The Effect of High Intensity Aerobic Exercise on Levels of Galectin-3 and Protein Kinase C in Diabetic Male Rats

Abolfazl Samiei, N. Behpoor, V. Tadibi, R. Fathi
{"title":"The Effect of High Intensity Aerobic Exercise on Levels of Galectin-3 and Protein Kinase C in Diabetic Male Rats","authors":"Abolfazl Samiei, N. Behpoor, V. Tadibi, R. Fathi","doi":"10.5812/jcrps.80362","DOIUrl":null,"url":null,"abstract":"Background: Cardiac fibrosis is one of the complications of diabetes. Physical activity may be effective in reducing cardiac fibrosis through affecting hyperglycemia. Objectives: Accordingly, the purpose of this study was to investigate the effect of high intensity aerobic exercise on levels of galectin-3 and protein kinase C in diabetic rats. Methods: In this study, 30 male wistar rats were randomly divided into 3 groups (control, diabetic control and exercise diabetic). The induction of diabetes was performed by intraperitoneally injected streptozotocin solution at a dose of 55 mg/kg of body weight. The training program included 8 weeks of treadmill running for 60 minutes and a speed of 34 m/min. Subjects in all experimental groups (48 hours after the last training session) were anesthetized and then the heart tissue was isolated from the aortic root area. Data analysis was performed using one-way ANOVA and Tukey’s post hoc test to determine the difference between the groups. Results: The results showed that galectin-3 and PKC had a significant increase in the diabetics control group compared to the healthy group. It was also found that endurance training with high intensity caused a significant decrease in galectin-3 and PKC compared to diabetic control group. Conclusions: It seems that endurance training in diabetes is an effective method for decreasing the activity of signaling cascade of the pathway of pathogenesis of fibrosis in the heart of diabetic rats.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"8 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5812/jcrps.80362","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

Background: Cardiac fibrosis is one of the complications of diabetes. Physical activity may be effective in reducing cardiac fibrosis through affecting hyperglycemia. Objectives: Accordingly, the purpose of this study was to investigate the effect of high intensity aerobic exercise on levels of galectin-3 and protein kinase C in diabetic rats. Methods: In this study, 30 male wistar rats were randomly divided into 3 groups (control, diabetic control and exercise diabetic). The induction of diabetes was performed by intraperitoneally injected streptozotocin solution at a dose of 55 mg/kg of body weight. The training program included 8 weeks of treadmill running for 60 minutes and a speed of 34 m/min. Subjects in all experimental groups (48 hours after the last training session) were anesthetized and then the heart tissue was isolated from the aortic root area. Data analysis was performed using one-way ANOVA and Tukey’s post hoc test to determine the difference between the groups. Results: The results showed that galectin-3 and PKC had a significant increase in the diabetics control group compared to the healthy group. It was also found that endurance training with high intensity caused a significant decrease in galectin-3 and PKC compared to diabetic control group. Conclusions: It seems that endurance training in diabetes is an effective method for decreasing the activity of signaling cascade of the pathway of pathogenesis of fibrosis in the heart of diabetic rats.
高强度有氧运动对糖尿病雄性大鼠半乳糖凝集素-3和蛋白激酶C水平的影响
背景:心脏纤维化是糖尿病的并发症之一。体育活动可能通过影响高血糖而有效减少心脏纤维化。因此,本研究的目的是探讨高强度有氧运动对糖尿病大鼠半乳糖凝集素-3和蛋白激酶C水平的影响。方法:将30只雄性wistar大鼠随机分为3组(对照组、糖尿病对照组和运动糖尿病组)。诱导糖尿病是通过腹腔注射链脲佐菌素溶液,剂量为55 mg/kg体重。训练计划包括8周的跑步机跑60分钟,速度为34米/分钟。所有实验组(最后一次训练后48小时)均麻醉,然后从主动脉根部区分离心脏组织。数据分析采用单因素方差分析和Tukey事后检验来确定组间差异。结果:糖尿病对照组半乳糖凝集素-3和PKC较健康组明显升高。研究还发现,与糖尿病对照组相比,高强度耐力训练导致半乳糖凝集素-3和PKC显著降低。结论:糖尿病耐力训练似乎是降低糖尿病大鼠心脏纤维化发病通路信号级联活性的有效方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信