Journal of endourology最新文献

{"title":"<i>Letter:</i> The Role of Tumor Volume Ratio in Predicting Clinically Significant Prostate Cancer on Transperineal Biopsy.","authors":"Ibrahim Hacibey","doi":"10.1089/end.2025.0281","DOIUrl":"https://doi.org/10.1089/end.2025.0281","url":null,"abstract":"","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritoneal Window Technique: A Novel Sutureless Technique to Decrease the Rate of Symptomatic Lymphocele after Robot-Assisted Radical Prostatectomy with Extended Pelvic Lymph Node Dissection.","authors":"Eric Qualkenbush, Yeonsoo S Lee, Amanda Kahn, Neda Qosja, Alex Hochwald, Amanda Myers, Andrew Zganjar, Ram Pathak, Raymond Pak","doi":"10.1089/end.2025.0093","DOIUrl":"https://doi.org/10.1089/end.2025.0093","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Robot-assisted radical prostatectomy (RARP) with extended pelvic lymph node dissection (PLND) represents the gold standard surgical treatment for high-risk localized prostate cancer. PLND carries the risk of lymphocele formation, which can lead to complications such as deep vein thrombosis (DVT), infection, and voiding dysfunction. Many techniques have been described to minimize lymphocele formation, yet no method has seen widespread use or been described as sutureless. The objective of this study is to describe the novel, sutureless peritoneal window (PWIN) technique and assess its efficacy in lymphocele prophylaxis for extended PLND. <b><i>Methods:</i></b> This was a retrospective review of patients with high-risk prostate cancer undergoing RARP with extended PLND by a single surgeon from 2018 to 2024. PLND was carried out in the usual manner with bipolar cautery. PWIN technique is performed by excising a 3 × 5 cm PWIN over the lymphadenectomy bed to maintain lymphatic communication with the abdominal cavity. The primary outcome was a comparison between the incidence of symptomatic lymphoceles (SLs) with PWIN <i>vs</i> standard technique. SLs were defined as lymphoceles presenting with pain, DVT, voiding dysfunction, or infectious symptoms. Patients with asymptomatic lymphoceles were excluded. <b><i>Results:</i></b> Our study included 199 patients who underwent RARP with extended PLND. There were 46 patients (23.1%) in the standard approach group and 153 patients (76.9%) in the PWIN group. We identified 5/46 (10.9%) SLs in the standard technique, which were significantly higher than the 3/153 (2.0%) observed in the PWIN group (p = 0.017). There was no difference between the standard and PWIN cohorts regarding symptomology or treatment of their lymphocele. <b><i>Conclusion:</i></b> This study describes a novel, sutureless PWIN technique that significantly decreases SL after extended PLND. This technique offers a practical, time-efficient, and cost-effective alternative for lymphocele prevention. Future prospective studies are warranted to validate these findings.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary Outcomes of Minimally Invasive Treatments for Prostate Cancer-A Systematic Review by Young Academic Urologists' Urotechnology Working Group.","authors":"Mark Taratkin, Alexander Androsov, Andrey Morozov, Camilla Azilgareeva, Juan Gomez Rivas, Stefano Puliatti, Enrico Checcucci, Ines Rivero Belenchon, Karl-Friedrich Kowalewski, Severin Rodler, Pietro Piazza, Loïc Baekelandt, Alessandro Veccia, Pieter De Backer, Harun Fajkovic, Dmitry Enikeev, Giovanni E Cacciamani","doi":"10.1089/end.2024.0129","DOIUrl":"https://doi.org/10.1089/end.2024.0129","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Minimally invasive treatments (MITs) have emerged as viable treatment options for carefully selected patients with localized disease. Their major advantage is that MITs enable the preservation of nearby healthy prostate tissue and critical structures such as the urethral sphincter and neurovascular bundles without compromising oncologic outcomes. The aim of the current review is to describe the impact of different MITs for prostate cancer (PCa) on urinary continence. <b><i>Materials and Methods:</i></b> A systematic literature search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Inclusion criteria were as follows: all clinical trials conducted and related to the urinary outcomes (UO) of PCa MITs. Exclusion criteria were as follows: any reviews, articles, conference abstracts, articles whose subject fell outside the scope of this review, or any articles published more than 5 years ago. <b><i>Results:</i></b> In the course of the last 5 years, a total of 114 articles on MITs of PCa have been published. Among them, only 36 dealt with the UO for MITs. Brachytherapy, cryoablation, and high-intensity focused ultrasound (HIFU) seem to be the most widely used technologies, whereas irreversible electroporation, focal brachytherapy, focal cryoablation, and multi-parametric magnetic resonance imaging-ultrasound-guided (mpMRI-US-guided) HIFU seem to be the safest techniques in terms of UO. <b><i>Conclusion:</i></b> The use of MITs for treating PCa is a fast-growing option that can help preserve functional parameters and urinary continence close to their normal levels. It should be noted that although there are currently limited data available on all MITs for the treatment of PCa, the ones that have been extensively studied have shown promising results.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Renal Function Recovery Following Treatment for Post-Robot-Assisted Partial Nephrectomy Renal Artery Pseudoaneurysm.","authors":"Amanda E Kahn, Laura E Geldmaker, Neda Qosja, Daniela A Haehn, Taylor F Fuqua, Vartika Tiwari, Alex Hochwald, Colleen S Thomas, David D Thiel","doi":"10.1089/end.2025.0046","DOIUrl":"https://doi.org/10.1089/end.2025.0046","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> To evaluate the impact of the treatment for renal artery pseudoaneurysm (RAP) on long-term renal function after robot-assisted partial nephrectomy (RAPN). <b><i>Materials:</i></b> We retrospectively reviewed 581 consecutive RAPNs performed by a single surgeon from February 2008 to February 2022. We evaluated patient variables, postoperative complications, and renal function at postoperative day one, 1 month, and 6 months after RAPN. Renal function was defined as estimated glomerular filtration rate (eGFR) based on the chronic kidney disease epidemiology collaboration Cr 2009 equation. We utilized the Fisher's exact test and Kruskal-Wallis rank sum test to analyze our data through categorical and continuous variables. <b><i>Results:</i></b> Twenty-one patients (3.61%) developed a symptomatic RAP after RAPN that was treated with Interventional Radiology embolization. Patients with a RAP had a median age of 61.8 years (IQR: 53.5-69.7), median preoperative eGFR of 83.9 (IQR: 69.5-85.2), median BMI of 29.4 (IQR: 25.4-33.1), and median mass size of 3 cm (IQR: 2.5-4.2). There was no statistical difference in baseline characteristics between patients with RAP and patients without RAP. Patients with RAP had a longer length of stay (LOS) (3.0 IQR: 2.0-4.0 <i>vs</i> 2.0 IQR: 2.0-3.0). Patients with a RAP had a larger change in absolute eGFR value based on the difference from baseline to 1 month and 6 months (1 month: 20.5 <i>vs</i> 11.2, <i>p</i> < 0.001; 6 months: 18.1 <i>vs</i> 10.4, <i>p</i> = 0.001). RAP patients were also less likely to be within 10% of pre-RAPN levels (1 month: 24% <i>vs</i> 49%, <i>p</i> = 0.021; 6 months: 18% <i>vs</i> 47%, <i>p</i> = 0.016). <b><i>Conclusions:</i></b> Patients treated for RAP post-RAPN had a decrease in renal function recovery at 1 month and 6-month intervals compared to patients not requiring post-RAPN RAP treatment.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an Alginate Gel Composite with Antibacterial Properties Capable of Binding Calcium-Based Residual Stone Fragments in Endoscopic Stone Surgery.","authors":"Won Hoon Song, Seung Soo Lee, Jong Kil Nam, Sung-Woo Park","doi":"10.1089/end.2024.0765","DOIUrl":"10.1089/end.2024.0765","url":null,"abstract":"<p><p><b><i>Background:</i></b> Complete removal of urinary stones remains a challenge, as residual fragments can contribute to recurrence and postoperative urinary tract infections. This study presents an initial laboratory investigation into the development of an alginate gel composite designed to bind calcium-based stone remnants and exhibit antibacterial properties. <b><i>Methods:</i></b> To evaluate gel formation, calcium oxalate powder reagent and sodium alginate (SA) powder reagent were mixed in a Becker glass and stirred on a hot plate. Stones from 17 patients who underwent stone surgery were crushed, and gel formation was confirmed using the same experimental conditions with SA powder reagent. A gel composite material containing silver nitrate and vancomycin was prepared, and antibacterial activity against <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> was tested over a 5-minute period. A mixture of 0.5 g alginic acid and 0.05 g calcium oxalate monohydrate powder reagent with 50 mL distilled water formed a gel after 30 minutes. <b><i>Results:</i></b> Sandy stones composed of calcium oxalate formed a better gel composite when mixed with SA than those composed of uric acid. In the antibacterial test of the alginate gel composite containing silver nitrate and vancomycin against <i>S. aureus</i> and <i>E. coli</i>, the number of live bacteria in the control and alginate gel composite was 3.5 × 10³ and <10, respectively. <b><i>Conclusion:</i></b> This study represents a preliminary laboratory investigation into the development of an alginate gel composite for potential use in urinary stone management. Further preclinical studies are necessary to evaluate its efficacy and safety before clinical translation.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"585-593"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hazem Elmansy, MD.","authors":"","doi":"10.1089/end.2025.98711.spot","DOIUrl":"10.1089/end.2025.98711.spot","url":null,"abstract":"","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"517"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Feasibility and Safety of the Glean Urodynamics System: The Modern Urodynamics System Efficacy Study.","authors":"Jason Kim, Keith Xavier, Tracy Cannon-Smith, Taylor Vaughan, Sreenivas Vemulapalli, Hanson Zhao, Arshia Aalami-Harandi, Nemi Shah","doi":"10.1089/end.2025.0270","DOIUrl":"10.1089/end.2025.0270","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Urodynamics is used to diagnose lower urinary tract dysfunction; however, conventional urodynamics results often poorly correlate to patient symptoms because of the nonphysiological nature of the test. The Glean^TM Urodynamics System is a novel, wireless, catheter-free ambulatory urodynamics system that allows clinicians to study lower urinary tract dysfunction in a more physiological manner. The objective of this study was to evaluate the feasibility, efficacy, and safety of the Glean Urodynamics System for use in clinic. <b><i>Materials and Methods:</i></b> This prospective, single-arm, multicenter interventional trial enrolled adults with lower urinary tract dysfunction. Participants underwent conventional urodynamics per standard of care followed by ambulatory urodynamics using the intravesical Glean bladder sensor. After the removal of the Glean sensor, participants completed comfort and preference questionnaires. Participants were followed up within 7-14 days to assess the incidence of adverse events. <b><i>Results:</i></b> Thirty-eight participants were enrolled. Glean sensor insertion was attempted in 33 participants and successful in 32 (97.0%). The median sensor insertion time was 33.62 seconds (range: 12.32-256). The Glean Urodynamics System recorded vesical pressure, and all 32 participants were able to void with the sensor indwelling. Median sensor removal time was 5.71 seconds (range: 0.79-22.15). There were 14 adverse events in 12 participants, of which 7 events (in 7 participants) were attributed to the Glean Urodynamics System. There were no serious adverse events. Overall participant feedback on the Glean Urodynamics System was positive, and clinicians reported it was easy to use. <b><i>Conclusions:</i></b> The Glean Urodynamics System is a feasible, efficacious, safe, and well-tolerated device that enables ambulatory urodynamics with physiological bladder filling and without catheters impeding lower urinary tract function.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"625-634"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Perioperative Glycated Hemoglobin (Hemoglobin A1C) and the Risk of Sepsis after Ureteroscopy with Laser Lithotripsy.","authors":"Richard Berman, Justin Lee, Adithya Balasubramanian, Ojas Shah","doi":"10.1089/end.2024.0710","DOIUrl":"10.1089/end.2024.0710","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Elevated glycated hemoglobin A1c (HbA1c) has not been specifically evaluated as a risk factor for urosepsis after kidney stone procedures. Moreover, there are no current guidelines for perioperative HbA1c optimization, nor recommendations for the optimal timing to treat non-urgent kidney stones in the setting of poor glycemic control. We evaluated the association between perioperative HbA1c levels and sepsis risk after ureteroscopy with lithotripsy. <b><i>Methods:</i></b> Patients undergoing ureteroscopy with lithotripsy from January 2020 to June 2023 at a tertiary center were retrospectively reviewed. Postoperative sepsis was defined as Systemic Inflammatory Response Syndrome scores ≥2 within 30 days after ureteroscopy. The risk of sepsis at various HbA1c thresholds was evaluated via multivariate logistic regression. <b><i>Results:</i></b> A total of 1454 patients underwent ureteroscopy with lithotripsy, and 319 patients had HbA1c collected within 90 days of their procedures. The mean preoperative Charlson Comorbidity Index (CCI) score was 3.22 (±2.77). An increased risk of sepsis was observed among patients with HbA1c levels between 8.0% and 9.9% (odds ratio [OR] 4.42, <i>p</i> = 0.025) and ≥10% (OR 8.17, <i>p</i> = 0.003). Positive preoperative urine culture despite treatment (OR 4.53, <i>p</i> < 0.001) and higher CCI (OR 1.17, <i>p</i> = 0.045) were also associated with increased odds of sepsis. <b><i>Conclusion:</i></b> The odds of sepsis after ureteroscopy with lithotripsy follow a dose-response relationship with elevated perioperative HbA1c. These data underscore the clinical utility of incorporating HbA1c into preprocedural optimization and may justify certain patients to delay elective ureteroscopy to improve glycemic control before endourologic intervention.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"549-555"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Most Accurate Technique and Formulation for Prostate Volume Estimation: A Comparative Analysis of Transrectal Ultrasonography, Magnetic Resonance Imaging, and Three-Dimensional Segmentation.","authors":"Sinharib Citgez, Kadir C Sahin, Göktuğ Kalender, Mehmet H Gultekin, Ugurcan Sayili, İpek Sertbudak, Iclal Gurses, Hamdi Ozkara","doi":"10.1089/end.2024.0839","DOIUrl":"10.1089/end.2024.0839","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Prostate volume estimation is of great importance for patient evaluation in a urologist's clinical practice. The accuracy and superiority of the techniques used in volume calculation have always been the subject of debate. Therefore, we conducted a comparative analysis between the volumes derived from transrectal ultrasonography (TRUS), multiparametric prostate magnetic resonance imaging (MpMRI), and three-dimensional (3D)-constructed MpMRI images of patients, who underwent retropubic radical prostatectomy at our institution. <b><i>Methods:</i></b> The data of patients with preoperative TRUS and MpMRI who underwent radical prostatectomy (Rp) in our clinic between August 2021 and February 2023 were retrospectively reviewed. The prostatectomy specimens were taken to the pathology department without exposure to any fixative and measured with the water displacement method. All axial T2-weighted sequences were segmented by a single surgeon using 3D Slicer (v. 5.6.2) software, and all measurements were compared with the specimen volume measured at the pathology laboratory. <b><i>Results:</i></b> A total of 150 patients were included in this study. The median prostate volumes estimated by TRUS-ellipsoid, TRUS-bullet, MpMRI, and 3D segmentation were 43.45 cc (min.-max.: 15.1-122.6), 54.32 cc (min.-max.: 18.9-153.3), 44.05 cc (min.-max.: 15.4-128.9), and 43.11 cc (min.-max.: 14.3-110.6), respectively. The median Rp specimen volume measurement in the pathology department was 42 cc (min.-max.: 12-114). When the measurement techniques were compared between each other, it has been shown that the statistically significant difference was caused by TRUS-bullet measurement. No statistically significant difference between the other three measurement techniques as well as between them and the specimen volume measurements were detected. <b><i>Conclusion:</i></b> Consistent with the findings of previous studies, MpMRI has provided estimations closer to pathology measurements and 3D segmentation allows even more precise measurements. However, considering accessibility, reproducibility, time efficiency, and cost, TRUS-based measurements can be safely used in clinical practice, especially using the ellipsoid formula.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"601-607"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustained-Release Rapamycin-Eluting Cobalt-Based Alloy Stent Ameliorates Ureteral Stricture in Mini-Pigs by Regulating TGF-β1/Smad3/mTOR/4EBP1/eIF4E Signaling Pathways.","authors":"Zhiwei Chen, Wei Zhao, Teng Zhang, Tengzhou Ren, Jie Chen, Lang Tian, Sheng Lu, Jie Wu, Yan Wang","doi":"10.1089/end.2024.0458","DOIUrl":"10.1089/end.2024.0458","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> To assess the feasibility and efficacy of sustained-release rapamycin-eluting metal stent in the repair of thermal injury-induced ureteral stricture in mini-pigs and explore its underlying mechanisms. <b><i>Materials and Methods:</i></b> A total of 18 female mini-pigs were used in this study. At 1 month after effective establishment of ureteral stricture model, they were randomly divided into normal control, model, bare-metal stent, and rapamycin-eluting stent groups. Before and at 4 weeks after stent placement, all animals underwent retrograde ureterography and single-photon emission computed tomography. Histologic examination was performed to assess the histomorphologic changes of the ureteral tissues. Real-time quantitative polymerase chain reaction and Western blot analysis were used to evaluate the expression levels of pro-fibrotic factors, transforming growth factor-beta1 (TGF-β1) and Smad3, as well as mammalian target of rapamycin (mTOR) downstream effectors, 4E binding protein 1 (4EBP1) and eukaryotic initiation factor 4E (eIF4E), in the ureteral stricture tissues. <b><i>Results:</i></b> Four weeks after stent placement, ureteral stricture was significantly ameliorated, and the glomerular filtration rate was significantly improved in the rapamycin-eluting stent group than the model and bare-metal stent groups (all <i>p</i> < 0.05). Pathologic examinations revealed obviously reduced fibroblasts and collagen fibers in the submucosa of the rapamycin-eluting stent group. The mRNA and protein expression levels of TGF-β1, Smad3, 4EBP1, and eIF4E were significantly decreased in the rapamycin-eluting stent group than the model and bare-metal stent groups (<i>p</i> < 0.05), whereas no significant difference was found between the model and bare-metal stent groups, indicating that rapamycin-eluting stent can inhibit fibroblast proliferation and attenuate fibrosis in the ureteral tissues. <b><i>Conclusion:</i></b> Sustained-release rapamycin-eluting stent can effectively ameliorate thermal injury-induced ureteral stricture in mini-pigs. The mechanism may be related to the role of rapamycin in inhibiting TGF-β1 and Smad3 expression, promoting the ureteral tissue remodeling through blocking mTOR, and suppressing 4EBP1 and eIF4E expression in the ureteral tissues. Sustained-release rapamycin-eluting stent deserves further investigation as a potentially effective means of treating iatrogenic ureteral strictures.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"570-584"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}