Journal of Clinical Research最新文献_第6页

Antenatal diagnoses of congenital cataracts and related surgical complications in a familial case of Nance-Horan Syndrome 家族性Nance-Horan综合征先天性白内障及相关手术并发症的产前诊断

Journal of Clinical Research Pub Date : 2020-05-18 DOI: 10.17352/2455-1414.000068

K SivakumarGayathri, Mhapankar Gunjan, Siu Victoria Mok, Sharan Sapna

引用次数: 0

Evaluation of two techniques for irrigation/aspiration retrolental viscoelastic removal in cataract surgery 白内障手术中两种灌吸后晶状体粘弹性去除技术的评价

Journal of Clinical Research Pub Date : 2020-05-09 DOI: 10.17352/2455-1414.000067

F. A. Balsalobre, P. O. Vila, F. H. Pardines, Víctor García Conca, S. N. Márquez, J. R. H. Abancéns

引用次数: 1

(OSMS)- One Step Melanoma Surgery for Nevoid melanoma? (OSMS)-一步黑色素瘤手术治疗痣黑色素瘤?

Journal of Clinical Research Pub Date : 2020-05-01 DOI: 10.15226/2378-1726/7/2/001111

G. Tchernev, I. Temelkova, I. Lozev, S. Sergieva, I. Terziev, T. Pirdopska, Malev

{"title":"(OSMS)- One Step Melanoma Surgery for Nevoid melanoma?","authors":"G. Tchernev, I. Temelkova, I. Lozev, S. Sergieva, I. Terziev, T. Pirdopska, Malev","doi":"10.15226/2378-1726/7/2/001111","DOIUrl":"https://doi.org/10.15226/2378-1726/7/2/001111","url":null,"abstract":"We describe a 48-year-old patient with a present cutaneous pigment lesion located in the left scapular area. About 15 years duration of the finding, as the lesion being suspected clinically and dermatoscopically for cutaneous melanoma. The patient was initially treated with a surgical margin of 0.5 cm in all directions, with a tumor thickness of 3 mm immediately established afterwards. The subsequent surgical session 9 days later (as recommended by the AJCC) included: 1) removal of 4 sentinel lymph nodes: 3 of them located infrascapularly and one axillary apically to the left and 2) reexcision of the primary surgical wound with a safety margin of 1.5 cm in all directions. Lymph node involvement data are lacking and the patient is staged as IIA (T3a N0M0). Using a worldwide medical database as PubMed/Medline, it could be at least suggested that the determination of the tumor thickness in clinically and dermatoscopically indicative for melanoma cutaneous lesions (especially when they are over 2 or 3 mm) should not be a serious challenge. In pigmented lesions with clear clinical and dermatoscopic data in the direction of cutaneous melanoma, the role of high-frequency pre-operative ultrasound could be essential for reducing the number of surgical sessions from two to one. The case presented is indicative of how lesions with similar clinical and dermatoscopic morphology could be treated and how guidelines can be individually optimized on the basis of the individual clinical experience. In fact, it turns out that one-step melanoma surgery (OSMS) could be a good therapeutic option in a specific type of patient.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"7 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87702914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory Effect of Mallotus Philippinensis Bark Extracts in a Mouse Atopic Dermatitis Model 菲律宾马丽花树皮提取物对小鼠特应性皮炎模型的抗炎作用

Journal of Clinical Research Pub Date : 2020-04-21 DOI: 10.15226/2378-1726/7/1/001110

S. Asayama, A. Iwasaki, Shunya Sahara, T. Okamoto, Koichi Nakaoji, K. Hamada, M. Ichihashi, Ken-ichi Mizutania

{"title":"Anti-Inflammatory Effect of Mallotus Philippinensis Bark Extracts in a Mouse Atopic Dermatitis Model","authors":"S. Asayama, A. Iwasaki, Shunya Sahara, T. Okamoto, Koichi Nakaoji, K. Hamada, M. Ichihashi, Ken-ichi Mizutania","doi":"10.15226/2378-1726/7/1/001110","DOIUrl":"https://doi.org/10.15226/2378-1726/7/1/001110","url":null,"abstract":"Background: InAtopic Dermatitis (AD) is a chronic inflammatory skin disease that causes functional disruption of the skin barrier. We previously found that ethanol Extracts of Mallotus PhilippinensisBark (EMPB) promoted migration of mesenchymal stem cells and improved wound healing probably through anti-inflammatory action. However, direct evidence of the anti-inflammatory effect of EMPB and the underlying mechanisms of this action remain unknown. In the present study, we evaluated whether EMPB has an effective action on anti-inflammation using an in vitro and in vivo model. We found that topical application of EMPB improved house dust mite-induced AD-like skin inflammation in NC/Nga mice. In addition, EMPB significantly inhibited various kinds of inflammatory mediators such as interleukin-1ß, inducible nitric oxide synthases, and nuclear factorkappa B in lipopolysaccharide-stimulated macrophage cells. Moreover, EMPB exhibited marked radical scavenging ability. Taken together, these results suggest that EMPB may be useful in the treatment of skin inflammatory diseases such as AD.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"18 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86111502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of atypical band shaped keratopathy following intravitreal silicone oil injection in an aphakic eye 无晶状体眼注射硅油致非典型带状角膜病变1例

Journal of Clinical Research Pub Date : 2020-04-09 DOI: 10.17352/2455-1414.000066

Nischala Balakrishna and Seema Channabasappa

引用次数: 0

The Relative Contribution of Cognitive and Physical Components in Volleyball Injuries Prediction 认知成分与身体成分在排球损伤预测中的相对贡献

Journal of Clinical Research Pub Date : 2020-04-04 DOI: 10.5812/jcrps.96303

Parvaneh Hesami, R. Balouchy, Mohammadreza Ghasemian

{"title":"The Relative Contribution of Cognitive and Physical Components in Volleyball Injuries Prediction","authors":"Parvaneh Hesami, R. Balouchy, Mohammadreza Ghasemian","doi":"10.5812/jcrps.96303","DOIUrl":"https://doi.org/10.5812/jcrps.96303","url":null,"abstract":"Background: Researchers have always sought to investigate the factors affecting sports injuries in order to identify ways of preventing and controlling such factors. These studies have more emphasis on physical aspects, while the cognitive and psychological components may also be effective. Objectives: The present study was conducted to answer the question whether or not injury can be predicted in volleyball athletes through physical and cognitive components. Methods: For this purpose, 50 volleyball players with the age range of 18 to 25 years old participated in the study. The subjects were evaluated using Barratt impulsiveness scale, Functional movement screen and continuous performance test (for sustained attention). Then, the injuries occurrence were recorded. Furthermore, logistic regression test was run to predict injury in athletes and the bi-serial correlation coefficient was used to investigate the relationship between the factors. Results: The findings showed that there was a significant negative correlation between functional movement screen scores and injuries occurrence. There was also a significant positive correlation between omission and commission errors and injury occurrence, meaning that alongside the increase in the omission and commission errors, the injury occurrence increased; however, there was no significant relationship between the scores of Barratt impulsiveness scale and the injury occurrence. Conclusions: The findings of this study showed that mental and cognitive components, along with the physical factor, play a significant role in injury occurrence in volleyball players, so it is better to consider it in prevention and rehabilitation programs.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90898724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Atypical Presentation of Lichen Planopilaris: Presentation of Two Cases and Review 扁平苔藓的非典型表现:两例报告并复习

Journal of Clinical Research Pub Date : 2020-03-16 DOI: 10.15226/2378-1726/7/1/001107

Nwanneka Okwundu, F. Ekpo, Jessica Ghaferri, D. Fivenson

{"title":"Atypical Presentation of Lichen Planopilaris: Presentation of Two Cases and Review","authors":"Nwanneka Okwundu, F. Ekpo, Jessica Ghaferri, D. Fivenson","doi":"10.15226/2378-1726/7/1/001107","DOIUrl":"https://doi.org/10.15226/2378-1726/7/1/001107","url":null,"abstract":"Lichen Planopilaris (LPP) is an uncommon scalp disorder of unknown etiology and prevalence. It is thought to be an autoimmune process triggered by unknown genetic and/or environmental factors that attack hair follicles of the scalp. LPP has been reported to mimic or present in association with various autoimmune diseases and immunomodulatory therapies. We present two atypical case of LPP in Caucasian patients; the first is a patient with generalized pruritus, skin eruptions, and scalp hair loss. Biopsy of the lesions revealed exocytosis of atypical lymphocytes at the Dermo-Epidermal Junction (DEJ) and formation of small Pautrier’s microabscesses in the interfollicular epidermis as well as a robust lymphocytic inflammatory infiltrate with destruction of perifollicular appendages. This led us to the diagnosis of LPP-like Folliculotropic Mycosis Fungoides (FMF). The second case is a patient with a history of Systemic Lupus Erythematosus (SLE) who presented clinically with perifollicular erythema and alopecic patches, with loss of follicular ostia on the frontal and vertex scalp and evidence of follicular tufting. Histologically, she had decreased number of follicles with a peri-infundibular lymphocytic infiltrate and vacuolization at the Dermoepidermal Junction (DEJ) and there was also thickening of the basement membrane highlighted with a periodic acidic Schiff stain. This led to a diagnosis of SLE/LPP overlap.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"11 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87775865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Triamcinolone to Reduce the Inflammation Associated with Kybella Injection 使用曲安奈德减少Kybella注射液相关的炎症

Journal of Clinical Research Pub Date : 2020-03-16 DOI: 10.15226/2378-1726/7/1/001108

M. Hosseinipour, Felicia Ekpo, Nwanneka Okwundu, Monica Huynh, S. Zarkhin, D. Papadopoulos, C. Hoffman

{"title":"Use of Triamcinolone to Reduce the Inflammation Associated with Kybella Injection","authors":"M. Hosseinipour, Felicia Ekpo, Nwanneka Okwundu, Monica Huynh, S. Zarkhin, D. Papadopoulos, C. Hoffman","doi":"10.15226/2378-1726/7/1/001108","DOIUrl":"https://doi.org/10.15226/2378-1726/7/1/001108","url":null,"abstract":"Background: Submental fullness has been a concern for patients in dermatology for years. Liposuction and cosmetic surgery were considered the mainstay for elimination of unwanted submental fat. However, these procedures are invasive and associated with major complications like prolonged recovery times, and the risk of contour irregularities. In 2015, Kybella (deoxycholic acid) was approved as a first-in-class injectable agent for the treatment of submental fullness. Although, it is non-invasive and has less complications than plastic surgery, it is still associated with adverse effects such as pain, swelling/edema, and bruising. The most concerning adverse effect for patients is the prolonged inflammation that may occur for up to 2 weeks post-injection. Objective: This is a comparison trial of deoxycholic acid injections with or without triamcinolone acetate for the reduction of submental fat in one patient. The study will also assess the effect of triamcinolone acetate on post-injection inflammation associated with deoxycholic acid injection in the treatment of submental fullness. Method: A 35-year-old female presented for evaluation of submental fullness and opted for treatment with Kybella. Her right submental treatment area was injected with 2ml of deoxycholic acid 10mg/ml plus 0.2ml triamcinolone acetate. The left submental treatment area was treated with 2ml of deoxycholic acid 10mg/ ml alone. The patient was observed over a duration of 3 months to evaluate inflammation and treatment response between the two treatment zones. Results: This split-neck study resulted in decreased postinjection swelling. However, at 3-month follow-up, there was no clinical improvement to the submental fullness bilaterally. Limitations: Small sample size, lack of objective measures, possible diffusion between treatment zones, and prior deoxycholic acid treatment. Conclusion: Triamcinolone can decrease post-injection swelling if given as an adjunct to Kybella treatment.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"43 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79423661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Accuracy of Liver Biopsy to Diagnose Biliary Atresia: A Meta-Analysis 肝活检诊断胆道闭锁的准确性:一项meta分析

Journal of Clinical Research Pub Date : 2020-03-13 DOI: 10.15344/2456-8007/2020/144

Yuan-Lung Yang, Xin Li, J. Zhan

引用次数: 0

A case series on ocular manifestations in Steven Johnson Syndrome and their varied presentation-Review of literature 史提芬强森症候群的眼部表现及其不同的表现-文献回顾

Journal of Clinical Research Pub Date : 2020-01-31 DOI: 10.17352/2455-1414.000063

N. Nagalakshmi, Tasneem Alhaj Farhath

引用次数: 0