Journal of Drugs in Dermatology最新文献_第5页

Postoperative Complication Risks in Melanoma in situ Treated With Mohs Surgery or Wide Local Excision. Mohs手术或大面积局部切除治疗原位黑色素瘤的术后并发症风险。

IF 2.2 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-09-01 DOI: 10.36849/JDD.10186

Christopher J Thang, David Garate, Christopher Richter, Mohamad Jabin, Mojahed Mohammad K Shalabi, Thomas L H Hocker, Stanislav N Tolkachjov

引用次数: 0

Secondary Intention Healing Over Periosteum: Challenging the Reconstruction Algorithm for Supraperiosteal Defects. 骨膜二次意向愈合：对骨上缺损重建算法的挑战。

IF 2.2 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-09-01 DOI: 10.36849/JDD.9760

Manan D Mehta, Sarah Romanelli, Jessica L Feig, Daniel M Siegel

引用次数: 0

Safety and Tolerability of Facial Skincare in Children and Adolescents: Clinical Testing and Multigenerational Insights. 儿童和青少年面部护肤的安全性和耐受性：临床试验和多代人的见解。

IF 2.2 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-09-01 DOI: 10.36849/JDD.10185

Rebecca Smith, Joshua Zeichner, Cheri Frey, Edward Ted Ted

{"title":"Safety and Tolerability of Facial Skincare in Children and Adolescents: Clinical Testing and Multigenerational Insights.","authors":"Rebecca Smith, Joshua Zeichner, Cheri Frey, Edward Ted Ted","doi":"10.36849/JDD.10185","DOIUrl":"https://doi.org/10.36849/JDD.10185","url":null,"abstract":"Background: Pediatric and adolescent interest in facial skincare is increasing, often driven by social media and early exposure to adult-formulated products.Objective: To evaluate the safety of skincare products suitable for all ages through the lens of generationally evolving skin attitudes and routine behaviors.Methods: A 3-product regimen (hydrating cream cleanser, hydrating moisturizer, daily mineral SPF 40) underwent pediatric safety‑in‑use studies under normal use, comedogenic/acnegenic assessments, and adult Human Repeat Insult Patch Test (HRIPT). In addition, a quantitative cross‑sectional survey across 3 age cohorts (8-17, 18-29, 30-45 years) assessed facial skincare behaviors and attitudes.Results: Across adult testing, the regimen showed low irritation and sensitization potential, non‑comedogenic performance, and no product‑related adverse events. In 4 pediatric safety‑in‑use studies, no clinically meaningful increases in erythema, dryness, or edema were observed. Among 855 eligible survey respondents, product use, routine complexity, and specialty-product exposure increased with age, whereas daily SPF use was suboptimal in 8-17 year‑olds. \"Tested on sensitive skin,\" \"clinically tested,\" and \"fragrance‑free\" claims were highly valued across cohorts. Dermatologists and other medical professionals emerged as the most trusted sources of guidance.Conclusion: A skincare regimen developed with dermatologists demonstrated favorable safety in controlled and real‑world conditions across a large age demographic. Multigenerational survey findings highlight early engagement, persistent gaps in photoprotection, and broad reliance on medically oriented guidance, supporting the need for simple, evidence‑based, age‑appropriate skincare recommendations and greater engagement from the dermatologic community.","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"807-813"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red Light Therapy in Cosmetic Dermatology: Marketing Claims Backed by Evidence? 化妆品皮肤科的红光疗法：有证据支持的营销声明？

IF 2.2 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-09-01 DOI: 10.36849/JDD.9844

Natasha E Barton, Thu Anh Ly, Gustavo Rodrigues de Moraes, Aaron Wang, Nicole Case, Robert P Dellavalle, Cory A Dunnick

{"title":"Red Light Therapy in Cosmetic Dermatology: Marketing Claims Backed by Evidence?","authors":"Natasha E Barton, Thu Anh Ly, Gustavo Rodrigues de Moraes, Aaron Wang, Nicole Case, Robert P Dellavalle, Cory A Dunnick","doi":"10.36849/JDD.9844","DOIUrl":"https://doi.org/10.36849/JDD.9844","url":null,"abstract":"Background: Red light therapy (RLT) is a non-invasive modality that uses visible red wavelengths (approximately 620–700 nm) to modulate cellular activity. By stimulating mitochondrial cytochrome c oxidase, RLT increases adenosine triphosphate production, regulates reactive oxygen species, and activates downstream pathways involved in inflammation control, tissue repair, and collagen synthesis. RLT has rapidly expanded into cosmetic dermatology and consumer wellness markets with widespread direct-to-consumer marketing. This review synthesizes current evidence on the mechanisms and cosmetic applications with particular attention to discrepancies between peer-reviewed data and commercial claims.Methods: The 6 most frequently targeted conditions were selected for analysis. A PubMed search was conducted to identify peer-reviewed studies evaluating RLT for cosmetic dermatologic indications. For each condition, the available evidence was synthesized and compared with claims made by leading commercial RLT devices.Results: Evidence supports RLT as a safe adjunctive therapy for select indications, including acne, androgenetic alopecia, mild photoaging, and wound healing, where modest and gradual improvements are observed with consistent, maintenance-based use. In contrast, marketing materials frequently exaggerate the speed, magnitude, and durability of clinical benefit, portraying RLT as a universal or transformative solution.Conclusion: RLT represents a biologically plausible and low-risk adjunct in cosmetic dermatology, but current consumer-facing narratives often exceed the available evidence.","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"793-797"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eyebrow Madarosis: An Updated Review of the Etiology and Management, Part II- Scarring Disorders. 眉毛肥大症：病因和治疗的最新综述，第二部分-疤痕障碍。

IF 2.2 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-09-01 DOI: 10.36849/JDD.9874

Janaya Nelson, Adam Friedman

{"title":"Eyebrow Madarosis: An Updated Review of the Etiology and Management, Part II- Scarring Disorders.","authors":"Janaya Nelson, Adam Friedman","doi":"10.36849/JDD.9874","DOIUrl":"https://doi.org/10.36849/JDD.9874","url":null,"abstract":"Background: Eyebrows play an essential role in facial symmetry, communication, and aesthetic identity. Scarring eyebrow alopecia results from inflammatory, autoimmune, infectious, genetic, traumatic, and iatrogenic processes that irreversibly damage follicular stem cells and limit regrowth potential. Despite its clinical and psychosocial impact, evidence-based guidance for diagnosis and management remains limited.Methods: A comprehensive PubMed search (1960–2025) was performed using terms related to \"eyebrow alopecia,\" \"eyebrow madarosis,\" and etiology-specific conditions. English-language original studies evaluating eyebrow involvement and reporting diagnostic or therapeutic outcomes were included. Review articles without original patient data and studies limited to scalp alopecia were excluded.Results: Scarring eyebrow alopecia included autoimmune conditions such as discoid lupus erythematosus and localized scleroderma; infectious etiologies such as lepromatous leprosy; genetic disorders including keratosis follicularis spinulosa decalvans; and inflammatory dermatoses such as ulerythema ophryogenes. Additional causes included radiation therapy, trauma, and hematologic malignancies. Reported treatments included corticosteroids, calcineurin inhibitors, antimalarials, methotrexate, mycophenolate, retinoids, JAK inhibitors, phototherapy, and reconstructive approaches. Emerging therapies, including biologics and regenerative techniques, have shown limited but evolving benefit.Conclusion: Scarring eyebrow madarosis involves diverse irreversible etiologies. Early diagnosis and etiology-directed treatment are essential to limit progression, highlighting the need for standardized management algorithms and eyebrow-specific outcome measures. &nbsp.","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"852-856"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body Contouring By Ultrasound-Induced Lipolysis. 通过超声诱导的脂肪分解来塑造身体轮廓。

IF 2.2 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-09-01 DOI: 10.36849/JDD.9711

Gerta Kapxhiu, Anna Blokh, Arie Orenstein

{"title":"Body Contouring By Ultrasound-Induced Lipolysis.","authors":"Gerta Kapxhiu, Anna Blokh, Arie Orenstein","doi":"10.36849/JDD.9711","DOIUrl":"https://doi.org/10.36849/JDD.9711","url":null,"abstract":"Background: The body contouring market has undergone a paradigm shift from invasive surgical procedures to advanced noninvasive treatments. Noninvasive fat-reducing devices based on nonfocused ultrasound waves induce lipolysis and ultimately reduce body fat, with minimal discomfort and downtime.Methods: A dosimetry analysis was conducted on skin of domesticated pigs to increasing doses of low-intensity ultrasound, followed by histological analysis of skin biopsies collected up to 14 days post-treatment. The clinical impact of ultrasound was retrospectively assessed by comparing skin laxity in before-and-after photographs of abdominal and facial regions subjected to up to 8 treatment sessions, at 7- to 14-day intervals. Circumference reduction and patient-rated pain and satisfaction levels were extracted from patient records.Results: Histological analysis of pig biopsy samples identified that treatment with ultrasound damages subcutaneous fat at cellular and tissue levels, without impact on neurovascular bundles, epidermal or dermal layers. Seventy-four (74) patients were treated in facial (2.3%) or abdominal, buttocks, or thigh (79.7%) areas, and followed up for 2 to 3 weeks after the last session. The ultrasound regimen induced a significant reduction in abdominal circumference (2.6±1.2 cm). Physician-rated improvements were significant in 57.9% of patients treated at the abdomen, trunk, or thighs, and 20.0% (3/15) of facial areas, with a positive correlation found between degree of improvement, number of sessions (rs=0.365, P=.002), and inter-session interval length (rs=0.257, P=.003). Treatment was highly tolerable, and patients were very satisfied with the outcomes.Conclusion: Nonfocused ultrasound is a safe and effective technology to reduce body fat, particularly in the abdominal area. &nbsp.","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 9","pages":"847-851"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hidradenitis Suppurativa in Psoriasis Patients Treated With Biologics. 生物制剂治疗银屑病患者的化脓性汗腺炎。

IF 2.2 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-08-01 DOI: 10.36849/JDD.9592

Dennis Chu, William Guo, Matthew Chen, James Briley

引用次数: 0

Reining in Medicare Spending on Skin Substitutes: What the 2026 Reforms Mean for Dermatology. 控制医疗保险在皮肤替代品上的支出：2026年的改革对皮肤病学意味着什么。

IF 2.2 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-08-01 DOI: 10.36849/JDD.10171

Kelly McCoy, Mustufa Jafry, C William Hanke

引用次数: 0

Decreased Nonmelanoma Skin Cancer Risk With Interleukin-17 and Interleukin-23 Inhibitors Versus TNF-α Inhibitors in Psoriasis. 白介素-17和白介素-23抑制剂与TNF-α抑制剂在银屑病中降低非黑色素瘤皮肤癌风险。

IF 2.2 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-08-01 DOI: 10.36849/JDD.9449

Brad R Woodie, Justin A Freking, Gabrielle M Rivin, Alan B Fleischer

{"title":"Decreased Nonmelanoma Skin Cancer Risk With Interleukin-17 and Interleukin-23 Inhibitors Versus TNF-α Inhibitors in Psoriasis.","authors":"Brad R Woodie, Justin A Freking, Gabrielle M Rivin, Alan B Fleischer","doi":"10.36849/JDD.9449","DOIUrl":"https://doi.org/10.36849/JDD.9449","url":null,"abstract":"Background: People with psoriasis are at increased risk for nonmelanoma skin cancers (NMSC) and melanoma. Conventional immunosuppressants and TNF-α inhibitors may further increase skin malignancies, while the risks associated with other biologics are less clear. This study aimed to determine skin malignancy risks in psoriasis patients treated with cyclosporine, methotrexate, TNF-α inhibitors, IL-12/23, IL-17, and IL-23 inhibitors.Methods: Using the TriNetX database, psoriasis patients without skin cancer risk factors who received at least 2 years or at least 5 years of systemic treatment were compared with non-systemically treated psoriasis patients. Cyclosporine, methotrexate, and TNF-α inhibitors were also compared with other psoriasis biologics. NMSC and melanoma over 2 and 5 years were evaluated using multivariable Cox proportional hazards.Results: Compared with non-systemically treated psoriasis patients, cyclosporine, methotrexate, TNF-α inhibitors, and the IL-12/23 inhibitor showed increased NMSC risk, whereas IL-17 inhibitors demonstrated a reduced risk. Compared with patients treated with cyclosporine, methotrexate, and TNF-α inhibitors, both IL-17 and IL-23 inhibitors demonstrated a reduced NMSC risk. Only cyclosporine was associated with elevated melanoma risk. The present study is limited by unmeasured factors, including psoriasis severity, ultraviolet radiation exposure, medication adherence, and dosing.Conclusions: Systemic therapies for psoriasis vary in skin malignancy risk, with IL-17 and IL-23 inhibitors having the lowest NMSC risk. &nbsp.","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 8","pages":"695-700"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148678992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Intermittent Fasting, Keto Diet vs Continuous Caloric Restriction on Psoriasis Severity: A Systematic Review and Meta-Analysis Protocol. 间歇性禁食、生酮饮食与持续热量限制对银屑病严重程度的影响：一项系统评价和荟萃分析方案。

IF 2.2 4区医学

Journal of Drugs in Dermatology Pub Date : 2026-08-01 DOI: 10.36849/JDD.9706

Ahmed N Alqefari, Hanadi M Almutairi, Mohammed Yousef Almohaimeed, Abdulelah Abdulhadi Aldossari, Ghaida Alqefari, Abdullah Alsaleam, Abdullateef A Alzolibani, Meshal Alhameedy

{"title":"Impact of Intermittent Fasting, Keto Diet vs Continuous Caloric Restriction on Psoriasis Severity: A Systematic Review and Meta-Analysis Protocol.","authors":"Ahmed N Alqefari, Hanadi M Almutairi, Mohammed Yousef Almohaimeed, Abdulelah Abdulhadi Aldossari, Ghaida Alqefari, Abdullah Alsaleam, Abdullateef A Alzolibani, Meshal Alhameedy","doi":"10.36849/JDD.9706","DOIUrl":"10.36849/JDD.9706","url":null,"abstract":"Background: Psoriasis is a chronic immune‑mediated inflammatory skin disease that is strongly associated with metabolic dysregulation and excess adiposity. Dietary strategies that reduce energy intake either by continuous daily caloric restriction (CCR) or time‑limited/periodic intake such as intermittent fasting (IF) or ketogenic diets (Keto) may improve psoriasis severity through weight loss, metabolic improvements, alterations in gut microbiota, and immune-metabolic effects.Objective: We aimed to compare the therapeutic effectiveness of IF, Keto, and CCR in reducing the severity of psoriasis.Methods: This study was designed as a systematic review and Meta Analysis. The clinical parameters such as psoriasis extent and outcome measures were evaluated at baseline at different follow up timeframes across studies. Outcome measures were assessed by changes in Psoriasis Area and Severity Index (PASI) scores, quality of life (dermatology life quality index [DLQI]), and metabolic scores.Results: There was a significant PASI decrease in Keto and CCR cohorts (10-25.6 kg weight loss) compared with IF (0-2kg weight loss). No serious adverse effects were recorded in all interventions.Limitations: The major limitations were study heterogeneity, lack of head-to-head comparisons, and follow up.Conclusion: CCR and Keto performed better than IF in managing psoriasis severity, suggesting personalized dietary routines as adjuncts to treatment. &nbsp.","PeriodicalId":15566,"journal":{"name":"Journal of Drugs in Dermatology","volume":"25 8","pages":"742-748"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148678438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0