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Predictive Factors for Ureteral Stone Passage in Children. 儿童输尿管结石通过的预测因素。
IF 2.9 2区 医学
Journal of endourology Pub Date : 2025-07-01 Epub Date: 2025-06-02 DOI: 10.1089/end.2024.0536
William Robert DeFoor, Joonsue Lee, Campbell Grant, Michael Nasser, Christopher Anton, Andrew Trout, Eugene Minevich, Marion Schulte, Andrew Angel, Brian VanderBrink
{"title":"Predictive Factors for Ureteral Stone Passage in Children.","authors":"William Robert DeFoor, Joonsue Lee, Campbell Grant, Michael Nasser, Christopher Anton, Andrew Trout, Eugene Minevich, Marion Schulte, Andrew Angel, Brian VanderBrink","doi":"10.1089/end.2024.0536","DOIUrl":"10.1089/end.2024.0536","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To determine if transverse or longitudinal ureteral stone length is associated with the rate of spontaneous stone passage in a pediatric population. <b><i>Methods:</i></b> A retrospective cohort study was performed of children presenting with a ureteral calculus to a single institution from 2010 to 2020. Inclusion criteria included a symptomatic ureteral stone diagnosed by CT. Images were independently reviewed by two pediatric radiologists. An effective stone passage was defined if a patient did not require surgical intervention and follow-up imaging within 6 weeks confirmed the absence of the stone. Univariate and multivariate logistic regression analysis was performed. <b><i>Results:</i></b> A total of 66 subjects (34 female) with a mean age of 14.5 years were included. Fifty-one (77%) were treated with medical expulsive pharmacotherapy. A total of 31/66 (47%) patients passed the stone spontaneously, whereas 35 underwent surgical intervention within 6 weeks. Both longitudinal (odds ratio [OR] = 1.9, 95% confidence interval [CI]: 1.2-3.0) and transverse (OR = 2.6, 95% CI: 1.5-4.7) stone dimensions were associated with likelihood of spontaneous passage on univariable logistic regression. On multivariable regression, transverse stone diameter (OR = 2.5, 95% CI: 1.3-4.5) and history of nephrolithiasis (OR = 4.3, 95% CI: 1.1-17) were the only independent predictors of stone passage. Based on Receiver Operator Curve (ROC) analysis, a transverse diameter of 3.5 mm was optimal to predict stone passage (area under the curve = 0.82, sensitivity = 84%, specificity = 77%). <b><i>Conclusions:</i></b> A ureteral stone measuring less than 3.5 mm in transverse dimension is more likely to pass spontaneously in children. CT scans should report ureteral stone dimensions in the transverse plane.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"748-754"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ureteral Stone Impaction with Its Possible Effects on the Outcomes of Endoscopic Management in Children: A Critical Evaluation with an Emphasis on Ureteral Wall Thickness. 输尿管结石嵌塞及其对儿童内镜治疗结果的可能影响:一项重点关注输尿管壁厚度的关键评估。
IF 2.9 2区 医学
Journal of endourology Pub Date : 2025-07-01 Epub Date: 2025-05-30 DOI: 10.1089/end.2024.0862
Ali Sezer, Bilge Turedi, Emre Bulbul, Hikmet Yasar, Kemal Sarıca
{"title":"Ureteral Stone Impaction with Its Possible Effects on the Outcomes of Endoscopic Management in Children: A Critical Evaluation with an Emphasis on Ureteral Wall Thickness.","authors":"Ali Sezer, Bilge Turedi, Emre Bulbul, Hikmet Yasar, Kemal Sarıca","doi":"10.1089/end.2024.0862","DOIUrl":"10.1089/end.2024.0862","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Ureteral stone impaction can significantly affect the success of ureteroscopy (URS) in children. While the factors predicting impaction have been well studied in adults, data in children are limited. This study aimed to identify factors that predict ureteral stone impaction in children undergoing URS and to compare the success rates and complications based on the stone impaction status. <b><i>Patients and Methods:</i></b> Pediatric patients undergoing URS for ureteral stones were retrospectively reviewed. Impaction status of the stones was evaluated by radiological parameters and the children were divided into two groups based on the presence of stone impaction. Peri- and postoperative findings were comparatively evaluated in patients with or without stone impaction. <b><i>Results:</i></b> A total of 102 pediatric patients were included (40 with impacted stones, 62 with nonimpacted ureteral stones). The mean age was 9.3 ± 5.3 years. Univariate analysis showed significant differences between the groups in degree of hydronephrosis, presenting symptoms, stone density (HU), stone size, upper ureteral diameter, and that of ureteral wall thickness (UWT) (<i>p</i> = 0.004, <i>p</i> = 0.044, <i>p</i> = 0.033, <i>p</i> = 0.005, <i>p</i> = 0.012, <i>p</i> = 0.000, respectively). Multivariate analysis revealed UWT as the only independent predictor of stone impaction, with a cutoff value of 2.63 mm showing 83% sensitivity and 82% specificity (<i>p</i> = 0.000). The highest UWT value in the nonimpacted stone group was 3.1 mm. The mean operation time was found to be significantly longer in cases with impacted stones (<i>p</i> = 0.000). Kids with impacted stones had lower mean success rate (impacted = 70%, nonimpacted = 88.7%) and higher mean rate of complications, longer duration of DJ-stenting, more anesthesia sessions (<i>p</i> = 0.018, <i>p</i> = 0.019, <i>p</i> = 0.000 and <i>p</i> = 0.000, respectively). <b><i>Conclusions:</i></b> Similar to the adult cases, UWT could be used as a reliable parameter in predicting the impaction status of ureteral stones in pediatric patients. Impacted ureteral stones may reveal decreased success and higher complications rates during and after endoscopic stone surgery in these cases.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"652-658"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraoperative Cone Beam Computed Tomography Increases Single Procedure Stone-Free Rates in Percutaneous Nephrolithotomy: Results of a Randomized Controlled Trial. 术中锥形束计算机断层扫描增加经皮肾镜取石术单次手术的结石清除率:一项随机对照试验的结果。
IF 2.9 2区 医学
Journal of endourology Pub Date : 2025-07-01 Epub Date: 2025-05-12 DOI: 10.1089/end.2024.0785
Stijn Roemeling, Riemer A Kingma, Chris A Suijker, Emanuela Altobelli, Mieke T J Bus, Marcel J W Greuter, Shekar V K Mahesh, Igle J de Jong
{"title":"Intraoperative Cone Beam Computed Tomography Increases Single Procedure Stone-Free Rates in Percutaneous Nephrolithotomy: Results of a Randomized Controlled Trial.","authors":"Stijn Roemeling, Riemer A Kingma, Chris A Suijker, Emanuela Altobelli, Mieke T J Bus, Marcel J W Greuter, Shekar V K Mahesh, Igle J de Jong","doi":"10.1089/end.2024.0785","DOIUrl":"10.1089/end.2024.0785","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Achieving a stone-free status during percutaneous nephrolithotomy (PCNL) is crucial to prevent additional morbidity or stone growth. Cone beam computed tomography (CBCT) in a hybrid operating room provides intraoperative imaging of the urinary tract, improving stone-free status assessment and enabling additional stone extraction. This study aimed to determine whether intraoperative CBCT leads to increased stone-free rates (SFR) after PCNL. <b><i>Materials and Methods:</i></b> We conducted a two-arm randomized trial involving adult patients undergoing PCNL at a tertiary referral center for complex kidney stone treatment. Intraoperative randomization took place when the kidney was deemed endoscopically stone free. Patients were assigned to either undergo an intraoperative CBCT scan or be placed in a control group, in which the procedure was ended without a CBCT scan. All patients underwent a low-dose noncontrast abdominal CT scan 4 weeks postoperatively. The primary outcome measure was the stone-free status evaluated by this scan. <b><i>Results:</i></b> This trial was prematurely terminated because of reaching the predefined criteria for superiority upon interim analysis, with 160 randomizations up to this point. SFR was 15% higher in the CBCT group (76% <i>vs</i> 61%, <i>p</i> = 0.04) using a 4-mm cut-off. With a 2-mm cut-off, the SFR difference was 14% (58% <i>vs</i> 44%, <i>p</i> = 0.08). Using a 0-mm cut-off, the difference was 9% (50% <i>vs</i> 41%, <i>p</i> = 0.27). Residual fragments were identified in 56% of CBCT scans, with additional extraction in 49% of these cases. No significant difference in 30-day postoperative complications was observed. <b><i>Conclusion:</i></b> Intraoperative CBCT during PCNL significantly increases single procedure SFR. <b><i>Trial registration:</i></b> Netherlands Trial Register (NTR) NL8168, ABR NL70728.042.19. Prospectively registered on 15 October 2019.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"671-678"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MRI Can Replace Early Protocol Biopsy in Patients Undergoing Focal Cryoablation for Prostate Cancer. MRI可以替代前列腺癌局灶性冷冻消融患者的早期活检。
IF 2.9 2区 医学
Journal of endourology Pub Date : 2025-07-01 Epub Date: 2025-06-04 DOI: 10.1089/end.2024.0780
Piroz Bahar, Eugene Oh, Karan Desai, Matthew Jordan, Michael Ayenew, Matthew S Davenport, Jeffrey S Montgomery, Arvin K George
{"title":"MRI Can Replace Early Protocol Biopsy in Patients Undergoing Focal Cryoablation for Prostate Cancer.","authors":"Piroz Bahar, Eugene Oh, Karan Desai, Matthew Jordan, Michael Ayenew, Matthew S Davenport, Jeffrey S Montgomery, Arvin K George","doi":"10.1089/end.2024.0780","DOIUrl":"10.1089/end.2024.0780","url":null,"abstract":"<p><p><b><i>Introduction and Objectives:</i></b> Assessing oncological success following focal ablation for prostate cancer (PCa) includes prostate-specific antigen (PSA) response and imaging. However, the value of protocol biopsy remains uncertain. Consensus recommendations include follow-up multiparametric MRI (mpMRI) and biopsy despite variable imaging quality, interpretation, and biopsy performance. We aim to determine mpMRI performance characteristics postablation for early in-field (within the ablation zone) failure following focal cryoablation (FC). <b><i>Methods:</i></b> Patients receiving FC from January 1, 2017, to April 21, 2023, at Michigan Medicine were enrolled in a multi-institutional, institutional review board-approved prospective registry. Per protocol, PSA, mpMRI, and ultrasound-MR fusion biopsy of the ablation bed were obtained at 6 to 12 months postablation. Residual PCa was suspected on mpMRI if there was persistent enhancement and impeded diffusion near the ablation zone colocalizing to the intended ablation target. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of postablation mpMRI for Gleason Grade Group (GG) ≥2 PCa were calculated. Chi-squared test was used to perform bivariate analysis. <b><i>Results:</i></b> A total of 76 patients underwent primary ablation, postablation mpMRI, and protocol biopsy. Eight patients underwent repeat cryoablation with postsalvage cryoablation mpMRI and biopsy (<i>N</i> = 84 postablation events). Postablation mpMRI showed persistent PCa in 13.4% (11/84). Postablation biopsy showed GG ≥2 PCa in 7.1% (6/84) of target lesions. MpMRI sensitivity, specificity, PPV, and NPV for detecting untreated GG ≥2 PCa postablation were 83.3%, 92.3%, 45.5%, and 98.6%, respectively, with significant association between positive MRI and biopsy detection of GG ≥2 PCa (<i>p</i> < 0.0001). The positive and negative likelihood ratios for residual disease detection were 10.8 and 0.18. <b><i>Conclusion:</i></b> Postablation mpMRI has a high sensitivity, NPV, and specificity for detecting untreated GG ≥2 PCa. If negative, near-term \"protocol\" biopsy may be safely avoided. Investigation into causes of false positive and negative postablation mpMRI will help identify those who warrant per-protocol biopsy.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"725-730"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing Stone Composition in Irrigation Fluid Using Raman Spectroscopy: A Blinded Comparative Study. 用拉曼光谱评估灌溉液中的石头成分:一项盲法比较研究。
IF 2.9 2区 医学
Journal of endourology Pub Date : 2025-07-01 Epub Date: 2025-05-05 DOI: 10.1089/end.2025.0088
Orit Raz, Iddo Pinkas, Amir Cooper, Dor Golomb
{"title":"Assessing Stone Composition in Irrigation Fluid Using Raman Spectroscopy: A Blinded Comparative Study.","authors":"Orit Raz, Iddo Pinkas, Amir Cooper, Dor Golomb","doi":"10.1089/end.2025.0088","DOIUrl":"10.1089/end.2025.0088","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> To assess the capability of Raman spectroscopy (RS) in the analysis of stone composition utilizing microscopic fragments from irrigation fluid during ureteroscopy (URS) and laser lithotripsy. <b><i>Patients and Methods:</i></b> A prospective, blinded study involving patients undergoing URS with laser lithotripsy. Irrigation fluid collected during the procedure was centrifuged, and microscopic particles were analyzed using RS. Simultaneously, stone fragments underwent formal analysis by Fourier-transform infrared spectroscopy (FTIR) in a different laboratory. The researcher conducting the RS was blinded to the results of the FTIR analysis. The RS results were compared with FTIR to evaluate concordance. <b><i>Results:</i></b> Between March 2022 and February 2023, 22 patients were enrolled. Stones were located in the kidney (41%), ureter (45%), and both (14%). The median stone size was 12 mm. RS accurately identified the major stone component in 82.6% (19) of cases, with a 17.4% (3) discrepancy. Concordance was observed for stones composed of calcium oxalate (CaOx) monohydrate/dihydrate, calcium phosphate, and uric acid. In discordant cases, FTIR identified CaOx monohydrate and dihydrate. <b><i>Conclusions:</i></b> This study introduces an innovative approach for analyzing stone composition using microparticles from irrigation fluid during stone fragmentation. The results demonstrated strong concordance with the standard FTIR technique, suggesting potential for stone analysis without the need to retrieve fragments during procedures. Further research is warranted to refine this method for broader clinical application.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"691-697"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Present Insights and Future Perspectives in Pediatric Percutaneous Nephrolithotomy: A Systematic Review by the EAU-YAU Pediatric Urology Working Group. 儿科经皮肾镜取石术的现状和未来展望:au - yau儿科泌尿外科工作组的系统综述。
IF 2.9 2区 医学
Journal of endourology Pub Date : 2025-07-01 Epub Date: 2025-05-07 DOI: 10.1089/end.2024.0727
Yesica Quiroz Madarriaga, Muhammet İrfan Dönmez, Rianne J M Lammers, Beatriz Bañuelos Marco, Numan Baydilli, Edoardo Bindi, Simone Sforza, Lisette Aimée 't Hoen
{"title":"Present Insights and Future Perspectives in Pediatric Percutaneous Nephrolithotomy: A Systematic Review by the EAU-YAU Pediatric Urology Working Group.","authors":"Yesica Quiroz Madarriaga, Muhammet İrfan Dönmez, Rianne J M Lammers, Beatriz Bañuelos Marco, Numan Baydilli, Edoardo Bindi, Simone Sforza, Lisette Aimée 't Hoen","doi":"10.1089/end.2024.0727","DOIUrl":"10.1089/end.2024.0727","url":null,"abstract":"<p><p><b><i>Background and Objective:</i></b> The incidence of stone disease in children has risen worldwide, leading to the development of more treatment options. Percutaneous nephrolithotomy (PCNL) is often the preferred approach in many pediatric cases. This systematic review aims to assess the effectiveness and safety of PCNL in children, as well as to identify future directions for improving procedural outcomes. <b><i>Methods:</i></b> For this systematic review a comprehensive electronic search was conducted in PubMed and EMBASE in August 2023. The search included patients younger than 18 with renal stones requiring any modality of PCNL, as well as to establish the deficiencies in the reports of outcomes. The search strategy adhered to PRISMA guidelines, and quality assessments were performed using the Cochrane tool and MINORS tool. <b><i>Key Findings and Limitations:</i></b> Regardless of age, PCNL is safe and efficient in children, with stone-free rate above 85% and complication rate below 7%. However, neither the definition of stone free nor the way of reporting complications is homogeneous among studies. In addition, aspects such as diagnostic imaging, antibiotic prophylaxis, postoperative drainage, metabolic study, or follow-up are not systematically or uniformly reported in the studies. <b><i>Conclusions and Clinical Implications:</i></b> PCNL maintains its efficiency and safety even when the working tract caliber is reduced. However, the lack of standardization when describing pre-, peri-, and postoperative aspects creates a gap that does not allow grouping outcomes and highlights the lack of clear guidelines when implementing this surgical procedure.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"659-670"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Timing of Definitive Intervention for Patients with Acute Renal Colic: A Population-Based Study. 急性肾绞痛患者决定性干预时机的影响:一项基于人群的研究。
IF 2.9 2区 医学
Journal of endourology Pub Date : 2025-07-01 Epub Date: 2025-06-02 DOI: 10.1089/end.2024.0657
Michael Ordon, Sarah Bota, Yuguang Kang, Blayne Welk
{"title":"The Impact of Timing of Definitive Intervention for Patients with Acute Renal Colic: A Population-Based Study.","authors":"Michael Ordon, Sarah Bota, Yuguang Kang, Blayne Welk","doi":"10.1089/end.2024.0657","DOIUrl":"10.1089/end.2024.0657","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To determine the impact of early intervention (EI) <i>vs</i> delayed intervention/expectant management for patients presenting to the emergency department (ED) with renal colic. <b><i>Methods:</i></b> We conducted a population-based cohort study in Ontario, Canada, utilizing linked administrative health data. Patients presenting to an ED with renal colic between April 1, 2010, and June 30, 2020, were included. Patients were divided into two groups. The EI group underwent shockwave lithotripsy, ureteroscopy, or percutaneous nephrolithotomy within 2 weeks of presentation. The delayed intervention/expectant management (non-EI) group represented all other patients, including those who did not receive intervention. Patients were followed forward in time for 3 months in the EI group and for 4 weeks postintervention or 3 months (whichever was longer) in the non-EI group, to assess for our outcomes. The outcomes included additional ED visits, hospitalizations, or imaging studies, stent/nephrostomy insertion, and urologist/primary care visits. These outcomes were compared across the two groups using a propensity score-matched generalized linear model with generalized estimating equations. <b><i>Results:</i></b> There were 397,185 index renal colic events (after propensity score matching EI = 27,741, non-EI = 80,230). The EI group had a lower risk for additional ED visits (relative risk (RR): 0.70, 95% confidence interval (CI): 0.68-0.72, <i>p</i> < 0.001) and hospital admissions (RR: 0.52, 95% CI: 0.50-0.55, <i>p</i> < 0.001) compared with the non-EI group. Similarly, the EI group had a lower risk for stent (RR: 0.62, 95% CI: 0.54-0.71, <i>p</i> < 0.001) or nephrostomy insertion (RR: 0.49, 95% CI: 0.42-0.57, <i>p</i> < 0.001), however, there was no difference for additional imaging. The EI group had a slightly increased risk for urologist/primary care visit (RR: 1.02, 95% CI: 1.02-1.03, <i>p</i> < 0.001). In the non-EI group, 17.31% underwent eventual intervention. <b><i>Conclusion:</i></b> Our study demonstrated a benefit to EI for those presenting with renal colic to the ED, but potentially with the risk of exposing some patients to unneeded treatment. These findings could influence practice patterns and guideline recommendations.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"708-715"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing Fragmentation while Minimizing Thermal Injury Risk with the Thulium Fiber Laser in Ureteral Stone Lithotripsy: An In Vitro Study. 输尿管结石碎石中使用铥光纤激光优化碎裂同时降低热损伤风险:一项体外研究。
IF 2.9 2区 医学
Journal of endourology Pub Date : 2025-07-01 Epub Date: 2025-05-09 DOI: 10.1089/end.2024.0637
Arpit Mishra, Ezra J Margolin, Aaron W Stewart, Robert E Medairos, Jodi Antonelli, Glenn M Preminger, Pei Zhong, Michael E Lipkin
{"title":"Optimizing Fragmentation while Minimizing Thermal Injury Risk with the Thulium Fiber Laser in Ureteral Stone Lithotripsy: An In Vitro Study.","authors":"Arpit Mishra, Ezra J Margolin, Aaron W Stewart, Robert E Medairos, Jodi Antonelli, Glenn M Preminger, Pei Zhong, Michael E Lipkin","doi":"10.1089/end.2024.0637","DOIUrl":"10.1089/end.2024.0637","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To optimize thulium fiber laser (TFL) settings for effective stone fragmentation although minimizing thermal injury in confined ureteral spaces using a three-dimensional ureter model. <b><i>Materials and Methods:</i></b> A hydrogel-based ureter model was maintained at 37.2 ± 0.5°C, with a cylindrical BegoStone (10 × 10 mm, 1.00 ± 0.07 gm) occluding the ureter. Ureteroscopy was performed using a 150 µm TFL fiber for 3 minutes with room temperature irrigation and differing rates (0, 20, 40 mL/min) and power settings (6.4 to 20 W). Maximum sustained temperature (MST) and cumulative thermal dose (cumulative equivalent minutes at 43°C) were assessed against a 120-minute safety threshold. We also evaluated the effects of ureter volume and irrigation temperature. Stone mass treated was calculated by subtracting the mass of residual fragments >3 mm from the initial mass. <b><i>Results:</i></b> At 6.4 and 10 W, MSTs were below body temperature, and thermal doses were under 1 minute, indicating minimal thermal risk. At 20 W with 20 mL/min irrigation, MST exceeded 43°C within seconds, and thermal doses surpassed 120 minutes. Treatment efficiency was highest at 20 W (1.58 mg/s), followed by 10 W (1.15 mg/s) and 6.4 W (0.78 mg/s). Among 10 W settings, 1.0 J/10 Hz was more efficient than 2.0 J/5 Hz and 3.0 J/3 Hz. Safe settings produced 95.5% fine dust, whereas high-energy pulses 2-3 J produced significantly more fragments (1-3 mm) compared with settings with pulse energy 0.5-1.0 J. Increasing irrigation to 40 mL/min or using 15°C irrigation effectively reduced MST and improved efficiency, particularly at 20 W. <b><i>Conclusion:</i></b> Our study demonstrates the risk of thermal injury with 20 W TFL treatment. Conversely, 10 W settings at 2.0 J/5 Hz are safe and effective for fragmentation. Future research will focus on validating these optimal settings for human stone treatment.</p>","PeriodicalId":15723,"journal":{"name":"Journal of endourology","volume":" ","pages":"698-707"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Letter: Reply Letter to Dr. Kumar et al. on: Enhanced Artificial Intelligence in Bladder Cancer Management: A Comparative Analysis and Optimization Study of Multiple Large Language Models. 回复:回复Dr. Kumar等人关于:膀胱癌管理中的增强人工智能:多个大型语言模型的比较分析和优化研究。
IF 2.9 2区 医学
Journal of endourology Pub Date : 2025-06-24 DOI: 10.1089/end.2025.0426
Kun-Peng Li, Chen-Yang Wang, Li Yang
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引用次数: 0
Letter: "The Safety and Feasibility of Ambulatory Minimally Invasive Partial Nephrectomy: A Systematic Review and Meta-Analysis" by Paynter et al. 信:“动态微创肾部分切除术的安全性和可行性:系统回顾和荟萃分析”,作者:Paynter等人。
IF 2.9 2区 医学
Journal of endourology Pub Date : 2025-06-23 DOI: 10.1089/end.2025.0363
Miao He, Kun-Peng Li
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引用次数: 0
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