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Recent Potential Treatment Approaches for the Management of Uveitis 葡萄膜炎的最新治疗方法
Journal of Clinical Research Pub Date : 2020-09-15 DOI: 10.17352/2455-1414.000080
N. Nikita, S. Yasmin
{"title":"Recent Potential Treatment Approaches for the Management of Uveitis","authors":"N. Nikita, S. Yasmin","doi":"10.17352/2455-1414.000080","DOIUrl":"https://doi.org/10.17352/2455-1414.000080","url":null,"abstract":"Uveitis is an infl ammatory disease affecting the uveal tract of the eye. Non-infectious uveitis [NIU] is known to be the main cause of blindness in people of all age groups in different parts of the world. NIU can be both due to autoimmune or idiopathic responses causing severe vision-related complications leading to irreversible vision loss. Thus, the treatment of this disease after the rapid diagnosis and evaluation by eminent ophthalmologists and rheumatologists is very important. The primary goal of treatment of uveitis is to limit the infl ammation process and prevent recurring responses and hence preserving the vision. The current treatment therapies include corticosteroids as fi rst-line agents followed by more potent drugs including synthetic immunosuppressants like calcineurin inhibitors, antimetabolites, and alkylating agents. However, some patients are reported to be intolerant to these therapies, therefore, biologic agents are adopted as an effective treatment approach in such cases. Anti TNF-α agents have shown promising results in the treatment process. This review enlightens about the current effective treatment approaches that are adopted as potential therapeutic agents preventing NIU. Short Communication Recent Potential Treatment Approaches for the Management of Uveitis Nikita1 and Yasmin Sultana2* 1Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard,","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"39 1","pages":"094-098"},"PeriodicalIF":0.0,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73732608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Keratinocytic Cancers - Ambulatory Surgical Approach: Case Series 角化细胞癌-门诊手术方法:病例系列
Journal of Clinical Research Pub Date : 2020-08-29 DOI: 10.15226/2378-1726/7/4/001121
T. Angelov, Ana Bitolska, G. Tchernev
{"title":"Keratinocytic Cancers - Ambulatory Surgical Approach: Case Series","authors":"T. Angelov, Ana Bitolska, G. Tchernev","doi":"10.15226/2378-1726/7/4/001121","DOIUrl":"https://doi.org/10.15226/2378-1726/7/4/001121","url":null,"abstract":"The Keratinocytic cancer is the most common form of skin cancer and the most common cancer in humans. Predisposing risk factors include ultraviolet radiation, genetic predisposition, chronic immune suppression, smoking, which also determines the risk groups middle and old age, light skin phenotype, outdoor work and frequent sunburns. The origin of the epidermal cell type determines the clinical division of keratinocytic cancer into basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Clinically, keratinocytic cancer is presented as a solitary, sometimes destructive, growing-sized lesion. The most lesions are characterized by a low degree of malignancy. Neglecting them by both the patient and medical professionals leads to their growth and metastasis, as SCC has a higher potential for metastasis. The main place in the treatment of keratinocytic cancer is the surgical method, and the most common in clinical practice is the so called elliptical excision. The gold standard in hardto-reach places is the Mohs micrographic operation. In this publication we present eleven clinical cases of patients with keratinocytic cancers in different topographic regions of the human body. Patients were treated surgically by elliptical excision and complete removal of tumor formations in accordance with the recommended fields of surgical safety. The defects were closed with single skin sutures and the sutures were removed on the 14th postoperative day. No complications were observed in the postoperative period.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"27 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2020-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72940497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Prevalence of Osteoporosis in Hiv Infected Patient and its Correlation with Cd4 Count/Clinical Staging in Indian Population 印度人群中Hiv感染患者骨质疏松的患病率及其与Cd4计数/临床分期的关系
Journal of Clinical Research Pub Date : 2020-08-25 DOI: 10.14302/issn.2324-7339.jcrhap-20-3003
S. Tiwari, Richa Patel
{"title":"The Prevalence of Osteoporosis in Hiv Infected Patient and its Correlation with Cd4 Count/Clinical Staging in Indian Population","authors":"S. Tiwari, Richa Patel","doi":"10.14302/issn.2324-7339.jcrhap-20-3003","DOIUrl":"https://doi.org/10.14302/issn.2324-7339.jcrhap-20-3003","url":null,"abstract":"Human immunodeficiency virus (HIV) is a retroviral disease in which the viruses copy their genetic material into the genetic material of the human beings. Infected cells remain infected for the whole of their life. First discovered in the year 1981, Human immunodeficiency virus infections is considered to be a pandemic by the World Health organization. DOI: 10.14302/issn.2324-7339.jcrhap-20-3003 Corresponding author: Tiwari Satya Kant, Department of internal medicine AIIMS, Email: satyakant.999@gmail.com","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"49 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2020-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88167331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidermal Cysts Surgery: Case Series 表皮囊肿手术:病例系列
Journal of Clinical Research Pub Date : 2020-08-21 DOI: 10.15226/2378-1726/7/3/001120
T. Angelov, V. Malev, G. Tchernev
{"title":"Epidermal Cysts Surgery: Case Series","authors":"T. Angelov, V. Malev, G. Tchernev","doi":"10.15226/2378-1726/7/3/001120","DOIUrl":"https://doi.org/10.15226/2378-1726/7/3/001120","url":null,"abstract":"Epidermal cysts are the most common scalp cysts in clinical practice. They are most commonly located in the region of the face, neck, and trunk, and have been reported in many other topographic areas of the body. Clinically, they are present as free-moving nodules located below the skin, ranging in size from a few millimeters to a few centimeters in diameter. Histopathologically, they are defined as benign tumor formations with a very low risk of malignancy. The differential diagnosis includes: lipoma, neurofibroma, salivary gland adenoma, vascular lesion and fibroid, and Trichilemmal cyst. The most common treatment for epidermal cysts is surgical excision with removal of all contents without compromising the integrity of the capsule. In this publication, we present five clinical cases of patients with epidermal cysts in different topographic regions of the body. The patients were treated surgically by elliptical excision and complete removal of epidermal cysts without rupture. The defects were closed with single discontinued skin sutures and the sutures were removed on an 8/ 14-postoperative day. No recurrence was observed in the postoperative period.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"26 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76464646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Valproic Acid Induced Pleural Effusion: A Rare Clinical and Pathophysiological Entity 丙戊酸引起的胸腔积液:一种罕见的临床和病理生理实体
Journal of Clinical Research Pub Date : 2020-08-21 DOI: 10.15344/2456-8007/2020/150
Efthymia Papadopoulou, Stavros Tryfon, M. Saroglou, D. Vlachopoulos, A. Georgopoulou, Evangelia Serasli
{"title":"Valproic Acid Induced Pleural Effusion: A Rare Clinical and Pathophysiological Entity","authors":"Efthymia Papadopoulou, Stavros Tryfon, M. Saroglou, D. Vlachopoulos, A. Georgopoulou, Evangelia Serasli","doi":"10.15344/2456-8007/2020/150","DOIUrl":"https://doi.org/10.15344/2456-8007/2020/150","url":null,"abstract":"Introduction: Among the reported cases of valproic acid - induced pleural effusion, recurrence of pleural fluid accumulation has scarcely been presented in the literature. Case presentation: This case study reports a 51-year-old man under treatment with valproic acid, who presented with recurrent pleural effusion characterized by transition from eosinophilic to lymphocytic predominance. The recurrence of the effusion upon re-administration of the drug, along with its resolution upon discontinuation of treatment with valproic acid, is strongly indicative of a causative association. Conclusion: This is the first reported case of recurrent valproic acid - induced pleural effusion presenting with transition from eosinophilic to lymphocytic predominance. We aim to highlight the importance of taking into consideration the causative role of valproic acid in inducing pleural effusion, even when the pleural fluid demonstrates alteration in the predominant cell type.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"2019 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73673946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Congenital left hemidiaphragm agenesis and use of glatiramer acetate 先天性左膈发育不全及醋酸格拉替默的应用
Journal of Clinical Research Pub Date : 2020-08-11 DOI: 10.17352/2455-1414.000079
Kalanie Hossein, H. Amini, Farajpoor Manije, M. Milad
{"title":"Congenital left hemidiaphragm agenesis and use of glatiramer acetate","authors":"Kalanie Hossein, H. Amini, Farajpoor Manije, M. Milad","doi":"10.17352/2455-1414.000079","DOIUrl":"https://doi.org/10.17352/2455-1414.000079","url":null,"abstract":"Congenital Diaphragmatic Hernia (CDH) is a congenital defect of the diaphragm through which intestine and other viscera herniate in to the chest. In extreme form of diaphragmatic maldevelopment, there might be a complete agenesis of diaphragm. Neonates with CDH present postnatally with respiratory distress and a characteristic absence of breath sounds in the ipsilateral chest. Here we present a 26-year-old gravida 1, para 1 woman with Multiple Sclerosis (MS) on glatiramer acetate who was admitted for elective caesarean section at 38 weeks of gestation. Abdominal ultrasonography had been performed for mother monthly from month 3 and all were reported normal. A baby girl (3300g) was born. Shortly after birth neonate became cyanotic with heavy shallow respiration. Chest x-ray showed massive gas filled intestinal herniation in left thoracic cavity along with right sided mediastinal shift and right sided pneumothorax. Orogastric tube was placed, intubation was performed and she was placed immediately on a ventilator but in the way to operating room she was expired.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"25 1","pages":"091-093"},"PeriodicalIF":0.0,"publicationDate":"2020-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78572451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Schizophrenia and Parkinson ’s disease as Risk Factors for Melanoma Development and Progression! 精神分裂症和帕金森病是黑色素瘤发生和发展的危险因素!
Journal of Clinical Research Pub Date : 2020-08-07 DOI: 10.15226/2378-1726/7/3/001119
V. Malev, G. Tchernev
{"title":"Schizophrenia and Parkinson ’s disease as Risk Factors for Melanoma Development and Progression!","authors":"V. Malev, G. Tchernev","doi":"10.15226/2378-1726/7/3/001119","DOIUrl":"https://doi.org/10.15226/2378-1726/7/3/001119","url":null,"abstract":"We present a 39-year-old male patient with skin tumor, localized on the scalp, paranoid schizophrenia and an idiopathic aplastic anemia. The patient presents with a lesion in Regio occipitalis, which occurred a few years ago and progressively enlarged to a big exophytic tumor, causing pain and occasional bleeding (Figure 1a-d). The patient has been diagnosed with a paranoid schizophrenia more than ten years ago, and since then is on therapy with Amisulpride 400mg/d and Haloperidol 2x1,5 mg/d. He does not follow his therapy strictly, but hospitalization has not been necessary.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"1 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79917813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Glaucoma awareness and knowledge among adults in woliso town, South West Ethiopia 埃塞俄比亚西南部woliso镇成年人对青光眼的认识和知识
Journal of Clinical Research Pub Date : 2020-08-06 DOI: 10.17352/2455-1414.000078
Mahlet Tsegaye, Abiye Mulugeta, Abeba T. Giorgis
{"title":"Glaucoma awareness and knowledge among adults in woliso town, South West Ethiopia","authors":"Mahlet Tsegaye, Abiye Mulugeta, Abeba T. Giorgis","doi":"10.17352/2455-1414.000078","DOIUrl":"https://doi.org/10.17352/2455-1414.000078","url":null,"abstract":"Glaucoma is the leading cause of irreversible blindness worldwide and it is next to cataract as common cause of blindness [1-4]. The global prevalence of glaucoma for population aged 40–80 years is 3.5%. The magnitude of glaucoma is expected to keep increasing with the world population growth and increasing number of ageing people [5]. Ninety percent of affected people in the developing countries and 50% in developed world do not know that they have the disease [6]. In Sub-Saharan Africa glaucoma is more prevalent and has been considered as a major public health issue for the region [7,8]. Up to 50% of glaucoma patients are already blind at least in one eye at presentation in Africa including Ethiopia [7,9].","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"35 1","pages":"087-090"},"PeriodicalIF":0.0,"publicationDate":"2020-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85154402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
On line webinars during time of COVID-19: Does it increase the clinical and surgical skills of egyptian ophthalmologists? 2019冠状病毒病期间的在线网络研讨会:它是否提高了埃及眼科医生的临床和手术技能?
Journal of Clinical Research Pub Date : 2020-07-28 DOI: 10.17352/2455-1414.000076
A MateenMossaElshimaa, Alimohammadi Mohammad, Hammad Alahmady
{"title":"On line webinars during time of COVID-19: Does it increase the clinical and surgical skills of egyptian ophthalmologists?","authors":"A MateenMossaElshimaa, Alimohammadi Mohammad, Hammad Alahmady","doi":"10.17352/2455-1414.000076","DOIUrl":"https://doi.org/10.17352/2455-1414.000076","url":null,"abstract":"Introduction: Since the appearance of COVID-19 pandemic by the end of 2019 and beginning of 2020 conferences, and events are canceled targeting the social distance to limit the spread and decrease the danger of the newly emerging virus webinars instead spread all over the world as an educational tool with no risk of communications. \u0000Purpose: to evaluate the efficacy of webinars in increasing the clinical and surgical skills of Egyptian ophthalmologists during the time of obligatory social distancing of COVID-19. \u0000Results: most of ophthalmologists in this survey consider the webinars is a good educational tool and hoping to progress after COVID-19 Pandemic. Most of them followed their topics of interest rather than the speaker or the organizing company and interested till the end due to the more comfortable situations. \u0000Conclusion: Webinars are readily available technology inexpensive, beneficial experience added to the clinical and surgical skills of Egyptian ophthalmologists who are hoping to be continued even after the COVID-19 pandemic time.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"85 1","pages":"075-080"},"PeriodicalIF":0.0,"publicationDate":"2020-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79355893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Comparative study of visual results obtained with two Trifocal lens models in cataract surgery 两种三焦晶体模型在白内障手术中视力效果的比较研究
Journal of Clinical Research Pub Date : 2020-07-16 DOI: 10.17352/2455-1414.000074
Alfredo Amigó-Francés, Alfredo Castillo‐Gómez, D. Carmona-González, Paula Martinez-Sorribes, A. Amigó
{"title":"Comparative study of visual results obtained with two Trifocal lens models in cataract surgery","authors":"Alfredo Amigó-Francés, Alfredo Castillo‐Gómez, D. Carmona-González, Paula Martinez-Sorribes, A. Amigó","doi":"10.17352/2455-1414.000074","DOIUrl":"https://doi.org/10.17352/2455-1414.000074","url":null,"abstract":"Purpose: To compare visual performance and Contrast Sensitivity (CS) outcomes, patient satisfaction and spectacle independence in patients implanted with two Models of trifocal Intraocular Lenses (MIOLs). \u0000Methods: This non-randomized prospective clinical study included 40 eyes of 20 patients undergoing cataract surgery with bilateral implantation of two different MIOLs, the trifocal Fine Vision MIOL (20 eyes) (PhysIOL, Liege, Belgium) and the trifocal Acriva Trinova MIOL (20 eyes) (VSY, Biotechnology, The Nederlands). Visual results, CS and patient satisfaction were evaluated 3 months after surgery.  \u0000Results: There was no statistically significant difference between groups regarding distance and intermediate visual acuity. Finevision showed better near visual outcomes than Acriva Trinova (p < 0.033). Both MIOLs provided similar CS within normal age ranges. Satisfaction test performed on uncorrected patients showed a variable presence of tolerable dysphotopsic phenomena with both MIOLs. \u0000Conclusions: When postoperative emmetropia was achieved, both MIOLs provided good outcomes for distance and intermediate vision with no differences in contrast sensitivity. Fine Vision MIOL gave better near visual acuity results. There were tolerable dysphotopsic phenomena in both groups.","PeriodicalId":15586,"journal":{"name":"Journal of Clinical Research","volume":"361 1","pages":"054-060"},"PeriodicalIF":0.0,"publicationDate":"2020-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76423038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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