Journal of Clinical Research最新文献

{"title":"Evaluation of corneal morphology among newly detected patients with primary open angle glaucoma","authors":"Nagalakshmi Narayana-Swamy, A. Tasneem","doi":"10.17352/2455-1414.000064","DOIUrl":"https://doi.org/10.17352/2455-1414.000064","url":null,"abstract":"Introduction: Glaucoma is an insidious blinding disease that may present in a variety of clinical scenarios. While Intraocular pressure is a major risk factor in its pathophysiology, patients have the disease without any documented elevation in pressure. To avoid missing a diagnosis of glaucoma, a thorough and careful evaluation of all the structural and functional components involved in glaucoma, should be performed. Although, most studies done so far have only focused on the Endothelial cell density among glaucoma patients, we highlighted its importance in the newly detected glaucoma patients.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"27 1","pages":"008-014"},"PeriodicalIF":0.0,"publicationDate":"2020-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74746986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular metastasis in a patient with squamous cell carcinoma tongue: A rare case","authors":"Nagalakshmi Narayana-Swamy, A. Tasneem","doi":"10.17352/2455-1414.000062","DOIUrl":"https://doi.org/10.17352/2455-1414.000062","url":null,"abstract":"Ophthalmic metastasis from an extraocular primary malignancy is a rare event. Tongue is the most common primary site after hypo-pharynx among the oral malignancies causing distant metastasis [1].","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"63 1","pages":"001-003"},"PeriodicalIF":0.0,"publicationDate":"2020-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75020540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of High Intensity Aerobic Exercise on Levels of Galectin-3 and Protein Kinase C in Diabetic Male Rats","authors":"Abolfazl Samiei, N. Behpoor, V. Tadibi, R. Fathi","doi":"10.5812/jcrps.80362","DOIUrl":"https://doi.org/10.5812/jcrps.80362","url":null,"abstract":"Background: Cardiac fibrosis is one of the complications of diabetes. Physical activity may be effective in reducing cardiac fibrosis through affecting hyperglycemia. Objectives: Accordingly, the purpose of this study was to investigate the effect of high intensity aerobic exercise on levels of galectin-3 and protein kinase C in diabetic rats. Methods: In this study, 30 male wistar rats were randomly divided into 3 groups (control, diabetic control and exercise diabetic). The induction of diabetes was performed by intraperitoneally injected streptozotocin solution at a dose of 55 mg/kg of body weight. The training program included 8 weeks of treadmill running for 60 minutes and a speed of 34 m/min. Subjects in all experimental groups (48 hours after the last training session) were anesthetized and then the heart tissue was isolated from the aortic root area. Data analysis was performed using one-way ANOVA and Tukey’s post hoc test to determine the difference between the groups. Results: The results showed that galectin-3 and PKC had a significant increase in the diabetics control group compared to the healthy group. It was also found that endurance training with high intensity caused a significant decrease in galectin-3 and PKC compared to diabetic control group. Conclusions: It seems that endurance training in diabetes is an effective method for decreasing the activity of signaling cascade of the pathway of pathogenesis of fibrosis in the heart of diabetic rats.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80619065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of 8 Weeks Yoga and Cardiac Rehabilitation Training on Interlukin-6 and High Sensitivity C-Reaction Proteins After Coronary Artery Bypass Surgery: A Randomized Controlled Trial","authors":"Z. Fathollahi, F. Ghazalian, H. Nikbakht, S. Lotfian, Akbar Nikpajouh","doi":"10.5812/jcrps.98289","DOIUrl":"https://doi.org/10.5812/jcrps.98289","url":null,"abstract":"Background: Coronary artery bypass surgery is a common method for coronary artery disease (CAD) treatment, which in turn activates pro-inflammatory biomarkers such as Interleukin-6 (IL-6) and high sensitivity C-reaction protein (hs-CRP). Objectives: The present study aimed to investigate the effects of 8 weeks Yoga and cardiac rehabilitation training on IL-6 and hs-CRP after coronary artery bypass surgery. Methods: The subjects of this randomized control trial study consist of 20 male patients (40 - 75 years old) who experienced coronary artery bypass surgery. They were randomly assigned in cardiac rehabilitation training group (CRT, n = 10) and combined training group (Yoga-cardiac rehabilitation) (YCRT, n = 10). Plasma levels of IL-6 and hs-CRP were assessed at baseline and end of the study. The CRT group performed cardiac rehabilitation program with 60% - 85% of maximum heart rate for 1 hour three days a week. The YCRT group performed one session in between cardiac rehabilitation and Yoga training for 1 hour three days in a week. All subjects completed training sessions at the cardiac rehabilitation center of Shahid Rajaie Cardiovascular, Medical and Research Center in Tehran for 8 weeks. SPSS software was used for analysis. Covariance analysis was used to compare groups (P ≤ 0.05). Results: Despite a small decline in IL-6 (10.90 to 8.77 in CRT group, 9.87 to 9.40 in YCRT group (and hs-CRP (2.58 to 2.00 in CRT group, 3.67 to 3.13 in YCRT group), there weren’t any significant differences in IL-6 (P = 0.160) and hs-CRP (P = 0.234) levels between two groups. Conclusions: It could be proposed to add Yoga training to cardiac rehabilitation program after coronary artery bypass surgery.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79061567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Conceptual Model of Succession Management at Medical Universities: Experience of Iranian Higher Education Based on Grounded Theory","authors":"Reza Pourmirza Kalhori, Susan Laei, Elham Kavyani, Faramarz Malekian","doi":"10.5812/jcrps.99978","DOIUrl":"https://doi.org/10.5812/jcrps.99978","url":null,"abstract":"Background: The higher education system needs to succession management based on academic environments and its professional dynamics. Objectives: The present study aimed to modeling succession management at medical universities based on grounded theory. Methods: Through reviewing the related texts, articles and 12 semi-structured interviews with faculty members of medical universities in three stages of open, axial and selective coding, the data were analyzed. Results: The results were indicative of twelve general categories as follows: main phenomenon (meritocracy, management skills and strategic management), causal conditions (organizational structure, human resources management, beliefs of senior manager and rules); strategies (career path development, knowledge-based management, productivity management, financial resources management, organizational stability and academic independence); underlying conditions (complexity, research orientation, interactions within the educational groups, the crisis of shortage of capable directors, native provincial management, appointment of directors from within universities, detecting talents, policy-making councils, non-competitive rewards, key positions, organizational misconduct, political atmosphere, and pressures to the university); interventional conditions (organizational culture and environment, managerial experience, physical fitness and knowledge capacity) and consequences (improving satisfaction, ethics management, using academic models, dynamic universities, increasing organizational motivation and the existence of counseling culture). Conclusions: This study suggested a succession management model in medical sciences universities. According to the findings, special differences such as meritocracy, environmental complexity, managers’ scientific and professional maturity, the centrality of science in production, the political sensitivities of the community and the use of proprietary scientific models of succession management in universities can be found between the establishment of succession management in higher education compared to other organizations.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81797927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Antimicrobial Effect of Ferulago angulata on Staphylococcus aureus Growth Isolated From Subclinical Mastitis, in Vitro Study","authors":"S. Bohlouli, Sara Hasanvand","doi":"10.5812/jcrps.97294","DOIUrl":"https://doi.org/10.5812/jcrps.97294","url":null,"abstract":"Background: Staphylococcus aureus is one of the important causative agents in mastitis. Objectives: The aim of this study was determination antimicrobial effect of Ferulago angulata and different common therapeutic antibiotics on growth of Staphylococcus aureus isolated from subclinical mastitis cases. Methods: In this study the antibacterial effect of Ferulago angulata essential oil, aqueous and hydro alcoholic extract on Staphylococcus aureus growth was done and compared with common therapeutic antibiotics such as tetracycline, erythromycin, kanamycin and gentamicin by diffusion disk method. Minimum inhibitory concentration and minimum bactericidal concentration were tested through tube standard method. Results: Antimicrobial effect of essential oil and hydro alcoholic extract was increased by dose-dependently. 40 mg/mL extract and 20% essential oil are the highest dose with antimicrobial effect. Extract of Ferulago angulata has maximum antibacterial activity on the growth of S. aureus. Conclusions: Ferulago angulata had remarkable anti-bacterial effect on Staphylococcus aureus growth isolated from subclinical mastitis cases. In comparison Ferulago angulata essential oil was more powerful than extract. Regarding the fact that antibiotic resistance is growing, Ferulago angulata as an herbal plant with anti-bacterial effect could be used in Staphylococcus aureus isolated from subclinical mastitis cases.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84267906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Brief Review on Clinical Examination of Endocrine Tumor","authors":"A. Franz","doi":"10.37421/JCRE.2020.4.114","DOIUrl":"https://doi.org/10.37421/JCRE.2020.4.114","url":null,"abstract":"Neuroendocrine Tumors (NETs) of all malignant tumors of the gastrointestinal system and the incidence of all noncarcinoid NETs is approximately one half that of all carcinoids. Diagnosis, and management of these rare tumors and briefly summarizes their main features. The majority of noncarcinoid NETs arise from the pancreas. A comprehension of the essential science extraordinary to NETs is fundamental for ideal administration of patients with these mind boggling tumors. There are in any event 14 endocrine cell types in the gut and these alongside the endocrine cells of the pancreas produce at any rate 33 hormones and biogenic amines. These cells have numerous likenesses to neural cells. They produce bioactive substances that serve transmitter capacities, yet through endocrine, autocrine, or paracrine modes, even without axons and neural connections. The clinical condition that might be related with every one of these tumors results from the over the top creation of the tumor's occupant hormones. Those NETs not creating an overabundance of clinically dynamic hormones cause no clinical endocrine condition, and are called non-working NETs. Be that as it may, there is impressive variety in the connection of blood levels of Pancreatic Endocrine Tumor (PET) hormonal items and clinical disorder.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"72 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85488940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Clinical Research","authors":"Joshim Khan","doi":"10.37421/JCRE.2020.4.115","DOIUrl":"https://doi.org/10.37421/JCRE.2020.4.115","url":null,"abstract":"Unfavorably susceptible conjunctival illnesses (ACDs) are fiery sicknesses of the conjunctiva and cornea caused transcendently by the IgE-intervened prompt extreme touchiness reaction. Unfavorably susceptible conjunctival illnesses incorporate hypersensitive conjunctivitis, Vernal Kerato Conjunctivitis (VKC), Atopic Kerato Conjunctivitis (AKC), and monster papillary conjunctivitis. In clinical act of ACDs, a visual hypersensitivity test utilizing biomarker estimation is an essential assessment method for diagnosing, assessing seriousness, and deciding the adequacy of clinical treatment. The visual sensitivity test incorporates the tear test for assessing the centralization of biomarkers in tears and a visual surface test for evaluating the articulation levels of courier ribonucleic corrosive (mRNA) biomarkers on the visual surface. The biomarkers for unfavorably susceptible aggravation in patients with constant ACDs including VKC and AKC were generous. In any case, the determination of biomarkers related with the beginning stage response of prompt extreme touchiness and inborn invulnerability reactions should be tended to in future examinations.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"145 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84776381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Clinical Research","authors":"A. Rock","doi":"10.37421/JCRE.2020.4.113","DOIUrl":"https://doi.org/10.37421/JCRE.2020.4.113","url":null,"abstract":"An abnormal development of cells which will in general multiply in an uncontrolled manner and, sometimes, to metastasize (spread) .Cancer isn't one infection. It is a gathering of in excess of 100 extraordinary and unmistakable infections. The cancer cell growth include any tissue of the body and have a wide range of structures in each body zone. There are many type of cancer are there depending up on the symptoms for example Acute Lymphoblastic Leukemia , AIDS Related lymphoma, Brest cancer ,Brain cancer, liver cancer, Bladder cancer, cervical cancer, Fallopian tube cancer, Gastric cancer, Renal cancer, lung cancer etc.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"23 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79524174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Breakthroughs in Genetic Engineering and Environmental Medicine for Chronic Epilepsy","authors":"P. Krishnan","doi":"10.21522/tijcr.2014.se.19.02.art002","DOIUrl":"https://doi.org/10.21522/tijcr.2014.se.19.02.art002","url":null,"abstract":"","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"307 1","pages":"15-25"},"PeriodicalIF":0.0,"publicationDate":"2019-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77061110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}