{"title":"肝活检诊断胆道闭锁的准确性:一项meta分析","authors":"Yuan-Lung Yang, Xin Li, J. Zhan","doi":"10.15344/2456-8007/2020/144","DOIUrl":null,"url":null,"abstract":"Objectives: A lot of prolonged jaundice patients may undergo many tests before confirmed diagnosis. Liver biopsy is an effective way in final stage of the course. This article aims to evaluate the accuracy of liver biopsy to diagnose biliary atresia (BA) in infants with cholestasis. Methods: We searched Pubmed, EMBASE and the Web of Science databases for articles evacuated the accuracy of liver biopsy to diagnose BA to obtain the sensitivity, specificity, TN, FN, FP, TP. The methodological quality of liver biopsy was assessed with version 2 of the Quality Assessment of Diagnostic Accuracy Studies tool. Screening, data extraction, and quality assessment were done in duplicated. Results: A total of 20 articles were included. The whole data results the Diagnostic Odds Ratio of liver biopsy was 170.39 (84.90 to 341.97), with a pooled sensitivity of 92% (90%-94%), pooled specificity of 95% (93%-95%). Conclusion: Quantitative analysis demonstrated liver biopsy to be high sensitivity, high specificity, high accuracy in diagnosing BA. The data analysis provides evidence of liver biopsy is a reliable diagnosis method to confirm diagnosis.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"17 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Accuracy of Liver Biopsy to Diagnose Biliary Atresia: A Meta-Analysis\",\"authors\":\"Yuan-Lung Yang, Xin Li, J. Zhan\",\"doi\":\"10.15344/2456-8007/2020/144\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives: A lot of prolonged jaundice patients may undergo many tests before confirmed diagnosis. Liver biopsy is an effective way in final stage of the course. This article aims to evaluate the accuracy of liver biopsy to diagnose biliary atresia (BA) in infants with cholestasis. Methods: We searched Pubmed, EMBASE and the Web of Science databases for articles evacuated the accuracy of liver biopsy to diagnose BA to obtain the sensitivity, specificity, TN, FN, FP, TP. The methodological quality of liver biopsy was assessed with version 2 of the Quality Assessment of Diagnostic Accuracy Studies tool. Screening, data extraction, and quality assessment were done in duplicated. Results: A total of 20 articles were included. The whole data results the Diagnostic Odds Ratio of liver biopsy was 170.39 (84.90 to 341.97), with a pooled sensitivity of 92% (90%-94%), pooled specificity of 95% (93%-95%). Conclusion: Quantitative analysis demonstrated liver biopsy to be high sensitivity, high specificity, high accuracy in diagnosing BA. The data analysis provides evidence of liver biopsy is a reliable diagnosis method to confirm diagnosis.\",\"PeriodicalId\":15586,\"journal\":{\"name\":\"Journal of Clinical Research\",\"volume\":\"17 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-03-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.15344/2456-8007/2020/144\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.15344/2456-8007/2020/144","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的:许多慢性黄疸患者在确诊前需进行多次检查。肝活检是治疗最后阶段的有效方法。本文旨在评价肝活检诊断胆汁淤积症患儿胆道闭锁(BA)的准确性。方法:检索Pubmed、EMBASE和Web of Science数据库中有关肝活检诊断BA准确性的文章,获取其敏感性、特异性、TN、FN、FP、TP。使用诊断准确性研究质量评估工具第2版评估肝活检的方法学质量。筛选、数据提取和质量评估重复进行。结果:共纳入20篇文献。整个数据结果肝活检诊断优势比为170.39(84.90 ~ 341.97),合并敏感性为92%(90% ~ 94%),合并特异性为95%(93% ~ 95%)。结论:定量分析表明肝活检诊断BA具有高敏感性、高特异性、高准确性。数据分析证明肝活检是一种可靠的确诊方法。
The Accuracy of Liver Biopsy to Diagnose Biliary Atresia: A Meta-Analysis
Objectives: A lot of prolonged jaundice patients may undergo many tests before confirmed diagnosis. Liver biopsy is an effective way in final stage of the course. This article aims to evaluate the accuracy of liver biopsy to diagnose biliary atresia (BA) in infants with cholestasis. Methods: We searched Pubmed, EMBASE and the Web of Science databases for articles evacuated the accuracy of liver biopsy to diagnose BA to obtain the sensitivity, specificity, TN, FN, FP, TP. The methodological quality of liver biopsy was assessed with version 2 of the Quality Assessment of Diagnostic Accuracy Studies tool. Screening, data extraction, and quality assessment were done in duplicated. Results: A total of 20 articles were included. The whole data results the Diagnostic Odds Ratio of liver biopsy was 170.39 (84.90 to 341.97), with a pooled sensitivity of 92% (90%-94%), pooled specificity of 95% (93%-95%). Conclusion: Quantitative analysis demonstrated liver biopsy to be high sensitivity, high specificity, high accuracy in diagnosing BA. The data analysis provides evidence of liver biopsy is a reliable diagnosis method to confirm diagnosis.