hypothesis of a role of homemade suppressors in enriching GSR populations in Fe is supported by our results. The presence of iron is indeed the only indication of the actual use of a suppressor, a piece of information that is useful for the correct interpretation of the lead patterns visualized on targets for muzzle-to-target determination.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"70 3","pages":"1165-1173"},"PeriodicalIF":1.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1556-4029.70025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Negative histopathology of Lichtenberg figures in lightning deaths supports physiologic phenomena as the cause 雷击死亡中利希滕贝格数字的阴性组织病理学支持生理现象作为原因。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2025-04-01 DOI: 10.1111/1556-4029.70036
Siva Sai Kumar Pulagura MD, Sathish Ayyappan MD, Vikas P. Meshram MD, Raghvendra Singh Shekhawat MD, Tanuj Kanchan MD
{"title":"Negative histopathology of Lichtenberg figures in lightning deaths supports physiologic phenomena as the cause","authors":"Siva Sai Kumar Pulagura MD,&nbsp;Sathish Ayyappan MD,&nbsp;Vikas P. Meshram MD,&nbsp;Raghvendra Singh Shekhawat MD,&nbsp;Tanuj Kanchan MD","doi":"10.1111/1556-4029.70036","DOIUrl":"10.1111/1556-4029.70036","url":null,"abstract":"<p>Lichtenberg figures are an uncommon consequence of lightning strikes, characterized by unique, branching patterns that resemble tree-like structures on the skin. There are several theories on the possible mechanism by which these Lichtenberg figures are produced on the body, supported mainly by the skin's conductivity and the path of the electrical discharge. There is not much literature on the potential histopathological findings of these burn marks. We are reporting a case of a teenage male found unresponsive in an open field during a rainy day. On autopsy examination, Lichtenberg figures were seen over the body with no significant internal findings apart from petechial hemorrhages in the heart. The histopathological examination of the Lichtenberg figures did not show any significant findings. The absence of histological findings in the Lichtenberg figures in our case supports the contention that these markings derive from physiologic changes and are not burns.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"70 3","pages":"1198-1201"},"PeriodicalIF":1.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research on adversarial identification methods for AI-generated image software Craiyon V3 人工智能生成图像软件 Craiyon V3 的对抗识别方法研究。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2025-03-29 DOI: 10.1111/1556-4029.70034
Weizheng Jin MSc, Hao Luo PhD, Yunqi Tang PhD
{"title":"Research on adversarial identification methods for AI-generated image software Craiyon V3","authors":"Weizheng Jin MSc,&nbsp;Hao Luo PhD,&nbsp;Yunqi Tang PhD","doi":"10.1111/1556-4029.70034","DOIUrl":"10.1111/1556-4029.70034","url":null,"abstract":"<p>With the rapid development of diffusion models, AI generation technology can now generate very realistic images. If such AI-generated images are used as evidence, they may threaten judicial fairness. Taking the adversarial identification of images generated by Craiyon V3 software as an example, this paper studies the adversarial identification methods for AI-generated image software. First, an AI-generated image set containing 18,000 images is constructed using Craiyon V3; then, an AI-generated image detection model based on deep learning is selected, and a score-based likelihood ratio method is introduced to evaluate the strength of evidence. Experimental results show that the proposed method achieves an accuracy of over 99% on multiple threshold classifiers including Swin-Transformer, ResNet-18, and so on, and the fitted likelihood ratio model also passes a series of validation criteria including Tippett plots. The research results of this paper are expected to be applied to judicial practice in the future, providing judges with a reliable and powerful decision-making basis, and laying a foundation for further exploration of AI-generated image identification methods.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"70 3","pages":"1044-1056"},"PeriodicalIF":1.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decision trees for estimating osteological sex from the skull using an expanded suite of morphological traits 利用一套扩展的形态学特征估计颅骨骨性别的决策树。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2025-03-28 DOI: 10.1111/1556-4029.70017
Morgan J. Ferrell, John J. Schultz, Donovan M. Adams PhD
{"title":"Decision trees for estimating osteological sex from the skull using an expanded suite of morphological traits","authors":"Morgan J. Ferrell,&nbsp;John J. Schultz,&nbsp;Donovan M. Adams PhD","doi":"10.1111/1556-4029.70017","DOIUrl":"10.1111/1556-4029.70017","url":null,"abstract":"<p>Osteological sex estimation utilizing morphological traits of the skull primarily focuses on a set of five traits. Developing new models with an expanded suite of traits has the potential to increase sex classification accuracies and improve the classification of partial and fragmentary remains. Thus, this study seeks to improve classification accuracies for osteological sex estimation from the skull by assessing an expanded suite of traits and generating multiple decision tree classification models. Twenty-one traits were evaluated for a sample of 403 adult males and females. Krippendorff's alpha was used to assess intraobserver error, and aligned rank transformation was used to examine the effects of sex, age, population, and secular change on the traits. Prior to generating the decision trees, the data were randomly split into 80% model training samples and 20% holdout validation testing samples to test the predictive accuracy of each tree. The trees were generated for traits from the skull, cranium, and mandible. Separate trees were also generated for African Americans and European Americans, as well as for the pooled population sample. Overall, the recommended decision trees for the skull and cranium achieved higher accuracies (91.0%–100%) than models generated for the mandible (75.8%–85.0%). Additionally, the recommended pooled population (81.3%–97.3%) decision trees achieved similar accuracies compared with the African American (75.8%–94.0%) and European American (85.0%–100%) trees. Further, the trees generated in this study achieved improved classification accuracies for the skull compared with the current five-trait method by incorporating an expanded suite of traits.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"70 3","pages":"835-853"},"PeriodicalIF":1.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human tissue oxygen and strontium isotope values in North America: A data compilation and assessment for forensic geolocation 北美人体组织氧和锶同位素值:用于法医地理定位的数据汇编和评估。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2025-03-26 DOI: 10.1111/1556-4029.70030
Kirsten A. Verostick PhD, Alejandro Serna PhD, Chris Stantis PhD, Gabriel J. Bowen PhD
{"title":"Human tissue oxygen and strontium isotope values in North America: A data compilation and assessment for forensic geolocation","authors":"Kirsten A. Verostick PhD,&nbsp;Alejandro Serna PhD,&nbsp;Chris Stantis PhD,&nbsp;Gabriel J. Bowen PhD","doi":"10.1111/1556-4029.70030","DOIUrl":"10.1111/1556-4029.70030","url":null,"abstract":"<p>The use of isotopic analysis for human mobility, geolocation, and forensic identification has become common over the past two decades, yet its effectiveness depends on the availability of well-documented reference data. Many reference data exist in the literature, but the suitability of these data for forensic applications has not been critically assessed. Here, we compile oxygen and strontium isotope data for North American human tissues (hair, nails, bone, and tooth enamel). We review the geographic distribution of these data, evaluate their relationship with the predicted geographic variation, and assess potential sources of bias that may limit the comparability of different datasets in the compilation. A substantial number of data are available for some of these substrates and isotope systems, but in most cases, their geographic distribution is patchy with many areas under sampled. Except for hair Sr isotopes, a robust relationship occurs between human tissue values and modeled local environmental values, suggesting theoretically expected relationships between human tissues and local sources of O and Sr are expressed. These relationships are noisy; we identify several methodological differences that produce systematic biases across the compiled data. Based on these findings, we suggest interpreting forensic isotope data using currently published reference data is problematic. We propose the adoption of consistent metadata reporting and standardized laboratory protocols to enhance the utility of data gathered in future research as these practices could lead to measurable improvements in the strength of forensic interpretations derived from human tissue isotope data.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"70 3","pages":"905-920"},"PeriodicalIF":1.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1556-4029.70030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The application of decision trees for estimating osteological sex from common measurements of the skull 决策树在估计颅骨性别中的应用。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2025-03-26 DOI: 10.1111/1556-4029.70031
Morgan J. Ferrell PhD, John J. Schultz PhD, Donovan M. Adams PhD
{"title":"The application of decision trees for estimating osteological sex from common measurements of the skull","authors":"Morgan J. Ferrell PhD,&nbsp;John J. Schultz PhD,&nbsp;Donovan M. Adams PhD","doi":"10.1111/1556-4029.70031","DOIUrl":"10.1111/1556-4029.70031","url":null,"abstract":"<p>Skull measurements are commonly evaluated for osteological sex estimation in forensic anthropology, and decision tree-based classification models for the skull may improve accuracy compared to current metric methods. Additionally, decision trees can provide accurate sex classification with a limited number of measurements, which is valuable when analyzing fragmentary remains. Thus, the present study seeks to test the utility of decision trees for generating sex classification models from metric variables of the skull. Twenty-one skull measurements were evaluated for 403 adult males and females. Relative technical error of measurement was used to assess intraobserver error, and two-way ANOVAs and aligned rank transformation were used to examine the effects of sex, population, age, and temporal period on the measurements. The data set was split into 80% training and 20% holdout testing samples to assess the predictive accuracy of each tree. Trees were generated for the skull and cranium, with models for European Americans, African Americans, and the pooled population sample. Overall, the recommended trees for the cranium achieved higher accuracies (85.3–95.0%) compared to the skull trees (84.0–92.5%). Accuracies for the population-inclusive trees ranged from 84.0% to 85.3%, whereas the European American (92.5–95.0%) and African American (90.9%) trees achieved slightly higher accuracies. Improved accuracies were achieved compared to previous decision tree research as well as compared to current metric methods for the skull. These trees provide an additional option for estimating osteological sex, particularly when morphological methods do not yield adequate classification accuracies or cannot be assessed due to damage.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"70 3","pages":"854-867"},"PeriodicalIF":1.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Massive intramuscular hemorrhage of the tongue caused by hanging 因上吊引起的舌头肌肉内大量出血。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2025-03-26 DOI: 10.1111/1556-4029.70029
Shojiro Takasu PhD, Sari Matsumoto PhD, Yuko Kanto PhD, Kyoko Iwadate MD
{"title":"Massive intramuscular hemorrhage of the tongue caused by hanging","authors":"Shojiro Takasu PhD,&nbsp;Sari Matsumoto PhD,&nbsp;Yuko Kanto PhD,&nbsp;Kyoko Iwadate MD","doi":"10.1111/1556-4029.70029","DOIUrl":"10.1111/1556-4029.70029","url":null,"abstract":"<p>Intramuscular hemorrhage of the tongue is frequently observed when the neck is compressed. Airway obstruction caused by massive hemorrhagic tongue edema has been reported. Herein, we report an autopsy case of massive intramuscular hemorrhage of the tongue caused by suicide via hanging. A 90-year-old woman was found dead in her living room in the right lateral position with a fabric band around her neck. Unenhanced computed tomography revealed massive intramuscular hemorrhage of the tongue. A ligature mark was observed around the neck. An autopsy revealed prominent swelling of the tongue caused by massive intramuscular hemorrhage. Bilateral ossification of the stylohyoid ligament was observed, and both lungs showed distension. We suspected that the woman fell after attempting suicide via hanging. In this case, the possibility that the lung distension was caused by the swollen tongue could not be ruled out. The direct pressure on the base of the tongue caused by the hyoid bone and the combination of pressure on the base of the tongue and jugular vein caused by ossification of the stylohyoid ligament likely caused the massive intramuscular hemorrhage of the tongue. This mechanism should be considered in survivors of hanging attempts.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"70 3","pages":"1193-1197"},"PeriodicalIF":1.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abuse of gabapentinoids in individuals with substance use disorders 药物使用障碍患者滥用加巴喷丁类药物的情况。
IF 1.5 4区 医学
Journal of forensic sciences Pub Date : 2025-03-26 DOI: 10.1111/1556-4029.70028
İnci Sağlam MD, Rukiye Aslan PhD, Serap Annette Akgür MD, PhD, Yusuf Kurtulmuş MD
{"title":"Abuse of gabapentinoids in individuals with substance use disorders","authors":"İnci Sağlam MD,&nbsp;Rukiye Aslan PhD,&nbsp;Serap Annette Akgür MD, PhD,&nbsp;Yusuf Kurtulmuş MD","doi":"10.1111/1556-4029.70028","DOIUrl":"10.1111/1556-4029.70028","url":null,"abstract":"<p>The abuse of gabapentinoids has increased rapidly, and death cases have been reported with increasing rates. This study examines the toxicological analysis data of substance abuse cases conducted after legal regulations were implemented in Türkiye. The focus will be on the medicolegal implications of gabapentinoid positivity in these cases. Urine samples collected between July 2021 and July 2022 from individuals (ages 18–45) presenting at Manisa Mental Health and Diseases Hospital with diagnosed or suspected substance use disorders were analyzed for the presence of pregabalin, gabapentin, and other accompanying substances. High-resolution liquid chromatography-mass spectrometry (Orbitrap) was employed for analysis. The analysis reports and sociodemographic data of 10,300 cases were retrieved from the patient record system and subjected to statistical analysis using SPSS 25.0. Gabapentinoid positivity was detected in 21.6% (<i>n</i> = 2224) of these cases (pregabalin (PGB) 18.9% (<i>n</i> = 1943) and gabapentin (GBP) 5.3% (<i>n</i> = 546)). Of the positive cases, 93.9% (<i>n</i> = 2089) were male, with an average age of 28 ± 6.7. Forensic cases (probation and judicial) represented the majority of admitted and positive cases 2.6% (<i>n</i> = 265) of cases tested positive for both pregabalin and gabapentin. While an overall increase in pregabalin and gabapentin positivity rates was observed over time, a statistically significant difference (<i>p</i> &lt; 0.05) was noted between years. Seven substances were detected with gabapentinoids. Methamphetamine was the most common accompanying substance, representing nearly half of the detected substances (46.8%, <i>n</i> = 1040), followed by THC-COOH (26.8%, <i>n</i> = 595). Despite legal regulations, the use of gabapentinoids is increasing rapidly. The study highlights the urgent need to include gabapentinoids in routine screening tests, enforce stricter prescribing guidelines, and actively prevent their illegal use.</p>","PeriodicalId":15743,"journal":{"name":"Journal of forensic sciences","volume":"70 3","pages":"1125-1132"},"PeriodicalIF":1.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1556-4029.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信